JP2022503989A - 投薬量インジケータを有する薬物送達デバイス - Google Patents
投薬量インジケータを有する薬物送達デバイス Download PDFInfo
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Abstract
Description
2018年10月5日に出願された米国仮特許出願第62/742,066号明細書に付与された優先権が主張される。その内容全体はこの参照により本明細書に組み込まれる。
(i)米国特許出願公開第2006/0040358号明細書(2006年2月23日公開)、同第2005/0008642号明細書(2005年1月13日公開)、同第2004/0228859号明細書(2004年11月18日公開)に記載されている、例えば、抗体1A(DSMZ寄託番号DSM ACC 2586)、抗体8(DSMZ寄託番号DSM ACC 2589)、抗体23(DSMZ寄託番号DSM ACC 2588)、及び抗体18を含むが、これらに限定されない。
(ii)PCT国際公開第06/138729号パンフレット(2006年12月28日公開)及び同第05/016970号パンフレット(2005年2月24日公開)、及びLu et al.(2004),J.Biol.Chem.279:2856-2865に記載されている抗体2F8、A12、及びIMC-A12を含むが、これらに限定されない。
(iii)PCT国際公開第07/012614号パンフレット(2007年2月1日公開)、同第07/000328号パンフレット(2007年1月4日公開)、同第06/013472号パンフレット(2006年2月9日公開)、同第05/058967号パンフレット(2005年6月30日公開)、及び同第03/059951号パンフレット(2003年7月24日公開)。
(iv)米国特許出願公開第2005/0084906号明細書(2005年4月21日公開)に記載されている、抗体7C10、キメラ抗体C7C10、抗体h7C10、抗体7H2M、キメラ抗体*7C10、抗体GM607、ヒト化抗体7C10バージョン1、ヒト化抗体7C10バージョン2、ヒト化抗体7C10バージョン3、及び抗体7H2HMを含むが、これらに限定されない。
(v)米国特許出願公開第2005/0249728号明細書(2005年11月10日公開)、同第2005/0186203号明細書(2005年8月25日公開)、同第2004/0265307号明細書(2004年12月30日公開)、及び同第2003/0235582号明細書(2003年12月25日公開)、並びにMaloney et al.(2003),Cancer Res.63:5073-5083に記載されている抗体EM164、再表面構成EM164、ヒト化EM164、huEM164 v1.0、huEM164 v1.1、huEM164 v1.2、及びhuEM164 v1.3を含むが、これらに限定されない。
(vi)米国特許第7,037,498号明細書(2006年5月2日発行)、同第2005/0244408号明細書(2005年11月30日公開)及び同第2004/0086503号明細書(2004年5月6日公開)、並びにCohen,et al.(2005),Clinical Cancer Res.11:2063-2073に記載されている、ATCC受託番号PTA-2792、PTA-2788、PTA-2790、PTA-2791、PTA-2789、PTA-2793、及び抗体2.12.1、2.13.2、2.14.3、3.1.1、4.9.2、及び4.17.3を有するハイブリドーマによって産生された抗体の各々を含むが、これらに限定されない、例えば、抗体CP-751,871。
(vii)米国特許出願公開第2005/0136063号明細書(2005年6月23日公開)及び同第2004/0018191号明細書(2004年1月29日公開)に記載されている、抗体19D12、及び、番号PTA-5214でATCCに寄託された、プラスミド15H12/19D12HCA(γ4)におけるポリヌクレオチドによってコードされる重鎖と、番号PTA-5220でATCCに寄託された、プラスミド15H12/19D12LCF(κ)におけるポリヌクレオチドによってコードされる軽鎖とを含む抗体を含むが、これらに限定されない。
