JP2021138774A - Insect pest repellent for human body - Google Patents
Insect pest repellent for human body Download PDFInfo
- Publication number
- JP2021138774A JP2021138774A JP2021101723A JP2021101723A JP2021138774A JP 2021138774 A JP2021138774 A JP 2021138774A JP 2021101723 A JP2021101723 A JP 2021101723A JP 2021101723 A JP2021101723 A JP 2021101723A JP 2021138774 A JP2021138774 A JP 2021138774A
- Authority
- JP
- Japan
- Prior art keywords
- pest repellent
- skin
- insect pest
- repellent component
- human body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000607479 Yersinia pestis Species 0.000 title claims abstract description 117
- 239000005871 repellent Substances 0.000 title claims abstract description 116
- 230000002940 repellent Effects 0.000 title claims abstract description 116
- 241000238631 Hexapoda Species 0.000 title abstract 11
- 235000020682 bottled natural mineral water Nutrition 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 241000282412 Homo Species 0.000 claims description 15
- 239000013535 sea water Substances 0.000 claims description 10
- MMOXZBCLCQITDF-UHFFFAOYSA-N N,N-diethyl-m-toluamide Chemical compound CCN(CC)C(=O)C1=CC=CC(C)=C1 MMOXZBCLCQITDF-UHFFFAOYSA-N 0.000 claims description 5
- 229960001673 diethyltoluamide Drugs 0.000 claims description 5
- LMXFTMYMHGYJEI-UHFFFAOYSA-N Menthoglycol Natural products CC1CCC(C(C)(C)O)C(O)C1 LMXFTMYMHGYJEI-UHFFFAOYSA-N 0.000 claims description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 24
- 239000003795 chemical substances by application Substances 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 12
- 238000002156 mixing Methods 0.000 abstract description 9
- 230000001629 suppression Effects 0.000 abstract description 5
- 238000005470 impregnation Methods 0.000 abstract 7
- 230000002688 persistence Effects 0.000 abstract 1
- -1 eucalyptor Chemical compound 0.000 description 20
- 230000035515 penetration Effects 0.000 description 20
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 8
- 239000003112 inhibitor Substances 0.000 description 8
- 229910052500 inorganic mineral Inorganic materials 0.000 description 8
- 230000007794 irritation Effects 0.000 description 8
- 239000011707 mineral Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 6
- 241000255925 Diptera Species 0.000 description 5
- QLHULAHOXSSASE-UHFFFAOYSA-N butan-2-yl 2-(2-hydroxyethyl)piperidine-1-carboxylate Chemical compound CCC(C)OC(=O)N1CCCCC1CCO QLHULAHOXSSASE-UHFFFAOYSA-N 0.000 description 5
- 229950011440 icaridin Drugs 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 4
- 206010004194 Bed bug infestation Diseases 0.000 description 3
- 241001414835 Cimicidae Species 0.000 description 3
- VZRKEAFHFMSHCD-UHFFFAOYSA-N Ethyl 3-(N-butylacetamido)propionate Chemical compound CCCCN(C(C)=O)CCC(=O)OCC VZRKEAFHFMSHCD-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 229940027359 ir-3535 Drugs 0.000 description 3
- 229930014626 natural product Natural products 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 2
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 241000723346 Cinnamomum camphora Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 241000257226 Muscidae Species 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 229930008380 camphor Natural products 0.000 description 2
- 229960000846 camphor Drugs 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000011033 desalting Methods 0.000 description 2
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000003021 water soluble solvent Substances 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- FDCJDKXCCYFOCV-UHFFFAOYSA-N 1-hexadecoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC FDCJDKXCCYFOCV-UHFFFAOYSA-N 0.000 description 1
- LQXBZWFNAKZUNM-UHFFFAOYSA-N 16-methyl-1-(16-methylheptadecoxy)heptadecane Chemical compound CC(C)CCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC(C)C LQXBZWFNAKZUNM-UHFFFAOYSA-N 0.000 description 1
- ZXDDPOHVAMWLBH-UHFFFAOYSA-N 2,4-Dihydroxybenzophenone Chemical compound OC1=CC(O)=CC=C1C(=O)C1=CC=CC=C1 ZXDDPOHVAMWLBH-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- 241000256111 Aedes <genus> Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 240000004784 Cymbopogon citratus Species 0.000 description 1
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 1
- 244000166675 Cymbopogon nardus Species 0.000 description 1
- 235000018791 Cymbopogon nardus Nutrition 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 244000147568 Laurus nobilis Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229940017545 cinnamon bark Drugs 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 210000004237 neck muscle Anatomy 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- VIKVSUVYUVJHOA-UHFFFAOYSA-N octyl 3-phenylprop-2-enoate Chemical compound CCCCCCCCOC(=O)C=CC1=CC=CC=C1 VIKVSUVYUVJHOA-UHFFFAOYSA-N 0.000 description 1
- 229930006948 p-menthane-3,8-diol Natural products 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
本発明は、蚊、ブヨ、サシバエ、イエダニ、ナンキンムシ等の害虫から人体を守るための人体用害虫忌避剤に関し、具体的には、この人体用害虫忌避剤に配合される害虫忌避成分の皮膚への浸透抑制剤、及び害虫忌避成分の皮膚への浸透抑制方法に関するものである。 The present invention relates to a human pest repellent for protecting the human body from pests such as mosquitoes, buyos, stable flies, bedbugs, and bed bugs. It relates to a permeation inhibitor and a method for suppressing the permeation of pest repellent components into the skin.
