JP4460261B2 - Pest repellent composition for human body - Google Patents
Pest repellent composition for human body Download PDFInfo
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- JP4460261B2 JP4460261B2 JP2003371396A JP2003371396A JP4460261B2 JP 4460261 B2 JP4460261 B2 JP 4460261B2 JP 2003371396 A JP2003371396 A JP 2003371396A JP 2003371396 A JP2003371396 A JP 2003371396A JP 4460261 B2 JP4460261 B2 JP 4460261B2
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- pest repellent
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- 239000005871 repellent Substances 0.000 title claims description 44
- 241000607479 Yersinia pestis Species 0.000 title claims description 40
- 239000000203 mixture Substances 0.000 title claims description 33
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
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- HBXWUCXDUUJDRB-UHFFFAOYSA-N 1-octadecoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC HBXWUCXDUUJDRB-UHFFFAOYSA-N 0.000 description 1
- LQXBZWFNAKZUNM-UHFFFAOYSA-N 16-methyl-1-(16-methylheptadecoxy)heptadecane Chemical compound CC(C)CCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC(C)C LQXBZWFNAKZUNM-UHFFFAOYSA-N 0.000 description 1
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
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Description
本発明は、蚊、ブヨ、サシバエ、イエダニ、ナンキンムシ等の害虫から人体を守るための人体用害虫忌避組成物に関する。更に詳しくは、人体への刺激性、使用感を改善し、水を配合することにより火気に対する安全性を向上させた人体用害虫忌避組成物に関するものである。 The present invention relates to a human pest repellent composition for protecting a human body from pests such as mosquitoes, gnats, sand flies, house dust mites, bedbugs and the like. More specifically, the present invention relates to a pest repellent composition for human body that has improved irritation to human body and feeling of use, and has improved safety against fire by blending water.
害虫忌避剤について、従来より、使用感の改善、刺激性の軽減を目的とした様々な特許が出願されている。害虫忌避剤は基本的に腕、足、首筋等、人体の露出した肌、即ち、外的な刺激を受けやすい部分に塗布するものであり、近年では害虫忌避成分に皮膚を保護する目的で、化粧品原料に用いられている紫外線吸収剤や紫外線散乱剤を配合し、害虫忌避と日焼け防止を目的とした特許（特開平５−９２９１５号公報、特開平８−１８３７２０号公報）が、また、保湿効果が期待できる成分、例えばアロエエキスやモモエキスを配合し、ディートの異臭の軽減を目的とした特許（特開２００３−１６０４１３号公報）が出願されている。
更に、組成物中に水を配合した水性害虫忌避剤の特許も出願されている。例えば、害虫忌避成分、水溶性溶剤及び水を配合し、水溶性溶剤と水の配合比率を規定することにより、皮膚感触と臭気を改善した特許（特開２００３−１９２５０３号公報）や、忌避成分、アルコール又はグリコール、界面活性剤及び水を配合し、忌避成分の安定化と更に敏感な皮膚に対する乾燥及び刺激の軽減を目的とした特許（特開平１１−３４９４０９号公報）が挙げられる。
Further, a patent for an aqueous pest repellent in which water is mixed in the composition has been filed. For example, a patent (Japanese Patent Laid-Open No. 2003-192503) that improves skin feel and odor by blending a pest repellent component, a water-soluble solvent, and water, and defining a blending ratio of the water-soluble solvent and water, and a repellent component , Alcohol or glycol, surfactant and water, and a patent (Japanese Patent Laid-Open No. 11-349409) aimed at stabilizing the repellent component and further reducing dryness and irritation to sensitive skin.
