JP2016534731A - 膵内分泌細胞への分化のためのヒト多能性幹細胞の懸濁及び集団化 - Google Patents
膵内分泌細胞への分化のためのヒト多能性幹細胞の懸濁及び集団化 Download PDFInfo
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- JP2016534731A JP2016534731A JP2016527338A JP2016527338A JP2016534731A JP 2016534731 A JP2016534731 A JP 2016534731A JP 2016527338 A JP2016527338 A JP 2016527338A JP 2016527338 A JP2016527338 A JP 2016527338A JP 2016534731 A JP2016534731 A JP 2016534731A
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361962158P | 2013-11-01 | 2013-11-01 | |
US61/962,158 | 2013-11-01 | ||
US13/998,974 | 2013-12-30 | ||
US13/998,974 US10377989B2 (en) | 2012-12-31 | 2013-12-30 | Methods for suspension cultures of human pluripotent stem cells |
PCT/US2014/038993 WO2015065524A2 (en) | 2013-11-01 | 2014-05-21 | Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells |
Publications (2)
Publication Number | Publication Date |
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JP2016534731A true JP2016534731A (ja) | 2016-11-10 |
JP2016534731A5 JP2016534731A5 (zh) | 2017-07-06 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016527338A Pending JP2016534731A (ja) | 2013-11-01 | 2014-05-21 | 膵内分泌細胞への分化のためのヒト多能性幹細胞の懸濁及び集団化 |
JP2016527450A Pending JP2017500013A (ja) | 2013-11-01 | 2014-06-17 | 膵内分泌細胞への分化のためのヒト多能性幹細胞の懸濁及び集団化 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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JP2016527450A Pending JP2017500013A (ja) | 2013-11-01 | 2014-06-17 | 膵内分泌細胞への分化のためのヒト多能性幹細胞の懸濁及び集団化 |
Country Status (12)
Country | Link |
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EP (2) | EP3063268A4 (zh) |
JP (2) | JP2016534731A (zh) |
KR (4) | KR20160079072A (zh) |
CN (2) | CN105793413A (zh) |
AU (4) | AU2014342995C1 (zh) |
BR (1) | BR112016009393A8 (zh) |
CA (2) | CA2928639A1 (zh) |
MX (2) | MX2016005657A (zh) |
PH (2) | PH12016500783A1 (zh) |
RU (2) | RU2689710C2 (zh) |
SG (2) | SG11201603045VA (zh) |
WO (2) | WO2015065524A2 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021510527A (ja) * | 2018-01-18 | 2021-04-30 | エージェンシー フォー サイエンス, テクノロジー アンド リサーチ | 懸濁培養におけるヒト多能性幹細胞系の分化のための方法 |
WO2022203051A1 (ja) * | 2021-03-25 | 2022-09-29 | 株式会社カネカ | 多能性幹細胞集団の製造方法 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2928639A1 (en) * | 2013-11-01 | 2015-05-07 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells |
MX2018016055A (es) * | 2016-06-23 | 2019-07-04 | Tithon Biotech Inc | Células que expresan receptor de hormona paratiroidea 1 y usos de las mismas. |
RU2758006C2 (ru) * | 2016-11-16 | 2021-10-25 | Сината Терапьютикс Лимитед | Анализ плюрипотентных стволовых клеток |
US10391156B2 (en) | 2017-07-12 | 2019-08-27 | Viacyte, Inc. | University donor cells and related methods |
CA3070596A1 (en) * | 2017-07-21 | 2019-01-24 | Semma Therapeutics, Inc. | Re-aggregation of stem cell-derived pancreatic beta cells |
JP7000896B2 (ja) * | 2017-08-23 | 2022-01-19 | 王子ホールディングス株式会社 | 細胞シート形成部材、細胞シート形成部材の製造方法、および、細胞シートの製造方法 |
CN111836886A (zh) * | 2018-01-05 | 2020-10-27 | 血小板生源说股份有限公司 | 用于产生巨核细胞的组合物和方法 |
KR102115360B1 (ko) * | 2018-05-30 | 2020-05-26 | 주식회사 바이블리오테카 | 성체 줄기세포 배양액 및 그 제조방법 |
US20200080107A1 (en) | 2018-09-07 | 2020-03-12 | Crispr Therapeutics Ag | Universal donor cells |
WO2020243668A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
CA3139585C (en) | 2019-05-31 | 2024-01-23 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
CN114173837A (zh) | 2019-05-31 | 2022-03-11 | W.L.戈尔及同仁股份有限公司 | 生物相容性膜复合材料 |
US20220234006A1 (en) | 2019-05-31 | 2022-07-28 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
EP4025690A1 (en) | 2019-09-05 | 2022-07-13 | CRISPR Therapeutics AG | Universal donor cells |
JP2022547053A (ja) | 2019-09-05 | 2022-11-10 | クリスパー セラピューティクス アクチェンゲゼルシャフト | ユニバーサルドナー細胞 |
US20220389378A1 (en) * | 2019-11-22 | 2022-12-08 | Novo Nordisk A/S | Spin-aggregated neural microspheres and the application thereof |
