JP2020525448A5 - - Google Patents
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- JP2020525448A5 JP2020525448A5 JP2019571269A JP2019571269A JP2020525448A5 JP 2020525448 A5 JP2020525448 A5 JP 2020525448A5 JP 2019571269 A JP2019571269 A JP 2019571269A JP 2019571269 A JP2019571269 A JP 2019571269A JP 2020525448 A5 JP2020525448 A5 JP 2020525448A5
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- JP
- Japan
- Prior art keywords
- composition according
- shh
- pathway activator
- composition
- degeneration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 20
- 239000012190 activator Substances 0.000 claims 11
- 206010061246 Intervertebral disc degeneration Diseases 0.000 claims 10
- 230000019491 signal transduction Effects 0.000 claims 6
- 201000002193 degenerative disc disease Diseases 0.000 claims 4
- 230000037361 pathway Effects 0.000 claims 4
- 240000001340 Gmelina philippensis Species 0.000 claims 3
- 230000004156 Wnt signaling pathway Effects 0.000 claims 3
- 230000008410 smoothened signaling pathway Effects 0.000 claims 3
- 230000002730 additional Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 208000008035 Back Pain Diseases 0.000 claims 1
- 102000001267 GSK3 Human genes 0.000 claims 1
- 108060006662 GSK3 Proteins 0.000 claims 1
- 210000001503 Joints Anatomy 0.000 claims 1
- 208000008930 Low Back Pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- MDLUYYGRCGDKGL-UHFFFAOYSA-N propyl 4-[(1-hexyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]benzoate Chemical group O=C1N(CCCCCC)C2=CC=CC=C2C(O)=C1C(=O)NC1=CC=C(C(=O)OCCC)C=C1 MDLUYYGRCGDKGL-UHFFFAOYSA-N 0.000 claims 1
Claims (18)
- 有効な量のソニックヘッジホッグ（ＳＨＨ）シグナル伝達経路活性化剤を含む、椎間円板変性の治療に使用するための組成物。
- ＳＨＨシグナル伝達経路活性化剤が、スムーズンドアゴニスト又はＳＡＧである、請求項１に記載の組成物。
- ＳＨＨシグナル伝達経路活性化剤が、ブラキウリのアップレギュレーターである、請求項１又は２に記載の組成物。
- ＳＨＨシグナル伝達経路活性化剤が、ＳＨＨの下流エフェクターである、請求項１〜３のいずれかに記載の組成物。
- ＳＨＨシグナル伝達経路活性化剤が、古典的Ｗｎｔシグナル伝達経路から独立している、請求項１〜４のいずれかに記載の組成物。
- 古典的Ｗｎｔシグナル伝達経路活性化剤をさらに含む、請求項１〜４のいずれかに記載の組成物。
- 古典的Ｗｎｔシグナル伝達経路活性化剤が、ＧＳＫ３阻害剤である、請求項６に記載の組成物。
- 注入に適している、請求項１〜７のいずれかに記載の組成物。
- 経口投与に適している、請求項１〜７のいずれかに記載の組成物。
- 変性が、病理学的又は加齢関連性である、請求項１〜９のいずれかに記載の組成物。
- 変性が、腰痛、頸椎円板疾患、又は胸椎円板疾患である、請求項１〜１０のいずれかに記載の組成物。
- 椎間円板変性を治療することが、脊椎円板変性を回復させること、又は脊椎円板変性の進行を遅延させることを含む、請求項１〜１１のいずれかに記載の組成物。
- 椎間円板変性を治療することが、前記円板変性に関連する痛みを減少させること、又は椎間円板変性と診断された脊椎関節の可動域を拡大することを含む、請求項１〜１２のいずれかに記載の組成物。
- 椎間円板変性を治療することが、変性を測定するために使用される、磁気共鳴画像法（ＭＲＩ）に基づく円板及び脊椎部分の測定値を、治療前の測定値と比較して改善することを含む、請求項１〜１３のいずれかに記載の組成物。
- 対象において椎間円板の機能を修復又は改善することに使用するための組成物であって、前記対象において椎間円板の機能を修復又は改善するために有効な量のソニックヘッジホッグ（ＳＨＨ）シグナル伝達経路活性化剤を含む、前記組成物。
- 対象において椎間円板変性の１又は２以上の症状を緩和することに使用するための組成物であって、前記対象において椎間円板変性の１又は２以上の症状を緩和するために有効な量のソニックヘッジホッグ（ＳＨＨ）シグナル伝達経路活性化剤を含む、前記組成物。
- ＳＨＨシグナル伝達経路活性化剤が、ＧＳＡ−１０である、請求項１〜１６のいずれかに記載の組成物。
- ＳＨＨシグナル伝達経路活性化剤が、パルモルファミンである、請求項１〜１６のいずれかに記載の組成物。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023115092A JP2023134646A (ja) | 2017-06-23 | 2023-07-13 | ソニックヘッジホッグシグナル伝達経路を介する脊椎円板変性を治療する組成物、使用及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762524121P | 2017-06-23 | 2017-06-23 | |
| US62/524,121 | 2017-06-23 | ||
