JP2017501154A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017501154A5 JP2017501154A5 JP2016539318A JP2016539318A JP2017501154A5 JP 2017501154 A5 JP2017501154 A5 JP 2017501154A5 JP 2016539318 A JP2016539318 A JP 2016539318A JP 2016539318 A JP2016539318 A JP 2016539318A JP 2017501154 A5 JP2017501154 A5 JP 2017501154A5
- Authority
- JP
- Japan
- Prior art keywords
- angiotensin
- rate
- catecholamine
- norepinephrine
- mcg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000005862 Angiotensin II Human genes 0.000 claims description 46
- 229950006323 Angiotensin ii Drugs 0.000 claims description 46
- 101800000733 Angiotensin-2 Proteins 0.000 claims description 46
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II dizwitterion Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims description 46
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims description 42
- SFLSHLFXELFNJZ-MRVPVSSYSA-N L-Noradrenaline Natural products NC[C@@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-MRVPVSSYSA-N 0.000 claims description 42
- 229960002748 Norepinephrine Drugs 0.000 claims description 42
- MGBKJKDRMRAZKC-UHFFFAOYSA-N 3-aminobenzene-1,2-diol Chemical compound NC1=CC=CC(O)=C1O MGBKJKDRMRAZKC-UHFFFAOYSA-N 0.000 claims description 39
- 230000000875 corresponding Effects 0.000 claims description 30
- 230000004872 arterial blood pressure Effects 0.000 claims description 17
- 150000003943 catecholamines Chemical class 0.000 claims description 17
- 230000035939 shock Effects 0.000 claims description 17
- 230000036772 blood pressure Effects 0.000 claims description 15
- 208000006148 High Cardiac Output Diseases 0.000 claims description 9
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 6
- UCTWMZQNUQWSLP-VIFPVBQESA-N Epinephrine Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims description 3
- 208000001953 Hypotension Diseases 0.000 claims description 3
- 229960001802 Phenylephrine Drugs 0.000 claims description 3
- SONNWYBIRXJNDC-VIFPVBQESA-N Phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims description 3
- 229960003638 dopamine Drugs 0.000 claims description 3
- 229960005139 epinephrine Drugs 0.000 claims description 3
- 230000036543 hypotension Effects 0.000 claims description 3
- 102000015427 Angiotensins Human genes 0.000 claims description 2
- 108010064733 Angiotensins Proteins 0.000 claims description 2
- 230000000033 vasopressor Effects 0.000 claims 16
- 239000005526 vasoconstrictor agent Substances 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 12
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 4
- 229960003726 vasopressin Drugs 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000001990 intravenous administration Methods 0.000 claims 2
- 230000003247 decreasing Effects 0.000 claims 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361917576P | 2013-12-18 | 2013-12-18 | |
US61/917,576 | 2013-12-18 | ||
US201461955706P | 2014-03-19 | 2014-03-19 | |
US61/955,706 | 2014-03-19 | ||
PCT/US2014/071186 WO2015095535A1 (en) | 2013-12-18 | 2014-12-18 | Angiotensin ii alone or in combination for the treatment of hypotension |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019153144A Division JP7175506B2 (ja) | 2013-12-18 | 2019-08-23 | 低血圧治療のための単独または併用使用されるアンギオテンシンii |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017501154A JP2017501154A (ja) | 2017-01-12 |
JP2017501154A5 true JP2017501154A5 (ko) | 2018-02-08 |
