JP2017043546A - 感冒用医薬組成物 - Google Patents
感冒用医薬組成物 Download PDFInfo
- Publication number
- JP2017043546A JP2017043546A JP2015165005A JP2015165005A JP2017043546A JP 2017043546 A JP2017043546 A JP 2017043546A JP 2015165005 A JP2015165005 A JP 2015165005A JP 2015165005 A JP2015165005 A JP 2015165005A JP 2017043546 A JP2017043546 A JP 2017043546A
- Authority
- JP
- Japan
- Prior art keywords
- ibuprofen
- hydrochloride
- pharmaceutical composition
- magnesium oxide
- ambroxol hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 16
- 201000009240 nasopharyngitis Diseases 0.000 title claims abstract description 11
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- 229960001680 ibuprofen Drugs 0.000 claims abstract description 42
- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229960000985 ambroxol hydrochloride Drugs 0.000 claims abstract description 39
- 239000000395 magnesium oxide Substances 0.000 claims abstract description 30
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims abstract description 30
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229960000869 magnesium oxide Drugs 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims description 11
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Landscapes
- Medicinal Preparation (AREA)
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Abstract
Description
変色試験:
表1示す処方に従い、イブプロフェン、アンブロキソール塩酸塩及び酸化マグネシウムを秤量し、全重量の10%の精製水を添加して混練した。得られた混合物をそれぞれ調製後、ガラス瓶に入れ70℃で保存し、24時間後の混合物の状態を下記評価基準により評価し、変色の有無を確認した。結果を併せて表1に示す。
(評価) (内容)
−: 変色が全くない
±: 変色がほとんどない
+: 変色がある
溶出試験:
(イブプロフェン、アンブロキソール塩酸塩及び酸化マグネシウム含有感冒薬1)
イブプロフェン300g、アンブロキソール塩酸塩30g、酸化マグネシウム200g、クロルフェニラミンマレイン酸塩5g、ジヒドロコデインリン酸塩16g、dl−メチルエフェドリン塩酸塩40g、無水カフェイン50g、ヨウ化イソプロパミド4g、低置換度ヒドロキシプロピルセルロース454g、D−マンニトール197g、トウモロコシデンプン40g、及び、乳糖水和物4gに精製水1380gを添加し、常法により湿式造粒後、乾燥・整粒し、造粒末を得た。この造粒末1273gに、結晶セルロース228g、軽質無水ケイ酸、7.6g、タルク15.2g及びステアリン酸マグネシウム405gを添加し均一に混合し、打錠用粉末を得た。この打錠用粉末を9.5mmφの臼杵を用いて1錠あたり405mgになるように、常法によりロータリー打錠機で圧縮成型し、素錠を得た。この素錠にヒプロメロース、酸化チタン、マクロゴール、タルク及び精製水(8.6:1.5:1.45:4.5:88)からなるフィルムコーティング剤を通気式コーティング装置にて噴霧し、425mg/錠のフィルムコーティング錠として発明品12を得た。
イブプロフェン300g、アンブロキソール塩酸塩30g、クロルフェニラミンマレイン酸塩5g、ジヒドロコデインリン酸塩16g、dl−メチルエフェドリン塩酸塩40g、無水カフェイン50g、ヨウ化イソプロパミド4g、低置換度ヒドロキシプロピルセルロース454g、D−マンニトール197g、トウモロコシデンプン40g、及び、乳糖水和物204gをに精製水1380gを添加し、常法により湿式造粒後、乾燥・整粒し、造粒末を得た。この造粒末1273gに、結晶セルロース228g、軽質無水ケイ酸、7.6g、タルク15.2g及びステアリン酸マグネシウム405gを添加し均一に混合し、打錠用粉末を得た。この打錠用粉末を9.5mmφの臼杵を用いて1錠あたり405mgになるように、常法によりロータリー打錠機で圧縮成型し、素錠を得た。この素錠に上記同様のフィルムコーティング剤を通気式コーティング装置にて噴霧し、425mg/錠のフィルムコーティング錠として比較品3を得た。
