JP2018507731A - 穿孔デバイスを備える放射性医薬品の製造のための装置 - Google Patents
穿孔デバイスを備える放射性医薬品の製造のための装置 Download PDFInfo
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Abstract
Description
(i)放射性同位元素が前記カセット(2)に導入される場合に、2バッチの前記放射性医薬品を生成するために必要な全ての試薬を含むカセット(2)であって、前記試薬の各々が、栓付き試薬バイアル(3a〜g)および/またはスパイク(4a〜g)の自動化された動きによって、前記スパイク(4a〜g)によって穿孔される前記栓付き試薬バイアル(3a〜g)に含められている、カセット(2);
(ii)前記カセットがそれに着脱可能に装着され、カセット(2)の操作を制御する可動部を含む、自動ラジオシンセサイザー(5)であって、そのような1つの可動部が、前記栓付き試薬バイアル(3a〜g)の1つの自動穿孔を促進するためのデバイス(6)であり、前記デバイス(6)が前記自動ラジオシンセサイザー(5)の外部に取り付けられ、支持体(7)と前記支持体(7)の中に収容される実質的に硬質なロッド(8)を含む、自動ラジオシンセサイザー(5)。
2 カセット
3a〜3g 栓付き試薬バイアル
4a〜4g スパイク
5 自動ラジオシンセサイザー
6 デバイス
7 支持体
8 ロッド
9 支持本体
10 ロッド固定手段
11 支持体固定具
12 自動ラジオシンセサイザー固定具
13 ウォーターボトルホルダー
14 スペーサー
14a 第1の端部
14b 第2の端部
15 ウォーターボトルハンガー
16 ウォーターボトル
Claims (12)
- 放射性医薬品の製造のためのシステム(1)であって:
(i)放射性同位元素が前記カセット(2)に導入される場合に、2バッチの前記放射性医薬品を生成するために必要な全ての試薬を含むカセット(2)であって、前記試薬の各々が、栓付き試薬バイアル(3a〜g)および/またはスパイク(4a〜g)の自動化された動きによって、前記スパイク(4a〜g)によって穿孔される前記栓付き試薬バイアル(3a〜g)に含められている、カセット(2);
(ii)前記カセットがそれに着脱可能に装着され、カセット(2)の操作を制御する可動部を含む、自動ラジオシンセサイザー(5)であって、そのような1つの可動部が、前記栓付き試薬バイアル(3a〜g)の1つの自動穿孔を促進するためのデバイス(6)であり、前記デバイス(6)が前記自動ラジオシンセサイザー(5)の外部に取り付けられ、支持体(7)と前記支持体(7)の中に収容される実質的に硬質なロッド(8)を含む、自動ラジオシンセサイザー(5)
を含む、システム(1)。 - 前記支持体(7)が、支持本体(9)およびロッド固定手段(10)を含む、請求項1に記載のシステム(1)。
- 前記ロッド固定手段(10)が、前記支持本体(9)に内腔を含み、前記内腔が、前記ロッド(8)の断面寸法と実質的に類似するが前記ロッド(8)を前記内腔の内部に確実に含むようにする前記断面寸法を有する、請求項2に記載のシステム(1)。
- 前記支持体(7)が、支持体固定具(11)および自動ラジオシンセサイザー固定具(12)の協働係合によって、前記自動ラジオシンセサイザー(5)の外部の適所に保持される、請求項1乃至3のいずれか1項に記載のシステム(1)。
- 前記ロッド(8)が硬質プラスチックで作製されている、請求項1乃至4のいずれか1項に記載のシステム(1)。
- 前記デバイス(6)が、前記支持体(7)の内部に収容されるウォーターボトルホルダー(13)をさらに含む、請求項1乃至5のいずれか1項に記載のシステム(1)。
- 前記ウォーターボトルホルダー(13)が、前記ロッド(8)の正反対に位置する、請求項6に記載のシステム(1)。
- 前記ウォーターボトルホルダー(13)が、前記支持体(7)の内部に収容される第1の端部(14a)およびウォーターボトルハンガー(15)を含む第2の端部(14b)を有する硬質のスペーサー(14)を含む、請求項6または請求項7のいずれかに記載のシステム(1)。
- 前記放射性医薬品が18F標識放射性医薬品である、請求項1乃至8のいずれか1項に記載のシステム(1)。
- 前記18F標識放射性医薬品が、18F−フルオロデオキシグルコース(18F−FDG)である、請求項9に記載のシステム(1)。
- 前記試薬が、18F溶出溶液、マンノーストリフラート、アセトニトリル、エタノールおよび緩衝液を含む、請求項10に記載のシステム(1)。
- 請求項1乃至11のいずれか1項に記載のシステム(1)に記載のデバイス(6)。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1504287.2 | 2015-03-13 | ||
GB201504287A GB201504287D0 (en) | 2015-03-13 | 2015-03-13 | Piercing device |
PCT/EP2016/055178 WO2016146482A1 (en) | 2015-03-13 | 2016-03-10 | Apparatus for the production of a radiopharmaceutical comprising a piercing device |
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JP2018507731A true JP2018507731A (ja) | 2018-03-22 |
JP6967454B2 JP6967454B2 (ja) | 2021-11-17 |
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US (1) | US10525435B2 (ja) |
EP (1) | EP3268124A1 (ja) |
JP (1) | JP6967454B2 (ja) |
KR (1) | KR102607180B1 (ja) |
CN (1) | CN107405595B (ja) |
GB (1) | GB201504287D0 (ja) |
HK (1) | HK1247153A1 (ja) |
