JP2016523260A5 - - Google Patents
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- Publication number
- JP2016523260A5 JP2016523260A5 JP2016521898A JP2016521898A JP2016523260A5 JP 2016523260 A5 JP2016523260 A5 JP 2016523260A5 JP 2016521898 A JP2016521898 A JP 2016521898A JP 2016521898 A JP2016521898 A JP 2016521898A JP 2016523260 A5 JP2016523260 A5 JP 2016523260A5
- Authority
- JP
- Japan
- Prior art keywords
- pruritus
- serlopitant
- octahydroisoindol
- cyclopent
- polymorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 208000003251 Pruritus Diseases 0.000 claims 2
- ZKBUZTAYJPNYSH-INPQDFLLSA-N (3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-2-(cyclopenten-1-yl)-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindole Chemical compound FC(C=1C=C(C=C(C1)C(F)(F)F)[C@@H](C)O[C@@H]1[C@H]([C@@H]2CN(C[C@H]2CC1)C1=CCCC1)C1=CC=C(C=C1)F)(F)F ZKBUZTAYJPNYSH-INPQDFLLSA-N 0.000 claims 1
- FLNYCRJBCNNHRH-OIYLJQICSA-N 3-[(3ar,4r,5s,7as)-5-[(1r)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluorophenyl)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]cyclopent-2-en-1-one Chemical compound C1([C@H]2[C@@H]3CN(C[C@H]3CC[C@@H]2O[C@H](C)C=2C=C(C=C(C=2)C(F)(F)F)C(F)(F)F)C=2CCC(=O)C=2)=CC=C(F)C=C1 FLNYCRJBCNNHRH-OIYLJQICSA-N 0.000 claims 1
- XTKDAFGWCDAMPY-UHFFFAOYSA-N azaperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCN(C=2N=CC=CC=2)CC1 XTKDAFGWCDAMPY-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229950011343 serlopitant Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
Claims (1)
- そう痒の処置を必要としている患者においてそう痒を処置する方法であって、該患者に3-[(3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-ビス(トリフルオロメチル)フェニル]エトキシ]-4-(4-フルオロフェニル)-1,3,3a,4,5,6,7,7a-オクタヒドロイソインドール-2-イル]シクロペンタ-2-エン-1-オン（セルロピタント（serlopitant））またはその薬学的に許容される塩、溶媒和物もしくは多形の治療的有効量を投与する段階を含む、方法。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361838784P | 2013-06-24 | 2013-06-24 | |
| US61/838,784 | 2013-06-24 | ||
| US13/925,509 US8906951B1 (en) | 2013-06-24 | 2013-06-24 | Use of NK-1 receptor antagonists in pruritus |
| US13/925,509 | 2013-06-24 | ||
| PCT/US2014/043811 WO2014209962A1 (en) | 2013-06-24 | 2014-06-24 | Use of nk-1 receptor antagonist serlopitant in pruritus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019087897A Division JP2019142960A (ja) | 2013-06-24 | 2019-05-07 | そう痒におけるｎｋ−１受容体アンタゴニストのセルロピタントの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016523260A JP2016523260A (ja) | 2016-08-08 |
| JP2016523260A5 true JP2016523260A5 (ja) | 2017-08-03 |
Family
ID=51230173
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016521898A Ceased JP2016523260A (ja) | 2013-06-24 | 2014-06-24 | そう痒におけるｎｋ−１受容体アンタゴニストのセルロピタントの使用 |
| JP2019087897A Pending JP2019142960A (ja) | 2013-06-24 | 2019-05-07 | そう痒におけるｎｋ−１受容体アンタゴニストのセルロピタントの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019087897A Pending JP2019142960A (ja) | 2013-06-24 | 2019-05-07 | そう痒におけるｎｋ−１受容体アンタゴニストのセルロピタントの使用 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP3013336A1 (ja) |
| JP (2) | JP2016523260A (ja) |
| KR (1) | KR20160023692A (ja) |
| CN (1) | CN105473138A (ja) |
| AU (2) | AU2014302694B2 (ja) |
| BR (1) | BR112015031724A2 (ja) |
| CA (1) | CA2915474A1 (ja) |
| HK (1) | HK1223820A1 (ja) |
| IL (1) | IL243189A0 (ja) |
| MX (2) | MX366728B (ja) |
| PH (2) | PH12015502777A1 (ja) |
| RU (1) | RU2666219C2 (ja) |
| WO (1) | WO2014209962A1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| EP3193830B1 (en) | 2014-09-19 | 2023-11-01 | Heron Therapeutics, Inc. | Emulson formulations of aprepitant |
