JP2019182819A - 抗酸化剤、及び化粧料 - Google Patents
抗酸化剤、及び化粧料 Download PDFInfo
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- JP2019182819A JP2019182819A JP2018079466A JP2018079466A JP2019182819A JP 2019182819 A JP2019182819 A JP 2019182819A JP 2018079466 A JP2018079466 A JP 2018079466A JP 2018079466 A JP2018079466 A JP 2018079466A JP 2019182819 A JP2019182819 A JP 2019182819A
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- extract
- acid
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- oil
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Abstract
Description
また、本発明は、(A)オタネニンジンの抽出物と、(B)タマサキツヅラフジ抽出物と、(C)グリチルリチン酸ジカリウムと、(D)イソプロピルメチルフェノールとを含む化粧料(医薬部外品も含む)である。
成分1(ニンジン抽出物)の調製
オタネニンジン乾燥物100gに精製水を500gとエタノール500gとを添加し、4℃で12時間浸漬した。これをろ過し、さらに、室温で1週間静置した。静置後の抽出物溶液を濾過して、褐色透明のニンジン抽出物溶液685g得た(固形分濃度2.75%)。
本発明の成分2として、常法により得られるビス型アルカロイド(セファランチン)を含む抽出物(以下「成分2」という)を使用した(山口一孝、植物成分分析法(南江堂)、上巻442 〜443頁、1958年、又は特開2000-169320号参照)。
DPPH2.4部をエタノール20部に溶解し、これに精製水20部を加えてDPPH溶液を調製した。このDPPH溶液24部に対して、18v/v%エタノール溶液を19.2部、2M酢酸-酢酸ナトリウム緩衝液(pH5.5)を4.8部加えて、DPPH添加溶液として調製した。また、試液そのものの色調が試験に及ぼす影響を差し引くため、DPPH溶液の代わりに50v/v%エタノール溶液を用いて、18v/v%エタノール溶液と2M酢酸−酢酸ナトリウム緩衝液を混合した液を対照液とした。次に、組成物1〜5の終濃度がそれぞれ表1の濃度のなるように50%エタノール溶液で調製したものを試料溶液とした。この試料溶液とDPPH添加溶液又は対照液とを1:3の割合で混合し、室温で10分静置後、各試験溶液をDPPH添加溶液と混合した場合の550nmにおける吸光度と、同じく各試験溶液を対照液と混合した場合の550nmにおける吸光度との差を測定し、DPPHラジカルの残存量を確認した。また、同時にコントロールとして試料溶液の代わりに、50%エタノール溶液を用いて上記と同様の操作を行い、ここに得られる DPPHラジカル残存率に対する各試料添加時のDPPHラジカル残存率の相対値を求めた。また、試験系が正常に機能しているかを確認するために、試料溶液の代わりに陽性対照として水溶性ビタミンE(終濃度25μM)を添加した場合についても、同様の試験を行った。
[表2]
[成分] 部
オリーブ油 1.0
ポリオキシエチレン(5.5)セチルアルコール 5.0
ブチルパラベン 0.1
成分1 2.0
成分2 0.001
成分3 0.1
成分4 0.1
成分5 0.1
エタノール 5.0
グリセリン 5.0
1,3−ブチレングリコール 5.0
水酸化カリウム 適量
精製水 全量が100部となる量
[成分] 部
流動パラフィン 6.0
ヘキサラン 4.0
ホホバ油 1.0
ポリオキシエチレン(20)ソルビタンモノステアレート 1.0
親油型ステアリン酸グリセリル 1.0
成分1 1.0
成分2 0.001
成分3 0.1
成分4 0.1
成分5 0.1
大豆レシチン 1.5
L−アスコルビン酸−2−グルコシド 2.0
水酸化カリウム 0.5
グリセリン 3.0
1、3−ブチレングリコール 2.0
カルボキシメチルセルロース 0.3
ヒアルロン酸ナトリウム 0.01
精製水 全量が100部となる量
[成分] 部
エタノール 10.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