人体用害虫忌避剤について、従来より、使用感の改善、刺激性の軽減を目的とした様々な特許が出願されている。人体用害虫忌避剤は基本的に腕、足、首筋等、人体の露出した肌、即ち、外的な刺激を受けやすい部分に塗布するものであり、近年では害虫忌避成分とともに、皮膚を保護する目的で化粧品原料に用いられている紫外線吸収剤や紫外線散乱剤を配合し、害虫忌避と日焼け防止を目的とした特許文献１（特開平５−９２９１５号公報）及び特許文献２（特開平８−１８３７２０号公報）が、また、保湿効果が期待できる成分、例えばアロエエキスやモモエキスを配合し、ディートの異臭の軽減を目的とした特許文献３（特開２００３−１６０４１３号公報）などが出願されている。 Various patents have been filed for the purpose of improving usability and reducing irritation of pest repellents for human body. The pest repellent for the human body is basically applied to the exposed skin of the human body such as the arms, legs, and neck muscles, that is, the parts that are susceptible to external stimuli. In recent years, it protects the skin together with the pest repellent component. blended cosmetic UV absorbers are used in materials and ultraviolet scattering agent for the purpose, Patent Document 1 (JP-a-5-92915 JP) for the purpose of sunscreen and repellent and Patent Document 2 (JP-a-8- 183720) has also been filed with Patent Document 3 (Japanese Unexamined Patent Publication No. 2003-160413), which contains components expected to have a moisturizing effect, such as aloe extract and peach extract, for the purpose of reducing the offensive odor of diet. There is.
一方、組成物中に水を配合することによって、使用感の改善や刺激性の軽減を目指した水性の人体用害虫忌避剤もいくつか提案されている。例えば、害虫忌避成分、水溶性溶剤及び水を配合し、水溶性溶剤と水の配合比率を規定することにより、皮膚感触と臭気を改善した特許文献４（特開２００３−１９２５０３号公報）や、害虫忌避成分、アルコール系化合物又はグリコール系化合物、界面活性剤及び水を配合し、害虫忌避成分の安定化と更に敏感な皮膚に対する乾燥及び刺激の軽減を目的とした特許文献５（特開平１１−３４９４０９号公報）が挙げられる。更に、特許文献６（特開２００５−１３２７８０号公報）は、配合する水として天然ミネラル水を選択し、刺激性が一層軽減された有用な人体用害虫忌避剤を開示している。 On the other hand, some aqueous pest repellents for humans have been proposed with the aim of improving usability and reducing irritation by blending water in the composition. For example, Patent Document 4 (Japanese Unexamined Patent Publication No. 2003-192503), which improves the skin feel and odor by blending a pest repellent component, a water-soluble solvent and water, and defining the blending ratio of the water-soluble solvent and water, Patent Document 5 (Japanese Patent Laid-Open No. 11-), which contains a pest repellent component, an alcohol-based compound or a glycol-based compound, a solvent, and water for the purpose of stabilizing the pest repellent component and reducing dryness and irritation to more sensitive skin. No. 349409). Further, Patent Document 6 (Japanese Unexamined Patent Publication No. 2005-132780) discloses a useful pest repellent for humans in which natural mineral water is selected as the water to be blended and the irritation is further reduced.
ところで、皮膚に塗布された害虫忌避成分が害虫忌避効果を持続して発揮するためには、害虫忌避成分をできるだけ皮膚上に留まらせ皮膚下に浸透させないことも重要である。従来、害虫忌避成分の配合量を増やして害虫忌避効果の持続性を高める方策がしばしば採られてきたが、害虫忌避成分の配合量を無闇に増やしてよいと言うわけではない。
例えば、天然ミネラル水を配合した特許文献６の水性の人体用害虫忌避剤は、使用感の改善や刺激性の軽減の点で有用なものであるが、害虫忌避成分の皮膚への浸透抑制や、害虫忌避効果の持続性に関しては何ら言及されておらず、更なる検討が求められていた。
By the way, in order for the pest repellent component applied to the skin to continuously exert the pest repellent effect, it is also important to keep the pest repellent component on the skin as much as possible and prevent it from penetrating under the skin. Conventionally, measures have often been taken to increase the amount of the pest repellent component to increase the sustainability of the pest repellent effect, but it is not always possible to increase the amount of the pest repellent component indiscriminately.
For example, the aqueous pest repellent for humans of Patent Document 6 containing natural mineral water is useful in terms of improving usability and reducing irritation, but it also suppresses the penetration of pest repellent components into the skin. No mention was made of the sustainability of the pest repellent effect, and further studies were required.
本発明はかかる現状に鑑みなされたもので、害虫忌避成分を含有する水性の人体用害虫忌避剤において、害虫忌避成分の皮膚への浸透を抑制し、害虫忌避成分の配合量を無闇に増やすことなく害虫忌避効果の持続性を向上させ得る、害虫忌避成分の皮膚への浸透抑制剤、及び害虫忌避成分の皮膚への浸透抑制方法を提供しようとするものである。 The present invention has been made in view of the present situation, and is an aqueous pest repellent for humans containing a pest repellent component, which suppresses the penetration of the pest repellent component into the skin and increases the amount of the pest repellent component blended indiscriminately. It is an object of the present invention to provide an agent for suppressing the penetration of a pest repellent component into the skin and a method for suppressing the penetration of the pest repellent component into the skin, which can improve the sustainability of the pest repellent effect.
