JP2015527405A - 口内洗浄剤及び歯過敏症治療組成物 - Google Patents
口内洗浄剤及び歯過敏症治療組成物 Download PDFInfo
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- JP2015527405A JP2015527405A JP2015531280A JP2015531280A JP2015527405A JP 2015527405 A JP2015527405 A JP 2015527405A JP 2015531280 A JP2015531280 A JP 2015531280A JP 2015531280 A JP2015531280 A JP 2015531280A JP 2015527405 A JP2015527405 A JP 2015527405A
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- composition
- acid
- menthol
- optionally
- surfactant
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- 239000000203 mixture Substances 0.000 title claims abstract description 123
- 206010020751 Hypersensitivity Diseases 0.000 title abstract description 7
- 239000002324 mouth wash Substances 0.000 title abstract description 7
- 208000026935 allergic disease Diseases 0.000 title abstract description 6
- 230000009610 hypersensitivity Effects 0.000 title abstract description 6
- 229940051866 mouthwash Drugs 0.000 title description 4
- 239000002253 acid Substances 0.000 claims abstract description 35
- 239000004135 Bone phosphate Substances 0.000 claims abstract description 15
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 32
- 239000004094 surface-active agent Substances 0.000 claims description 30
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 24
- 229940041616 menthol Drugs 0.000 claims description 19
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 18
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical group CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 claims description 16
- -1 tetracarboxylic acid salt Chemical class 0.000 claims description 16
- 239000008371 vanilla flavor Substances 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 229940073505 ethyl vanillin Drugs 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 7
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 claims description 6
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- 235000009499 Vanilla fragrans Nutrition 0.000 claims description 5
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- 150000001298 alcohols Chemical class 0.000 claims description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 claims description 4
- SATCULPHIDQDRE-UHFFFAOYSA-N piperonal Chemical compound O=CC1=CC=C2OCOC2=C1 SATCULPHIDQDRE-UHFFFAOYSA-N 0.000 claims description 4
- VVGOCOMZRGWHPI-UHFFFAOYSA-N trans-hept-4-enal Natural products CCC=CCCC=O VVGOCOMZRGWHPI-UHFFFAOYSA-N 0.000 claims description 4
- WJUFSDZVCOTFON-UHFFFAOYSA-N veratraldehyde Chemical compound COC1=CC=C(C=O)C=C1OC WJUFSDZVCOTFON-UHFFFAOYSA-N 0.000 claims description 4
- IKWIHXXSGVHFEZ-UHFFFAOYSA-N (4-tert-butyl-2-methylphenyl) acetate Chemical compound CC(=O)OC1=CC=C(C(C)(C)C)C=C1C IKWIHXXSGVHFEZ-UHFFFAOYSA-N 0.000 claims description 3
- VMUXSMXIQBNMGZ-UHFFFAOYSA-N 3,4-dihydrocoumarin Chemical compound C1=CC=C2OC(=O)CCC2=C1 VMUXSMXIQBNMGZ-UHFFFAOYSA-N 0.000 claims description 3
- MRABAEUHTLLEML-UHFFFAOYSA-N Butyl lactate Chemical compound CCCCOC(=O)C(C)O MRABAEUHTLLEML-UHFFFAOYSA-N 0.000 claims description 3
- RZTOWFMDBDPERY-UHFFFAOYSA-N Delta-Hexanolactone Chemical compound CC1CCCC(=O)O1 RZTOWFMDBDPERY-UHFFFAOYSA-N 0.000 claims description 3
- 239000000309 butter starter distillate Substances 0.000 claims description 3
- 239000001191 butyl (2R)-2-hydroxypropanoate Substances 0.000 claims description 3
- SKQYTJLYRIFFCO-UHFFFAOYSA-N delta-Tetradecalactone Chemical compound CCCCCCCCCC1CCCC(=O)O1 SKQYTJLYRIFFCO-UHFFFAOYSA-N 0.000 claims description 3
- 229940116333 ethyl lactate Drugs 0.000 claims description 3
- LPTIRUACFKQDHZ-UHFFFAOYSA-N hexadecyl sulfate;hydron Chemical compound CCCCCCCCCCCCCCCCOS(O)(=O)=O LPTIRUACFKQDHZ-UHFFFAOYSA-N 0.000 claims description 3
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 claims description 3
- 229940104261 taurate Drugs 0.000 claims description 3
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical group NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 3
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 claims description 3
- 229940071088 methyl cocoyl taurate Drugs 0.000 claims description 2
- 244000263375 Vanilla tahitensis Species 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 6
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 19
- 239000000796 flavoring agent Substances 0.000 description 15
- 235000019634 flavors Nutrition 0.000 description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 229940112822 chewing gum Drugs 0.000 description 10
- 235000015218 chewing gum Nutrition 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 10
- 239000000341 volatile oil Substances 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 8
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 7
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical group [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol Substances OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 235000006408 oxalic acid Nutrition 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 235000006679 Mentha X verticillata Nutrition 0.000 description 5
- 235000002899 Mentha suaveolens Nutrition 0.000 description 5
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 5
- 239000002280 amphoteric surfactant Substances 0.000 description 5
- 239000002585 base Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 239000005844 Thymol Substances 0.000 description 4
- 244000290333 Vanilla fragrans Species 0.000 description 4
- 239000003945 anionic surfactant Substances 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 229960005233 cineole Drugs 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000003906 humectant Substances 0.000 description 4
- 239000002736 nonionic surfactant Substances 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 229960004063 propylene glycol Drugs 0.000 description 4
- 235000013772 propylene glycol Nutrition 0.000 description 4
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- 229960000790 thymol Drugs 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 3
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 3
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- 210000004268 dentin Anatomy 0.000 description 3
- 201000002170 dentin sensitivity Diseases 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 3
- 229960001047 methyl salicylate Drugs 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 235000019477 peppermint oil Nutrition 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- 210000005239 tubule Anatomy 0.000 description 3
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 3
- 235000012141 vanillin Nutrition 0.000 description 3
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- KWXMFUWSONYRSO-UHFFFAOYSA-N 2-hydroxy-6-methyl-3-propan-2-ylcyclohexan-1-one Chemical compound OC1C(C(CCC1C(C)C)C)=O KWXMFUWSONYRSO-UHFFFAOYSA-N 0.000 description 2
- WXUAQHNMJWJLTG-UHFFFAOYSA-N 2-methylbutanedioic acid Chemical compound OC(=O)C(C)CC(O)=O WXUAQHNMJWJLTG-UHFFFAOYSA-N 0.000 description 2
- 241000272814 Anser sp. Species 0.000 description 2
- 241000207199 Citrus Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- UJNOLBSYLSYIBM-NOOOWODRSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2s)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@H](C)O UJNOLBSYLSYIBM-NOOOWODRSA-N 0.000 description 2
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
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- 239000000551 dentifrice Substances 0.000 description 2
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- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- XWENCHGJOCJZQO-UHFFFAOYSA-N ethane-1,1,2,2-tetracarboxylic acid Chemical compound OC(=O)C(C(O)=O)C(C(O)=O)C(O)=O XWENCHGJOCJZQO-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
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- QQVIHTHCMHWDBS-UHFFFAOYSA-N isophthalic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 2
- 229960004873 levomenthol Drugs 0.000 description 2
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- OSCILYIQKAVULO-UHFFFAOYSA-N 2-hydroxyethyl hydrogen carbonate;5-methyl-2-propan-2-ylcyclohexan-1-ol Chemical compound OCCOC(O)=O.CC(C)C1CCC(C)CC1O OSCILYIQKAVULO-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
本発明の組成物は、少なくとも1つのC2〜C5二塩基酸、三塩基酸、又は四塩基酸塩を含む。好適なC2〜C5二塩基酸、三塩基酸、又は四塩基酸塩としては、シュウ酸、クエン酸、及びプロパン−1,2,3−トリカルボン酸塩が挙げられるがこれらに限定されない、ナトリウム又はカリウム塩が挙げられる。
本発明の組成物は、少なくとも1つのバニラ風味成分を更に含む。好適なバニラ風味成分の例示的であるが限定されない例としては、バニリン、エチルバニリン、ヘリオトロピン、プロペニルグエトール、バニラ抽出物、ベラトルムアルデヒド、4−シス−ヘプテナール、ジアセチル、ブチルラクテート、エチルラクテート、メチル−パラ−tert−ブチルフェニルアセテート、γ及びδヘキサラクトン、及びヘプタラクトン、ベンゾジヒドロピロン、バタースターター蒸留物、δテトラデカラクトン、ブチルアルデヒド、及びこれらの混合物が挙げられる。ある特定の実施形態では、バニラ風味成分は、バニリン、エチルバニリン、ヘリオトロピン、4−シス−ヘプテナール、ジアセチル、及びメチル−パラ−tert−ブチルフェニルアセテート、又はこれらの混合物から選択される。ある特定の他の実施形態では、バニラは、バニリン、エチルバニリン、又はこれらの混合物からなる群から選択される。エチルバニリン又はバニリンの供給業者としては、Symrise(Goose Creek,SC)、Firmenich、IFF、Givaudan、AM Todd、Virginia Dareなどが挙げられる。好適な溶媒又は希釈剤としては、プロピレングリコール、ネオビー(Stepan Lipid Nutritionによって供給される中鎖トリグリセリド)、及び香料業界で一般的に使用される他のもの、並びにこれらの組み合わせが挙げられるがこれらに限定されない。バニラ風味抽出物のより詳細な考察は、米国特許公開第US 2006/0280852号(Harveyら)で見ることができ、その全体が参照により本明細書に組み込まれる。
本発明の組成物は、ヘキサヒドロチモールとしても既知の、メントール(CH3C6H9(C3H7)OH)を更に含む。メントールは、いくらかの消毒剤特性に加えて、冷却、ヒリヒリ感を提供する。メントール誘導体もまた本明細書で有用である。好適なメントール誘導体としては、(+)−ネオ−メントール;メントン;(+)−イソ−メントン;メンチルアセテート;メンチルイソバレレート;(−)−メンチルラクテート;パラ−メンタ−1−エン−3オール;ピペリトン;(−)−メントールエチレングリコールカーボネート;(−)−メントール1−及び2−プロピレングリコールカーボネート;(−)−メントン1,2−グリセロールケタール;(+)−メントン1,2−グリセロールケタール;モノ−メンチルスクシネート、及びこれらの混合物が挙げられるがこれらに限定されない。メントール及び/又はメントール誘導体は、以下のうちの1つ以上が挙げられるがこれらに限定されない、ミント油の形態で提供され得る:ペパーミント油;ハッカミント油;クールミント油;スペアミント油;ローズミッチャムミント油;コーンミント油;日本ペパーミント油;中国ペパーミント油;及びこれらの組み合わせ。メントール又はメントール誘導体の供給業者としては、Jindal Drugs Limited(Navi Mumbai,India)及びSymrise(Goose Creek,SC)が挙げられる。
本発明の組成物は、限定されない例と共に以下の段落に記載される、任意の成分(集合的に経口に許容できる担体又は賦形剤と称される)を更に含む。これらの経口に許容できる担体材料としては、局所的経口投与に好適である、1つ以上の相溶性のある固体又は液体賦形剤又は希釈剤が挙げられる。「相溶性のある」とは、組成物の成分が、組成物の安定性及び/又は有効性を実質的に低減し得る方法で相互作用することなく、混合され得ることを意味する。好適な担体又は賦形剤は、当該技術分野において周知である。それらの選択は、味、費用、及び貯蔵性などの二次的な検討事項によって決まる。任意の成分の大まかなリストが以下に提供されるが、好適な任意の成分(賦形剤及び担体を含む)のより詳細な考察は、米国特許公開第20110089073号(Baigら)で見ることができ、その全体が参照により本明細書に組み込まれる。
経口用液体組成物はまた、少なくとも1つのアルキルサルフェート界面活性剤を含有する。ある特定の実施形態では、好適なアルキルサルフェート界面活性剤としては、アルキルサルフェート界面活性剤が偶数個のC8〜C18、任意にC10〜C16の鎖長を有するような、硫酸化C8〜C18、任意に硫酸化C10〜C16の偶数個の短鎖鎖長の、炭酸ナトリウム又は水酸化ナトリウムなどの好適な塩基性塩、及びこれらの混合物で中和されたアルコールが挙げられるがこれらに限定されない。ある実施形態においては、アルキルサルフェートは、ナトリウムラウリルサルフェ−ト、ヘキサデシルサルフェ−ト及びこれらの混合物からなる群から選択される。ある実施形態においては、市販のアルキルサルフェートの混合物が使用される。市販のナトリウムラウリルサルフェ−ト(SLS)の、アルキル鎖長による代表的な百分率ブレークダウンは次の通りである。
ある特定の実施形態では、本発明は、存在する場合に精油の可溶化を補助するために、アルキルサルフェート界面活性剤に加えて界面活性剤を含有するが、ただしそのような追加の界面活性剤は、精油の生物学的利用能に影響を及ぼさない。好適な例には、追加のアニオン性界面活性剤、非イオン性界面活性剤、両性界面活性剤及びこれらの混合物が挙げられる。
ある特定の実施形態では、本発明の組成物は、メントール及び/又はメントール誘導体の源としてすでに記載された油によって提供され得るものに加えて、少なくとも1つの精油を含有してもよい。
シュウ酸カリウムを含有する本発明の組成物を、風味許容性に対して評価した。190人のメンバーの試験群によって、組成物の風味の評価を実施した。メンバーに、10mlの実施例A〜Eの組成物のそれぞれ(表1)で、60秒間口の中をすすぎ、吐き出し、以下の風味の全体的な嗜好スケールを使用して、1〜9のスケールの風味許容性評価を提供するよう求めた:0〜4=許容できない;5=どちらでもない;及び6〜9=許容できる。従来の混合技術を使用して、表1の組成物を調製した。
(1) 過敏な歯を治療するための組成物であって、
i.約0.1%〜約3%の少なくとも1つのC2〜C5二塩基酸、三塩基酸、又は四塩基酸塩と、
ii.少なくとも1つのバニラ風味抽出物と、
iii.約0.001%〜約0.25%のメントール又はその誘導体と、
iv.少なくとも1つの経口に許容できる溶媒と、を含む、組成物。
(2) 約0.01%〜約2%のアルキルサルフェート界面活性剤を更に含む、実施態様1に記載の組成物。
(3) 前記アルキルサルフェート界面活性剤が、偶数個のC8〜C18鎖長(even numbered C8 to C18 chain length)を有する、アルキルサルフェート界面活性剤である、実施態様2に記載の組成物。
(4) 前記アルキルサルフェート界面活性剤が、ナトリウムラウリルサルフェート、ヘキサデシルサルフェート、及びこれらの混合物からなる群から選択される、実施態様3に記載の組成物。
(5) 約0.01%〜約2%の追加の界面活性剤を更に含む、実施態様2に記載の組成物。
(7) 前記追加の界面活性剤が、メチルココイルタウレート(methyl cocoyl taurate)である、実施態様6に記載の組成物。
(8) 前記バニラ風味抽出物が、バニリン、エチルバニリン、ヘリオトロピン、プロペニルグエトール、バニラ抽出物、ベラトルムアルデヒド、4−シス−ヘプテナール、ジアセチル、ブチルラクテート、エチルラクテート、メチル−パラ−tert−ブチルフェニルアセテート、γ及びδヘキサラクトン及びヘプタラクトン、ベンゾジヒドロピロン、バタースターター蒸留物、δテトラデカラクトン、ブチルアルデヒド、及びこれらの混合物からなる群から選択される、実施態様1に記載の組成物。
(9) 前記バニラ風味抽出物が、エチルバニリンである、実施態様8に記載の組成物。
(10) 前記組成物が、約0.001%〜約0.12%の前記バニラ風味抽出物を含有する、実施態様1に記載の組成物。
(12) 前記メントール又はその誘導体が、メントールである、実施態様1に記載の組成物。
(13) 前記組成物が、C2〜C4の一価アルコールを本質的に含まない、実施態様1に記載の組成物。
(14) 前記組成物が、C2〜C4の一価アルコールを含まない、実施態様1に記載の組成物。
(15) 実施態様1に記載の組成物を少なくとも1つの過敏な歯に適用する工程を含む、過敏な歯を治療する方法。
Claims (14)
- 過敏な歯を治療するための組成物であって、
i.約0.1%〜約3%の少なくとも1つのC2〜C5二塩基酸、三塩基酸、又は四塩基酸塩と、
ii.少なくとも1つのバニラ風味抽出物と、
iii.約0.001%〜約0.25%のメントール又はその誘導体と、
iv.少なくとも1つの経口に許容できる溶媒と、を含む、組成物。 - 約0.01%〜約2%のアルキルサルフェート界面活性剤を更に含む、請求項1に記載の組成物。
- 前記アルキルサルフェート界面活性剤が、偶数個のC8〜C18鎖長を有する、アルキルサルフェート界面活性剤である、請求項2に記載の組成物。
- 前記アルキルサルフェート界面活性剤が、ナトリウムラウリルサルフェート、ヘキサデシルサルフェート、及びこれらの混合物からなる群から選択される、請求項3に記載の組成物。
- 約0.01%〜約2%の追加の界面活性剤を更に含む、請求項2に記載の組成物。
- 前記追加の界面活性剤が、タウレートである、請求項5に記載の組成物。
- 前記追加の界面活性剤が、メチルココイルタウレートである、請求項6に記載の組成物。
- 前記バニラ風味抽出物が、バニリン、エチルバニリン、ヘリオトロピン、プロペニルグエトール、バニラ抽出物、ベラトルムアルデヒド、4−シス−ヘプテナール、ジアセチル、ブチルラクテート、エチルラクテート、メチル−パラ−tert−ブチルフェニルアセテート、γ及びδヘキサラクトン及びヘプタラクトン、ベンゾジヒドロピロン、バタースターター蒸留物、δテトラデカラクトン、ブチルアルデヒド、及びこれらの混合物からなる群から選択される、請求項1に記載の組成物。
- 前記バニラ風味抽出物が、エチルバニリンである、請求項8に記載の組成物。
- 前記組成物が、約0.001%〜約0.12%の前記バニラ風味抽出物を含有する、請求項1に記載の組成物。
- 前記組成物が、約0.01%〜約0.15%の前記メントール又はその誘導体を含有する、請求項1に記載の組成物。
- 前記メントール又はその誘導体が、メントールである、請求項1に記載の組成物。
- 前記組成物が、C2〜C4の一価アルコールを本質的に含まない、請求項1に記載の組成物。
- 前記組成物が、C2〜C4の一価アルコールを含まない、請求項1に記載の組成物。
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