JP2018527066A - 干渉電流での脊髄刺激 - Google Patents
干渉電流での脊髄刺激 Download PDFInfo
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Abstract
Description
ただし、Xは容量抵抗(リアクタンス)であり、fは電流の周波数であり、Cは組織の分極容量である。
Claims (24)
- 脊髄の電気刺激を用いた脊髄刺激治療のための方法であって、
所定の位置で対象者の脊髄に近接する硬膜上腔内の硬膜に埋め込み型電極の第1ペアを配置することと、
所定の位置で前記対象者の脊髄に近接する前記硬膜上腔内の前記硬膜に埋め込み型電極の第2ペアを配置することと、
前記対象者の脊髄に近接する少なくとも1つのビート信号を生み出すように第1周波数及び第2周波数の信号が互いに干渉するように、埋め込み型電極の前記第1ペア及び前記第2ペアを通じて前記第1周波数及び前記第2周波数の信号をそれぞれ伝送することであって、前記少なくとも1つのビート信号は250Hzよりも高く約15,000Hzまでの範囲内の周波数を有する、ことと、を有する方法。 - 請求項1に記載の方法であって、埋め込み型電極の前記第1ペアは第1埋め込み型リードに含まれ、埋め込み型電極の前記第2ペアは第2埋め込み型リードに含まれる、方法。
- 請求項1に記載の方法であって、埋め込み型電極の前記第1ペア及び埋め込み型電極の前記第2ペアは同じ埋め込み型リードに含まれる、方法。
- 請求項1に記載の方法であって、埋め込み型電極の前記第1ペアを配置すること及び埋め込み型電極の前記第2ペアを配置することは、
埋め込み型電極の前記第1ペアの間に生成される第1回路が、埋め込み型電極の前記第2ペアの間に生成される第2回路と交差するように、埋め込み型電極の前記第1ペア及び埋め込み型電極の前記第2ペアを交差構成に配置することを含む、方法。 - 請求項1に記載の方法であって、埋め込み型電極の前記第1ペアを配置すること及び埋め込み型電極の前記第2ペアを配置することは、
埋め込み型電極の前記第1ペアの間に生成される第1回路が、埋め込み型電極の前記第2ペアの間に生成される第2回路と平行になるように、埋め込み型電極の前記第1ペア及び埋め込み型電極の前記第2ペアを平行構成に配置することを含む、方法。 - 請求項5に記載の方法であって、前記第1回路及び前記第2回路は第1場及び第2場を生成し、埋め込み型電極の前記第1ペアを配置すること及び埋め込み型電極の前記第2ペアを配置することは、
前記少なくとも1つのビート信号を生み出すように前記第1場及び前記第2場が重畳するように、埋め込み型電極の前記第1ペアを配置すること及び埋め込み型電極の前記第2ペアを配置することを含む、方法。 - 請求項6に記載の方法であって、埋め込み型電極の一方のペアのアノード及びカソードが垂直に位置合わせされ、埋め込み型電極の他方のペアのアノード及びカソードが垂直に且つ前記第1場及び前記第2場の重畳のエリアを形成するように互いに近接するように位置合わせされるように、集中の対象領域で前記第1場及び前記第2場の位置合わせを行うように埋め込み型電極の前記第1ペア及び埋め込み型電極の前記第2ペアをバイアスすることを更に有する、方法。
- 請求項6に記載の方法であって、集中の非対象の領域について前記第1場及び前記第2場が位置合わせされないように、埋め込み電極の前記第1ペア及び埋め込み電極の前記第2ペアをバイアスすることを更に有する、方法。
- 請求項1に記載の方法であって、
約2mmから約10mmまでの縦方向の分離距離で埋め込み電極の前記第1ペアを配置することと、
約2mmから約10mmまでの縦方向の分離距離で埋め込み電極の前記第2ペアを配置することと、を更に有する、方法。 - 請求項1に記載の方法であって、埋め込み型電極の前記第1ペア及び前記第2ペアを通じて第1周波数及び第2周波数の信号をそれぞれ伝送することは、
埋め込み型電極の前記第1ペアを通じて約20,000Hzの第1周波数の信号を伝送することと、
埋め込み型電極の前記第2ペアを通じて約10,000Hzの第2周波数の信号を伝送することと、を含み、
前記対象者の脊髄に近接する約10,000Hzの前記少なくとも1つのビート信号を生み出すように前記第1周波数及び前記第2周波数の前記信号が互いに干渉する、方法。 - 請求項1に記載の方法であって、埋め込み型電極の前記第1ペア及び前記第2ペアを通じて第1周波数及び第2周波数の信号をそれぞれ伝送することは、