本発明は、以下の構成が上記目的を達成するために優れた効果を奏することを見出したものである。
上記課題を解決するため、本発明は、以下の構成を採用する。
（１）害虫忌避成分を含有する人体用害虫忌避剤に配合され、かつ、電気伝導率が１．５ｍＳ／ｍ〜３０ｍＳ／ｍの天然ミネラル水である、前記害虫忌避成分の皮膚への浸透抑制剤。
（２）前記天然ミネラル水は、脱塩された海洋深層水を含む水である（１）に記載の皮膚への浸透抑制剤。
（３）前記害虫忌避成分は、２−（２−ヒドロキシエチル）−１−ピペリジンカルボン酸１−メチルプロピル、３−（Ｎ−ｎ−ブチルアセトアミド）プロピオン酸エチル、ディート、及びｐ−メンタン−３，８−ジオールから選ばれた１種又は２種以上である（１）又は（２）に記載の皮膚への浸透抑制剤。
（４）前記害虫忌避成分は、２−（２−ヒドロキシエチル）−１−ピペリジンカルボン酸１−メチルプロピルである（３）に記載の皮膚への浸透抑制剤。
（５）前記人体用害虫忌避剤は、更に、炭素数が２ないし６のアルコール系化合物及び／又はグリコール系化合物から選ばれた１種又は２種以上を含有する（１）ないし（４）のいずれか一に記載の皮膚への浸透抑制剤。
（６）害虫忌避成分を含有する人体用害虫忌避剤に、電気伝導率が１．５ｍＳ／ｍ〜３０ｍＳ／ｍの天然ミネラル水を配合する、前記害虫忌避成分の皮膚への浸透抑制方法。
（７）前記天然ミネラル水は、脱塩された海洋深層水を含む水である（６）に記載の皮膚への浸透抑制方法。
The present invention has found that the following configuration exerts an excellent effect in achieving the above object.
In order to solve the above problems, the present invention adopts the following configuration.
(1) Suppression of permeation of the pest repellent component into the skin, which is a natural mineral water containing a pest repellent component for human body and having an electrical conductivity of 1.5 mS / m to 30 mS / m. Agent.
(2) The permeation inhibitor to the skin according to (1), wherein the natural mineral water is water containing desalted deep sea water.
(3) The pest repellent components are 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl, 3- (Nn-butylacetamide) ethyl propionate, DEET, and p-menthane-3. , The skin penetration inhibitor according to (1) or (2), which is one or more selected from 8-diols.
(4) The skin penetration inhibitor according to (3), wherein the pest repellent component is 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl.
(5) The pest repellent for humans further contains one or more selected from alcohol compounds and / or glycol compounds having 2 to 6 carbon atoms (1) to (4). The skin penetration inhibitor according to any one.
(6) A method for suppressing permeation of the pest repellent component into the skin, which comprises blending a natural mineral water having an electrical conductivity of 1.5 mS / m to 30 mS / m with a pest repellent for human body containing the pest repellent component.
(7) The method for suppressing permeation into the skin according to (6), wherein the natural mineral water is water containing desalted deep sea water.
本発明の害虫忌避成分の皮膚への浸透抑制剤は、害虫忌避成分を含有する水性の人体用害虫忌避剤において、害虫忌避成分の皮膚への浸透を抑制し、害虫忌避成分の配合量を無闇に増やすことなく害虫忌避効果の持続性を向上させ得るので非常に有用なものである。そして、これを用いた害虫忌避成分の皮膚への浸透抑制方法の実用性も極めて高い。 The permeation inhibitor of the pest repellent component of the present invention is an aqueous pest repellent for humans containing the pest repellent component, which suppresses the permeation of the pest repellent component into the skin, and the amount of the pest repellent component blended is innocent. It is very useful because it can improve the sustainability of the pest repellent effect without increasing it. The practicality of the method for suppressing the penetration of the pest repellent component into the skin using this is also extremely high.
本発明で用いる害虫忌避成分としては、害虫に対して忌避作用あるいは吸血阻害作用を有する合成あるいは天然の各種化合物が挙げられる。例えば、２−（２−ヒドロキシエチル）−１−ピペリジンカルボン酸１−メチルプロピル［以降、イカリジンと称す］、３−（Ｎ−ｎ−ブチルアセトアミド）プロピオン酸エチル［以降、ＩＲ３５３５と称す］、ディート、ｐ−メンタン−３，８−ジオール、ヘキシレングリコール、ユーカリプトール、α−ピネン、ゲラニオール、シトロネラール、カンファー、リナロール、カラン−３，４−ジオールなどを例示できる。更に天然物としては、桂皮、シトロネラ、レモングラス、クローバ、ベルガモット、月桂樹、ユーカリなどから採れる精油、抽出液などを例示でき、これらの１種または２種以上を選択して用いることができる。上記化合物及び天然物のなかでは、特に、イカリジン、ＩＲ３５３５、ディート、及びｐ−メンタン−３，８−ジオールが好ましく、なかんずくイカリジンが好ましい。
害虫忌避成分は各薬剤の害虫忌避効果等により異なるが、本発明の人体用害虫忌避剤全体量に対して１〜５０質量％、好ましくは３〜３０質量％配合される。
Examples of the pest repellent component used in the present invention include various synthetic or natural compounds having a repellent action or a blood sucking inhibitory action against pests. For example, 2- (2-hydroxyethyl) -1-piperidincarboxylic acid 1-methylpropyl [hereinafter referred to as icaridin], ethyl 3- (Nn-butylacetamide) propionate [hereinafter referred to as IR3535], DEET. , P-menthane-3,8-diol, hexylene glycol, eucalyptor, α-pinene, geraniol, citronellal, camphor, linalol, curan-3,4-diol and the like. Further, examples of natural products include essential oils and extracts obtained from cinnamon bark, citronella, lemongrass, clover, bergamot, laurel, eucalyptus and the like, and one or more of these can be selected and used. Among the above compounds and natural products, icaridin, IR3535, DEET, and p-menthane-3,8-diol are particularly preferable, and icaridin is particularly preferable.
The pest repellent component varies depending on the pest repellent effect of each drug, but is blended in an amount of 1 to 50% by mass, preferably 3 to 30% by mass, based on the total amount of the pest repellent for humans of the present invention.
