JP2022503829A - 組成物及びこれを用いて皮膚障壁を強化させる方法 - Google Patents
組成物及びこれを用いて皮膚障壁を強化させる方法 Download PDFInfo
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Abstract
Description
R1~R4はそれぞれ独立して、水素原子、ヒドロキシ基またはカルボキシル基であるが、前記R1~R4のうちの少なくとも一つはヒドロキシ基であり、前記R1~R4のうちの少なくとも一つはカルボキシル基である。
R1~R4はそれぞれ独立して、水素原子、ヒドロキシ基またはカルボキシル基であるが、前記R1~R4のうちの少なくとも一つはヒドロキシ基であり、前記R1~R4のうちの少なくとも一つはカルボキシル基である。
試験例:keratinocyte分化マーカー(KRT10)およびdesmosome構成因子(DSC1)発現程度確認
ヒト角化細胞(normal human epidermal keratinocyte、NHEK)を6-well平板培養器で培養した。24時間後、phosphote-buffered saline(PBS)で交替してUVB(25mJ/cm2)を照射し、NHEK培養培地に下記化学式1-1で表される化合物(Cayman chemical)10nMを添加して培養した。培養4日目に細胞を収穫してRNAを分離し、RT-PCR(reverse transcriptional polymerase chain reaction)を通じてcDNAを合成した後、前記合成されたcDNAを使用してTaqman real-time PCRを行ってkeratinocyte分化マーカーであるKRT10とdesmosome構成因子であるDSC1の遺伝子発現量を測定した。その結果を下記図1および図2に示した。図1および図2を参照すれば、紫外線照射後、keratin10(KRT10)およびDSC1の遺伝子発現量が減少するが、下記化学式1-1で表される化合物処理後、keratin10(KRT10)およびDSC1の遺伝子発現量が再び増加するのを確認することができ、これから下記化学式1-1で表される化合物が紫外線によって損傷された皮膚障壁を改善させるのが分かる。
R1~R4はそれぞれ独立して、水素原子、ヒドロキシ基またはカルボキシル基であるが、前記R1~R4のうちの少なくとも一つはヒドロキシ基であり、前記R1~R4のうちの少なくとも一つはカルボキシル基である。
R1~R4はそれぞれ独立して、水素原子、ヒドロキシ基またはカルボキシル基であるが、前記R1~R4のうちの少なくとも一つはヒドロキシ基であり、前記R1~R4のうちの少なくとも一つはカルボキシル基である。
試験例:keratinocyte分化マーカー(KRT10)およびdesmosome構成因子(DSC1)発現程度確認
ヒト角化細胞(normal human epidermal keratinocyte、NHEK)を6-well平板培養器で培養した。24時間後、phosphote-buffered saline(PBS)で交替してUVB(25mJ/cm2)を照射し、NHEK培養培地に下記化学式1-1で表される化合物(Cayman chemical)10nMを添加して培養した。培養4日目に細胞を収穫してRNAを分離し、RT-PCR(reverse transcriptional polymerase chain reaction)を通じてcDNAを合成した後、前記合成されたcDNAを使用してTaqman real-time PCRを行ってkeratinocyte分化マーカーであるKRT10とdesmosome構成因子であるDSC1の遺伝子発現量を測定した。その結果を下記図1および図2に示した。図1および図2を参照すれば、紫外線照射後、keratin10(KRT10)およびDSC1の遺伝子発現量が減少するが、下記化学式1-1で表される化合物処理後、keratin10(KRT10)およびDSC1の遺伝子発現量が再び増加するのを確認することができ、これから下記化学式1-1で表される化合物が紫外線によって損傷された皮膚障壁を改善させるのが分かる。
Claims (6)
- 前記R1~R3はそれぞれ独立して、ヒドロキシ基であり、前記R4はカルボキシル基である、請求項1に記載の組成物。
- 前記化学式1で表される化合物は、0.01pM~100μMの濃度範囲で含まれる、請求項1に記載の組成物。
- 前記皮膚障壁強化は、皮膚の水分損失を減少させて皮膚保湿力を向上させることを特徴とする、請求項1に記載の組成物。
- 前記皮膚障壁強化は、紫外線によって損傷された皮膚障壁を強化させることを特徴とする、請求項1に記載の組成物。
- 前記組成物は、化粧料組成物である、請求項1に記載の組成物。
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KR1020180127637A KR20200046458A (ko) | 2018-10-24 | 2018-10-24 | 피부장벽 강화용 조성물 |
KR10-2018-0127637 | 2018-10-24 | ||
PCT/KR2019/013920 WO2020085776A1 (ko) | 2018-10-24 | 2019-10-23 | 피부장벽 강화용 조성물 |
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Citations (4)
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JP2016525116A (ja) * | 2013-07-16 | 2016-08-22 | ザ プロクター アンド ギャンブル カンパニー | 老化した皮膚の外観を改善するための方法 |
JP2017141204A (ja) * | 2016-02-12 | 2017-08-17 | 二村 芳弘 | NF−κB抑制作用を呈するグランジフロル酸誘導体及びその製造方法 |
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JP2016525116A (ja) * | 2013-07-16 | 2016-08-22 | ザ プロクター アンド ギャンブル カンパニー | 老化した皮膚の外観を改善するための方法 |
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US20210378929A1 (en) | 2021-12-09 |
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KR20200046458A (ko) | 2020-05-07 |
WO2020085776A1 (ko) | 2020-04-30 |
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