近年、アレルギー性物質や刺激性物質に対し過敏な反応を起こす人が増加している。このような社会的状況を背景にして、化粧品メーカーでは従来の化粧品に一般的に配合していた紫外線吸収剤、タール色素、パラベン、エタノール等の刺激やアレルギーの原因となりやすい原料の配合を減らし、肌の乾燥を防ぐ保湿剤、消炎剤の配合に重点を置いた処方を指向する動きが活発になっている。更に、ウエストナイルウィルスが蚊を媒介してアメリカに上陸したニュース等が広まって、日本国内でも忌避製剤の必要性が増しており、消費者ニーズにあった製剤の開発が重要となっている。 In recent years, an increasing number of people have a hypersensitive reaction to allergic substances and irritating substances. Against this backdrop of social conditions, cosmetic manufacturers have reduced the amount of ingredients that are commonly used in conventional cosmetics, such as UV absorbers, tar pigments, parabens, and ethanol, which can cause irritation and allergies, There is an active movement toward prescribing prescriptions with an emphasis on formulating moisturizers and anti-inflammatory agents to prevent dry skin. Furthermore, the news that West Nile virus has landed in the United States through mosquitoes has spread, and the need for repellent preparations has increased in Japan, and development of preparations that meet consumer needs is important.
本発明はかかる現状に鑑みなされたもので、人体への刺激性、使用感を改善し、かつ、水を配合することで、火気に対する安全性を向上させた人体用害虫忌避組成物を提供しようとするものである。 The present invention has been made in view of the present situation, and is intended to provide a pest repellent composition for a human body that improves the irritation to the human body, the feeling of use, and contains water to improve safety against fire. It is what.
本発明者らは、現在市場にて主流のアルコールベースのエアゾール製剤ではなく、刺激性が少なく安全性の高い水ベースの製剤に着目し、更には最近飲料として話題の天然ミネラル水を配合することにより、使用感の良好な人体用害虫忌避組成物を目標に鋭意検討を重ね、本発明を完成するに至った。すなわち、本発明は、上記課題を解決するため、次のような構成を採用する。
（１）（ａ）害虫忌避成分、（ｂ）Ｃ2〜Ｃ6のアルコール及び／又はグリコールから選ばれた１種又は２種以上及び（ｃ）水からなり、界面活性剤を含有しない人体用害虫忌避組成物において、（ｃ）水が硬度５ないし７００の天然ミネラル水であり、かつ（ｃ）水に対する上記（ｂ）アルコール及び／又はグリコールの総量の重量比が１．1以下である人体用害虫忌避組成物。
（２）（ａ）害虫忌避成分がディートである（１）に記載の人体用害虫忌避組成物
（３）前記天然ミネラル水が、脱塩された海洋深層水である（１）又は（２）に記載の人体用害虫忌避組成物。
（４）前記脱塩された海洋深層水の硬度が５〜１００の範囲である（３）に記載の人体用害虫忌避組成物。
（５）（ｂ）Ｃ2〜Ｃ6のアルコールが醸造エタノールである（１）ないし（４）のいずれかに記載の人体用害虫忌避組成物。
The present inventors pay attention to water-based preparations that are less irritating and safer than alcohol-based aerosol preparations that are currently the mainstream in the market, and moreover, the topical natural mineral water has been recently added as a beverage. Thus, the present invention was completed by intensive investigations aimed at a pest repellent composition for human body having a good feeling of use. That is, the present invention adopts the following configuration in order to solve the above-described problems.
(1) (a) pest repellent component, the body containing no (b) C 2 ~C 6 1, two or more selected from alcohols and / or glycols and (c) Ri Do from the water, surfactant In the pest repellent composition, (c) water is a natural mineral water having a hardness of 5 to 700, and (c) the weight ratio of the total amount of (b) alcohol and / or glycol to water is 1.1 or less. A pest repellent composition for human body.
(2) (a) pest repellent component is DEET (1) for human body pest repellent composition according to (3) the natural mineral water is desalinated deep ocean water (1) or (2 ) The pest repellent composition for human body according to the above.
(4) The pest repellent composition for human body according to (3), wherein the hardness of the desalted deep sea water is in the range of 5 to 100.
(5) (b) The pest repellent composition for human body according to any one of (1) to (4), wherein the alcohol of C 2 to C 6 is brewed ethanol.
