JP2017039697A - 組成物 - Google Patents
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Abstract
Description
図1で示す葉の破砕試料、茎(枝)の破砕試料及び樹液の固形分試料を、それぞれ70質量%のエタノール(EtOH)を用いて溶媒抽出した。具体的には、各試料を20倍の質量のエタノール(EtOH)に入れて、常温で24時間、2回繰り返し抽出を行った。その後、常温で一日放置した後、抽出物を濾紙(Whatman NO.1、Whatman International Ltd.、Maidstone、England)で濾過した。次に、ロータリーエバポレーター(rotary evaporator)(UT−1000、EYELA、Tokyo、Japan)を用いて、55℃で抽出物を濃縮した後、濃縮した抽出物を凍結乾燥させた。
図1で示す葉の粉砕試料、および茎(枝)の破砕試料を表1で示す条件で、それぞれ超臨界抽出し、葉および茎の精油成分(抽出液)をそれぞれ得た。
図1で示す葉の破砕試料、および茎(枝)の破砕試料を、それぞれ水蒸気蒸留抽出機を用いて抽出した。図2は、本抽出工程で使用された水蒸気蒸留抽出機を示す写真である。具体的には、不織布に各試料を入れた後、不織布で包んだ各試料を水蒸気蒸留抽出機に投入し、約100℃の水蒸気で120分間加熱した。気化した蒸気を捕集した後、冷却することで抽出物を得た。
上記で製造したチョウセンカクレミノの各部位別(葉、茎及び樹液)および抽出法別(超臨界抽出、溶媒抽出及び水蒸気蒸留抽出)の各抽出物をBSTFA(N,O−ビス(トリメチルシリル)トリフロオロアセトアミド)で誘導体化した後、GC/MSで分析した。具体的には、誘導体化した各抽出物に対して、極性物質の除去のためにヘキサン(hexane)/蒸留水(D.W)=1:1を用いた溶媒系分画を行った。得られたヘキサン層(hexane fraction)を300ppmの濃度に希釈した後、各抽出物の構成成分及び含有量をGC/MSを介して定性及び定量分析した。なお、分析には、Wiley 8N Libraryプログラムを用い、各抽出物の構成成分の中から上位20個を選択して分析した。分析機器及び分析条件は、以下のとおりである。
装置:GC/MS−QP2010 Plus(島津製作所)
カラム(Column):DB−5(0.25mm×30m、0.25μm)
カラムオーブン温度(Column oven temp.):まず、40℃に設定して10分間維持し、その後4℃/分の速度で220℃まで昇温した後、5分間維持する。
インジェクション温度(Injection temp.):280℃
カラム流量(Column flow):1.09mL/min
分割比(Split ratio):10
イオン源温度(Ion source temp.):250℃
界面温度(Interface temp.):280℃
質量範囲(Mass range):60〜600
図3は、葉の溶媒抽出物に対する成分分析の結果であり、図4は、茎の溶媒抽出物に対する成分分析の結果である。
一定の大きさに切断したチョウセンカクレミノの葉および茎を2:1の質量比で混合した後、常温でミョウバン水溶液に2時間浸漬し、日光で乾燥させた。その後、乾燥物と精製水とを質量比1:4の割合で混合し、80℃で12時間加温抽出した。
瞑想ヒーリング用芳香剤(ストレス緩和剤)として、ホホバ油と杏仁油とを混合した混合油に、上記製造例1の溶媒抽出を介して製造した樹液抽出物および茎抽出物を添加した後、瞑想ヒーリング用芳香剤として使用した。このとき、下記表3に示すように、実施例ごとに、ホホバ油と杏仁油との混合割合及び各抽出物の使用量が異なるように、混合および添加した。下記表3において、比較例は、チョウセンカクレミノの抽出物を添加していないものであり、具体的には、ホホバ油と杏仁油との混合油のみを使用したものである。
<評価基準>
1点:改善なし
2点:少し改善あり
3点:たくさん改善あり
Claims (8)
- チョウセンカクレミノの抽出物を有効成分として含むことを特徴とする、組成物。
- チョウセンカクレミノの抽出物をストレス緩和、紫外線カット及び芳香の中から選ばれた少なくとも一つ以上のための有効成分として含むことを特徴とする、組成物。
- 前記チョウセンカクレミノの抽出物は、葉抽出物、茎抽出物、及び樹液抽出物の中から選ばれた一つ以上を含むことを特徴とする、請求項1又は2に記載の組成物。
- 前記葉抽出物は、超臨界抽出物であり、前記茎抽出物は、溶媒抽出物であることを特徴とする、請求項3に記載の組成物。
- 前記葉抽出物は、溶媒抽出物であり、前記溶媒抽出物の全質量に対してプロパン酸エチルエステルを30質量%〜40質量%で含み、
前記茎抽出物は、超臨界抽出物であり、前記超臨界抽出物の全質量に対してプロパン酸エチルエステルを50質量%〜60質量%で含むことを特徴とする、請求項3に記載の組成物。 - 前記葉抽出物は、超臨界抽出物であり、前記超臨界抽出物の全質量に対してテルペンを5質量%〜40質量%で含むことを特徴とする、請求項3に記載の組成物。
- 前記茎抽出物は、溶媒抽出物であり、前記溶媒抽出物の全質量に対してテルペンを10質量%〜50質量%で含むことを特徴とする、請求項3に記載の組成物。
- 前記樹液抽出物は、溶媒分画抽出物であり、前記溶媒分画抽出物の全質量に対してテルペンを10質量%〜20質量%で含むことを特徴とする、請求項3に記載の組成物。
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KR10-2015-0117387 | 2015-08-20 | ||
KR1020150117387A KR101739518B1 (ko) | 2015-08-20 | 2015-08-20 | 황칠나무의 추출물을 포함하는 조성물 |