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GB201504287D0 (en) | 2015-03-13 | 2015-04-29 | Ge Healthcare Ltd | Piercing device |
CN108218651B (zh) * | 2018-02-27 | 2023-11-03 | 首都医科大学宣武医院 | 用于制备放射性药物的一次性辅助装置及方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10148628A (ja) * | 1996-11-19 | 1998-06-02 | Shimadzu Corp | マイクロチップ電気泳動装置 |
JP2004515330A (ja) * | 2000-12-22 | 2004-05-27 | イヨン ベアム アプリカスィヨン エッス.アー. | 放射性医薬品の合成装置 |
JP2009501138A (ja) * | 2005-06-17 | 2009-01-15 | エッケルト ウント ツィーグラー ユーロトープ ゲーエムベーハー | 化学物質を処理するためのシステム及び方法、このようなシステムを制御するためのコンピュータプログラム、並びにコンピュータ読み取り可能な記憶媒体 |
WO2010021719A1 (en) * | 2008-08-19 | 2010-02-25 | The Regents Of The University Of California | Modular radiochemistry synthesis system |
JP2015501418A (ja) * | 2011-09-30 | 2015-01-15 | ジーイー・ヘルスケア・リミテッド | 放射性医薬品合成用カセット |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2017359A3 (en) * | 2007-06-11 | 2009-08-05 | Trasis S.A. | Method for the elution of 18F fluoride trapped on an anion-exchange resin in a form suitable for efficient radiolabeling without any evaporation step |
US20130334443A1 (en) * | 2010-12-27 | 2013-12-19 | Ge Healthcare Limited | Radiopharmacy and devices |
CN104011802B (zh) | 2011-09-30 | 2016-09-07 | 通用电气健康护理有限公司 | 合成器诊断盒模拟器 |
JP2015501260A (ja) | 2011-09-30 | 2015-01-15 | ジーイー・ヘルスケア・リミテッド | 容器コネクタ |
EP3068747A1 (en) | 2013-11-13 | 2016-09-21 | GE Healthcare Limited | Dual run cassette for the synthesis of 18f-labelled compounds |
GB201504287D0 (en) | 2015-03-13 | 2015-04-29 | Ge Healthcare Ltd | Piercing device |
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2015
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2016
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10148628A (ja) * | 1996-11-19 | 1998-06-02 | Shimadzu Corp | マイクロチップ電気泳動装置 |
JP2004515330A (ja) * | 2000-12-22 | 2004-05-27 | イヨン ベアム アプリカスィヨン エッス.アー. | 放射性医薬品の合成装置 |
JP2009501138A (ja) * | 2005-06-17 | 2009-01-15 | エッケルト ウント ツィーグラー ユーロトープ ゲーエムベーハー | 化学物質を処理するためのシステム及び方法、このようなシステムを制御するためのコンピュータプログラム、並びにコンピュータ読み取り可能な記憶媒体 |
WO2010021719A1 (en) * | 2008-08-19 | 2010-02-25 | The Regents Of The University Of California | Modular radiochemistry synthesis system |
JP2015501418A (ja) * | 2011-09-30 | 2015-01-15 | ジーイー・ヘルスケア・リミテッド | 放射性医薬品合成用カセット |
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US20180008949A1 (en) | 2018-01-11 |
JP6967454B2 (ja) | 2021-11-17 |
WO2016146482A1 (en) | 2016-09-22 |
EP3268124A1 (en) | 2018-01-17 |
IL253413B (en) | 2022-08-01 |
CN107405595B (zh) | 2020-07-31 |
CN107405595A (zh) | 2017-11-28 |
IL253413A0 (en) | 2017-09-28 |
KR102607180B1 (ko) | 2023-11-29 |
HK1247153A1 (zh) | 2018-09-21 |
US10525435B2 (en) | 2020-01-07 |
KR20170128274A (ko) | 2017-11-22 |
GB201504287D0 (en) | 2015-04-29 |
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