JP2020509080A - バイオフィルムの抗菌処理のための作用増強抗菌組成物 - Google Patents
バイオフィルムの抗菌処理のための作用増強抗菌組成物 Download PDFInfo
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- JP2020509080A JP2020509080A JP2019562465A JP2019562465A JP2020509080A JP 2020509080 A JP2020509080 A JP 2020509080A JP 2019562465 A JP2019562465 A JP 2019562465A JP 2019562465 A JP2019562465 A JP 2019562465A JP 2020509080 A JP2020509080 A JP 2020509080A
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Classifications
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/40—Liliopsida [monocotyledons]
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- C—CHEMISTRY; METALLURGY
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- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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- C02F1/72—Treatment of water, waste water, or sewage by oxidation
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- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
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Abstract
Description
a)少なくとも1つの植物抽出物と、8〜18のHLB値を有する少なくとも1つの乳化剤と、水とを含むミセル形成可溶化物(Solubilisat)、及び、
b)過酸(Peroxicarbonsaeuren)及びH2O2を含む過酸化物、次亜塩素酸塩、次亜塩素酸及びこれらの組み合わせからなる群から選択される少なくとも1つの生分解性抗菌作用物質
を含む。
a)少なくとも1つの植物抽出物と水とを凡そ45〜50℃で混合すること;
b)有利には凡そ50℃に加熱された8〜18のHLB値を有する少なくとも1つの乳化剤を、植物抽出物と水の混合物に加えること;
c)植物抽出物、水及び乳化剤の混合物を、有利には凡そ90℃に、加熱し、この混合物をミセル形成可溶化物が得られるまで均質化すること;
d)過酸及びH2O2を含む過酸化物、次亜塩素酸塩、次亜塩素酸及びこれらの組み合わせからなる群から選択される少なくとも1つの生分解性抗菌作用物質、有利にはH2O2を加えること;及び
e)場合により果実酸、有利にはL-(+)-乳酸を加えること。
試験結果はL. pneumophilia(ATCC33152)に対する対数(log10)(での)減少ファクタ(Reduktionsfaktor)で表した;n.d.=不実施;WSH=標準硬度水;PSb80=ポリソルベート80;PE=ファイトエキス(P150);fPE=機能化ファイトエキス(=ミセル形成可溶化物);WVAG=作用増強抗菌混合物。
試験結果はP. aeruginosa(PAO1)に対する対数減少ファクタで表した;WSH=標準硬度水;fPE=機能化ファイトエキス(=ミセル形成可溶化物);MS=L-(+)-乳酸;WVAG=本発明の作用増強抗菌混合物。
Bacha, K., Tariki, Y., Gebreyesus, F., Zerihun, S., Mohammed, A., Weiland-Braeuer, N., Schmitz, R. A., Mulat, M. Antimicrobial and anti-Quorum sensing activities of selected medical plants of Ethiopia: Implication for development of potent antimicrobial agents. BMC Microbiol 2016; 16: 139
Bridier, A., Dubois-Brissonnet, F., Greub, G., Thomas, V., Briandet, R. Dynamics of the action of biocides in Pseudomonas aeruginosa Biofilms. Antimicrob Agents Chemother 2011; 55: 2648-54