カルボキシビニルポリマー 0.1
キサンタンガム 0.1
成分1 2.0
成分2 0.001
成分3 0.2
成分4 0.2
成分5 0.2
水酸化カリウム 適量
精製水 全量が100部となる量
[成分] 部
エタノール 2.0
グリセリン 5.0
1、3−ブチレングリコール 5.0
メチルパラベン 0.1
ヒアルロン酸 0.1
クエン酸 0.3
クエン酸ナトリウム 0.6
成分1 1.0
成分2 0.005
成分3 0.1
成分4 0.2
成分5 0.2
精製水 全量が100部となる量
[成分] 部
N−ラウロイルメチルアラニンナトリウム 25.0
ヤシ油脂肪酸カリウム液(40%) 26.0
ヤシ油脂肪酸ジエタノールアミド 3.0
メチルパラベン 0.1
成分1 1.0
成分2 0.005
成分3 0.2
成分4 0.2
成分5 0.5
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
[成分] 部
N−ヤシ油脂肪酸メチルタウリンナトリウム 10.0
ポリオキシエチレン(3)アルキルエーテル硫酸ナトリウム 20.0
ラウリルジメチルアミノ酢酸ベタイン 10.0
ヤシ油脂肪酸ジエタノールアミド 4.0
メチルパラベン 0.1
クエン酸 0.1
成分1 2.0
成分2 0.001
成分3 0.5
成分4 0.5
成分5 0.5
1、3−ブチレングリコール 2.0
精製水 全量が100部となる量
[成分] 部
ポリオキシエチレン(10)硬化ヒマシ油 1.0
塩化ジステアリルジメチルアンモニウム 1.5
塩化ステアリルトリメチルアンモニウム 2.0
2−エチルヘキサン酸グリセリル 1.0
セタノール 3.2
ステアリルアルコール 1.0
メチルパラベン 0.1
1,3−ブチレングリコール 5.0
成分1 2.0
成分2 0.001
成分3 0.3
成分4 0.3
成分5 0.3
精製水 全量が100部となる量
[成分] 部
アデノシン 1.0
1,3−ブチレングリコール 10.0
フェノキシエタノール 0.2
エタノール 20.0
成分1 2.0
成分2 0.001
成分3 0.5
成分4 0.5
成分5 0.5
センブリ抽出物 0.3
精製水 全量が100部となる量
処方例8の成分中、アデノシンに代えて、ミノキシジルを用いるほかは処方例8と同様にして育毛料を得た。
処方例8の成分中、アデノシンに代えて6−ベンジルアミノプリンを用いるほかは処方例8と同様にして育毛料を得た。
[成分] 部
l−メントール 0.1
成分1 2.0
成分2 0.001
成分3 0.1
成分4 0.1
成分5 0.1
大豆レシチン 0.2
1,3−ブチレングリコール 10.0
エタノール 20.0
タケノコ皮エキス 3.0
褐藻エキス 3.0
アッケシソウエキス 3.0
ゲンチアナエキス 3.0
アマモエキス 3.0
センブリ抽出物 3.0
精製水 全量が100部となる量
処方例12において、タケノコエキスに代えて葛根エキスを用い、ゲンチアナエキスに代えてパウダルコ樹皮エキスを用いる他は、処方例12と同様にして育毛料を得た。
処方例12において、アマモエキスに代えて黒大豆加水分解エキスを用い、アッケシソウエキスに代えて豆乳発酵液を用いる他は、処方例12と同様にして育毛料を得た。
[成分] 部
流動パラフィン 15.0
ワセリン 15.0
サラシミツロウ 2.0
成分1 2.0
成分2 0.001
成分3 0.5
成分4 0.5
成分5 0.5
褐藻エキス 0.3
カルボキシビニルポリマー 0.1
キサンタンガム 0.1
グリセリン 5.0
1、3−ブチレングリコール 2.0
ポリオキシエチレン硬化ヒマシ油 3.0
キレート剤 0.1
防腐剤 0.1
香料 0.1
色素 0.01
精製水 全量が100部となる量
Claims (4)
- 以下の(A)〜(D)の成分を含む抗酸化剤。
(A)オタネニンジン抽出物
(B)タマサキツヅラフジ抽出物
(C)グリチルリチン酸ジカリウム
(D)イソプロピルメチルフェノール - 請求項1の抗酸化剤において、(E)パントテニルエチルエーテル、又は(F)酢酸トコフェロールをさらに含むことを特徴とする抗酸化剤。
- 以下の(A)〜(D)の成分を含む化粧料。
(A)オタネニンジン抽出物
(B)タマサキツヅラフジ抽出物
(C)グリチルリチン酸ジカリウム
(D)イソプロピルメチルフェノール - 請求項3の化粧料において、(E)パントテニルエチルエーテル又は(F)酢酸トコフェロールをさらに含むことを特徴とする化粧料。
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