本発明の人体用害虫忌避組成物は、内容液の安定性に優れ、また、塗布した際の使用感が良好なので、その実用性は極めて高い。 The pest repellent composition for human body of the present invention is excellent in the stability of the content liquid and has a good feeling when applied, so that its practicality is extremely high.
本発明で用いる（ａ）害虫忌避成分としては、害虫に対して忌避作用あるいは吸血阻害作用を有する合成あるいは天然の各種化合物が挙げられる。例えば、ディート、ユーカリ、プトール、α―ピネン、ゲラニオール、シトロネラール、カンファー、リナロール、カランー３，４−ジオールなどを例示できる。更に天然物としては、桂皮、シトロネラ、レモングラス、クローバ、ベルガモット、月桂樹、ユーカリなどから採れる精油、抽出液などを例示でき、これらの１種または２種以上を選択して用いることができる。上記化合物及び天然物のなかでは、特にディートが好ましい。
害虫忌避成分は各薬剤の忌避効力等により異なるが、本発明の人体用害虫忌避組成物全体量に対して１〜２０重量％、好ましくは３〜１０重量％配合される。
Examples of the pest repellent component (a) used in the present invention include various synthetic or natural compounds having a repellent action or blood sucking inhibitory action against pests. Examples thereof include diet, eucalyptus, putol, α-pinene, geraniol, citronellal, camphor, linalool, caran-3,4-diol and the like. Furthermore, examples of natural products include essential oils and extracts from cinnamon bark, citronella, lemongrass, clover, bergamot, laurel, eucalyptus, etc., and one or more of these can be selected and used. Of the above compounds and natural products, diet is particularly preferred.
The pest repellent component varies depending on the repellent efficacy and the like of each drug, but is 1 to 20% by weight, preferably 3 to 10% by weight, based on the total amount of the pest repellent composition for human body of the present invention.
本発明で用いる（ｂ）Ｃ2〜Ｃ6のアルコール及び／又はグリコールとしては、炭素数２〜３の低級一価アルコールであるエタノール、イソプロパノールや、グリコールであるエチレングリコール、ジエチレングリコール、プロピレングリコール、ジプロピレングリコール、１，３−ブチレングリコール等が挙げられ、これらを単独でまたは混合して使用することができる。Ｃ2〜Ｃ6のアルコール及び／又はグリコールは水に不溶の忌避成分を可溶化するために用いる。なお、エタノールを用いる場合、肌への作用が緩和で、かつ食品用として一般的な醸造エタノールが好ましい。 Examples of (b) C 2 -C 6 alcohol and / or glycol used in the present invention include ethanol, isopropanol, which are lower monohydric alcohols having 2 to 3 carbon atoms, and ethylene glycol, diethylene glycol, propylene glycol, dialkyl which are glycols. Examples thereof include propylene glycol and 1,3-butylene glycol, and these can be used alone or in combination. C 2 -C 6 alcohols and / or glycols are used to solubilize repellent components insoluble in water. In addition, when using ethanol, the effect | action on a skin is relieve | moderated and general brewed ethanol for foods is preferable.