本発明は、害虫忌避成分を含有する人体用害虫忌避剤に、前記害虫忌避成分の皮膚への浸透抑制剤として、電気伝導率が１．５ｍＳ／ｍ〜３０ｍＳ／ｍ、好ましくは、２．５ｍＳ／ｍ〜１５ｍＳ／ｍの天然ミネラル水を配合することを特徴とする。
天然ミネラル水としては、山麓の涌き水、地下深層水、海洋表層水、海洋深層水等が挙げられ、マグネシウムイオン、カルシウムイオン、カリウムイオン等の金属イオンを含むことから、その用途が各方面で注目されている。例えば、逆浸透膜法等により濾過、脱塩処理を行い硬度を１００〜１０００程度に調整したものは、人体に不足しがちなミネラル成分を補給する目的で飲料水として販売されている。
According to the present invention, a pest repellent for humans containing a pest repellent component has an electrical conductivity of 1.5 mS / m to 30 mS / m, preferably 2.5 mS, as an agent for suppressing the penetration of the pest repellent component into the skin. It is characterized by blending natural mineral water of / m to 15 mS / m.
Examples of natural mineral water include water at the foot of the mountain, deep sea water, deep sea water, deep sea water, etc., and since they contain metal ions such as magnesium ion, calcium ion, and potassium ion, their uses are attracting attention in various fields. Has been done. For example, those whose hardness is adjusted to about 100 to 1000 by filtering and desalting treatment by a reverse osmosis membrane method or the like are sold as drinking water for the purpose of replenishing mineral components that tend to be deficient in the human body.
このようなミネラル水を含む人体用害虫忌避剤を皮膚に直接塗布したときに、ミネラル成分による保湿感、さっぱり感を付与できることは知られていたが、ミネラル成分が害虫忌避成分の皮膚への浸透にどのように影響するかについてはこれまで全く言及されていなかった。これは、汗成分によって害虫忌避成分が皮膚から流失しやすくなることを考慮すると、ミネラル成分による害虫忌避成分の皮膚浸透抑制作用は期待できないと考えられていたためと推測される。
しかるに、本発明者らは、人体用害虫忌避剤におけるミネラル成分の作用について鋭意検討を重ねたところ、驚くべきことに、特定の電気伝導率を有する天然ミネラル水を配合することによって、この天然ミネラル水が害虫忌避成分の皮膚への浸透抑制剤として機能することを知見した。そして、害虫忌避効果の持続性を向上させ得ることを検証し、本発明を完成するに至ったものである。
It has been known that when such a pest repellent for human body containing mineral water is directly applied to the skin, a moisturizing feeling and a refreshing feeling can be imparted by the mineral component, but the mineral component permeates the skin. No mention has been made of how it affects the skin. It is presumed that this is because it was thought that the effect of the mineral component on suppressing the skin penetration of the pest repellent component could not be expected, considering that the pest repellent component is easily washed away from the skin by the sweat component.
However, as a result of diligent studies on the action of mineral components in human pest repellents, the present inventors surprisingly found that natural mineral water having a specific electrical conductivity was added to this natural mineral. It was found that water functions as an inhibitor of the penetration of pest repellent components into the skin. Then, it was verified that the sustainability of the pest repellent effect could be improved, and the present invention was completed.
本発明は、配合される天然ミネラル水の電気伝導率を１．５ｍＳ／ｍ〜３０ｍＳ／ｍ、好ましくは、２．５ｍＳ／ｍ〜１５ｍＳ／ｍの範囲に規定するが、この電気伝導率は、金属イオン濃度と関連するものの、通常よく用いられる硬度とは別異の指標である。
電気伝導率が１．５ｍＳ／ｍ未満であると、害虫忌避成分の皮膚浸透抑制作用は期待できず、一方、３０ｍＳ／ｍを超えると、相応の皮膚浸透抑制作用が得られないばかりか、人体用害虫忌避剤組成物の安定性に支障を来たす恐れがあるので好ましくない。
なお、本発明では、天然ミネラル水由来であれば、これを脱イオン水や精製水で希釈した水をも含めて「天然ミネラル水」と定義し、その配合量は人体用害虫忌避剤全体量に対して２０〜６０質量％が適当である。
上記の天然ミネラル水のうち、水深２００ｍ以上の無光層より採取された海洋深層水は、ミネラル成分のバランスが良く、清浄性、安定性が良好である。そして、この原水に脱塩行程を施し、必要ならばこれを脱イオン水や精製水で希釈し、その電気伝導率が１．５ｍＳ／ｍ〜３０ｍＳ／ｍの範囲に調整されたものは本発明に特に適したものとなる。
The present invention defines the electric conductivity of the blended natural mineral water in the range of 1.5 mS / m to 30 mS / m, preferably 2.5 mS / m to 15 mS / m. Although it is related to the metal ion concentration, it is an index different from the hardness that is usually used.
If the electrical conductivity is less than 1.5 mS / m, the skin permeation inhibitory effect of the pest repellent component cannot be expected, while if it exceeds 30 mS / m, not only the appropriate skin permeation inhibitory effect cannot be obtained, but also the human body. It is not preferable because it may interfere with the stability of the pest repellent composition.
In the present invention, if it is derived from natural mineral water, it is defined as "natural mineral water" including water diluted with deionized water or purified water, and the blending amount is the total amount of pest repellent for human body. 20 to 60% by mass is suitable.
Of the above-mentioned natural mineral waters, deep sea water collected from an aphotic zone having a water depth of 200 m or more has a good balance of mineral components, and has good cleanliness and stability. Then, the raw water is subjected to a desalting process, diluted with deionized water or purified water if necessary, and the electric conductivity thereof is adjusted to the range of 1.5 mS / m to 30 mS / m according to the present invention. It will be particularly suitable for.