埋め込み型電極の前記第1ペアを通じて約20,000Hzの第1周波数の信号を伝送することと、
埋め込み型電極の前記第2ペアを通じて約5,000Hzの第2周波数の信号を伝送することと、を含み、
前記対象者の脊髄に近接する約15,000Hzの前記少なくとも1つのビート信号を生み出すように前記第1周波数及び前記第2周波数の前記信号が互いに干渉する、方法。 - 請求項1に記載の方法であって、前記少なくとも1つのビート信号の周波数の範囲は約3,000Hzから約15,000Hzまでの間である、方法。
- 請求項1に記載の方法であって、前記少なくとも1つのビート信号の周波数の範囲は約10,000Hzから約15,000Hzまでの間である、方法。
- 請求項1に記載の方法であって、前記少なくとも1つのビート信号の周波数の範囲は250Hzよりも高く約10,000Hzまでである、方法。
- 請求項1に記載の方法であって、前記対象者の脊髄に近接する少なくとも1つのビート信号を生み出すように前記第1周波数及び前記第2周波数の前記信号が互いに干渉するように、埋め込み型電極の前記第1ペア及び前記第2ペアを通じて第1周波数及び第2周波数の前記信号をそれぞれ伝送することは、
錯感覚型のビート信号を生み出すことを含む、方法。 - 請求項1に記載の方法であって、前記対象者の脊髄に近接する少なくとも1つのビート信号を生み出すことと、指向性制御を通じて前記対象者の後索に近接する脳脊髄液に前記少なくとも1つのビート信号が留まり短絡することを避けることと、を更に有する、方法。
- 請求項1に記載の方法であって、脊髄視床路、脊髄網様体路、脊髄中脳路、頸視床路及び脊髄視床下部路のうちの1つ以上を含む、前記脊髄から前記対象者の視床までの上行経路のうちの1つ以上に近接する前記対象者の組織へ前記少なくとも1つのビート信号を深く突き出すことと、前記対象者の後索に近接する脳脊髄液に前記少なくとも1つのビート信号が留まり短絡することを避けることと、を更に有する、方法。
- 脊髄治療のための電気刺激器であって、
相異なる第1周波数及び第2周波数を有する第1信号及び第2信号を含む干渉出力を生成する干渉電流生成器と、
第1端及び第2端を有する埋め込み型電極の少なくとも2つのペアと、を備え、前記第1端は前記干渉電流生成器に接続され、前記第2端は対象者の脊髄に近接する所定の位置において硬膜上腔内の硬膜に埋め込まれるように構成され、埋め込み型電極の前記少なくとも2つのペアのそれぞれは、前記対象者の脊髄に近接する少なくとも1つのビート信号を生み出すように前記第1周波数及び前記第2周波数が互いに干渉するように、前記第1信号及び前記第2信号のうちの1つを伝え、前記少なくとも1つのビート信号は250Hzよりも高く約15,000Hzまでの範囲内の周波数を有する、電気刺激器。 - 請求項18に記載の電気刺激器であって、前記干渉電流生成器は前記対象者に埋め込み可能である、電気刺激器。
- 請求項18に記載の電気刺激器であって、前記干渉電流生成器に接続される電源を更に備え、前記電源は前記対象者に埋め込み可能である、電気刺激器。
- 請求項18に記載の電気刺激器であって、前記干渉電流生成器は埋め込み型電極の前記少なくとも2つのペアと無線リンクを介して通信する、電気刺激器。
- 請求項21に記載の電気刺激器であって、前記干渉電流生成器は、約8.5GHzから約10THzまでの範囲内のキャリア周波数を有する少なくとも1つの入力無線周波数(RF)を用いて通信する、電気刺激器。
- 請求項18に記載の電気刺激器であって、埋め込み型電極の前記第1ペアの間に生成される第1回路が、埋め込み型電極の前記第2ペアの間に生成される第2回路と交差するように、埋め込み型電極の前記第1ペア及び埋め込み型電極の前記第2ペアが交差構成に配置される、電気刺激器。
- 請求項18に記載の電気刺激器であって、埋め込み型電極の前記第1ペアの間に生成される第1回路が、埋め込み型電極の前記第2ペアの間に生成される第2回路と平行になるように、埋め込み型電極の前記第1ペア及び埋め込み型電極の前記第2ペアが平行構成に配置される、電気刺激器。
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