(イブプロフェン、アンブロキソール塩酸塩及び酸化マグネシウム含有感冒薬2)
イブプロフェン400g、アンブロキソール塩酸塩30g、酸化マグネシウム200g、クロルフェニラミンマレイン酸塩、5g、ジヒドロコデインリン酸塩16g、dl−メチルエフェドリン塩酸塩40g、無水カフェイン50g、ヨウ化イソプロパミド4g、低置換度ヒドロキシプロピルセルロース452g、D−マンニトール197g、トウモロコシデンプン40g、及び、乳糖水和物4gをに精製水1420gを添加し、常法により湿式造粒後、乾燥・整粒し、造粒末を得た。この造粒末1368gに、結晶セルロース228g、軽質無水ケイ酸、7.6g、タルク15.2g及びステアリン酸マグネシウム405gを添加し均一に混合し、打錠用粉末を得た。この打錠用粉末を9.5mmφの臼杵を用いて1錠あたり430mgになるように、常法によりロータリー打錠機で圧縮成型し、素錠を得た。この素錠に上記同様のフィルムコーティング剤を通気式コーティング装置にて噴霧し、450mg/錠のフィルムコーティング錠として発明品13を得た。
(イブプロフェン、アンブロキソール塩酸塩及び酸化マグネシウム含有感冒薬3)
イブプロフェン200g、アンブロキソール塩酸塩15g、酸化マグネシウム100g、クロルフェニラミンマレイン酸塩2.5g、ジヒドロコデインリン酸塩8g、dl−メチルエフェドリン塩酸塩20g、無水カフェイン25g、ヨウ化イソプロパミド2g、低置換度ヒドロキシプロピルセルロース460g、カルメロースカルシウム368.6g、及び、酒石酸35gに精製水1880gを添加し、常法により湿式造粒後、乾燥・整粒し、造粒末を得た。この造粒末1174.3gに、サッカリンナトリウム57g、軽質無水ケイ酸1.235g、タルク1.235g及び香料1.235gを添加し均一に混合し、1包あたり1300mgになるようにアルミ3方シールで分包し、顆粒剤として発明品14を得た。
Claims (5)
- イブプロフェン、アンブロキソール塩酸塩及び酸化マグネシウムを含有することを特徴とする感冒用医薬組成物。
- イブプロフェン、アンブロキソール塩酸塩及び酸化マグネシウムをそれぞれ質量比で10〜70:1〜5:2〜60の割合で含有する請求項1記載の感冒用医薬組成物。
- さらに抗炎症・解熱鎮痛薬、抗ヒスタミン薬、抗アレルギー薬、鎮咳去痰薬、中枢神経興奮薬、制酸剤、ビタミン及び生薬から選ばれる1種以上を含有する請求項1又は2に記載の感冒用医薬組成物。
- 請求項1〜3の何れかに記載の感冒用医薬組成物を含有する内服固形製剤。
- 請求項1〜3の何れかに記載の感冒用医薬組成物を含有する経口液剤。
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JP2018076306A (ja) * | 2016-10-31 | 2018-05-17 | エスエス製薬株式会社 | 感冒薬 |
WO2018163929A1 (ja) | 2017-03-08 | 2018-09-13 | 三菱マテリアル株式会社 | 低屈折率膜形成用液組成物及びこれを用いた低屈折率膜の形成方法 |
JP2019038801A (ja) * | 2017-08-24 | 2019-03-14 | 興和株式会社 | 医薬品 |
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JP2018076306A (ja) * | 2016-10-31 | 2018-05-17 | エスエス製薬株式会社 | 感冒薬 |
JP7163014B2 (ja) | 2016-10-31 | 2022-10-31 | エスエス製薬株式会社 | 感冒薬 |
WO2018163929A1 (ja) | 2017-03-08 | 2018-09-13 | 三菱マテリアル株式会社 | 低屈折率膜形成用液組成物及びこれを用いた低屈折率膜の形成方法 |
JP2019038801A (ja) * | 2017-08-24 | 2019-03-14 | 興和株式会社 | 医薬品 |
JP7264606B2 (ja) | 2017-08-24 | 2023-04-25 | 興和株式会社 | 医薬品 |
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JP2020083884A (ja) * | 2018-11-16 | 2020-06-04 | エスエス製薬株式会社 | イブプロフェン含有経口用医薬製剤 |
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JP7406349B2 (ja) | 2018-11-16 | 2023-12-27 | エスエス製薬株式会社 | イブプロフェン含有経口用医薬製剤 |
RU2820239C2 (ru) * | 2018-11-16 | 2024-05-31 | ЭсЭсПи КО., ЛТД. | Содержащий ибупрофен пероральный фармацевтический состав |
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