JP2021123564A - 皮膚外用液剤 - Google Patents
皮膚外用液剤 Download PDFInfo
- Publication number
- JP2021123564A JP2021123564A JP2020018165A JP2020018165A JP2021123564A JP 2021123564 A JP2021123564 A JP 2021123564A JP 2020018165 A JP2020018165 A JP 2020018165A JP 2020018165 A JP2020018165 A JP 2020018165A JP 2021123564 A JP2021123564 A JP 2021123564A
- Authority
- JP
- Japan
- Prior art keywords
- content
- tocopherol
- skin
- mass
- astaxanthin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
各実施例及び各比較例において得られた外用液剤について、(i)製造直後、(ii)製造後、透明ガラス瓶に封入して25℃で暗所に7日間静置した後、(iii)製造後、透明ガラス瓶に封入して25℃で暗所に1ヶ月間静置した後、又は(iv)製造後、透明ガラス瓶に封入して5℃で暗所に7日間静置した後、の外観を、それぞれ目視にて確認し、以下の評価スコア:
[評価スコア]
A:白濁及び不溶物のいずれも確認されない
B:白濁が確認される
C:不溶物が確認される
に準拠して白濁及び不溶物の生成の有無を評価した。評価結果は、スコアがAを許容と判定した。
各実施例及び各比較例において得られた外用液剤について、(i)製造直後と、(ii)製造後、透明ガラス瓶に封入して60℃で暗所に1ヶ月間静置した後、又は(iii)製造後、透明ガラス瓶に封入して120万lx・hrの光(光源:CIE標準光源D65)を照射した後と、において、以下の手順:
[測定手順]
(I)分光側色計(測定機器:CM−700d、コニカミノルタオプティクス株式会社製)にて、各外用製剤の(i)製造直後のL*値、a*値、及びb*値を求め、それぞれ、L0 *、a0 *、及びb0 *とした
(II)前記分光側色計にて、上記(ii)又は(iii)の後の各外用製剤のL*値、a*値、及びb*値を求めた
(III)次式:
ΔE*ab={(L*−L0 *)2+(a*−a0 *)2+(b*−b0 *)2}1/2
により、上記(ii)又は(iii)について、製造直後との色差(ΔE*ab)を算出した
によって求めた色差(ΔE*ab)により、外用液剤の褪色を評価した。評価結果は、色差(ΔE*ab)が27以下を許容と判定した。
ヘマトオイル(アスタキサンチン含有量:11.2質量%、商品名「アスタキサンチンオイル原液」、国産ヘマトコッカス藻色素由来、)0.006質量部、ジプロピレングリコール10質量部、トコフェロール(DSM株式会社製、商品名「dl−α−トコフェロール」)0.05質量部、及び精製水を合計100質量部となるように秤取して混合し、外用液剤を得た。
トリオレイン酸ソルビタン(HLB値:2.0、日光ケミカルズ株式会社製、商品名「NIKKOL SO−30V」)(比較例2)、ポリオキシエチレン(5)硬化ヒマシ油(酸化エチレンの平均付加モル数:5、POE(5)硬化ヒマシ油、HLB値:6.0、日光ケミカルズ株式会社製、商品名「NIKKOL HCO−5」)(比較例3)、ポリオキシエチレン(2)セチルエーテル(酸化エチレンの平均付加モル数:2、POE(2)セチルエーテル、HLB値:8.0、日光ケミカルズ株式会社製、商品名「NIKKOL BC−2」)(比較例4)、ポリオキシエチレン(60)硬化ヒマシ油(酸化エチレンの平均付加モル数:60、POE(60)硬化ヒマシ油、HLB値:14.0、日光ケミカルズ株式会社製、商品名「NIKKOL HCO−60」)(比較例5)、又はポリオキシエチレン(23)セチルエーテル(酸化エチレンの平均付加モル数:23、POE(23)セチルエーテル、HLB値:15.5、日光ケミカルズ株式会社製、商品名「NIKKOL BC−23」)(比較例6)を、それぞれ0.8質量部さらに添加し、下記の表1に示す組成となるようにしたこと以外は比較例1と同様にして、各外用液剤を得た。
下記の表2に示す組成となるようにしたこと以外は比較例5と同様にして、外用液剤を得た。
オレイン酸(日油株式会社製、商品名「EXTRA OS−85」)(実施例1)又はラウリン酸(日油株式会社製、商品名「NAA−122」)(比較例8)を、それぞれ0.1質量部さらに添加し、下記の表2に示す組成となるようにしたこと以外は比較例7と同様にして、各外用液剤を得た。
トコフェロールを用いず、下記の表2に示す組成となるようにしたこと以外は実施例1又は比較例8と同様にして、各外用液剤を得た。
下記の表3に示す組成となるようにしたこと以外は実施例1と同様にして、各外用液剤(ローション剤)を得た。表3において、ヒドロキシプロピルメチルセルロースの2質量%水溶液の粘度は91,800mPa・sであり、カルボキシビニルポリマーの0.2質量%水溶液の粘度は4,060mPa・sであった。
POE(60)硬化ヒマシ油(HLB値:14.0)の含有量を変更し、下記の表4に示す組成となるようにしたこと以外は実施例2と同様にして、各外用液剤(ローション剤)を得た。
Claims (6)
- アスタキサンチン、水、ジプロピレングリコール、トコフェロール、オレイン酸、並びに、HLB値が13〜16のポリオキシエチレン硬化ヒマシ油及びポリオキシエチレンセチルエーテルからなる群から選択される少なくとも1種の非イオン性界面活性剤を含有し、かつ、前記非イオン性界面活性剤の含有量が全質量に対して0.3〜3質量%であることを特徴とする、皮膚外用液剤。
- 前記トコフェロールの含有量が全質量に対して0.03〜0.3質量%であることを特徴とする、請求項1に記載の皮膚外用液剤。
- 前記オレイン酸の含有量が全質量に対して0.03〜0.8質量%であることを特徴とする、請求項1又は2に記載の皮膚外用液剤。
- 前記オレイン酸の含有量と前記トコフェロールの含有量との質量比(オレイン酸の含有量/トコフェロールの含有量)が0.1〜27であることを特徴とする、請求項1〜3のうちのいずれか一項に記載の皮膚外用液剤。
- 前記非イオン性界面活性剤の含有量と前記トコフェロールの含有量との質量比(非イオン性界面活性剤の含有量/トコフェロールの含有量)が1〜100であることを特徴とする、請求項1〜4のうちのいずれか一項に記載の皮膚外用液剤。
- ローション剤であり、かつ、ヒドロキシプロピルメチルセルロース及びカルボキシビニルポリマーからなる群から選択される少なくとも1種をさらに含有することを特徴とする、請求項1〜5のうちのいずれか一項に記載の皮膚外用液剤。
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JP2015221755A (ja) * | 2014-05-22 | 2015-12-10 | 富士フイルム株式会社 | コーニファイド・エンベロープタンパク産生促進剤 |
JP2016084321A (ja) * | 2014-10-28 | 2016-05-19 | 富士フイルム株式会社 | 化粧料 |
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JPH09143063A (ja) * | 1995-11-22 | 1997-06-03 | Kose Corp | 外用に適する組成物 |
JP2015221755A (ja) * | 2014-05-22 | 2015-12-10 | 富士フイルム株式会社 | コーニファイド・エンベロープタンパク産生促進剤 |
JP2016084321A (ja) * | 2014-10-28 | 2016-05-19 | 富士フイルム株式会社 | 化粧料 |
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