JP2022521721A - 生物学的材料の均質で再現性のある凍結・解凍のためのポータブルエアブラストシステム - Google Patents
生物学的材料の均質で再現性のある凍結・解凍のためのポータブルエアブラストシステム Download PDFInfo
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Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D17/00—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces
- F25D17/04—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces for circulating air, e.g. by convection
- F25D17/06—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces for circulating air, e.g. by convection by forced circulation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
- A01N1/0257—Stationary or portable vessels generating cryogenic temperatures
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0278—Physical preservation processes
- A01N1/0284—Temperature processes, i.e. using a designated change in temperature over time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
- A61M1/0277—Frames constraining or supporting bags, e.g. during freezing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2400/00—General features of, or devices for refrigerators, cold rooms, ice-boxes, or for cooling or freezing apparatus not covered by any other subclass
- F25D2400/20—Carts specially adapted for transporting objects to be cooled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2600/00—Control issues
- F25D2600/04—Controlling heat transfer
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Mechanical Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Combustion & Propulsion (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
Description
Claims (16)
- 容器内の生物学的溶液を凍結および解凍するポータブルエアブラストシステムであって、
壁を有するベントエンクロージャ;
側壁を有する容器を収容するように構成されたスタンド;および
少なくとも1つのファンを備え、
前記ファンが、前記容器の前記壁における熱伝導率を均一にするために、空気を前記ベントエンクロージャに通過させ;
前記ベントエンクロージャの前記壁と前記容器の前記側壁の距離は、前記容器の全ての前記側壁の周りで同様の垂直気流速度を確保するためにほぼ一定している、ポータブルエアブラストシステム。 - 前記垂直気流速度を制御するコントローラをさらに備える、請求項1に記載のポータブルエアブラストシステム。
- ファンエンクロージャをさらに備える、請求項2に記載のポータブルエアブラストシステム。
- 壁を有するベントエンクロージャ;
側壁を有する容器を収容するように構成されたスタンド;および
少なくとも1つのファンを備え、
前記スタンドと前記ベントエンクロージャの距離が1cm~10cmであり;
前記容器の前記壁における熱伝導率を均一にするために、前記ファンが空気を前記ベントエンクロージャに通過させ;
前記ベントエンクロージャの前記壁と前記容器の前記側壁の距離は1cm~10cmであり、前記容器の全ての前記側壁の周りで同様の垂直気流速度を確保するためにほぼ一定している、請求項1~3のいずれか一項に記載のポータブルエアブラストシステム。 - 前記スタンドは、該スタンドを前記ベントエンクロージャに接続するためのソリッドベースおよびピンをさらに備える、請求項1~4のいずれか一項に記載のポータブルエアブラストシステム。
- 前記スタンドは、前記容器の位置が前記ベントエンクロージャの中央に維持できるように構成される、請求項1~5のいずれか一項に記載のポータブルエアブラストシステム。
- 前記スタンドと前記ベントエンクロージャの距離が2cm~5cmである、請求項1~6のいずれか一項に記載のポータブルエアブラストシステム。
- 前記ベントエンクロージャの前記壁と前記容器の前記側壁の距離が、1cm~3cmで、前記容器の全ての前記側壁の周りで同様の垂直気流速度を確保するためにほぼ一定している、請求項1~7のいずれか一項に記載のポータブルエアブラストシステム。
- 前記垂直気流速度は約0.5m/s~約20m/s、好適には約1m/s~約10m/s、より好適には約2m/s~約8m/sである、請求項1~8のいずれか一項に記載のポータブルエアブラストシステム。
- 前記システムは硬質素材、好適にはプラスチック、より好適にはポリマーで作られる、請求項1~9のいずれか一項に記載のポータブルエアブラストシステム。
- 前記ファンは前記ファンエンクロージャ内に配置される、請求項1~10のいずれか一項に記載のポータブルエアブラストシステム。
- 前記ファンは軸流ファンである、請求項1~11のいずれか一項に記載のポータブルエアブラストシステム。
- 請求項1~12のいずれか一項に記載のポータブルエアブラストシステムを使用して容器内の生物学的溶液を凍結および解凍する方法であって、
生物学的溶液の充填された容器を得るステップ;
前記容器を前記ベントエンクロージャ内および前記エアブラストシステムの前記スタンド上に設置するステップ;
前記エアブラストシステムを前記容器と共に加熱または冷却チャンバ内に設置するステップ;および
前記エアブラストシステム内の前記ファンを起動させて前記エアブラストシステムを起動させるステップを含む方法。 - 複数のエアブラストシステムをチャンバ内に設置するステップをさらに含む、請求項13に記載の容器内の生物学的溶液を凍結および解凍する方法。
- 前記容器の位置は前記ベントエンクロージャの中央に維持される、請求項13に記載の容器内の生物学的溶液を凍結および解凍する方法。
- 各エアブラストシステムは、該エアブラストシステムの前記ベントの外側の空気の速度が0.05m/s~1m/s、好適には0.1m/s~0.5m/sになるように、互いに距離を置いて設置される、請求項14に記載の容器内の生物学的溶液を凍結および解凍する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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PT115345 | 2019-02-27 | ||
PT11534519 | 2019-02-27 | ||
PCT/IB2020/051479 WO2020174338A1 (en) | 2019-02-27 | 2020-02-21 | Portable air blast system for homogeneous and reproducible freezing and thawing of biological materials |
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JP2022521721A true JP2022521721A (ja) | 2022-04-12 |
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Country Status (6)
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US (1) | US20220136757A1 (ja) |
EP (1) | EP3930658A1 (ja) |
JP (1) | JP2022521721A (ja) |
CN (1) | CN113473959A (ja) |
CA (1) | CA3131492A1 (ja) |
WO (1) | WO2020174338A1 (ja) |
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GB201721824D0 (en) * | 2017-12-22 | 2018-02-07 | Asymptote Ltd | Apparatus and methods relating to freezing at least part of a biological sample |
US20240099937A1 (en) * | 2021-01-20 | 2024-03-28 | Smartfreez, Lda | Multi-purpose single-use transporter for biopharmaceutical solutions |
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US6684646B2 (en) * | 2001-05-22 | 2004-02-03 | Integrated Biosystems, Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical material |
GB2390418B (en) * | 2002-03-27 | 2005-10-12 | Dyson Ltd | Refrigerating apparatus |
US7343748B2 (en) * | 2005-12-29 | 2008-03-18 | Whirlpool Corporation | Device for rapidly chilling articles in a refrigerator |
US8028532B2 (en) * | 2006-03-06 | 2011-10-04 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
WO2007125294A2 (en) * | 2006-04-25 | 2007-11-08 | Christopher Rusius | Cooling means |
GB201318405D0 (en) * | 2013-10-17 | 2013-12-04 | Gray David | A portable temperature controlled container |
KR102450661B1 (ko) * | 2015-10-16 | 2022-10-04 | 토키태 엘엘씨 | 온도-제어형 휴대형 냉각 유닛 |
US20170246084A1 (en) * | 2016-02-08 | 2017-08-31 | Sahar M. H Jaffal | Medical transport bag |
CA3060204A1 (en) | 2017-05-16 | 2018-11-22 | Smartfreez Lda | System for scale-down the processes of freezing and thawing aqueous solutions of thermo-sensitive pharmaceuticals |
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2020
- 2020-02-21 CA CA3131492A patent/CA3131492A1/en active Pending
- 2020-02-21 US US17/427,825 patent/US20220136757A1/en active Pending
- 2020-02-21 CN CN202080016797.8A patent/CN113473959A/zh active Pending
- 2020-02-21 WO PCT/IB2020/051479 patent/WO2020174338A1/en unknown
- 2020-02-21 JP JP2021547759A patent/JP2022521721A/ja active Pending
- 2020-02-21 EP EP20713368.7A patent/EP3930658A1/en active Pending
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Publication number | Publication date |
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EP3930658A1 (en) | 2022-01-05 |
CN113473959A (zh) | 2021-10-01 |
CA3131492A1 (en) | 2020-09-03 |
US20220136757A1 (en) | 2022-05-05 |
WO2020174338A1 (en) | 2020-09-03 |
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