JP2022037274A - 発毛促進剤 - Google Patents
発毛促進剤 Download PDFInfo
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- JP2022037274A JP2022037274A JP2020141317A JP2020141317A JP2022037274A JP 2022037274 A JP2022037274 A JP 2022037274A JP 2020141317 A JP2020141317 A JP 2020141317A JP 2020141317 A JP2020141317 A JP 2020141317A JP 2022037274 A JP2022037274 A JP 2022037274A
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- Prior art keywords
- proteoglycan
- hair growth
- promoting agent
- hair
- agent according
- Prior art date
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Abstract
Description
〔1〕 プロテオグリカンを含有する発毛促進剤。
〔2〕 プロテオグリカンの分子量が100kDa以上800kDa以下である、〔1〕に記載の発毛促進剤。
〔3〕 前記プロテオグリカンは、コンドロイチン硫酸を構成要素として含む、〔1〕または〔2〕に記載の発毛促進剤。
〔4〕 前記プロテオグリカンは、サケ鼻軟骨由来である、〔1〕~〔3〕のいずれかに記載の発毛促進剤。
〔5〕 サケ鼻軟骨から酢酸を用いて抽出したプロテオグリカンを含む、発毛促進剤。
〔6〕 経口剤である、〔1〕~〔5〕のいずれかに記載の発毛促進剤。
〔7〕 保健機能食品、健康補助食品またはサプリメントである、〔6〕に記載の発毛促進剤。
〔8〕 外用剤である、〔1〕~〔5〕のいずれかに記載の発毛促進剤。
〔9〕 プロテオグリカンを含有する、血管内皮細胞増殖因子(VEGF)産生促進剤。
〔10〕 毛乳頭細胞のVEGF産生を促進する、〔9〕に記載のVEGF産生促進剤。
〔11〕 プロテオグリカンを含有する経口剤およびプロテオグリカンを含有する外用剤を含む発毛促進セット。
本発明に係る発毛促進剤は、プロテオグリカンを含有する。プロテオグリカンは、発毛促進、育毛促進、養毛促進、脱毛抑制作用等を有している。本発明に係る発毛促進剤は、育毛促進剤、養毛剤、抗脱毛剤ということもできる。本発明に係る発毛促進剤は、摂取、投与または塗布された対象の毛の発生を促進し、薄毛および抜け毛を予防および低減することができる。
プロテオグリカンは、コアタンパク質とそれに結合したグリコサミノグリカン(酸性ムコ多糖)からなる糖タンパク質である。プロテオグリカンは、細胞外マトリックスの主な構成要素として、皮膚、軟骨、骨、血管壁等に存在する。
本発明に係る発毛促進剤は、経口剤または外用剤として哺乳動物に投与することができる。
本発明に係るVEGF産生促進剤は、プロテオグリカンを含有する。VEGF産生促進剤は、好ましくは毛乳頭細胞のVEGF産生を促進する。プロテオグリカンが毛乳頭細胞を活性化し、毛乳頭細胞のVEGF産生が促進されると、発毛が促進されると考えられる。
マウスを用いて、プロテオグリカンの発毛促進作用を評価した。マウスは、日本エスエルシー株式会社が取り扱うSPF C3H/HeN Slc(雄性)を使用した。各試験群の平均体重がなるべく均等になるよう無作為に個体を振り分けた。マウスの飼育条件は1ケージあたり5匹、室温25℃、明暗12時間サイクルとした。試験開始前において、飼料はマウス・ラット・ハムスター用MF飼料(オリエンタル酵母)を、飲料水は公共水道水をそれぞれ自由に摂取させた。
毛乳頭細胞を用いて、VEGFの産生量を測定した。対数増殖期にあるヒト頭髪毛乳頭細胞(HFDPC、Cell Applications,Inc.)を毛乳頭細胞増殖培地(PCGM、Cell Applications,Inc.)で3×104cells/mlに調製し、1mlを24-well plate(collagen-coated)に植え継いで前培養を行った。
Claims (11)
- プロテオグリカンを含有する発毛促進剤。
- プロテオグリカンの分子量が100kDa以上800kDa以下である、請求項1に記載の発毛促進剤。
- 前記プロテオグリカンは、コンドロイチン硫酸を構成要素として含む、請求項1または2に記載の発毛促進剤。
- 前記プロテオグリカンは、サケ鼻軟骨由来である、請求項1~3のいずれか1項に記載の発毛促進剤。
- サケ鼻軟骨から酢酸を用いて抽出したプロテオグリカンを含む、発毛促進剤。
- 経口剤である、請求項1~5のいずれか1項に記載の発毛促進剤。
- 保健機能食品、健康補助食品またはサプリメントである、請求項6に記載の発毛促進剤。
- 外用剤である、請求項1~5のいずれか1項に記載の発毛促進剤。
- プロテオグリカンを含有する、血管内皮細胞増殖因子(VEGF)産生促進剤。
- 毛乳頭細胞のVEGF産生を促進する、請求項9に記載のVEGF産生促進剤。
- プロテオグリカンを含有する経口剤およびプロテオグリカンを含有する外用剤を含む発毛促進セット。
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