(viii)特にIGF-1受容体を標的とする前述の抗体、ペプチボディ、及び関連タンパク質などに関して参照により各々の全体が本明細書に組み込まれる、米国特許出願公開第2004/0202655号明細書(2004年10月14日公開)に記載されている、抗体PINT-6A1、PINT-7A2、PINT-7A4、PINT-7A5、PINT-7A6、PINT-8A1、PINT-9A2、PINT-11A1、PINT-11A2、PINT-11A3、PINT-11A4、PINT-11A5、PINT-11A7、PINT-11A12、PINT-12A1、PINT-12A2、PINT-12A3、PINT-12A4、及びPINT-12A5を含むが、これらに限定されない。
Activase(登録商標)(アルテプラーゼ、tPA)、Aranesp(登録商標)(ダルベポエチン)、Epogen(登録商標)(エポエチンアルファ、又はエリスロポエチン)、GLP-1、Avonex(登録商標)(インタフェロンベータ1a)、Bexxar(登録商標)(トシツモマブ、抗CD22モノクローナル抗体)、Betaseron(登録商標)(インタフェロン-ベータ)、Campath(登録商標)(アレムツズマブ、抗CD52モノクローナル抗体)、Dynepo(登録商標)(エポエチンデルタ)、Velcade(登録商標)(ボルテゾミブ)、MLN0002(抗α4β7 mAb)、MLN1202(抗CCR2ケモカイン受容体mAb)、Enbrel(エタネルセプト、TNF-受容体/Fc融合タンパク質、TNFブロッカ)、Eprex(登録商標)(エポエチンアルファ)、Erbitux(登録商標)(セツキシマブ、抗EGFR/HER1/c-ErbB-1)、Genotropin(登録商標)(ソマトロピン、ヒト成長ホルモン)、Herceptin(登録商標)(トラスツズマブ、抗HER2/neu(erbB2)受容体mAb)、Humatrope(登録商標)(ソマトロピン、ヒト成長ホルモン)、Humira(登録商標)(アダリムマブ)、インスリン溶液、Infergen(登録商標)(インタフェロンアルファコン-1)、Natrecor(登録商標)(ネシリチド、組み換えヒトB型ナトリウム利尿ペプチド(hBNP)、Kineret(登録商標)(アナキンラ)、Leukine(登録商標)(サルガモスチム、rhuGM-CSF)、LymphoCide(登録商標)(エプラツズマブ、抗CD22 mAb)、Benlysta(商標)(lymphostat B、ベリムマブ、抗BlySmAb)、Metalyse(登録商標)(テネクテプラーゼ、t-PA類似体)、Mircera(登録商標)(メトキシポリエチレングリコールエポエチンベータ)、Mylotarg(登録商標)(ゲムツズマブオゾガマイシン)、Raptiva(登録商標)(エファリズマブ)、Cimzia(登録商標)(セルトリズマブペゴル、CDP 870)、Soliris(商標)(エクリズマブ)、ペキセリズマブ(抗C5補体)、Numax(登録商標)(MEDI-524)、Lucentis(登録商標)(ラニビズマブ)、Panorex(登録商標)(17-1A、エドレコロマブ)、Trabio(登録商標)(lerdelimumab)、TheraCim hR3(ニモツズマブ)、Omnitarg(ペルツズマブ、2C4)、Osidem(登録商標)(IDM-1)、OvaRex(登録商標)(B43.13)、Nuvion(登録商標)(ビジリズマブ)、cantuzumab mertansine(huC242-DM1)、NeoRecormon(登録商標)(エポエチンベータ)、Neumega(登録商標)(オプレルベキン、ヒトインタロイキン-11)、Neulasta(登録商標)(PEG化フィルガストリム、PEG化G-CSF、PEG化hu-Met-G-CSF)、Neupogen(登録商標)(フィラグラスチム、G-CSF、hu-MetG-CSF)、Orthoclone OKT3(登録商標)(ムロモナブ-CD3、抗CD3モノクローナル抗体)、Procrit(登録商標)(エポエチンアルファ)、Remicade(登録商標)(インフリキシマブ、抗TNFαモノクローナル抗体)、Reopro(登録商標)(アブシキシマブ、抗GP llb/llia受容体モノクローナル抗体)、Actemra(登録商標)(抗IL6受容体mAb)、Avastin(登録商標)(ベバシズマブ)、HuMax-CD4(ザノリムマブ)、Rituxan(登録商標)(リツキシマブ、抗CD20 mAb)、Tarceva(登録商標)(エルロチニブ)、Roferon-A(登録商標)-(インタフェロンアルファ-2a)、Simulect(登録商標)(バシリキシマブ)、Prexige(登録商標)(ルミラコキシブ)、Synagis(登録商標)(パリビズマブ)、146B7-CHO(抗IL 15抗体、米国特許第7,153,507号明細書参照)、Tysabri(登録商標)(ナタリズマブ、抗α4integrin