| EP3265087B1 (en) * | 2015-03-04 | 2020-07-22 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| US9974742B2 (en) | 2016-02-01 | 2018-05-22 | Heron Therapeutics, Inc. | Emulsion formulations of an NK-1 receptor antagonist and uses thereof |
| WO2017135923A1 (en) * | 2016-02-01 | 2017-08-10 | Heron Therapeutics, Inc. | Emulsion comprising an nk-1 receptor antagonist |
| EP3478283A4 (en) * | 2016-06-29 | 2020-07-22 | Menlo Therapeutics Inc. | USE OF NEUROKININ-1 ANTAGONISTS FOR TREATING VARIOUS PRURIGINAL DISORDERS |
| KR20200054232A (ko) * | 2017-09-13 | 2020-05-19 | 반다 파마슈티칼즈, 인코퍼레이티드. | 트라디피탄트를 이용한 아토피 피부염의 개선된 치료 |
| US11426408B2 (en) * | 2017-11-01 | 2022-08-30 | National University Of Singapore | Use of serotonergic drugs to treat virus-induced thrombocytopenia |
| US10960006B2 (en) * | 2018-01-31 | 2021-03-30 | Twi Pharmaceuticals, Inc. | Topical formulations comprising tofacitinib |
| CN115015440A (zh) * | 2022-07-08 | 2022-09-06 | 江苏杜瑞制药有限公司 | 一种生物样品中纳呋拉啡的检测方法 |
| CN117503699A (zh) * | 2023-12-08 | 2024-02-06 | 斯坦德医药研发(江苏)有限公司 | 阿瑞匹坦口服液制剂及制剂制造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030100565A1 (en) | 2001-09-21 | 2003-05-29 | Boehringer Ingelheim International Gmbh | Method for the treatment or prevention of atopic dermatitis |
| CN100582093C (zh) * | 2004-01-27 | 2010-01-20 | 默克公司 | 氢异二氢吲哚速激肽受体拮抗剂 |
| AR047439A1 (es) | 2004-01-27 | 2006-01-18 | Merck & Co Inc | Antagonistas del receptor hidroisoindolina taquiquinina |
| EP1904445B1 (en) | 2005-07-11 | 2011-03-02 | Merck Sharp & Dohme Corp. | Process for making hydroisoindoline tachykinin receptor antagonists |
| ATE511842T1 (de) | 2005-10-04 | 2011-06-15 | Merck Sharp & Dohme | Kombinationstherapie zur behandlung von erhöhter miktionsfrequenz, akutem harndrang und inkontinenz |
| WO2007146224A2 (en) | 2006-06-12 | 2007-12-21 | Merck & Co., Inc. | Combination therapy for the treatment of urinary frequency, urinary urgency and urinary incontinence |
| JP2010502703A (ja) | 2006-09-06 | 2010-01-28 | メルク エンド カムパニー インコーポレーテッド | 置換アミドの経口投与のための液体及び半固体の医薬製剤 |
| EP2089019A4 (en) | 2006-11-02 | 2011-05-04 | Merck Sharp & Dohme | POLYMORPHS OF AN ANTAGONIST OF TACHYKININ HYDRO-ISO-INDOLIC RECEPTORS |
| JP2010522751A (ja) | 2007-03-29 | 2010-07-08 | メルク・シャープ・エンド・ドーム・コーポレイション | 下部尿路症状の治療のための併用療法 |
| RU2370265C1 (ru) * | 2008-03-04 | 2009-10-20 | Лев Давидович Раснецов | Гель, обладающий противовоспалительным и противоаллергическим действием |
-
2014
- 2014-06-24 AU AU2014302694A patent/AU2014302694B2/en not_active Ceased
- 2014-06-24 CN CN201480035219.3A patent/CN105473138A/zh active Pending
- 2014-06-24 KR KR1020157035921A patent/KR20160023692A/ko not_active Application Discontinuation
- 2014-06-24 CA CA2915474A patent/CA2915474A1/en not_active Abandoned
- 2014-06-24 MX MX2015017763A patent/MX366728B/es active IP Right Grant
- 2014-06-24 WO PCT/US2014/043811 patent/WO2014209962A1/en active Application Filing
- 2014-06-24 EP EP14744671.0A patent/EP3013336A1/en not_active Withdrawn
- 2014-06-24 RU RU2015154037A patent/RU2666219C2/ru active
- 2014-06-24 BR BR112015031724A patent/BR112015031724A2/pt not_active Application Discontinuation
- 2014-06-24 JP JP2016521898A patent/JP2016523260A/ja not_active Ceased
-
2015
- 2015-12-14 PH PH12015502777A patent/PH12015502777A1/en unknown
- 2015-12-17 IL IL243189A patent/IL243189A0/en unknown
- 2015-12-18 MX MX2019008643A patent/MX2019008643A/es unknown
-
2016
- 2016-09-23 HK HK16111172.9A patent/HK1223820A1/zh unknown
-
2019
- 2019-05-07 JP JP2019087897A patent/JP2019142960A/ja active Pending
-
2020
- 2020-01-14 AU AU2020200259A patent/AU2020200259A1/en not_active Abandoned
- 2020-02-04 PH PH12020500255A patent/PH12020500255A1/en unknown
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