本発明に用いる（ｃ）天然ミネラル水としては、山麓の涌き水、地下深層水、海洋表層水、海洋深層水等が挙げられる。これらのミネラル水はカルシウムイオン、マグネシウムイオン、カリウムイオン等の金属イオンを含み、人体に不足しがちなミネラル成分を補給しやすいことから各方面で注目されている。例えば、逆浸透膜法等により濾過、脱塩処理を行い硬度を１００〜１０００程度に調整したものが飲料として販売されているが、本発明では硬度７００以下のミネラル水が適合し、これらを皮膚に直接塗布することで、少量のミネラル成分による保湿感、さっぱり感が付与される。硬度が７００を超えると、組成物の安定性に支障をきたすので好ましくない。
上記の天然ミネラル水のうち、特に海洋深層水はミネラル成分のバランスが良く、また水深２００ｍ以上の無光層より採取しているため、清浄性、安定性が良好で、製剤化した際、使用感、製剤安定性に優れる。本発明の更に好ましい組成物は硬度が５〜１００に調整された海洋深層水を用いたものであり、一層良好な使用感を得ることができる。
Examples of (c) natural mineral water used in the present invention include foothill water, deep underground water, ocean surface water, ocean deep water, and the like. These mineral waters are attracting attention in various directions because they contain metal ions such as calcium ions, magnesium ions, and potassium ions, and are easy to replenish mineral components that tend to be deficient in the human body. For example, a beverage that is filtered and desalted by the reverse osmosis membrane method and adjusted to a hardness of about 100 to 1000 is sold as a beverage. In the present invention, mineral water having a hardness of 700 or less is suitable, and these are applied to the skin. Applying directly to the surface gives a moisturizing feeling and a refreshing feeling due to a small amount of mineral components. If the hardness exceeds 700, the stability of the composition will be hindered.
Among the above natural mineral waters, especially deep ocean water has a good balance of mineral components and is collected from a non-light layer with a depth of 200 m or more, so it has good cleanliness and stability and is used when formulated. Excellent feeling and formulation stability. A more preferable composition of the present invention uses deep ocean water whose hardness is adjusted to 5 to 100, and can provide a better feeling of use.
本発明においては、（ｃ）水に対する（ｂ）アルコール及び／又はグリコールの重量比が１．1以下であることを特徴としている。アルコールとして炭素数２〜３の低級一価アルコールを用いる場合、重量比が１．1を超えると塗布面にざらざらした感触が残る。また、多価アルコールの場合、塗布面にべとつき感が残って使用感が悪くなる。 In the present invention, (c) the weight ratio of (b) alcohol and / or glycol to water is 1.1 or less. When a lower monohydric alcohol having 2 to 3 carbon atoms is used as the alcohol, if the weight ratio exceeds 1.1, a rough feel remains on the coated surface. Moreover, in the case of polyhydric alcohol, a sticky feeling remains on the coated surface and the feeling of use becomes worse.
また、本発明の人体用害虫忌避組成物には、上記成分以外に内容液の安定性を更に確保するために界面活性剤を配合することができる。界面活性剤としては、特にＨＬＢが１１〜１６のノニオン系界面活性剤が好ましく、ポリオキシエチレン（１０モル）オレイルエーテル｛ＨＬＢ＝１２．４｝、ポリオキシエチレン（２０モル）オレイルエーテル｛ＨＬＢ＝１５．１｝、ポリオキシエチレン（９モル）ラウリルエーテル｛ＨＬＢ＝１３．６｝、ポリオキシエチレン（１０モル）セチルエーテル｛ＨＬＢ＝１２．９｝、ポリオキシエチレン（１５モル）ステアリルエーテル｛ＨＬＢ＝１４．２｝、ポリオキシエチレン（１５モル）イソステアリルエーテル｛ＨＬＢ＝１４．２｝等のポリオキシエチレンアルキルエーテル類、ポリオキシエチレン（２０モル）ソルビタンモノオレエート｛ＨＬＢ＝１５．７｝、ポリオキシエチレン（１０モル）ソルビタンモノラウレート｛ＨＬＢ＝１４．９｝、ポリオキシエチレン（２０モル）ソルビタンモノステアレート｛ＨＬＢ＝１５．７｝等のポリオキシエチレンソルビタン脂肪酸エステル類、ポリオキシエチレン（１４モル）モノオレエート｛ＨＬＢ＝１３．７｝、ポリオキシエチレン（９モル）モノラウレート｛ＨＬＢ＝１３．３｝、ポリオキシエチレン（１４モル）ミリステート｛ＨＬＢ＝１４．６｝等のポリオキシエチレンアルキルエステル類等が挙げられ、これらを単独でまたは混合して使用することができる。