| US201862631184P | 2018-02-15 | 2018-02-15 | |
| US62/631,184 | 2018-02-15 | ||
| PCT/US2018/039178 WO2018237368A1 (en) | 2017-06-23 | 2018-06-23 | COMPOSITION, USES, AND METHODS FOR TREATING VERTEBRAL DISC DEGENERATION, THROUGH A SONIC HEDGEHOG SIGNAL PATH |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023115092A Division JP2023134646A (ja) | 2017-06-23 | 2023-07-13 | ソニックヘッジホッグシグナル伝達経路を介する脊椎円板変性を治療する組成物、使用及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020525448A JP2020525448A (ja) | 2020-08-27 |
| JP2020525448A5 true JP2020525448A5 (ja) | 2021-07-29 |
Family
ID=64735810
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019571269A Pending JP2020525448A (ja) | 2017-06-23 | 2018-06-23 | ソニックヘッジホッグシグナル伝達経路を介する脊椎円板変性を治療する組成物、使用及び方法 |
| JP2023115092A Pending JP2023134646A (ja) | 2017-06-23 | 2023-07-13 | ソニックヘッジホッグシグナル伝達経路を介する脊椎円板変性を治療する組成物、使用及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023115092A Pending JP2023134646A (ja) | 2017-06-23 | 2023-07-13 | ソニックヘッジホッグシグナル伝達経路を介する脊椎円板変性を治療する組成物、使用及び方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US11690834B2 (ja) |
| EP (1) | EP3641757A4 (ja) |
| JP (2) | JP2020525448A (ja) |
| WO (1) | WO2018237368A1 (ja) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040230309A1 (en) * | 2003-02-14 | 2004-11-18 | Depuy Spine, Inc. | In-situ formed intervertebral fusion device and method |
| US20110280838A1 (en) * | 2007-12-27 | 2011-11-17 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of intervertebral disc degeneration using human umbilical cord tissue-derived cells |
| US20060078499A1 (en) * | 2003-12-01 | 2006-04-13 | Rene Hen | Use of hedgehog agonist to treat depression |
| AU2007217366A1 (en) * | 2006-02-27 | 2007-08-30 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| US20080103116A1 (en) | 2006-11-01 | 2008-05-01 | Jennings-Spring Barbara L | Method of treatment and compositions of D-chiro inositol and phosphates thereof |
| US8530456B2 (en) * | 2008-04-21 | 2013-09-10 | President And Fellows Of Harvard College | Sonic hedgehog modulators |
| FR2967353B1 (fr) * | 2010-11-16 | 2013-08-16 | Centre Nat Rech Scient | Derives de quinolinone |
| NZ710034A (en) * | 2013-03-14 | 2020-06-26 | Boehringer Ingelheim Int | Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
| US9694036B2 (en) * | 2014-03-21 | 2017-07-04 | Cellular Dynamics International, Inc. | Production of midbrain dopaminergic neurons and methods for the use thereof |
| CN107208045B (zh) * | 2014-11-25 | 2018-11-02 | 宾州研究基金会 | 人神经胶质细胞转化成用于大脑和脊髓修复的神经细胞的化学重编程 |
-
2018
- 2018-06-23 WO PCT/US2018/039178 patent/WO2018237368A1/en active Application Filing
- 2018-06-23 US US16/625,164 patent/US11690834B2/en active Active
- 2018-06-23 EP EP18821602.2A patent/EP3641757A4/en active Pending
- 2018-06-23 JP JP2019571269A patent/JP2020525448A/ja active Pending
-
2023
- 2023-05-26 US US18/202,790 patent/US20230414594A1/en active Pending
- 2023-07-13 JP JP2023115092A patent/JP2023134646A/ja active Pending
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