本発明の人体用害虫忌避剤には、水に不溶の害虫忌避成分を可溶化するために、通常、炭素数が２ないし６のアルコール系化合物及び／又はグリコール系化合物から選ばれた１種又は２種以上が配合される。
かかるアルコール系化合物やグリコール系化合物としては、炭素数が２ないし３の低級一価アルコールであるエタノール、イソプロパノールや、グリコール系化合物であるエチレングリコール、ジエチレングリコール、プロピレングリコール、ジプロピレングリコール、１，３−ブチレングリコール等が挙げられ、これらを単独でまたは混合して使用することができる。なお、エタノールを用いる場合、肌への作用が緩和で、かつ食品用として一般的な醸造エタノールが好ましい。
本発明においては、アルコール系化合物やグリコール系化合物の配合量を、人体用害虫忌避剤全体量に対して３０〜７０質量％に設定すれば、製剤として良好な性状を保持することが可能となる。
The pest repellent for humans of the present invention is usually one selected from alcohol compounds and / or glycol compounds having 2 to 6 carbon atoms in order to solubilize water-insoluble pest repellent components. Two or more types are mixed.
Examples of such alcohol-based compounds and glycol-based compounds include ethanol and isopropanol, which are lower monohydric alcohols having 2 to 3 carbon atoms, and ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-, which are glycol-based compounds. Butylene glycol and the like can be mentioned, and these can be used alone or in combination. When ethanol is used, brewed ethanol, which has a mild effect on the skin and is generally used for food, is preferable.
In the present invention, if the blending amount of the alcohol-based compound or the glycol-based compound is set to 30 to 70% by mass with respect to the total amount of the pest repellent for human body, it is possible to maintain good properties as a preparation. ..
本発明では、本発明の趣旨に支障を来たさない限りにおいて、上記成分以外に、人体用害虫忌避剤組成物の安定性を確保するために界面活性剤を配合してもよい。このような界面活性剤としては、特にＨＬＢが１１〜１６のノニオン系界面活性剤が好ましく、ポリオキシエチレン（１０モル）オレイルエーテル｛ＨＬＢ＝１２．４｝、ポリオキシエチレン（２０モル）オレイルエーテル｛ＨＬＢ＝１５．１｝、ポリオキシエチレン（９モル）ラウリルエーテル｛ＨＬＢ＝１３．６｝、ポリオキシエチレン（１０モル）セチルエーテル｛ＨＬＢ＝１２．９｝、ポリオキシエチレン（１５モル）ステアリルエーテル｛ＨＬＢ＝１４．２｝、ポリオキシエチレン（１５モル）イソステアリルエーテル｛ＨＬＢ＝１４．２｝等のポリオキシエチレンアルキルエーテル類、ポリオキシエチレン（２０モル）ソルビタンモノオレエート｛ＨＬＢ＝１５．７｝、ポリオキシエチレン（１０モル）ソルビタンモノラウレート｛ＨＬＢ＝１４．９｝、ポリオキシエチレン（２０モル）ソルビタンモノステアレート｛ＨＬＢ＝１５．７｝等のポリオキシエチレンソルビタン脂肪酸エステル類、ポリオキシエチレン（１４モル）モノオレエート｛ＨＬＢ＝１３．７｝、ポリオキシエチレン（９モル）モノラウレート｛ＨＬＢ＝１３．３｝、ポリオキシエチレン（１４モル）ミリステート｛ＨＬＢ＝１４．６｝等のポリオキシエチレンアルキルエステル類等が挙げられ、これらを単独でまたは混合して使用することができる。
界面活性剤は肌への刺激性を考えると極力低減するのが好ましいが、ＨＬＢが１１〜１６のノニオン系界面活性剤は少量の配合で人体用害虫忌避剤組成物の安定化に効果を有することが知られている。
また、分子量が２００〜５０００程度のポリアルキレングリコール、例えば、ポリエチレングリコールやポリプロピレングリコールは、害虫忌避成分の皮膚への浸透を抑制し皮膚に対する刺激を軽減でき得るとの報告もあり、これらを少量添加してもよい。
In the present invention, a surfactant may be added in addition to the above components in order to ensure the stability of the pest repellent composition for humans, as long as the gist of the present invention is not hindered. As such a surfactant, a nonionic surfactant having an HLB of 11 to 16 is particularly preferable, and polyoxyethylene (10 mol) oleyl ether {HLB = 12.4} and polyoxyethylene (20 mol) oleyl ether. {HLB = 15.1}, polyoxyethylene (9 mol) lauryl ether {HLB = 13.6}, polyoxyethylene (10 mol) cetyl ether {HLB = 12.9}, polyoxyethylene (15 mol) stearyl Polyoxyethylene alkyl ethers such as ether {HLB = 14.2}, polyoxyethylene (15 mol) isostearyl ether {HLB = 14.2}, polyoxyethylene (20 mol) sorbitan monooleate {HLB = 15 .7}, Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (10 mol) sorbitan monolaurate {HLB = 14.9}, polyoxyethylene (20 mol) sorbitan monostearate {HLB = 15.7} , Polyoxyethylene (14 mol) monooleate {HLB = 13.7}, polyoxyethylene (9 mol) monolaurate {HLB = 13.3}, polyoxyethylene (14 mol) millistate {HLB = 14.6 } And the like, and polyoxyethylene alkyl esters and the like can be mentioned, and these can be used alone or in combination.
It is preferable to reduce the amount of the surfactant as much as possible in consideration of the irritation to the skin, but the nonionic surfactant having an HLB of 11 to 16 is effective in stabilizing the pest repellent composition for human body in a small amount. It is known.
