JP2018530582A5 - - Google Patents
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- Publication number
- JP2018530582A5 JP2018530582A5 JP2018519276A JP2018519276A JP2018530582A5 JP 2018530582 A5 JP2018530582 A5 JP 2018530582A5 JP 2018519276 A JP2018519276 A JP 2018519276A JP 2018519276 A JP2018519276 A JP 2018519276A JP 2018530582 A5 JP2018530582 A5 JP 2018530582A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- halo
- alkyl
- compound according
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- -1 amino acid ester Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 206010001897 Alzheimer's disease Diseases 0.000 claims 2
- 208000004296 Neuralgia Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 206010012378 Depression Diseases 0.000 claims 1
- 206010061536 Parkinson's disease Diseases 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003053 piperidines Chemical group 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrugs Drugs 0.000 claims 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN3309DE2015 | 2015-10-14 | ||
| IN3309/DEL/2015 | 2015-10-14 | ||
| PCT/US2016/056716 WO2017066368A1 (en) | 2015-10-14 | 2016-10-13 | Selective nr2b antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018530582A JP2018530582A (ja) | 2018-10-18 |
| JP2018530582A5 true JP2018530582A5 (hr) | 2019-11-21 |
| JP6843853B2 JP6843853B2 (ja) | 2021-03-17 |
Family
ID=57208377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018519276A Active JP6843853B2 (ja) | 2015-10-14 | 2016-10-13 | 選択的ｎｒ２ｂアンタゴニスト |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10501451B2 (hr) |
| EP (1) | EP3362447B1 (hr) |
| JP (1) | JP6843853B2 (hr) |
| KR (1) | KR20180064507A (hr) |
| CN (1) | CN108368101B (hr) |
| AU (1) | AU2016340239A1 (hr) |
| BR (1) | BR112018007181A2 (hr) |
| CA (1) | CA3001894A1 (hr) |
| EA (1) | EA201890764A1 (hr) |
| ES (1) | ES2822830T3 (hr) |
| IL (1) | IL258611A (hr) |
| MX (1) | MX2018004257A (hr) |
| WO (1) | WO2017066368A1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2818254T3 (es) * | 2015-10-14 | 2021-04-09 | Bristol Myers Squibb Co | Antagonistas selectivos de NR2B |
| BR112021004993A2 (pt) * | 2018-10-17 | 2021-06-08 | Boehringer Ingelheim International Gmbh | derivados de 4-pirqazin-2-ilmetil-morfolina e o uso dos mesmos com medicamento |
| JP7093470B2 (ja) * | 2018-10-17 | 2022-06-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ４－ピリミジン－５－イルメチル－モルホリン誘導体および医薬としてのその使用 |
| CN112867508B (zh) * | 2018-10-17 | 2023-09-15 | 勃林格殷格翰国际有限公司 | 4-吡啶基甲基-吗啉衍生物及其作为药物的用途 |
| TW202237103A (zh) * | 2020-12-04 | 2022-10-01 | 瑞士商諾華公司 | 用於治療抑鬱症的ｎｒ２ｂ－ｎｍｄａ受體ｎａｍ之劑量方案 |
| CN113620896A (zh) * | 2021-08-31 | 2021-11-09 | 青岛科技大学 | 2-(2-氯苯基)甲基-4,4-二甲基-3-异恶唑酮的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
| US7022728B2 (en) | 2001-03-09 | 2006-04-04 | Abbott Laboratories | Benzimidazoles that are useful in treating male sexual dysfunction |
| WO2003035641A1 (fr) | 2001-10-22 | 2003-05-01 | Shionogi & Co., Ltd. | Nouveau derive carbamoyl-pyrrolidone |
| ATE403651T1 (de) | 2003-06-04 | 2008-08-15 | Merck & Co Inc | 3-fluoro-piperidine als nmda/nr2b antagonisten |
| EP1673367A1 (en) | 2003-10-08 | 2006-06-28 | Pfizer, Inc. | Fused lactam compounds |
| EP1736474A4 (en) * | 2004-04-07 | 2010-04-21 | Kyowa Hakko Kirin Co Ltd | piperidine |
| JPWO2006137465A1 (ja) * | 2005-06-24 | 2009-01-22 | 塩野義製薬株式会社 | 含窒素複素環誘導体 |
| US7935706B2 (en) | 2006-02-23 | 2011-05-03 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
| CN103497114A (zh) | 2007-06-29 | 2014-01-08 | 埃莫里大学 | 用于神经保护的nmda受体拮抗剂 |
| JP2009067784A (ja) * | 2007-08-21 | 2009-04-02 | Shionogi & Co Ltd | 環式基で置換された含窒素複素環誘導体を含有する鎮痛剤 |
| SG10201811584RA (en) * | 2010-02-11 | 2019-01-30 | Univ Northwestern | Secondary Structure Stabilized NMDA Receptor Modulators And Uses Thereof |
| US9187506B2 (en) * | 2014-01-09 | 2015-11-17 | Bristol-Myers Squibb Company | (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders |
| US9221796B2 (en) | 2014-01-09 | 2015-12-29 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
-
2016
- 2016-10-13 CN CN201680073103.8A patent/CN108368101B/zh active Active
- 2016-10-13 JP JP2018519276A patent/JP6843853B2/ja active Active
- 2016-10-13 EA EA201890764A patent/EA201890764A1/ru unknown
- 2016-10-13 CA CA3001894A patent/CA3001894A1/en not_active Abandoned
- 2016-10-13 US US15/767,385 patent/US10501451B2/en active Active
- 2016-10-13 ES ES16787974T patent/ES2822830T3/es active Active
- 2016-10-13 MX MX2018004257A patent/MX2018004257A/es unknown
- 2016-10-13 AU AU2016340239A patent/AU2016340239A1/en not_active Abandoned
- 2016-10-13 EP EP16787974.1A patent/EP3362447B1/en active Active
- 2016-10-13 WO PCT/US2016/056716 patent/WO2017066368A1/en active Application Filing
- 2016-10-13 KR KR1020187013128A patent/KR20180064507A/ko not_active Application Discontinuation
- 2016-10-13 BR BR112018007181A patent/BR112018007181A2/pt not_active Application Discontinuation
-
2018
- 2018-04-10 IL IL258611A patent/IL258611A/en unknown
-
2019
- 2019-12-09 US US16/707,382 patent/US10954225B2/en active Active
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