Burt, S. Essential Oils: their antibacterial properties and potential applications in foods -a review; Int J Food Microbiol 2000; 94: 223-53
Cascaes, M. M., Guihon, G. M., Andrade, E. H., Zoghbi, M. D., Santos Lda, S. Constituents and pharmacological activities of Myrcia (Myrtaceae): A review of an aromatic and medical group of plants. Int J Mol Sci 2015; 16: 23881-904
Keyal, U., Huang, X, Bhatta, A. K. Antifungal effect of plant extract and essential oil. Chin J Integr Med 2016, DOI: 10.1007/s11655-016-2524-z
Kramer, A., Assadian, O. (Hrsg.) Wallhaeussers Praxis der Sterilisation, Desinfektion und Antiseptik. 6. Ausgabe, 2009, Georg Thieme Verlag, Stuttgart. Kapitel 70, pp 887-891
Rios, J.L., Recio, M.C. Medical plants and antimicrobial activity; J Ethnopharmacol 2005; 100: 80-4
Stewart, P. S. Antimicrobial tolerance in biofilm. Microbiol Spectr 2015; 3: 1-30
Claims (29)
- 含水液体中に存在するバイオフィルムの抗菌及び/又は抗酸化処理のための組成物の使用であって、
該組成物は、
a)少なくとも1つの植物抽出物と、8〜18のHLB値を有する少なくとも1つの乳化剤と、水とを含むミセル形成可溶化物、及び、
b)過酸及びH2O2を含む過酸化物、次亜塩素酸塩、次亜塩素酸及びこれらの組み合わせからなる群から選択される少なくとも1つの生分解性抗菌作用物質
を含み、
含水液体は人間又は動物の体液ではないこと
を特徴とする、使用。 - 請求項1に記載の使用において、
生分解性抗菌作用物質はH2O2であること
を特徴とする、使用。 - 請求項1又は2に記載の使用において、
組成物は、更に、果実酸を含むこと
を特徴とする、使用。 - 請求項3に記載の使用において、
果実酸はL-(+)-乳酸であること
を特徴とする、使用。 - 請求項3又は4に記載の使用において、
組成物は、生分解性抗菌作用物質としてのH2O2と、L-(+)-乳酸とを含むこと
を特徴とする、使用。 - 請求項1〜5の何れかに記載の使用において、
乳化剤は、少なくとも80質量%のポリソルベート、有利にはポリオキシエチレン-(20)-ソルビタンモノラウレート(ポリソルベート20)及び/又はポリオキシエチレン-(20)-ソルビタンモノオレート(ポリソルベート80)、を含むこと
を特徴とする、使用。 - 請求項1〜6の何れかに記載の使用において、
ミセル形成可溶化物は、5〜40質量%の植物抽出物と、30〜85質量%の乳化剤と、10〜40質量%の水とを含有すること
を特徴とする、使用。 - 請求項7に記載の使用において、
組成物は、13〜19質量%のH2O2と、1〜2.5質量%のL-(+)-乳酸とを含有すること
を特徴とする、使用。 - 請求項1〜8の何れかに記載の使用において、
植物抽出物は、香辛料植物又はその部分からの抽出物、柑橘類植物又はその部分からの抽出物及びこれらの抽出物の組み合わせからなる群から選択されること
を特徴とする、使用。 - 請求項9に記載の使用において、
植物抽出物は、オリーブ、ニンニク、タマネギ及び/又は柑橘類果物に由来すること
を特徴とする、使用。 - 請求項1〜10の何れかに記載の使用において、
ミセルは、1〜100nmの、有利には3〜50nmの、特に好ましくは5〜20nmの、平均径を有すること
を特徴とする、使用。 - 請求項1〜11の何れかに記載の使用ないし請求項20〜29の何れかに記載の組成物の使用において、
含水液体は、プロセス水、廃水、表層水及び充填水からなる群から選択されること
を特徴とする、使用。 - 請求項12に記載の使用において、
プロセス水は、技術装置、医療技術装置、工業装置ないし商業装置中の水であること
を特徴とする、使用。 - 請求項12又は13に記載の使用において、
プロセス水は、冷却水システムの、とりわけ冷却塔のための冷却水システムの、冷却水として存在するか、又は、冷却水システムにおける、とりわけ冷却塔のための冷却水システムにおける、使用のために処理されること
を特徴とする、使用。 - 請求項12又は13に記載の使用において、
プロセス水は、ビール醸造装置、貫流式水冷却装置及び/又は酒瓶閉栓装置の導水要素に存在するか、又は、ビール醸造装置、貫流式水冷却装置及び/又は酒瓶閉栓装置における使用のために処理されること
を特徴とする、使用。 - 請求項12又は13に記載の使用において、