It has also been reported that polyalkylene glycols having a molecular weight of about 200 to 5000, such as polyethylene glycol and polypropylene glycol, can suppress the penetration of pest repellent components into the skin and reduce irritation to the skin, and a small amount of these is added. You may.
また、使用感（塗布面のさらさら感等）の改善のため、無水ケイ酸、タルク、カオリン等の無機粉末及び変性デンプン、シルク繊維粉末等の有機粉末を配合してもよい。更に、グリチルリチン酸ジカリウム、アラントイン、塩化アルキルトリメチルアンモニウム、酢酸トコフェロール、カンフル等の消炎剤、パラアミノ安息香酸、アミルサリシネート、オクチルシンナメート、メトキシ桂皮酸オクチル、２,４−ジヒドロキシベンゾフェノン等の紫外線吸収剤や紫外線散乱剤、あるいは硫酸アルミニウム、クロルヒドロキシアルミニウム、フェノールスルホン酸亜鉛等の制汗剤、安定剤、香料等を人体用害虫忌避剤組成物の安定性に影響のない範囲で配合することも可能である。 Further, in order to improve the feeling of use (smoothness of the coated surface, etc.), an inorganic powder such as silicic acid anhydride, talc or kaolin and an organic powder such as modified starch or silk fiber powder may be blended. Furthermore, anti-inflammatory agents such as dipotassium glycyrrhizinate, allantin, alkyltrimethylammonium chloride, tocopherol acetate, camphor, paraaminobenzoic acid, amylsalicinate, octyl cinnamate, octyl methoxycinnamate, UV absorption of 2,4-dihydroxybenzophenone, etc. Agents, UV scatterers, antiperspirants such as aluminum sulfate, chlorohydroxyaluminum, zinc phenolsulfonate, stabilizers, fragrances, etc. may be blended within a range that does not affect the stability of the pest repellent composition for humans. It is possible.
こうして調製された人体用害虫忌避剤は、水ベースで火気に対する安全性が高く、人体への刺激性をほとんど有さない。その使用形態については特に制限はないが、具体的な使用例としては、非エアゾール型スプレー剤やロールオンタイプの容器に充填する形態、不織布等のシート基材に含浸させる形態などの他、液化石油ガス、ジメチルエーテル、圧縮ガス（窒素ガスや圧縮空気等）等を噴射剤に用いてエアゾール剤とすることももちろん可能であり、適用範囲は極めて広い。 The human pest repellent prepared in this way is water-based, highly safe against fire, and has almost no irritation to the human body. The form of use is not particularly limited, but specific examples of use include a form of filling in a non-aerosol type spray agent or a roll-on type container, a form of impregnating a sheet base material such as a non-woven fabric, and liquefied petroleum. Of course, it is also possible to use gas, dimethyl ether, compressed gas (nitrogen gas, compressed air, etc.) as the propellant to make an aerosol agent, and the range of application is extremely wide.
本発明の害虫忌避成分の皮膚への浸透抑制剤は、かかる人体用害虫忌避剤に配合されるが、害虫忌避成分の皮膚への浸透を抑制し、蚊、ブヨ、サシバエ、イエダニ、ナンキンムシ等に対する害虫忌避効果の持続性を向上させ得るので、刺咬被害防除に非常に有用なものである。そして、これを用いた害虫忌避成分の皮膚への浸透抑制方法の実用性も極めて高い。 The pest repellent component of the present invention is incorporated into such a pest repellent for humans, but it suppresses the permeation of the pest repellent component into the skin and is effective against mosquitoes, buyo, stable flies, bedbugs, etc. It is very useful for controlling bite damage because it can improve the sustainability of the pest repellent effect. The practicality of the method for suppressing the penetration of the pest repellent component into the skin using this is also extremely high.
次に具体的な実施例ならびに試験例に基づき、本発明の害虫忌避成分の皮膚への浸透抑制剤、及び害虫忌避成分の皮膚への浸透抑制方法について更に詳細に説明する。 Next, the skin penetration inhibitor of the pest repellent component of the present invention and the method for suppressing the penetration of the pest repellent component into the skin will be described in more detail based on specific examples and test examples.
害虫忌避成分としてイカリジン５．０ｇを醸造エタノール５５．０ｇに均一に溶解させた後、脱塩処理した海洋深層水（電気伝導率：３．８ｍＳ／ｍ）４０．０ｇを加え、人体用害虫忌避剤を得た。
この人体用害虫忌避剤組成物は、５℃及び４０℃の恒温槽に１ヶ月間保存しても均一澄明であった。次に、本人体用害虫忌避剤を蓄圧式のポンプ容器に充填して使用した。手の甲に約１ｍＬ塗布し塗り延ばした後、１分経過後の塗布面の状態を観察したところ、べたつきはなく、さっぱりとした感触であった。また、本人体用害虫忌避剤は害虫忌避成分の皮膚への浸透抑制剤を含むため、塗布部の害虫忌避効果は約１０時間まで持続し、その間、蚊などの害虫に悩まされることはなかった。
5.0 g of icaridin as a pest repellent component was uniformly dissolved in 55.0 g of brewed ethanol, and then 40.0 g of desalted deep sea water (electrical conductivity: 3.8 mS / m) was added to repel human pests. I got the agent.
This pest repellent composition for human body was uniformly clear even when stored in a constant temperature bath at 5 ° C. and 40 ° C. for 1 month. Next, the pest repellent for the human body was filled in a pressure-accumulation type pump container and used. After applying about 1 mL to the back of the hand and spreading it, the condition of the coated surface after 1 minute was observed, and it was not sticky and had a refreshing feel. In addition, since the pest repellent for the human body contains a pest repellent component that suppresses the penetration of the pest repellent component into the skin, the pest repellent effect of the applied portion lasted for up to about 10 hours, during which time it was not bothered by pests such as mosquitoes. ..
