JP2019170335A - 腸内短鎖脂肪酸生成促進組成物 - Google Patents
腸内短鎖脂肪酸生成促進組成物 Download PDFInfo
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Abstract
Description
1.被験材料
フコースとして、L−フコース(焼津水産化学工業株式会社製、海藻由来、純度98%以上)を用いた。
市販の動物用飼料(商品名「AIN−76」、オリエンタル酵母工業株式会社製)を対照群飼料とした(表1)。対照群飼料中のコーンスターチと置き換えでフコースを1質量%添加した飼料をフコース群飼料とした。
6週齢のWistar系雄ラット(日本SLC)12匹を、室温23±2℃、相対湿度45〜55%で12時間の明暗周期(7:00に点灯)の条件下、ステンレス製ケージ内で個別飼育した。試験に用いたラットは搬入後、対照群飼料で3日間予備飼育をした後、試験に供した。試験開始時に、ラットの体重を基準に2群に振り分け、対照群飼料又はフコース群飼料と水道水を2週間自由摂取させた。投与最終日に解剖を行い、盲腸を摘出した。盲腸は、内容物を採取し有機酸分析、内容物重量測定、及びpH測定に供した。
盲腸内容物の水溶性画分から有機酸を抽出し,電気伝導度検出HPLCを用いて内部標準法により分析した。
表2に示すように、盲腸内容物重量は、対照群に比べフコース群で有意に増加し、盲腸内容物pHは、対照群に比べフコース群で有意に低下した。
上記「3.試験動物」で得られたラットの試験飼料投与終了時の糞便から細菌のDNAを抽出した。これを、16S rRNA遺s伝子領域(V3−V4領域)をPCRにて増幅したのち、シーケンスを行った。
Claims (4)
- フコースを有効成分として含有することを特徴とする腸内短鎖脂肪酸生成促進組成物。
- 腸内のプロピオン酸及び/又は酢酸の濃度を上昇させる、請求項1に記載の腸内短鎖脂肪酸生成促進組成物。
- 腸内細菌叢を改善するために用いられる、請求項1又は2に記載の腸内短鎖脂肪酸生成促進組成物。
- 飲食品、機能性食品、医薬品、及び動物飼料から選ばれたものである、請求項1〜3のいずれか1項に記載の腸内短鎖脂肪酸生成促進組成物。
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