界面活性剤は肌への刺激性を考えると極力低減するのが好ましいが、ＨＬＢが１１〜１６のノニオン系界面活性剤は少量の配合で内容液の安定化に効果がある。また、使用感（塗布面のさらさら感等）の改善のため、無水ケイ酸、タルク、カオリン等の無機粉末及び変性デンプン、シルク繊維粉末等の有機粉末を配合することができる。更に、グリチルリチン酸ジカリウム、アラントイン、塩化アルキルトリメチルアンモニウム、酢酸トコフェロール、カンフル等の消炎剤、酸化チタン、酸化亜鉛、ベンガラ、酸化セリウム等の紫外線散乱剤等を内容液の安定性に影響のない範囲で配合することができる。 In addition to the above components, a surfactant may be added to the human pest repellent composition of the present invention in order to further ensure the stability of the content liquid. As the surfactant, nonionic surfactants having HLB of 11 to 16 are particularly preferable, and polyoxyethylene (10 mol) oleyl ether {HLB = 12.4}, polyoxyethylene (20 mol) oleyl ether {HLB = 15.1}, polyoxyethylene (9 mol) lauryl ether {HLB = 13.6}, polyoxyethylene (10 mol) cetyl ether {HLB = 12.9}, polyoxyethylene (15 mol) stearyl ether {HLB = 14.2}, polyoxyethylene alkyl ethers such as polyoxyethylene (15 mol) isostearyl ether {HLB = 14.2}, polyoxyethylene (20 mol) sorbitan monooleate {HLB = 15.7} , Polyoxyethylene (10 mol) sorbitan monolaurate {HLB 14.9}, polyoxyethylene (20 mol) sorbitan monostearate {HLB = 15.7} and other polyoxyethylene sorbitan fatty acid esters, polyoxyethylene (14 mol) monooleate {HLB = 13.7}, poly Examples include polyoxyethylene alkyl esters such as oxyethylene (9 mol) monolaurate {HLB = 13.3} and polyoxyethylene (14 mol) myristate {HLB = 14.6}. Or it can be mixed and used. The surfactant is preferably reduced as much as possible considering the irritation to the skin, but the nonionic surfactant having an HLB of 11 to 16 is effective in stabilizing the content liquid with a small amount. Moreover, in order to improve the feeling of use (such as the dry feeling of the coated surface), inorganic powders such as silicic anhydride, talc and kaolin, and organic powders such as modified starch and silk fiber powder can be blended. In addition, flame retardants such as dipotassium glycyrrhizinate, allantoin, alkyltrimethylammonium chloride, tocopherol acetate, camphor, etc., UV scattering agents such as titanium oxide, zinc oxide, bengara, cerium oxide, etc., in a range that does not affect the stability of the content liquid. Can be blended.
こうして調製された本発明の人体用害虫忌避組成物の実用上の使用形態については特に制限はないが、具体的な使用例としては、非エアゾール型スプレー剤やロールオンタイプの容器に充填する形態、不織布等のシート基材に含浸させる形態などの他、圧縮ガス（窒素ガスや圧縮空気等）を噴射剤に用いたエアゾール剤とすることももちろん可能であり、適用範囲は極めて広い。 Although there is no particular limitation on the practical use form of the human body pest repellent composition of the present invention prepared in this manner, as a specific use example, a form filled in a non-aerosol type spray or a roll-on type container, In addition to the form of impregnating a sheet substrate such as a nonwoven fabric, it is of course possible to use an aerosol agent using a compressed gas (nitrogen gas, compressed air, etc.) as a propellant, and the applicable range is extremely wide.
次に具体的な実施例ならびに試験例に基づき、本発明の人体用害虫忌避組成物について更に詳細に説明する。 Next, the pest repellent composition for human body of the present invention will be described in more detail based on specific examples and test examples.