プロセス水は、医療技術装置の導水要素に存在するか、又は、医療技術装置における使用のために処理されること
を特徴とする、使用。 - 請求項12に記載の使用において、
充填水は、水槽、貯水タンク、家庭用給水管及び温水循環装置のための充填水であること
を特徴とする、使用。 - 含水液体中に存在するバイオフィルムの抗菌及び/又は抗酸化処理のための、とりわけ含水液体中に存在するバイオフィルムに発生するグラム陽性及びグラム陰性菌、真菌及び/又は原生生物の増殖の抑制及び予防のための、方法であって、
含水液体は人間又は動物の体液ではないこと、
該方法は、組成物の有効量の導入を含むこと、及び、
組成物は、請求項1〜11の何れかに又は請求項20〜29の何れかに記載されたものであること
を特徴とする、方法。 - 請求項18に記載の方法において、
組成物は、バイオフィルムを含有する導水管に、とりわけ冷却水管に、導入されること
を特徴とする、方法。 - 含水液体中に存在するバイオフィルムの抗菌及び/又は抗酸化処理のための組成物であって、
a)少なくとも1つの植物抽出物と、8〜18のHLB値を有する少なくとも1つの乳化剤と、水とを含むミセル形成可溶化物、
b)過酸及びH2O2を含む過酸化物、次亜塩素酸塩、次亜塩素酸及びこれらの組み合わせからなる群から選択される少なくとも1つの生分解性抗菌作用物質、及び、
c)果実酸
を含むこと
を特徴とする、組成物。 - 請求項20に記載の組成物において、
果実酸はL-(+)-乳酸であること
を特徴とする、組成物。 - 請求項20又は21に記載の組成物において、
生分解性抗菌作用物質はH2O2であること
を特徴とする、組成物。 - 請求項20に記載の組成物において、
該組成物は、H2O2を生分解性抗菌作用物質としてかつL-(+)-乳酸を果実酸として含むこと
を特徴とする、組成物。 - 請求項20〜23の何れかに記載の組成物において、
乳化剤は、少なくとも80質量%のポリソルベート、有利にはポリオキシエチレン-(20)-ソルビタンモノラウレート(ポリソルベート20)及び/又はポリオキシエチレン-(20)-ソルビタンモノオレート(ポリソルベート80)、を含むこと
を特徴とする、組成物。 - 請求項20〜24の何れかに記載の組成物において、
ミセル形成可溶化物は、5〜40質量%の植物抽出物と、30〜85質量%の乳化剤と、10〜40質量%の水とを含有すること
を特徴とする、組成物。 - 請求項25に記載の組成物において、
組成物は、13〜19質量%のH2O2と、1〜2.5質量%のL-(+)-乳酸とを含有すること
を特徴とする、組成物。 - 請求項20〜26の何れかに記載の組成物において、
植物抽出物は、香辛料植物又はその部分からの抽出物、柑橘類植物又はその部分からの抽出物及びこれらの抽出物の組み合わせからなる群から選択されること
を特徴とする、組成物。 - 請求項27に記載の組成物において、
植物抽出物は、オリーブ、ニンニク、タマネギ及び/又は柑橘類果物に由来すること
を特徴とする、組成物。 - 請求項20〜28の何れかに記載の組成物において、
ミセルは、1〜100nmの、有利には3〜50nmの、特に好ましくは5〜20nmの、平均径を有すること
を特徴とする、組成物。
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EP3576530B1 (de) | 2021-10-27 |
BR112019015815B1 (pt) | 2023-12-19 |
SG11201906643PA (en) | 2019-08-27 |
MA50766A (fr) | 2019-12-11 |
ES2901483T3 (es) | 2022-03-22 |
BR112019015815A2 (pt) | 2020-03-31 |
IL268166B2 (en) | 2023-05-01 |
MX2019009078A (es) | 2019-09-26 |
RU2019127314A3 (ja) | 2021-05-24 |
CN110402082A (zh) | 2019-11-01 |
PH12019501761A1 (en) | 2020-06-08 |
IL268166B1 (en) | 2023-01-01 |
RU2760876C2 (ru) | 2021-12-01 |
EP3576530A1 (de) | 2019-12-11 |
JP7041173B2 (ja) | 2022-03-23 |
US20190350198A1 (en) | 2019-11-21 |
IL268166A (en) | 2019-09-26 |
AU2018215882A1 (en) | 2019-08-08 |
MY193762A (en) | 2022-10-27 |
AU2018215882B2 (en) | 2022-02-24 |
CA3050602A1 (en) | 2018-08-09 |
RU2019127314A (ru) | 2021-03-02 |
KR20190112001A (ko) | 2019-10-02 |
CA3050602C (en) | 2024-04-23 |
US11109590B2 (en) | 2021-09-07 |
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