JP2022509359A - 生体内での最適な真皮白色脂肪組織形成を促進するための局所組成物および方法 - Google Patents
生体内での最適な真皮白色脂肪組織形成を促進するための局所組成物および方法 Download PDFInfo
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Abstract
Description
本出願は、その全体が参照により本明細書に明示的に組み込まれる2018年10月26日に出願された米国仮出願第62/751,222号に対する優先権およびその利益を主張する。
本発明の分野
発明の要約
本発明の他の実施形態では、組成物を塗布した後、体積欠損の外観の目に見える減少がある。本発明の他の実施形態では、組成物を塗布した後に、たるみの外観または体積過剰の外観の目に見える減少、またはその両方が見られる。本発明の他の実施形態では、皮膚外観の改善は、日光暴露、体重減少、体重増加または身体運動によって部分的に必然的に生じる。本発明のいくつかの実施形態では、眼窩周囲部、頬骨領域、顔面の頬上部領域に組成物を塗布した後、顔面の空洞の外観の目に見える減少がある。本発明のいくつかの実施形態では、頬骨領域の端部、眼窩周囲部、頬上部、頬下部、または下顎の輪郭に、たるみの外観の目に見える減少または改善がある。
Claims (43)
- 皮膚の外観改善に有効な局所組成物であって、少なくとも1つの脂肪生成成分、少なくとも1つの脂肪分解剤および少なくとも1つの浸透剤を含み、前記改善が、体積欠損の外観の改善を含む、上記組成物。
- 皮膚の外観改善に有効な局所組成物であって、少なくとも1つの脂肪生成成分、少なくとも1つの脂肪分解剤および少なくとも1つの浸透剤を含み、前記改善が、たるみの外観の改善を含む、上記組成物。
- 日焼け、体重増加、体重減少または身体運動によって引き起こされる皮膚の損傷を防止するのに有効な局所組成物であって、少なくとも1つの脂肪生成成分、少なくとも1つの脂肪分解剤および少なくとも1つの浸透剤を含み、前記防止されるべき損傷が皮膚脂肪細胞数の減少およびそれらの肥大に関連する、上記組成物。
- 前記体積欠損の外観の改善が、体積過剰の外観の増加を引き起こすことなく発生する、請求項1に記載の局所組成物。
- 前記体積欠損の外観の改善が、たるみの外観の改善とともに発生する、請求項1に記載の局所組成物。
- 前記外観改善が、顔に発生する、請求項1に記載の局所組成物。
- 前記体積欠損の改善が、眼窩周囲部の体積の増加を含む、請求項1に記載の局所組成物。
- 前記体積欠損の改善が、頬骨に沿った体積の増加を含む、請求項1に記載の局所組成物。
- 前記体積欠損の改善が、頬上部の体積の増加を含む、請求項1に記載の局所組成物。
- 前記たるみの外観の改善が、頬下部の鼻唇溝に近接した部分の体積の減少を含む、請求項2に記載の局所組成物。
- 前記たるみの外観の改善が、頬骨下の頬上部の体積の増加を含む、請求項2に記載の局所組成物。
- 前記たるみの外観の改善が、頬中部の窪みの体積の増加を含む、請求項2に記載の局所組成物。
- 前記少なくとも1つの脂肪生成成分が、炭素鎖長が18以上の天然由来の不飽和脂肪酸からなる群から選択される、請求項1に記載の局所組成物。
- 前記少なくとも1つの脂肪生成成分が、アクレアチン、アスコルビン酸、黒大豆エキス、クロロゲン酸、シナニッケイエキス、セイロンニッケイエキス、シンナムタンニンB1、ダイダイエキス、ロマティウム・スクスドルフ(Lomatium suksdorfii)エキス、メラトニン、フィトール、シネンセチン、スクスドルフィン、ミズレンブ葉エキスおよびサルカケミカンエキスからなる群から選択される、請求項1に記載の局所組成物。