JP6824739B2 JP6824739B2 (ja) | 2021-02-03 |
Family
ID=53367119
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016539318A Active JP6824739B2 (ja) | 2013-12-18 | 2014-12-18 | 低血圧治療のための単独または併用使用されるアンギオテンシンii |
JP2019153144A Active JP7175506B2 (ja) | 2013-12-18 | 2019-08-23 | 低血圧治療のための単独または併用使用されるアンギオテンシンii |
JP2022113327A Pending JP2022137224A (ja) | 2013-12-18 | 2022-07-14 | 低血圧治療のための単独または併用使用されるアンギオテンシンii |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019153144A Active JP7175506B2 (ja) | 2013-12-18 | 2019-08-23 | 低血圧治療のための単独または併用使用されるアンギオテンシンii |
JP2022113327A Pending JP2022137224A (ja) | 2013-12-18 | 2022-07-14 | 低血圧治療のための単独または併用使用されるアンギオテンシンii |
Country Status (23)
Country | Link |
---|---|
US (7) | US9220745B2 (ko) |
EP (2) | EP2986308B1 (ko) |
JP (3) | JP6824739B2 (ko) |
KR (3) | KR20220028125A (ko) |
CN (3) | CN112546197A (ko) |
AU (2) | AU2014364528C1 (ko) |
BR (1) | BR112016013961A2 (ko) |
CA (1) | CA2933601A1 (ko) |
CY (1) | CY1122604T1 (ko) |
DK (1) | DK2986308T3 (ko) |
EA (1) | EA037823B1 (ko) |
ES (1) | ES2771749T3 (ko) |
HR (1) | HRP20200009T1 (ko) |
HU (1) | HUE047062T2 (ko) |
IL (1) | IL246162B (ko) |
LT (1) | LT2986308T (ko) |
MX (2) | MX2016008108A (ko) |
NZ (1) | NZ721089A (ko) |
PL (1) | PL2986308T3 (ko) |
PT (1) | PT2986308T (ko) |
RS (1) | RS59804B1 (ko) |
SI (1) | SI2986308T1 (ko) |
WO (1) | WO2015095535A1 (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9572856B2 (en) | 2009-12-16 | 2017-02-21 | The George Washington University a Congressionally Chartered Not-for-Profit Corporation | Method of treating low blood pressure |
CN112546197A (zh) | 2013-12-18 | 2021-03-26 | 乔治华盛顿大学国会特许非营利公司 | 血管紧张素ii单独或以组合方式用于治疗低血压 |
MX2017000306A (es) * | 2014-07-08 | 2017-07-10 | La Jolla Pharma Co | Metodos para tratar hipotension. |
WO2016153558A1 (en) | 2015-03-20 | 2016-09-29 | Atkinson Arthur J | Use of angiotensin ii (aii) receptor agonists to prevent or reduce hemodialysis-associated skeletal muscle cramps |
EP3400001A1 (en) * | 2016-01-07 | 2018-11-14 | La Jolla Pharmaceutical Company | Methods of administering vasopressors |
EP3400000B1 (en) | 2016-01-07 | 2023-12-06 | La Jolla Pharma, LLC | Methods for administering angiotensin ii |
US11583568B2 (en) | 2017-04-14 | 2023-02-21 | La Jolla Pharma, Llc | Methods for administering angiotensin II |
TW201927331A (zh) * | 2017-12-15 | 2019-07-16 | 美商拉荷亞製藥公司 | 血管收縮素組合物及與其相關之方法 |
WO2023244552A1 (en) * | 2022-06-15 | 2023-12-21 | Virginia Commonwealth University | Methods for fluid resuscitation of an organ donor |
WO2024129057A1 (en) * | 2022-12-12 | 2024-06-20 | Proletariat Therapeutics, Inc. | Methods of treating cardiac injury |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU181008B (en) | 1980-01-18 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing angiotenzin-ii analogues of antagonistic activity containing sarcosyl-group at the 1-positon,and an alpha-hydroxy-carboxylic acid at the 8-position |
US5216025A (en) | 1989-09-13 | 1993-06-01 | Board Of Regents, The University Of Texas System | Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients |
US5444067A (en) | 1993-08-30 | 1995-08-22 | Merck & Co., Inc. | Pharmaceutical treatment methods using angiotensin II receptor agonists bearing a thiophene moiety |
CA2448051A1 (en) | 2001-06-04 | 2002-12-12 | Human Genome Sciences, Inc. | Methods and compositions for modulating ace-2 activity |
US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