実施例１に準じて表１に示す各種人体用害虫忌避剤を調製し、下記に示す試験を行った。
（１）使用感
手の甲に約１ｍＬ塗布し塗り延ばした後、１分経過後の塗布面に指先で触れ、感触を評価した。表１にその結果を、〇（さっぱり感あり）、△（ややべたつきあり）、×（べたつく、肌がざらざらする）で示した。
（２）害虫忌避効果試験
試験者の手の腕に約３ｍＬ塗布し、ヤブカが多数生息する屋外の試験地に佇み、蚊が腕に止まるまでの時間を計った。試験は試験者を替えて４連行い、平均の害虫忌避効果持続時間を求めた。表１にその結果を、◎（９時間以上）、○（７〜９時間）、
△（６〜７時間）、×（６時間未満）で示した。
Various pest repellents for humans shown in Table 1 were prepared according to Example 1, and the tests shown below were carried out.
(1) Usability After applying about 1 mL to the back of the hand and spreading it, the applied surface was touched with a fingertip after 1 minute, and the feel was evaluated. The results are shown in Table 1 by 〇 (with a refreshing feeling), Δ (slightly sticky), and × (sticky, rough skin).
(2) Pest repellent effect test Approximately 3 mL was applied to the arm of the examiner's hand, and the mosquito stood in an outdoor test site where many Aedes inhabited, and the time until the mosquito stopped on the arm was measured. The test was carried out four times in a row with different testers, and the average duration of pest repellent effect was determined. Table 1 shows the results: ◎ (9 hours or more), ○ (7-9 hours),
It is indicated by Δ (6 to 7 hours) and × (less than 6 hours).
試験の結果、本発明の害虫忌避成分の皮膚への浸透抑制剤、即ち、電気伝導率が１．５ｍＳ／ｍ〜３０ｍＳ／ｍ、好ましくは２．５ｍＳ／ｍ〜１５ｍＳ／ｍの天然ミネラル水を配合した人体用害虫忌避剤は、手の甲に塗布して実用に供したところ、ベタツキが無くさっぱりとした使用感で、害虫忌避成分の皮膚への浸透が抑制され皮膚上に残留する割合が増えたことに起因して害虫忌避効果の持続性にも優れることが確認された。
なお、天然ミネラル水としては、脱塩された海洋深層水を含む水が好ましく、また、害虫忌避成分としては、天然ミネラル水との組合せを考慮すると、ＩＲ３５３５、ディートやｐ−メンタン−３，８−ジオールよりもイカリジンが本発明の趣旨により適合することも明らかとなった。
これに対し、比較例１ないし５（脱イオン水や、電気伝導率が１．５ｍＳ／ｍ〜３０ｍＳ／ｍの範囲から外れる水を含む害虫忌避剤）は、使用感や害虫忌避効果の持続性の点で幾分劣った。
更に、本発明品１０と比較例６との対比から、脱イオン水を用いた場合でも、害虫忌避成分の配合量を増やし害虫忌避効果の持続性を高めることは可能であるが、使用感の低下に繋がる場合があり、必ずしも有効な方法とは言えないことは明らかである。
As a result of the test, an agent for suppressing the penetration of the pest repellent component of the present invention into the skin, that is, natural mineral water having an electrical conductivity of 1.5 mS / m to 30 mS / m, preferably 2.5 mS / m to 15 mS / m. When the compounded pest repellent for human body was applied to the back of the hand and put into practical use, it had a refreshing feel without stickiness, and the penetration of the pest repellent component into the skin was suppressed and the proportion of the pest repellent component remaining on the skin increased. As a result, it was confirmed that the pest repellent effect was also excellent in sustainability.
The natural mineral water is preferably water containing desalted deep sea water, and the pest repellent component is IR3535, DEET or p-menthane-3,8 in consideration of the combination with natural mineral water. It was also clarified that icaridin is more suitable for the purpose of the present invention than −diol.
On the other hand, Comparative Examples 1 to 5 (a pest repellent containing deionized water and water whose electrical conductivity falls outside the range of 1.5 mS / m to 30 mS / m) have a feeling of use and a long-lasting pest repellent effect. It was somewhat inferior in that respect.
Further, from the comparison between the product 10 of the present invention and Comparative Example 6, it is possible to increase the blending amount of the pest repellent component and enhance the sustainability of the pest repellent effect even when deionized water is used, but the feeling of use is improved. It is clear that this may lead to a decline and is not always an effective method.
本発明の害虫忌避成分の皮膚への浸透抑制剤、及び害虫忌避成分の皮膚への浸透抑制方法は、人体用以外の害虫忌避分野に適用できる可能性がある。 The agent for suppressing the penetration of the pest repellent component into the skin and the method for suppressing the penetration of the pest repellent component into the skin of the present invention may be applicable to the field of pest repellent other than for the human body.