mAb)、Valortim(登録商標)(MDX-1303、抗B、炭そ菌防御抗原mAb)、ABthrax(商標)、Vectibix(登録商標)(パニツムマブ)、Xolair(登録商標)(オマリズマブ)、ETI211(抗MRSA mAb)、IL-1トラップ(ヒトIgG1のFc部及び両IL-1受容体成分(I型受容体と受容体補助タンパク質)の細胞外ドメイン)、VEGFトラップ(IgG1 Fcに融合されたVEGFR1のIgドメイン)、Zenapax(登録商標)(ダクリズマブ)、Zenapax(登録商標)(ダクリズマブ、抗IL-2Rα mAb)、Zevalin(登録商標)(イブリツモマブチウキセタン)、Zetia(登録商標)(エゼチミブ)、Orencia(登録商標)(アタシセプト、TACI-Ig)、抗CD80モノクローナル抗体(ガリキシマブ)、抗CD23 mAb(ルミリキシマブ)、BR2-Fc(huBR3/huFc融合タンパク質、可溶性BAFFアンタゴニスト)、CNTO 148(ゴリムマブ、抗TNFα mAb)、HGS-ETR1(マパツムマブ、ヒト抗TRAIL受容体-1 mAb)、HuMax-CD20(オクレリズマブ、抗CD20ヒトmAb)、HuMax-EGFR(ザルツムマブ)、M200(ボロシキシマブ、抗α5β1インテグリンmAb)、MDX-010(イピリムマブ、抗CTLA-4 mAb及びVEGFR-1(IMC-18F1)、抗BR3 mAb、抗C、ディフィシルトキシンA及びトキシンB C mAbs MDX-066(CDA-1)及びMDX-1388)、抗CD22 dsFv-PE38コンジュゲート(CAT-3888及びCAT-8015)、抗CD25 mAb(HuMax-TAC)、抗CD3 mAb(NI-0401)、アデカツムマブ、抗CD30 mAb(MDX-060)、MDX-1333(抗IFNAR)、抗CD38 mAb(HuMax CD38)、抗CD40L mAb、抗Cripto mAb、抗CTGF突発性肺線維症フェーズIフィブロゲン(FG-3019)、抗CTLA4 mAb、抗エオタキシン1 mAb(CAT-213)、抗FGF8 mAb、抗ガングリオシドGD2 mAb、抗ガングリオシドGM2 mAb、抗GDF-8ヒトmAb(MYO-029)、抗GM-CSF受容体mAb(CAM-3001)、抗HepC mAb(HuMax HepC)、抗IFNα mAb(MEDI-545、MDX-1103)、抗IGF1R mAb、抗IGF-1R mAb(HuMax-Inflam)、抗IL12 mAb(ABT-874)、抗IL 12/IL23 mAb(CNTO 1275)、抗IL 13 mAb(CAT-354)、抗IL2Ra mAb(HuMax-TAC)、抗IL5受容体mAb、抗インテグリン受容体mAb(MDX-018、CNTO 95)、抗IP10潰瘍性大腸炎mAb(MDX-1100)、抗LLY抗体、BMS-66513、抗マンノース受容体/hCGβ mAb(MDX-1307)、抗メソテリンdsFv-PE38コンジュゲート(CAT-5001)、抗PD1 mAb(MDX-1106(ONO-4538))、抗PDGFRα抗体(IMC-3G3)、抗TGFβ mAb(GC-1008)、抗TRAIL受容体2ヒトmAb(HGS-ETR2)、抗TWEAK mAb、抗VEGFR/Flt-1 mAb、抗ZP3 mAb(HuMax-ZP3)、NVS抗体#1、及びNVS抗体#2を含む他の例示的なタンパク質。
Claims (18)
- 薬物送達デバイスであって、
ハウジングであって、近位端と、遠位端と、その前記近位端と前記遠位端との間に延びる縦軸とを有するシェルを画定するハウジングと、
前記シェルの前記近位端において前記ハウジング内に少なくとも部分的に配置された針アセンブリであって、薬剤を収容するシリンジと、針又はカニューレとを備える前記針アセンブリと、
前記ハウジング内に少なくとも部分的に配置され且つ前記針アセンブリに動作可能に連結された駆動アセンブリであって、初期位置と、前記シリンジからの前記薬剤の排出をもたらす第2の位置との間で移動可能である前記駆動アセンブリと、
可聴インジケータであって、前記駆動アセンブリが前記第2の位置に位置決めされた時点で、前記可聴インジケータが、前記駆動アセンブリに係合して、前記シリンジから前記薬剤が排出されたことを示す可聴音を発生させるように、前記駆動アセンブリに動作可能に連結された前記可聴インジケータと
を備える薬物送達デバイス。 - 前記可聴インジケータが、前記第1の位置から前記第2の位置に向かう前記駆動アセンブリの移動開始時に前記駆動アセンブリとの係合を少なくとも部分的に解除するようになされる、請求項1に記載の薬物送達デバイス。
- 前記駆動アセンブリが、第1の端部と、第2の端部と、前記第2の端部に位置決めされた第1の戻り止めとを有するプランジャロッドを備える、請求項1又は2に記載の薬物送達デバイス。