- 前記少なくとも1つの脂肪生成成分が、(2S)-7,4’-ジヒドロキシ-8-プレニルフラバン、モスル・ユンナネンシス(Morus yunnanensis)エキス、3-ブチルヒドロキシアニソール、4-メトキシカルコン、ハナスゲエキス、アルテミシア・サントリニフォリア(Artemisia santolinifolia)エキス、ハマヨモギ、ババキン、ハウチワノキエキス、オオバノボタン属エキス、パイパー・チャバ果実エキス、フロレチン、オランダビユ果実エキス、セージエキス、サクラネチン、サルサポゲニン(Sarsapogenin)、テンヨウケンコウシエキスおよびバナジウムからなる群から選択される、請求項1に記載の局所組成物。
- 前記少なくとも1つの脂肪生成成分が、10-oxo-l2(Z)-オクタデセン酸、13-Oxo-9(Z),ll(E),l5(Z)-オクタデカトリエン酸、l5-(S)-ヒドロキシエイコサテトラエン酸、アクリルアミド、センダングサ属エキス、ブラジル産レッドプロポリスエキス、ブチルヒドロキシアニソール、ケブラジン酸、クロレラ・ブルガリスエキス、ノアザミエキス、シアニジン-3-グルコシド、ダイゼイン、ジアリルジスルフィド、エキナセア・プルプレア根エキス、エモジン、フラバノン、フラン脂肪酸9M5、ゲラニルゲラニオール、ジンセノサイド20S-プロトパナキサトリオール、ジンセノサイドRbl、ジンセノサイドRe、ジンセノサイドRh2、グラブリジン、へラクレウム・ディセクタム(Heracleum dissectum Lebb)エキス、硫化水素、シキミエキス、カバノアナタケエキス、イソインペラトリン、乳酸、レシチン、甘草エキス、ネズミムギエキス、モリンガ・コンカネンシス(Moringa concanensis nimmo)エキス、N-オレイルグリシン、ホシザキスイレン(N. nouchali)種子エキス、ノルウォゴニン、キョウカツ(Notopterygium incisum)根エキス、パルミトイル乳酸、ペンタメチルケルセチン、フェニル乳酸、キニーネ、レトロフラクタミドA、ショウヨウダイオウ(Rheum palmatum L)根茎、S-アデノシルメチオニン、サンゲンノール(Sangennol)F、エゾノネジモクエキス、大豆ピニトール、スペルミジン、テクトクリシン、ミロバラン果実エキス、テトラセラ・インディカ(Tetracera indica merr.)エキス、テトラメチルケンペロール、ウンベリフェロン、ワカメエキス、ビタミンB3およびビタミンB6からなる群から選択される、請求項1に記載の局所組成物。
- 前記少なくとも1つの脂肪分解成分が、アスコルビン酸、ブチレート、クリサンセマムエキス、クロロゲン酸、ダイダイエキス、エイコサペンタエン酸、没食子酸、ヒドロコルチゾン、酢酸ヒドロコルチゾン、酪酸ヒドロコルチゾン、INDUS810、黒ショウガエキス、リコピン、マグノロール、コウボクエキス、ヤマグワエキス、クズ根エキス、レスベラトロール、チョウセンゴミシエキス、酪酸ナトリウム、ソレノステムマ・アーゲル(Solenostemma argel)エキス、ミズレンブエキス、フェヌグリーク(T. foenum graecum)種子エキス、リン酸トリフェニルおよびチラミンからなる群から選択される、請求項1に記載の局所組成物。
- 前記少なくとも1つの脂肪分解剤が、黒ショウガエキスである、請求項17に記載の局所組成物。
- 前記少なくとも1つの脂肪分解成分が、3-ヨードチロナミン、ベルノキ葉エキス、アネクトキルス・フォルモサヌス(Anoectochilus formosanus)エキス、アルギニン、ニガキモドキエキス、ブルセインA、ブルセインB、ブルセインC、3′-ヒドロキシブルセインA、ブルサトール、ブルセアンチノール、エビスグサ種子エキス、ツボクサ葉エキス、カンランエキス、サイロピア・マクラータ(Cyclopia maculata)エキス、発酵したクリ(castanea crenata)内殻エキス、フォルスコリン、サンシンエキス、ゲニピン、ヘメロカリスフルバエキス、マンシュウグルミエキス、リカリンA、ライチ果実エキス、マグネシウム、リンゴ酸、オカダ酸、ペシロマイセスヘピアリ菌糸体エキス、パルミトレイン酸、インゲンマメエキス、ポシドニア・オセアニカ(Posidonia oceanica (L.) delile)エキス、コタラヒムブツ(Salacia (S.) reticulata)エキス、ナマコサポニンエキノシドA、サルトリイバラ葉エキス、大豆加水分解物、ソヤサポゲノールA、ソヤサポゲノールB、オクトパミン、N-メチルチラミン、ムラサキフトモモ、TAT-グリシン-リジン-ヒスチジン複合体、テルミナリアセリセアエキス、チャンチンエキスおよびイヌザンショウ種油からなる群から選択される、請求項1に記載の局所組成物。
- 前記少なくとも1つの脂肪分解成分が、アセチル-ケト-β-ボスウェル酸、熟成黒ニンニクエキス、アーモンド皮エキス、アンディローバエキス、アピゲニン、リンゴエキス、イワヨモギエキス、アスチルベ・シネンシス(Astilbe chinensis Franch. et Savet.)エキス、シラカンバ樹皮、B.プラチフィロシド、ベルベリン、ベルガモチン、ベツリン酸、ビロバライド、黒あずきエキス、紅茶エキス、ブラッシカ・カンペストリス(Brassica campestris spp. rapa)根エキス、カフェイン、カプサンチン、トウガラシ種油、カプサイシン、カルニチン,キトサン、クリソファノール、シンナムアルデヒド、シルシマリン、コウライアザミ(Cirsium setidens nakai)エキス、ベルガモットエキス、ウンシュウミカンエキス、クローブエキス、コーヒーエキス、コミフォーラ・ムーカル(Commiphora mukul)、クロシン、ニホンカボチャエキス、ウコンエキス、ハニーブッシュ(Cyclopia intermedia)、エピガロカテキンガラート、ユーグレナ、ユーリコマノン(Eurycomanone)、ナガエカサエキス、フコイダン、フコキサンチン、ブラダーラック(Fucus vesiculosus)エキス、ガルシニア(Garcinia gummi-gutta)エキス、テングサエキス、ゲニステイン、発芽大豆タンパク質加水分解産物、イチョウエキス、ジンセノシドRgl、ゴミシン、ブドウ種子エキス、ブドウ果皮エキス、緑茶エキス、カナムグラ、ヒドロキシチロソール、ヒドロキシサフロールイエローA、イソプロピルノルシネフィリン、ケンペロール、韓国Chungtaejeon茶エキス、リポ酸、ハス葉エキス、ハス種子エキス、ルテオリン、霊香草(Lysimachia foenum-graecum)エキス モリンガ種子エキス、モルシン、バナナパルプエキス、ミリカノール、ナリンゲニン-7-O-グルコシド、ニュージーランドブラックカラントエキス、オレアノール酸、オレオレジンカプシカム,
オレウロペイン、P-シネフリン、梨の搾りかすエキス、梅エキス、ソバ、プテロスチルベン、ピクノジェノール、クェルセチン、キナ酸、ラズベリーケトン、セイヨウヤブイチゴエキス、紫芋エキス、ルチン、カラコトジソウエキス、セリコシド、シネンセチン、スピラントール、ステムブロメラインエキス、チョウセンニンジンエキス、シネフリン、シリング酸、タンシノンIIA、セイヨウタンポポエキス、トリアムシノロンアセトニド、ウルソール酸、ビタミンD、ウィドロール、ザンシゲンおよびキサントフモールから選択される、請求項1に記載の局所組成物。 - 前記少なくとも1つの浸透剤が、尿素、イミド尿素、パルミテート、イソプロピルパルミテート、ミリスチン酸イソプロピル、プロピレングリコール、および非イオン性洗剤からなる群から選択される、請求項1に記載の局所組成物。
- 前記炭素鎖長が18以上の天然由来の不飽和脂肪酸が、組成物中に約5%(w/w)から約40%(w/w)存在する、請求項13に記載の局所組成物。
- 前記浸透剤が約5%(w/w)から約25%(w/w)の割合で組成物中に存在する、請求項1に記載の局所組成物。
- 組成物中に存在する脂肪生成成分の重量%が、組成物中に存在する脂肪分解剤の重量%よりも大きい、請求項1に記載の局所組成物。
- 間接的な脂肪生成活性を有する薬剤をさらに含む、請求項1に記載の局所組成物。
- 間接的な脂肪分解活性を有する薬剤をさらに含む、請求項1に記載の局所組成物。
- 必要に応じて、皮下脂肪体積を増加もしくは減少させるのに有効な局所組成物であって、少なくとも1つの脂肪生成成分、少なくとも1つの脂肪分解剤、および少なくとも1つの浸透性薬剤を含む、上記組成物。
- 個人の皮膚の外観を改善する方法であって、脂肪分解活性を有する少なくとも1つの脂肪分解剤と、脂肪生成活性を有する少なくとも1つの脂肪生成成分と、少なくとも1つの浸透剤とを含む組成物を皮膚に局所的に適用することを含む、上記方法。
- 前記組成物が、ケラチンベースの皮膚表面の重なり合った領域に適用される、請求項28に記載の方法。
- 前記組成物が、太陽にさらされた体の部分に適用される、請求項28に記載の方法。
- 前記組成物が、顔に適用される、請求項29に記載の方法。
- 前記脂肪分解活性を有する脂肪分解剤が、脂肪生成活性を有する脂肪生成成分を含む組成物とは別に、組成物に含まれる、請求項28に記載の方法。
- 前記2つの別々の組成物の局所的な適用が、時間的に近接して、または調整されたレジメンの一部として行われる、請求項32に記載の方法。
- 顔の目窩周囲部、頬骨部および頬上部に組成物を適用した後に、窪みの外観に目に見える減少がある、請求項33に記載の方法。
- たるみの外観の目に見える減少または頬骨部、眼窩周囲部、頬上部、頬下部、または顎の輪郭の鮮明度の目に見える改善がある、請求項34に記載の方法。
- 皮膚の外観の改善が、日光暴露、体重増加、体重減少、または身体的な運動によって部分的に必要とされる、請求項35に記載の方法。
- 脂肪分解活性および脂肪生成活性を有する薬剤の組み合わせが、単一の組成物に含まれる、請求項28に記載の方法。
- 脂肪生成成分と脂肪分解剤の組み合わせを用いて、皮膚の外観の欠陥を治療または予防する方法。
- そのような治療または予防が、脂肪分解剤および脂肪生成成分を別々に含む2つ以上の組成物の使用を伴い、脂肪分解剤および脂肪生成成分を含む組成物が皮膚の同じ領域に適用されてもよい、請求項38に記載の方法。
- 個人がそれを必要とする皮膚の領域において体積の外観を増加させるため、および同じ個人がそれを必要とする皮膚の領域において体積の外観を減少させるための方法であって、個人の皮膚領域に、脂肪生成成分、脂肪分解剤および少なくとも1つの浸透剤を含む組成物を局所的に適用することを含む、上記方法。
- 個人がそれを必要としない皮膚の領域において体積の外観を増加させることなく、同じ個人がそれを必要とする皮膚の領域において体積の外観を増加させるための方法であって、個人の皮膚領域に、脂肪生成成分、脂肪分解剤および少なくとも1つの浸透剤を含む組成物を局所的に適用することを含む、上記方法。
- 個人がそれを必要としない皮膚の領域において体積の外観を減少させることなく、同じ個人がそれを必要とする皮膚の領域において体積の外観を減少させるための方法であって、個人の皮膚領域に、脂肪生成成分、脂肪分解剤および少なくとも1つの浸透剤を含む組成物を局所的に適用することを含む、上記方法。
- 個人がそれを必要とする皮膚の領域において脂肪組織の体積を増加させるため、および同じ個人がそれを必要とする皮膚の領域において脂肪組織の体積を減少させるための方法であって、個人の皮膚領域に、脂肪生成成分、脂肪分解剤および少なくとも1つの浸透剤を含む組成物を局所的に適用することを含む、上記方法。
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US5939082A (en) | 1995-11-06 | 1999-08-17 | The Procter & Gamble Company | Methods of regulating skin appearance with vitamin B3 compound |
US6361806B1 (en) * | 2000-02-23 | 2002-03-26 | Michael P. Allen | Composition for and method of topical administration to effect changes in subcutaneous adipose tissue |
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