JP2007510643A (ja) | 2003-11-06 | 2007-04-26 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 医薬化合物 |
NO20034952D0 (no) | 2003-11-06 | 2003-11-06 | Amersham Health As | Farmasöytiske forbindelser |
FR2880807B1 (fr) * | 2005-01-19 | 2007-04-13 | Aguettant Sa Lab | Composition pharmaceutique injectable |
JP2009510056A (ja) | 2005-09-29 | 2009-03-12 | ファイブローゲン、インコーポレーテッド | 血圧を低下させる方法 |
EP1971358A4 (en) * | 2005-12-30 | 2010-05-26 | Florey Howard Inst | Methods of Treatment |
US20070293552A1 (en) | 2006-06-15 | 2007-12-20 | Gorczynski Richard J | Antihypertensive therapy method |
WO2008130217A1 (en) * | 2006-08-08 | 2008-10-30 | Applied Nanosystems B.V. | Cyclic angiotensin analogs |
JP2010510196A (ja) | 2006-11-17 | 2010-04-02 | ダ・ボルテラ | オイドラギット被覆を施した亜鉛/ペクチンビーズを使用する結腸送達 |
WO2009009907A1 (en) * | 2007-07-18 | 2009-01-22 | The University Of British Columbia | Use of vasopressin-receptor agonists for the treatment of septic shock |
EP2161030A1 (en) * | 2008-09-09 | 2010-03-10 | Rijksuniversiteit te Groningen | Oxytocin formulations and uses thereof |
RU2011126338A (ru) | 2008-11-28 | 2013-01-10 | Эбботт Лэборетриз | Стабильные композиции антител и способы их стабилизации |
US9572856B2 (en) | 2009-12-16 | 2017-02-21 | The George Washington University a Congressionally Chartered Not-for-Profit Corporation | Method of treating low blood pressure |
FR2959414B1 (fr) * | 2010-04-30 | 2016-01-08 | Luc Quintin | Combinaison de molecules aux fins de traitement d'hypotension survenant au cours du choc septique, cardiogenique, ou anaphylactique refractaire, ou hemorragique terminal, apres correction de la volemie et de l'etat de mal asthmatique refractaire |
BR112013000744A2 (pt) | 2010-07-14 | 2020-07-14 | Cumberland Emerging Technologies, Inc | uso de um antagonista de receptor de tromboxana a2 para prevenção ou tratamento de síndrome hepatorrenal,encefalopatia hepática,e doenças associadas |
CN105592855A (zh) | 2013-04-26 | 2016-05-18 | 拉卓拉药物公司 | 用于治疗肾衰竭的组合物和方法 |
CN112546197A (zh) | 2013-12-18 | 2021-03-26 | 乔治华盛顿大学国会特许非营利公司 | 血管紧张素ii单独或以组合方式用于治疗低血压 |
US20150286797A1 (en) | 2014-04-02 | 2015-10-08 | David R. Ratto | System and method for administering medication |
MX2017000306A (es) | 2014-07-08 | 2017-07-10 | La Jolla Pharma Co | Metodos para tratar hipotension. |
EP3400001A1 (en) | 2016-01-07 | 2018-11-14 | La Jolla Pharmaceutical Company | Methods of administering vasopressors |
EP3400000B1 (en) | 2016-01-07 | 2023-12-06 | La Jolla Pharma, LLC | Methods for administering angiotensin ii |
US11583568B2 (en) | 2017-04-14 | 2023-02-21 | La Jolla Pharma, Llc | Methods for administering angiotensin II |
TW201927331A (zh) | 2017-12-15 | 2019-07-16 | 美商拉荷亞製藥公司 | 血管收縮素組合物及與其相關之方法 |
-
2014
- 2014-12-18 CN CN202011494632.XA patent/CN112546197A/zh active Pending
- 2014-12-18 US US14/575,127 patent/US9220745B2/en active Active
- 2014-12-18 PT PT148726847T patent/PT2986308T/pt unknown
- 2014-12-18 EP EP14872684.7A patent/EP2986308B1/en active Active
- 2014-12-18 AU AU2014364528A patent/AU2014364528C1/en active Active
- 2014-12-18 JP JP2016539318A patent/JP6824739B2/ja active Active
- 2014-12-18 RS RS20200021A patent/RS59804B1/sr unknown
- 2014-12-18 HU HUE14872684A patent/HUE047062T2/hu unknown
- 2014-12-18 CN CN201480075899.1A patent/CN106061493A/zh active Pending
- 2014-12-18 DK DK14872684.7T patent/DK2986308T3/da active
- 2014-12-18 EA EA201691258A patent/EA037823B1/ru unknown