害虫忌避成分としてディート５．０ｇをエタノール４５．０ｇに均一に溶解させた後、脱塩処理した硬度５００の海洋深層水５０．０ｇ（水に対するアルコールの重量比０．９）を加え、本発明の人体用害虫忌避組成物を得た。
この組成物は、５℃及び４０℃の恒温槽に１ヶ月間保存しても均一澄明であった。次に、本組成物を蓄圧式のポンプ容器に充填して使用した。手の甲に約１ｍＬ塗布し塗り延ばした後、１分経過後の塗布面の状態を観察したところ、べたつきはなく、さっぱりとした感触であった。
As a pest repellent component, 5.0 g of diet is uniformly dissolved in 45.0 g of ethanol, and then 50.0 g of a desalted 500 deep sea water (weight ratio of alcohol to water is 0.9) is added to the present invention. A pest repellent composition for human body was obtained.
This composition was clear even when stored in a thermostatic bath at 5 ° C. and 40 ° C. for 1 month. Next, this composition was filled into a pressure-accumulating pump container and used. After applying and spreading about 1 mL on the back of the hand, the state of the coated surface after 1 minute was observed, and there was no stickiness and a refreshing feel.
実施例１に準じて表１に示す各種人体用害虫忌避組成物を調製し、下記に示す試験を行った。
（１）内容液の安定性
透明ガラス容器に各成分を配合した組成物を入れ、密栓した後、５℃及び４０℃の恒温槽に１ヶ月間保存し、内容液の外観を評価した。結果を〇（均一澄明）、△（若干白濁しているが、澄明感あり）、×（白濁または析出）で示した。
（２）使用感
手の甲に約１ｍＬ塗布し塗り延ばした後、１分経過後の塗布面に指先で触れ、感触を評価した。結果を〇（さっぱり感あり）、△、×（べたつく、肌がざらざらする）で示した。
According to Example 1, various human pest repellent compositions shown in Table 1 were prepared, and the tests shown below were conducted.
(1) Stability of content liquid After putting the composition which mix | blended each component into the transparent glass container and sealing, it preserve | saved for one month at 5 degreeC and a 40 degreeC thermostat, and evaluated the external appearance of the content liquid. The results are indicated by ◯ (uniformly clear), Δ (slightly cloudy but clear) and x (white turbidity or precipitation).
(2) Feeling of use After about 1 mL was applied to the back of the hand and spread, the coated surface after 1 minute was touched with a fingertip to evaluate the feel. The results were indicated by ◯ (feeling refreshed), Δ, × (sticky, rough skin).
本発明の人体用害虫忌避組成物は、その原液を５℃及び４０℃で１ヶ月保存後もほぼ均一澄明であった。また、手の甲に塗布し、使用感を確認したところ、ベタツキが無くさっぱりとした優れた使用感が認められ、人体用害虫忌避組成物として高い実用性が認められた。
これに対し、比較例１及び３のように、ミネラル水の硬度が７００を超える場合、５℃及び４０℃での保存で、白色の沈殿が生じた。また比較例２及び４のように水に対するアルコール類の重量比が１．１を超えると、肌がざらざらするといった感じやべたつき感が残った。更に、比較例５のようにＣ6を超えるグリコールを使用した場合、べたつき感が残り好ましくなかった。
The pest repellent composition for human body of the present invention was almost uniform and clear even after the stock solution was stored at 5 ° C. and 40 ° C. for 1 month. Moreover, when it was applied to the back of the hand and the usability was confirmed, it was found that it had no stickiness and had a refreshing and excellent usability, and was highly practical as a pest repellent composition for human bodies.
On the other hand, as in Comparative Examples 1 and 3, when the hardness of the mineral water exceeded 700, a white precipitate was produced by storage at 5 ° C. and 40 ° C. Moreover, when the weight ratio of alcohol to water exceeded 1.1 as in Comparative Examples 2 and 4, the feeling of rough skin and stickiness remained. Further, when a glycol exceeding C 6 was used as in Comparative Example 5, the sticky feeling remained unfavorably.
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