- 前記プランジャロッドが、前記第1の端部と前記第2の端部との間に距離をおいて位置決めされた第2の戻り止めを更に備える、請求項3に記載の薬物送達デバイス。
- 前記可聴インジケータが、係合タブを有する弾性リングを備える、請求項1~4のいずれか一項に記載の薬物送達デバイス。
- 前記可聴インジケータが、ポリマー又は金属材料の少なくとも一方から作製される、請求項5に記載の薬物送達デバイス。
- 前記駆動アセンブリが磁性部材を更に備え、且つ前記駆動アセンブリが前記第2の位置に位置決めされた時点で、金属部材が前記磁石に係合して前記可聴音を発生させるように、前記可聴インジケータが前記金属部材を含む、請求項1~4のいずれか一項に記載の薬物送達デバイス。
- 前記駆動アセンブリが前記第2の位置にあるとき、前記可聴インジケータが弛緩構成にある、請求項1~7のいずれか一項に記載の薬物送達デバイス。
- 前記駆動アセンブリが前記初期位置にあるときに、前記可聴インジケータが弛緩構成にある、請求項1~8のいずれか一項に記載の薬物送達デバイス。
- 薬物送達デバイスであって、
ハウジングであって、近位端と、遠位端と、その前記近位端と前記遠位端との間に延びる縦軸とを有するシェルを画定するハウジングと、
前記シェルの前記近位端において前記ハウジング内に少なくとも部分的に配置された針アセンブリであって、薬剤を収容するシリンジと、針又はカニューレとを備える前記針アセンブリと、
前記ハウジング内に少なくとも部分的に配置され且つ前記針アセンブリに動作可能に連結された駆動アセンブリであって、初期位置と、前記シリンジからの前記薬剤の排出をもたらす第2の位置との間で移動可能である前記駆動アセンブリと、
可聴インジケータであって、前記針アセンブリを通しての前記薬剤の送達完了時に、前記可聴インジケータが、前記駆動アセンブリに係合して、前記シリンジから前記薬剤が排出されたことを示す可聴音を発生させるように、前記駆動アセンブリに動作可能に連結された前記可聴インジケータと
を備える薬物送達デバイス。 - 前記可聴インジケータが、前記薬剤の送達開始時に前記駆動アセンブリとの係合を少なくとも部分的に解除する、請求項10に記載の薬物送達デバイス。
- 前記駆動アセンブリが、第1の端部と、第2の端部と、前記第2の端部に位置決めされた第1の戻り止めとを有するプランジャロッドを備える、請求項10又は11に記載の薬物送達デバイス。
- 前記駆動アセンブリが、前記第1の端部と前記第2の端部との間に距離をおいて位置決めされた第2の戻り止めを更に備える、請求項12に記載の薬物送達デバイス。
- 前記可聴インジケータが、係合タブを有する弾性リングを備える、請求項10~13のいずれか一項に記載の薬物送達デバイス。
- 前記可聴インジケータが、ポリマー又は金属材料の少なくとも一方から作製される、請求項14に記載の薬物送達デバイス。
- 前記駆動アセンブリが磁性部材を更に備え、且つ前記駆動アセンブリが前記第2の位置に位置決めされた時点で、金属部材が前記磁性部材に係合して前記可聴音を発生させるように、前記可聴インジケータが前記金属部材を含む、請求項10~13のいずれか一項に記載の薬物送達デバイス。
- 前記駆動アセンブリが前記第2の位置にあるときに、前記可聴インジケータが弛緩構成にある、請求項10~16のいずれか一項に記載の薬物送達デバイス。
- 前記駆動アセンブリが前記初期位置にあるときに、前記可聴インジケータが弛緩構成にある、請求項10~17のいずれか一項に記載の薬物送達デバイス。
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MA53818A (fr) | 2022-01-12 |
WO2020072846A1 (en) | 2020-04-09 |
TW202408605A (zh) | 2024-03-01 |
CA3112214A1 (en) | 2020-04-09 |
TW202023641A (zh) | 2020-07-01 |
AU2019355979A1 (en) | 2021-03-18 |
TWI824026B (zh) | 2023-12-01 |
MX2021003491A (es) | 2021-06-18 |
EP3860686A1 (en) | 2021-08-11 |
US20210338936A1 (en) | 2021-11-04 |
AR116607A1 (es) | 2021-05-26 |
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