Claims (4)
電気伝導率が２．５ｍＳ／ｍ〜１５ｍＳ／ｍの天然ミネラル水である脱塩された海洋深層水と、
エタノールと、
を含有する人体用害虫忌避剤。 Pest repellent ingredients and
Desalted deep sea water, which is a natural mineral water with an electrical conductivity of 2.5 mS / m to 15 mS / m,
With ethanol
A pest repellent for the human body containing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021101723A JP7230117B2 (en) | 2017-01-25 | 2021-06-18 | pest repellent for humans |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017011102A JP6905720B2 (en) | 2017-01-25 | 2017-01-25 | Human pest repellent |
| JP2021101723A JP7230117B2 (en) | 2017-01-25 | 2021-06-18 | pest repellent for humans |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017011102A Division JP6905720B2 (en) | 2017-01-25 | 2017-01-25 | Human pest repellent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021138774A true JP2021138774A (en) | 2021-09-16 |
| JP7230117B2 JP7230117B2 (en) | 2023-02-28 |
Family
ID=63043473
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017011102A Active JP6905720B2 (en) | 2017-01-25 | 2017-01-25 | Human pest repellent |
| JP2021101723A Active JP7230117B2 (en) | 2017-01-25 | 2021-06-18 | pest repellent for humans |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017011102A Active JP6905720B2 (en) | 2017-01-25 | 2017-01-25 | Human pest repellent |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP6905720B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6905720B2 (en) * | 2017-01-25 | 2021-07-21 | 大日本除蟲菊株式会社 | Human pest repellent |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005132780A (en) * | 2003-10-31 | 2005-05-26 | Dainippon Jochugiku Co Ltd | Pest-repelling composition for human body |
| JP2007269792A (en) * | 2006-03-10 | 2007-10-18 | Dainippon Jochugiku Co Ltd | Pest-repelling aerosol preparation |
| JP2010132602A (en) * | 2008-12-04 | 2010-06-17 | Izu Shinsosui:Kk | Normal saline solution based on deep ocean water and method for producing normal saline solution |
| JP2010274214A (en) * | 2009-05-29 | 2010-12-09 | Dhc Co | Manufacturing method of drinking water, and drinking water |
| JP2013053129A (en) * | 2011-08-09 | 2013-03-21 | Dainippon Jochugiku Co Ltd | Insect repellent aerosol for human body, and method of repelling insect and giving coolness using the same |
| JP2018118922A (en) * | 2017-01-25 | 2018-08-02 | 大日本除蟲菊株式会社 | Agent and method for inhibiting penetration of pest repellent component into the skin |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4084735B2 (en) * | 2003-11-18 | 2008-04-30 | 株式会社浅川自然食品工業 | Deep sea water desalination equipment |
| JP2007029899A (en) * | 2005-07-28 | 2007-02-08 | Hakatako Kanri Kk | Mineral water |
| JP4836169B2 (en) * | 2005-08-01 | 2011-12-14 | 大日本除蟲菊株式会社 | Gel pest repellent composition for human body |
-
2017
- 2017-01-25 JP JP2017011102A patent/JP6905720B2/en active Active
-
2021
- 2021-06-18 JP JP2021101723A patent/JP7230117B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005132780A (en) * | 2003-10-31 | 2005-05-26 | Dainippon Jochugiku Co Ltd | Pest-repelling composition for human body |
| JP2007269792A (en) * | 2006-03-10 | 2007-10-18 | Dainippon Jochugiku Co Ltd | Pest-repelling aerosol preparation |
| JP2010132602A (en) * | 2008-12-04 | 2010-06-17 | Izu Shinsosui:Kk | Normal saline solution based on deep ocean water and method for producing normal saline solution |
| JP2010274214A (en) * | 2009-05-29 | 2010-12-09 | Dhc Co | Manufacturing method of drinking water, and drinking water |
| JP2013053129A (en) * | 2011-08-09 | 2013-03-21 | Dainippon Jochugiku Co Ltd | Insect repellent aerosol for human body, and method of repelling insect and giving coolness using the same |
| JP2018118922A (en) * | 2017-01-25 | 2018-08-02 | 大日本除蟲菊株式会社 | Agent and method for inhibiting penetration of pest repellent component into the skin |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7230117B2 (en) | 2023-02-28 |
| JP2018118922A (en) | 2018-08-02 |
| JP6905720B2 (en) | 2021-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009126804A (en) | Noxious insect repellent for human body | |
| JP3468865B2 (en) | Antimicrobial composition | |
| KR20120058571A (en) | Use of 1,3-diols as biocides | |
| JP2021042254A (en) | Insect pest repellent, and insect pest evasion product | |
| JP2009001501A (en) | Insect pest repellent for human body | |
| JP7230117B2 (en) | pest repellent for humans | |
| CN113226032A (en) | Pest repellent composition | |
| CN109843055B (en) | Method for inhibiting penetration of pest repellent into skin and penetration inhibitor for inhibiting penetration of pest repellent into skin | |
| JP6099888B2 (en) | Pest repellent aerosol agent for human body, and pest repellent and cooling method using the same. | |
| CN113226031B (en) | Pest repellent composition | |
| CN114206111B (en) | Arthropod repellent composition | |
| JP6095427B2 (en) | Tick repellent efficacy enhancer and tick repellent method using tick repellent composition containing the same | |
| JP4460261B2 (en) | Pest repellent composition for human body | |
| JP6214135B2 (en) | Pest repellent aerosol agent for human body, and pest repellent and cooling method using the same. | |
| JP2014205648A (en) | Ixodes repelling efficacy promoter, method of repelling ixodes using ixodes repelling composition containing the same | |
| JP4868743B2 (en) | Pest repellent aerosol for human body | |
| JP6836930B2 (en) | How to prevent bee and bug bites | |
| AU2017363988B2 (en) | Larvicide compositions and methods | |
| JP2003160413A (en) | Noxious insect repelling composition for human body | |
| JP2023062665A (en) | Pest repellent for human bodies | |
| CN113226030A (en) | Pest repellent composition | |
| JP2007277196A (en) | Pest-repelling composition for human body | |
| WO2008082028A1 (en) | Mosquito repellent comprising an esterified glycerol. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20210618 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20220307 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220329 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220519 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220823 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20221021 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221122 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20221122 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230131 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230215 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7230117 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |