JP2016506359A - プロスタグランジンを主成分とした気管支拡張剤 - Google Patents
プロスタグランジンを主成分とした気管支拡張剤 Download PDFInfo
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- JP2016506359A JP2016506359A JP2015508895A JP2015508895A JP2016506359A JP 2016506359 A JP2016506359 A JP 2016506359A JP 2015508895 A JP2015508895 A JP 2015508895A JP 2015508895 A JP2015508895 A JP 2015508895A JP 2016506359 A JP2016506359 A JP 2016506359A
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- keto
- dihydroxy
- prostadienoic acid
- bronchodilator
- nitroprostone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (13)
- 気管支拡張物質として有効量の有効成分11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルと、薬学的に許容される担体または希釈液とを含む、炎症性もしくは閉塞性呼吸器疾患の治療のための薬剤。
- 前記炎症性もしくは閉塞性呼吸器疾患は、気管支喘息および閉塞性気管支炎からなる群から選択される、請求項1に記載の薬剤。
- 吸入に適した形態の請求項1に記載の薬剤。
- 生理溶液である前記有効成分の溶液である、請求項3に記載の薬剤。
- 前記炎症性もしくは閉塞性呼吸器疾患の治療方法であって、そのような治療を必要としている患者に、前記有効量の11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルを気管支拡張剤として投与することを含む方法。
- 前記炎症性もしくは閉塞性呼吸器疾患は、気管支喘息および閉塞性気管支炎からなる群から選択される、請求項5に記載の方法。
- 前記11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルを、前記患者に吸入により投与する、請求項5に記載の方法。
- 前記11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルを、前記患者に、生理溶液である溶液の形態で投与する、請求項7に記載の方法。
- 患者に送達される11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルの量は、1回の吸入当たり5〜20μgの範囲である、請求項7に記載の方法。
- 患者に送達される11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルの量は、1回の吸入当たり5〜7.5μgの範囲である、請求項9に記載の方法。
- そのような治療を必要としている患者に、前記有効量の11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルを繰り返し投与する、請求項5〜10のいずれか1項に記載の方法。
- 11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルの気管支拡張剤としての使用。
- 炎症性もしくは閉塞性呼吸器疾患の治療のための薬剤を製造するための、11(S),15(S)−ジヒドロキシ−9−ケト−5Z,13E−プロスタジエン酸の1’,3’−ジニトログリセリンエステルの気管支拡張剤としての使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2012116226 | 2012-04-24 | ||
RU2012116226/15A RU2500397C1 (ru) | 2012-04-24 | 2012-04-24 | Бронхолитическое средство на основе простагландина |
PCT/RU2013/000163 WO2013162416A1 (ru) | 2012-04-24 | 2013-03-01 | Бронхолитическое средство на основе простагландина |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2016506359A true JP2016506359A (ja) | 2016-03-03 |
JP2016506359A5 JP2016506359A5 (ja) | 2016-05-19 |
JP6126204B2 JP6126204B2 (ja) | 2017-05-10 |
Family
ID=49446371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015508895A Expired - Fee Related JP6126204B2 (ja) | 2012-04-24 | 2013-03-01 | プロスタグランジンを主成分とした気管支拡張剤 |
Country Status (10)
Country | Link |
---|---|
US (1) | US9408820B2 (ja) |
EP (1) | EP2842554B1 (ja) |
JP (1) | JP6126204B2 (ja) |
CN (1) | CN104470510A (ja) |
AU (1) | AU2013253042B2 (ja) |
BR (1) | BR112014026610A2 (ja) |
CA (1) | CA2871601C (ja) |
EA (1) | EA027724B1 (ja) |
RU (1) | RU2500397C1 (ja) |
WO (1) | WO2013162416A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2968757A1 (en) * | 2014-12-09 | 2016-06-16 | Nestec S.A. | Uses of bioactive lipids |
RU2662099C1 (ru) * | 2017-10-16 | 2018-07-23 | Общество с ограниченной ответственностью "Гурус БиоФарм" | Фармацевтические композиции для ингаляций, содержащие нитропростон |
RU2695068C1 (ru) * | 2018-06-26 | 2019-07-19 | Общество с ограниченной ответственностью "Гурус БиоФарм" | Средство для лечения хронических облитерирующих заболеваний периферических сосудов на основе простагландина |
CN117924133A (zh) * | 2022-10-17 | 2024-04-26 | 广州楷石医药有限公司 | 一种前列地尔偶联一氧化氮供体药物及其应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2067094C1 (ru) * | 1993-09-27 | 1996-09-27 | Владимир Виленович Безуглов | 1,3-динитроглицериновые эфиры полиненасыщенных жирных кислот, гидроксипроизводных полиненасыщенных жирных кислот и простагландинов и способы их получения |
US5625083A (en) * | 1995-06-02 | 1997-04-29 | Bezuglov; Vladimir V. | Dinitroglycerol esters of unsaturated fatty acids and prostaglandins |
-
2012
- 2012-04-24 RU RU2012116226/15A patent/RU2500397C1/ru active
-
2013
- 2013-03-01 EA EA201401178A patent/EA027724B1/ru not_active IP Right Cessation
- 2013-03-01 CA CA2871601A patent/CA2871601C/en active Active
- 2013-03-01 CN CN201380022111.6A patent/CN104470510A/zh active Pending
- 2013-03-01 WO PCT/RU2013/000163 patent/WO2013162416A1/ru active Application Filing
- 2013-03-01 EP EP13781656.7A patent/EP2842554B1/en not_active Not-in-force
- 2013-03-01 US US14/397,092 patent/US9408820B2/en active Active
- 2013-03-01 BR BR112014026610A patent/BR112014026610A2/pt not_active Application Discontinuation
- 2013-03-01 JP JP2015508895A patent/JP6126204B2/ja not_active Expired - Fee Related
- 2013-03-01 AU AU2013253042A patent/AU2013253042B2/en not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2067094C1 (ru) * | 1993-09-27 | 1996-09-27 | Владимир Виленович Безуглов | 1,3-динитроглицериновые эфиры полиненасыщенных жирных кислот, гидроксипроизводных полиненасыщенных жирных кислот и простагландинов и способы их получения |
US5625083A (en) * | 1995-06-02 | 1997-04-29 | Bezuglov; Vladimir V. | Dinitroglycerol esters of unsaturated fatty acids and prostaglandins |
Also Published As
Publication number | Publication date |
---|---|
RU2012116226A (ru) | 2013-10-27 |
EA027724B1 (ru) | 2017-08-31 |
EA201401178A1 (ru) | 2015-10-30 |
AU2013253042A1 (en) | 2014-12-11 |
JP6126204B2 (ja) | 2017-05-10 |
CN104470510A (zh) | 2015-03-25 |
US20150141505A1 (en) | 2015-05-21 |
US9408820B2 (en) | 2016-08-09 |
CA2871601A1 (en) | 2013-10-31 |
AU2013253042B2 (en) | 2017-08-31 |
CA2871601C (en) | 2020-02-18 |
BR112014026610A2 (pt) | 2017-07-18 |
EP2842554B1 (en) | 2018-10-24 |
WO2013162416A1 (ru) | 2013-10-31 |
EP2842554A4 (en) | 2016-01-06 |
EP2842554A1 (en) | 2015-03-04 |
RU2500397C1 (ru) | 2013-12-10 |
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