JP2022520156A - 閉塞性睡眠時無呼吸の処置の為のシステム及び方法 - Google Patents
閉塞性睡眠時無呼吸の処置の為のシステム及び方法 Download PDFInfo
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Abstract
Description
本出願は、「脂肪組織の冷凍融解を利用する閉塞性睡眠時無呼吸の処置の為の器具及び方法(APPARATUS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA UTILIZING CRYOLYSIS OF ADIPOSE TISSUES)」の名称で2018年12月31日に出願された米国仮特許出願第62/787,125号と、「閉塞性睡眠時無呼吸の処置の為のシステム及び方法(SYSTEMS AND METHODS FOR TREATMENT OF OBSTRUCTIVE SLEEP APNEA)」の名称で2019年8月23日に出願された米国仮特許出願第62/890,884号との優先権を主張し、両出願は参照によりその全体が本明細書に援用される。
本明細書に言及される特許及び特許出願を含む全ての公報は、個々の公報がそれぞれ参照により具体的かつ個別的に指摘された場合と同じ程度に参照によりその全体が本明細書に援用される。
式1
により求められ、
Pはワットでの熱出力であり、
kは材料の伝導率であり、
Aは材料の断面であり、
Lは材料の長さであり、
ΔTは材料の二つの端部の間の温度差である。
式3
のハーゲン・ポアズイユの式により求められ、
φは流体流速であり、
ΔPはパイプの二つの端部の間の圧力差であり、
Dはパイプの内径であり、
μは流体の動的粘度であり、
Lはパイプの長さである。
102 口内アプリケータ
104 冷凍防止剤
106 温度判定手段
108 制御器
202 平坦底部アプリケータ
210 中空空洞
212 管材料
214 流路
302 アプリケータ
316 冷凍流体流入口
318 流出口
320 バッフル
402 アプリケータ
403 熱導体
406 熱抽出器
502 アプリケータ
506 外部冷却ユニット
508 ポンプ
510 導管
902 アプリケータ
910 組織接触表面
912 流入管路
914 流出管路
1102 貫通アプリケータ
1202 アプリケータ
1202a 遠位部分
1202b 近位部分
1203 貫通コンポーネント
1302 アプリケータ
1304 二段熱抽出器
1502 円筒形アプリケータ
1503 アプリケータ
1512 流入管路
1514 流出管路
1516 扁桃腺接触延出部
1518 口蓋垂接触部分
1520 接続部材部分
1602 バルーンアプリケータ
1612 流入管路
1614 流出管路
1622,1624 膨張構造
1702 アプリケータ
1713 流入/流出管路
1726 絶縁体
1902 アプリケータ
1913 流入/流出管路
2302 アプリケータ
2330 力センサ
2432 温度センサ
3334 中実伝導体
3412 流入管路
3414 流出管路
Claims (29)
- 閉塞性睡眠時無呼吸の処置の為の装置であって、
冷却流体を加冷する為の冷却ユニットと、
前記冷却流体を受容するように構成されるアプリケータであって、複数の冷凍治療針を有する遠位部分と近位部分とを包含するアプリケータであり、前記複数の冷凍治療針が、対象者の舌の背面部分へ挿入されるように形成及び構成され、前記近位部分が、前記舌の隣接部分と接触するように形成及び構成される、アプリケータと、
前記アプリケータと前記冷却流体との間での熱伝達を促進するように構成される再循環導管と、
を包含し、
前記アプリケータと前記冷却ユニットとが、前記舌の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記舌の冷却を協働的に行うことにより前記脂肪組織の体積を減少させるように構成される、
装置。 - 前記複数の冷凍治療針が平面構成で配置される、請求項1に記載の装置。
- 前記複数の冷凍治療針が三次元構成で配置される、請求項1に記載の装置。
- 前記遠位部分が湾曲している、請求項1に記載の装置。
- 前記近位部分が湾曲している、請求項1に記載の装置。
- 前記遠位部分が実質的に平坦である、請求項1に記載の装置。
- 前記近位部分が実質的に平坦である、請求項1に記載の装置。
- 前記冷却流体が、前記複数の冷凍治療針の中で循環するように構成される、請求項1に記載の装置。
- 前記冷却ユニットが二段冷却ユニットを包含する、請求項1に記載の装置。
- 前記二段冷却ユニットが更に、
加冷器と第1流体回路とポンプとを有する第1段と、
ポンプと第2流体回路とを有する第2段と、
前記第1段と前記第2段との間に配設されるペルティエブースタと、
を包含する、請求項9に記載の装置。 - 対象者の閉塞性睡眠時無呼吸を処置する為の方法であって、
閉塞性睡眠時無呼吸を患う対象者の顎下三角から前記対象者の中咽頭組織へ貫通冷却装置を挿入するステップと、
前記中咽頭組織の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記貫通冷却装置を冷却するステップと、
前記中咽頭組織の中の前記脂肪組織の体積を減少させるステップと、
を包含する方法。 - 中咽頭組織の標的面が軟口蓋、口蓋垂、舌、又は咽頭壁のうち一以上を含む、請求項11に記載の方法。
- およそ1分とおよそ100分との間にわたって前記中咽頭組織の表面との接触状態に載置されて前記中咽頭組織の中の脂肪組織の冷凍融解を起こすように前記冷却面が構成される、請求項11に記載の方法。
- 前記中咽頭組織の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたる前記閉塞性睡眠時無呼吸を患う対象者の前記中咽頭組織又は前記下層組織の前記標的面の冷却が、約0℃と体温との間の温度に前記脂肪組織を冷却することを含む、請求項11に記載の方法。
- 前記貫通冷却装置が、冷却流体を加冷する為の冷却ユニットとの流体連通状態にあり、前記貫通冷却装置の冷却に先立って前記冷却ユニットで前記冷却流体を加冷することを更に包含する、請求項11に記載の方法。
- 前記中咽頭組織の表面に冷凍防止剤を塗着することを更に包含する、請求項11に記載の方法。
- 閉塞性睡眠時無呼吸の処置の為の装置であって、
冷却流体を加冷する為の冷却ユニットと、
前記冷却流体を受容するように構成されるアプリケータであって、口蓋垂の上にアプリケータが載置された時に睡眠時無呼吸を患う対象者の前記口蓋垂を受容するように構成される中空円筒形状を包含するアプリケータと、
前記アプリケータと前記冷却流体との間での熱伝達を促進するように構成される再循環導管と、
を包含し、
前記アプリケータと前記冷却ユニットとが、前記口蓋垂の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記口蓋垂の冷却を協働的に行うことにより前記脂肪組織の体積を減少させるように構成される、
装置。 - 閉塞性睡眠時無呼吸の処置の為の装置であって、
冷却流体を加冷する為の冷却ユニットと、
前記冷却流体を受容するように構成されるアプリケータであって、対象者の口腔の口蓋垂と一以上の扁桃腺と一以上の脂肪体とを同時に接触するように形成及び構成されるアプリケータと、
前記アプリケータと前記冷却流体との間での熱伝達を促進するように構成される再循環導管と、
を包含し、
前記アプリケータと前記冷却ユニットとが、前記口蓋垂と前記一以上の扁桃腺と前記一以上の脂肪体の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記口蓋垂と前記一以上の扁桃腺と前記一以上の脂肪体との冷却を協働的に行うことにより前記脂肪組織の体積を減少させるように構成される、
装置。 - 前記アプリケータが一対の扁桃腺接触延出部を前記アプリケータの各側に包含する、請求項18に記載の装置。
- 前記アプリケータが口蓋垂接触部分を包含する、請求項19に記載の装置。
- 前記口蓋垂接触部分が円筒形状を包含する、請求項20に記載の装置。
- 前記扁桃腺接触部分と前記口蓋垂接触部分との間の一対の接続部材部分を更に包含する、請求項20に記載の装置。
- 閉塞性睡眠時無呼吸の処置の為の装置であって、
冷却流体を加冷する為の冷却ユニットと、
対象者の中咽頭組織と接触するように構成される膨張式アプリケータであって、前記冷却流体を受容するように構成される治療部分と、前記冷却流体を受容しない絶縁部分とを有する膨張式アプリケータと、
前記アプリケータの前記治療部分と前記冷却流体との間での熱伝達を促進するように構成される再循環導管と、
を包含し、
前記アプリケータの前記治療部分と前記冷却ユニットとが、前記中咽頭組織の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記対象者の前記中咽頭組織の冷却を協働的に行うことにより前記脂肪組織の体積を減少させるように構成される、
装置。 - 対象者の閉塞性睡眠時無呼吸を処置する為の方法であって、
閉塞性睡眠時無呼吸を患う対象者の中咽頭組織に膨張式アプリケータを適用するステップと、
前記中咽頭組織の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記膨張式アプリケータの治療部分に冷却流体を適用するステップと、
前記中咽頭組織の中の前記脂肪組織の体積を減少させるステップと、
前記膨張式アプリケータの絶縁部分で前記中咽頭組織の標的箇所を絶縁するステップと、
を包含する方法。 - 対象者の閉塞性睡眠時無呼吸を処置する為の方法であって、
閉塞性睡眠時無呼吸を患う対象者の中咽頭組織にアプリケータを適用するステップと、
前記アプリケータの一以上の力センサで前記中咽頭組織の一以上の箇所に前記アプリケータにより印加される力を測定するステップと、
測定された前記力に基づいて前記アプリケータにより前記中咽頭組織に印加される力を調節するステップと、
前記中咽頭組織の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記アプリケータに冷却流体を適用するステップと、
前記中咽頭組織の中の前記脂肪組織の体積を減少させるステップと、
を包含する方法。 - 対象者の閉塞性睡眠時無呼吸を処置する為の方法であって、
閉塞性睡眠時無呼吸を患う対象者の中咽頭組織にアプリケータを適用するステップと、
前記アプリケータの一以上の温度センサで前記中咽頭組織の一以上の箇所の温度を測定するステップと、
前記中咽頭組織の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記アプリケータに冷却流体を適用するステップと、
前記中咽頭組織の中の前記脂肪組織の体積を減少させるステップと、
を包含する方法。 - 対象者の閉塞性睡眠時無呼吸を処置する為の方法であって、
閉塞性睡眠時無呼吸を患う対象者の中咽頭組織にアプリケータを適用するステップと、
前記中咽頭組織の中の脂肪組織の冷凍融解を起こすのに充分な時間にわたって前記アプリケータに冷却流体を適用するステップと、
前記中咽頭組織の中の前記脂肪組織の体積を減少させるステップと、
前記冷却流体の適用の直後に前記中咽頭組織を急速に加温して、前記中咽頭組織に隣接する粘膜層への損傷を防止するステップと、
を包含する方法。 - 前記冷却流体が5℃から-20℃の範囲の温度を有する、請求項27に記載の方法。
- 前記急速加温ステップが前記冷却流体を加熱することを包含する、請求項27に記載の方法。
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US20160354234A1 (en) * | 2012-12-14 | 2016-12-08 | Zoll Circulation, Inc. | System And Method For Management Of Body Temperature |
US20170246032A1 (en) * | 2014-10-01 | 2017-08-31 | Cryosa, Llc | Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues |
WO2018044825A1 (en) * | 2016-08-30 | 2018-03-08 | The General Hospital Corporation | Cryotherapy and cryoablation systems and methods for treatment of tissue |
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CA3125291A1 (en) | 2020-07-09 |
EP3905976A4 (en) | 2022-09-21 |
WO2020142519A1 (en) | 2020-07-09 |
EP3905976A1 (en) | 2021-11-10 |
US20220071802A1 (en) | 2022-03-10 |
AU2019419502A1 (en) | 2021-07-22 |
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