- 2014-12-18 KR KR1020227004084A patent/KR20220028125A/ko active Application Filing
- 2014-12-18 MX MX2016008108A patent/MX2016008108A/es unknown
- 2014-12-18 BR BR112016013961A patent/BR112016013961A2/pt not_active Application Discontinuation
- 2014-12-18 SI SI201431450T patent/SI2986308T1/sl unknown
- 2014-12-18 ES ES14872684T patent/ES2771749T3/es active Active
- 2014-12-18 CN CN202010824424.5A patent/CN111920939A/zh active Pending
- 2014-12-18 KR KR1020237012136A patent/KR20230051721A/ko not_active Application Discontinuation
- 2014-12-18 EP EP19197866.7A patent/EP3607962A1/en active Pending
- 2014-12-18 NZ NZ721089A patent/NZ721089A/en unknown
- 2014-12-18 WO PCT/US2014/071186 patent/WO2015095535A1/en active Application Filing
- 2014-12-18 PL PL14872684T patent/PL2986308T3/pl unknown
- 2014-12-18 LT LTEP14872684.7T patent/LT2986308T/lt unknown
- 2014-12-18 KR KR1020167019427A patent/KR102399383B1/ko active IP Right Grant
- 2014-12-18 CA CA2933601A patent/CA2933601A1/en active Pending
-
2015
- 2015-11-13 US US14/941,301 patent/US10028995B2/en active Active
-
2016
- 2016-06-09 IL IL246162A patent/IL246162B/en active IP Right Grant
- 2016-06-17 MX MX2020011190A patent/MX2020011190A/es unknown
-
2018
- 2018-03-01 US US15/909,617 patent/US10493124B2/en active Active
- 2018-09-19 US US16/135,608 patent/US10765722B2/en active Active
-
2019
- 2019-04-12 US US16/382,850 patent/US11096983B2/en active Active
- 2019-08-23 JP JP2019153144A patent/JP7175506B2/ja active Active
-
2020
- 2020-01-03 HR HRP20200009TT patent/HRP20200009T1/hr unknown
- 2020-01-13 CY CY20201100026T patent/CY1122604T1/el unknown
- 2020-11-26 AU AU2020277230A patent/AU2020277230A1/en active Pending
-
2021
- 2021-07-20 US US17/380,311 patent/US11559559B2/en active Active
-
2022
- 2022-07-14 JP JP2022113327A patent/JP2022137224A/ja active Pending
-
2023
- 2023-01-23 US US18/157,933 patent/US20230226141A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2017501154A5 (ko) | ||
EP4233861A3 (en) | Compositions for treatment of essential tremor | |
RU2015134581A (ru) | Доноры нитроксила с улучшенным терапевтическим индексом | |
JP2022009125A5 (ko) | ||
NZ598534A (en) | Dosage regimen of an s1p receptor modulator | |
JP2015512418A5 (ko) | ||
JP2016516016A5 (ko) | ||
RU2014141893A (ru) | Применение производной пиразола в лечении острых приступов хронической обструктивной болезни легких | |
PH12016501357A1 (en) | Pharmaceutical preparation containing pyridylamino acetic acid compound | |
RU2018121615A (ru) | Модуляторы активности комплемента | |
JP2020172520A (ja) | 腹水の治療 | |
JP2017519799A5 (ko) | ||
JP2018526460A5 (ko) | ||
JP2015532293A5 (ja) | 糖尿病患者における心不全の治療用組成物 | |
JP2019507786A5 (ko) | ||
Sahu et al. | Comparison of bolus phenylephrine, ephedrine and mephentermine for maintenance of arterial pressure during spinal anaesthesia in caesarean section–a clinical study | |
RU2016103098A (ru) | Способ предотвращения и/или лечения хронической травматической энцефалопатии - ii | |
JP2015512923A5 (ko) | ||
RU2018114457A (ru) | Лечение syd985 пациентов с t-dm1 рефрактерным раком | |
RU2012116226A (ru) | Бронхолитическое средство на основе простагландина | |
NZ708511A (en) | Methods for controlling blood pressure and reducing dyspnea in heart failure | |
JP2015535258A5 (ko) | ||
PH12015502465A1 (en) | Use of landiolol hydrochloride in the long-term treatment of tachyarrhythmias | |
JP2019535830A5 (ko) | ||
JP2017508768A5 (ko) |