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JP2017039697A true JP2017039697A (ja) | 2017-02-23 |
JP6412901B2 JP6412901B2 (ja) | 2018-10-24 |
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CN (1) | CN106466331A (ja) |
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KR101956620B1 (ko) * | 2017-07-25 | 2019-03-11 | 조선대학교산학협력단 | 황칠나무 추출물을 유효성분으로 포함하는 섬유화 질환의 예방 또는 치료용 조성물 |
KR102167111B1 (ko) * | 2017-07-28 | 2020-10-20 | 경희대학교 산학협력단 | 황칠나무 추출물을 포함하는 산화아연 나노복합체 제조용 조성물 및 이의 용도 |
JP7125591B2 (ja) | 2018-04-04 | 2022-08-25 | シンフォニアテクノロジー株式会社 | ロードポート及びefem |
KR102265463B1 (ko) * | 2019-02-21 | 2021-06-15 | 가천대학교 산학협력단 | 탄화 처리된 황칠 추출물을 포함하는 자외선 및 블루라이트 차단용 화장료 조성물 |
CN113845603B (zh) * | 2021-10-19 | 2022-08-09 | 上海交通大学 | 醇溶性均一多糖及其抗抑郁用途 |
KR20230061090A (ko) * | 2021-10-28 | 2023-05-08 | 국제뇌교육종합대학원대학교 산학협력단 | 황칠나무 수액 추출물 또는 이의 유래 화합물을 유효성분으로 포함하는 대사증후군 관련 질환의 예방 또는 치료용 약학적 조성물 |
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KR20150062299A (ko) * | 2013-11-29 | 2015-06-08 | 재단법인 전남생물산업진흥원 | 초임계 추출을 이용한 식물 유래 β-시토스테롤의 분리방법 |
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KR101242596B1 (ko) | 2010-11-30 | 2013-03-19 | 건국대학교 산학협력단 | 동충하초 추출물 또는 이로부터 분리된 코디세핀을 유효성분으로 하는 불면증 개선 및 치료용 약학 조성물 |
KR101207781B1 (ko) | 2012-03-29 | 2012-12-05 | (주) 와이디생명과학 | 감국 추출물로부터 분리된 화합물을 유효성분으로 함유하는 신경안정 및 뇌신경계 관련 불안증의 예방 및 치료용 조성물 |
KR101468551B1 (ko) | 2013-07-05 | 2014-12-04 | 재단법인 전남생물산업진흥원 | 황칠나무 추출물을 유효성분으로 포함하는 불면증 치료 또는 개선용 조성물 |
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KR20150052946A (ko) * | 2013-11-07 | 2015-05-15 | 조창수 | 황칠나무 추출액과 녹차 추출액을 함유하는 비누와 그 제조방법 |
KR101576887B1 (ko) * | 2013-12-16 | 2015-12-11 | (주)디지탈옵틱 | 황칠 추출물을 포함하는 중금속 중독으로 인한 질환의 치료 및 예방용 조성물 |
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KR20110078527A (ko) * | 2009-12-31 | 2011-07-07 | 주식회사 코리아나화장품 | 황칠나무 추출물을 유효성분으로 함유하는 화장료 조성물 |
KR20120012918A (ko) * | 2010-08-03 | 2012-02-13 | 박숙우 | 황칠나무 추출물을 이용한 미백 화장품 조성물 및 제조방법 |
KR20120119227A (ko) * | 2011-04-20 | 2012-10-31 | 경희대학교 산학협력단 | 황칠나무 추출물로부터 분리된 페놀성 화합물을 함유하는 피부미백 조성물 |
KR20130127043A (ko) * | 2012-05-14 | 2013-11-22 | 박철환 | 황금색 효소소금 제조방법 |
KR20150017198A (ko) * | 2013-08-06 | 2015-02-16 | 조창수 | 약재의 진액추출물 및 그 추출방법 |
KR20150062299A (ko) * | 2013-11-29 | 2015-06-08 | 재단법인 전남생물산업진흥원 | 초임계 추출을 이용한 식물 유래 β-시토스테롤의 분리방법 |
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JP6412901B2 (ja) | 2018-10-24 |
CN106466331A (zh) | 2017-03-01 |
KR101739518B1 (ko) | 2017-05-26 |
KR20170022431A (ko) | 2017-03-02 |
US20170049832A1 (en) | 2017-02-23 |
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