JP2022500346A - 皮膚美白活性を持つペプチド及びその用途 - Google Patents
皮膚美白活性を持つペプチド及びその用途 Download PDFInfo
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- JP2022500346A JP2022500346A JP2020508340A JP2020508340A JP2022500346A JP 2022500346 A JP2022500346 A JP 2022500346A JP 2020508340 A JP2020508340 A JP 2020508340A JP 2020508340 A JP2020508340 A JP 2020508340A JP 2022500346 A JP2022500346 A JP 2022500346A
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- skin whitening
- skin
- tyrosinase
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Birds (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract
Description
自動ペプチド合成器(Milligen 9050,Millipore、アメリカ)を用いて、下記の表1に記載の配列番号1のアミノ酸配列を持つペプチドを合成し、C18逆相の高性能液体クロマトグラフィ(HPLC)(Waters Associates、アメリカ)を用いて、これらの合成されたペプチドを純水分離した。カラムは、ACQUITY UPLC BEH300 C18(2.1mmX100mm,1.7um,Waters Co、アメリカ)を用いた。
マウス黒色腫細胞であるB16F10細胞を6−ウェルプレートに、5×104 cells/wellの密度で接種した後、これを16時間培養した。次いで、培養培地を、2%(v/v)血清の含まれている培地に入れ替えた後、これに、メラニンの生成を促進するために、200ng/mlのα−MSH(α−melanocyte−stimulating hormones)を添加し、これと共に、配列番号1のアミノ酸配列からなるペプチドそれぞれを10μM、50μM、100μM、または200μMで添加した後、これを72時間培養した。次いで、培養された細胞を1NのNaOHで溶解させた後、450nmでの吸光度を測定した。一方、対照群として、未処理群(Con)を使い、陰性対照群として、α−MSHのみを添加した群、陽性対照群として、皮膚美白剤として知られている200μMまたは500μMのアルブチン及びα−MSHを添加した群を使った。
配列番号1のペプチドの、メラニン生成の核心酵素のチロシナーゼに対する活性抑制効果を確認した。
配列番号1のペプチドのメラニン生成関連遺伝子の発現が抑制されるかどうかを確認した。
配列番号1のペプチドのメラニン生成関連タンパク質の発現が抑制されるかどうかを確認した。
Claims (8)
- 配列番号1のアミノ酸配列からなるペプチド。
- 前記ペプチドのN−末端は、アセチル基、フルオレニルメトキシカルボニル基、ホルミル基、パルミトイル基、ミリスチル基、ステアリル基、及びポリエチレングリコール(PEG)からなる群から選択されるいずれか一つの保護基と結合されたものである請求項1に記載のペプチド。
- 前記ペプチドのC−末端は、アミノ基(−NH2)及びアジド(−NHNH2)からなる群から選択されるいずれか一つの保護基と結合されたものである請求項1に記載のペプチド。
- 前記ペプチドは、下記のような特性から選択されるいずれか一つ以上を示すものである請求項1に記載のペプチド:
(a)メラニン生成の抑制、
(b)チロシナーゼ活性の抑制、及び
(c)Rab27a、メラノフィリン(Mlph)、ミオシン VA、MITF(melanocyte inducing transcription factor)、チロシナーゼ、またはTRP1(Tyrosinase−related protein1)発現の抑制。 - 請求項1ないし4のうちいずれか1項に記載のペプチドを有効成分として含む皮膚美白用化粧料組成物。
- 請求項1ないし4のうちいずれか1項に記載のペプチドを有効成分として含む、過色素浸着性疾患の予防または治療用の薬剤学的組成物。
- 前記過色素浸着性疾患は、シミ、そばかす、肝班、くすみ、老人性色素斑、または日光黒色腫である請求項6に記載の薬剤学的組成物。
- 請求項1ないし4のうちいずれか一項に記載のペプチドを有効成分として含む化粧料組成物を、個体の皮膚に塗布する段階を含む、皮膚美白方法。
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PCT/KR2019/013269 WO2021033833A1 (ko) | 2019-08-20 | 2019-10-10 | 피부 미백 활성을 갖는 펩타이드 및 이의 용도 |
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WO2024078534A1 (zh) * | 2022-10-12 | 2024-04-18 | 北京键凯科技股份有限公司 | 一种抑制黑素亲和素(mlph)基因表达的干扰rna及其应用 |
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