KR20230146008A (ko) | 2020-12-31 | 2023-10-18 | 크리스퍼 테라퓨틱스 아게 | 범용 공여자 세포 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013095953A1 (en) * | 2011-12-22 | 2013-06-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
JP2013528356A (ja) * | 2010-06-15 | 2013-07-11 | 国立大学法人京都大学 | ヒト人工多能性幹細胞の選択方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA04004311A (es) * | 2001-11-09 | 2005-03-31 | Artecel Sciences Inc | DIFERENCIACION DEL PáNCREAS ENDOCRINOS DE CELULAS ESTROMALES DERIVADAS DEL TEJIDO ADIPOSO Y USOS DE LAS MISMAS. |
DK3441459T3 (da) * | 2006-08-02 | 2021-06-07 | Technion Res & Dev Foundation | Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur |
JP5067949B2 (ja) * | 2006-11-09 | 2012-11-07 | 独立行政法人国立国際医療研究センター | 霊長類動物胚性幹細胞の培養及び継代方法、並びにその分化誘導方法 |
WO2008148105A1 (en) * | 2007-05-25 | 2008-12-04 | Medistem Laboratories, Inc. | Endometrial stem cells and methods of making and using same |
JP2010532172A (ja) * | 2007-07-01 | 2010-10-07 | ライフスキャン・インコーポレイテッド | 単細胞の分化万能性幹細胞の培養 |
GB0800524D0 (en) * | 2008-01-14 | 2008-02-20 | Univ Brighton | Cell culture system |
WO2009116951A2 (en) * | 2008-03-17 | 2009-09-24 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
CA2729121C (en) * | 2008-06-30 | 2019-04-09 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
US8895300B2 (en) * | 2008-11-04 | 2014-11-25 | Viacyte, Inc. | Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof |
US8008075B2 (en) * | 2008-11-04 | 2011-08-30 | Viacyte, Inc. | Stem cell aggregate suspension compositions and methods of differentiation thereof |
KR101755214B1 (ko) * | 2009-08-12 | 2017-07-07 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 만능줄기세포의 신경전구세포로의 분화 유도 방법 |
US9085757B2 (en) * | 2010-06-17 | 2015-07-21 | Regents Of The University Of Minnesota | Production of insulin producing cells |
ES2658146T3 (es) * | 2010-08-31 | 2018-03-08 | Janssen Biotech, Inc. | Diferenciación de células madre embrionarias humanas |
WO2012117333A1 (en) * | 2011-02-28 | 2012-09-07 | Stempeutics Research Malaysia Sdn Bhd | Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof |
WO2013056072A1 (en) * | 2011-10-13 | 2013-04-18 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
US10519422B2 (en) * | 2012-02-29 | 2019-12-31 | Riken | Method of producing human retinal pigment epithelial cells |
CN105705634A (zh) * | 2012-12-31 | 2016-06-22 | 詹森生物科技公司 | 用于分化成胰腺内分泌细胞的人多能细胞的悬浮和群集 |
CA2928639A1 (en) * | 2013-11-01 | 2015-05-07 | Janssen Biotech, Inc. | Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells |
-
2014
- 2014-05-21 CA CA2928639A patent/CA2928639A1/en not_active Abandoned
- 2014-05-21 JP JP2016527338A patent/JP2016534731A/ja active Pending
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-
2016
- 2016-04-27 PH PH12016500783A patent/PH12016500783A1/en unknown
- 2016-04-27 PH PH12016500782A patent/PH12016500782A1/en unknown
-
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- 2018-07-26 AU AU2018208717A patent/AU2018208717A1/en not_active Abandoned
- 2018-07-26 AU AU2018208707A patent/AU2018208707A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013528356A (ja) * | 2010-06-15 | 2013-07-11 | 国立大学法人京都大学 | ヒト人工多能性幹細胞の選択方法 |
WO2013095953A1 (en) * | 2011-12-22 | 2013-06-27 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
Non-Patent Citations (5)
Title |
---|
BIOTECHNOLOGY AND BIOENGINEERING, 2004, VOL.86, P.493-502, JPN6018028514 * |
BIOTECHNOLOGY AND BIOENGINEERING, 2006, VOL.94, P.938-948, JPN6018028516 * |
DIABETES, 2001, VOL.50, P.1691-1697, JPN6018028512 * |
NATURE PROTOCOLS, JAN-2013, VOL.8, P.162-175, JPN7018002517 * |
TISSUE ENGINEERING: PART A, 2009, VOL.15, P.2051-2063, JPN6018028518 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021510527A (ja) * | 2018-01-18 | 2021-04-30 | エージェンシー フォー サイエンス, テクノロジー アンド リサーチ | 懸濁培養におけるヒト多能性幹細胞系の分化のための方法 |
WO2022203051A1 (ja) * | 2021-03-25 | 2022-09-29 | 株式会社カネカ | 多能性幹細胞集団の製造方法 |
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