JP2015507033A - プロテアーゼおよびアミラーゼを含有する貯蔵安定性液状洗剤または洗浄剤 - Google Patents
プロテアーゼおよびアミラーゼを含有する貯蔵安定性液状洗剤または洗浄剤 Download PDFInfo
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- JP2015507033A JP2015507033A JP2014546434A JP2014546434A JP2015507033A JP 2015507033 A JP2015507033 A JP 2015507033A JP 2014546434 A JP2014546434 A JP 2014546434A JP 2014546434 A JP2014546434 A JP 2014546434A JP 2015507033 A JP2015507033 A JP 2015507033A
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- amino acid
- detergent
- protease
- amylase
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000002887 multiple sequence alignment Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N n-hexadecyl alcohol Natural products CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 150000002903 organophosphorus compounds Chemical class 0.000 description 1
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 1
- HWGNBUXHKFFFIH-UHFFFAOYSA-I pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O HWGNBUXHKFFFIH-UHFFFAOYSA-I 0.000 description 1
- 210000001322 periplasm Anatomy 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical group [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920000083 poly(allylamine) Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920001444 polymaleic acid Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- POSICDHOUBKJKP-UHFFFAOYSA-N prop-2-enoxybenzene Chemical compound C=CCOC1=CC=CC=C1 POSICDHOUBKJKP-UHFFFAOYSA-N 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- YLQLIQIAXYRMDL-UHFFFAOYSA-N propylheptyl alcohol Chemical compound CCCCCC(CO)CCC YLQLIQIAXYRMDL-UHFFFAOYSA-N 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 239000001054 red pigment Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 125000005017 substituted alkenyl group Chemical group 0.000 description 1
- 125000004426 substituted alkynyl group Chemical group 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 229940086735 succinate Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003470 sulfuric acid monoesters Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical class CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 125000004299 tetrazol-5-yl group Chemical class [H]N1N=NC(*)=N1 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000012250 transgenic expression Methods 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- JLGLQAWTXXGVEM-UHFFFAOYSA-N triethylene glycol monomethyl ether Chemical compound COCCOCCOCCO JLGLQAWTXXGVEM-UHFFFAOYSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- POSZUTFLHGNLHX-KSBRXOFISA-N tris maleate Chemical compound OCC(N)(CO)CO.OCC(N)(CO)CO.OC(=O)\C=C/C(O)=O POSZUTFLHGNLHX-KSBRXOFISA-N 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000012224 working solution Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38618—Protease or amylase in liquid compositions only
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Description
(a)SEQ ID no.1で示されるアミノ酸配列とその全長にわたって少なくとも70%同一であって、SEQ ID no.1のナンバリングにおいてS3T、V4IおよびV199Iからなる群から選択される少なくとも2つのアミノ酸置換と組み合わせて更なるアミノ酸置換R99EまたはR99Dを有するアミノ酸配列を含んでなるプロテアーゼ、および
(b)アミラーゼ
を含んでなる液状洗剤または洗浄剤を提供する。
・SEQ ID no.1で示されるアミノ酸配列とその全長にわたって少なくとも71%、72%、73%、74%、75%、76%、77%、78%、79%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、90.5%、91%、91.5%、92%、92.5%、93%、93.5%、94%、94.5%、95%、95.5%、96%、96.5%、97%、97.5%、98%、98.5%および98.8%同一であって、SEQ ID no.1のナンバリングにおいてアミノ酸置換S3TおよびV4Iと組み合わせてアミノ酸置換R99Eを有するアミノ酸配列を含んでなるプロテアーゼ、具体的には、アミノ酸置換S3T、V4IおよびR99Eを有するSEQ ID no.1に従ったプロテアーゼ、
・SEQ ID no.1で示されるアミノ酸配列とその全長にわたって少なくとも71%、72%、73%、74%、75%、76%、77%、78%、79%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、90.5%、91%、91.5%、92%、92.5%、93%、93.5%、94%、94.5%、95%、95.5%、96%、96.5%、97%、97.5%、98%および98.5%同一であって、SEQ ID no.1のナンバリングにおいてアミノ酸置換S3T、V4IおよびV199Iと組み合わせてアミノ酸置換R99Eを有するアミノ酸配列を含んでなるプロテアーゼ、具体的には、アミノ酸置換S3T、V4I、R99EおよびV199Iを有するSEQ ID no.1に従ったプロテアーゼ(このようなプロテアーゼは、SEQ ID no.2で示される)、
(a)SEQ ID no.4に従ったα−アミラーゼAA560に関して、α−アミラーゼAA560のナンバリングにおいて1個、2個、3個、4個、5個または6個の下記配列修飾:R118K、D183*(欠失)、G184*(欠失)、N195F、R320K、R458Kを有するα−アミラーゼ変異体。このα−アミラーゼ変異体は、より好ましくは、6個全ての上記配列修飾を有する。
(1)M9L/M202I,
(2)M9L/M202I/M323T,
(3)M9L/M202I/M323T/M382Y,
(4)M9L/M202I/Y295F/A339S,
(5)M9L/M202I/Y295F,
(6)M9L/M202I/A339S,
(7)M9L/M202I/Y295F/A339S,
(8)M9L/M202I/Y295F/A339S/E345R,
(9)M9L/G149A/M202I/Y295F/A339S/E345R,
(10)M9L/M202L,
(11)M9L/M202L/M323T,
(12)M9L/M202L/M323T/M382Y,
(13)M9L/M202L/Y295F/A339S,
(14)M9L/M202L/Y295F,
(15)M9L/M202L/A339S,
(16)M9L/M202L/Y295F/A339S,
(17)M9L/M202L/Y295F/A339S, E345R,
(18)M9L/G149A/M202L/Y295F/A339S/E345R,
(19)M9L/M202T,
(20)M9L/M202T/M323T,
(22)M9L/M202T/Y295F/A339S,
(23)M9L/M202T/Y295F,
(24)M9L/M202T/A339S,
(25)M9L/M202T/Y295F/A339S,
(26)M9L/M202T/Y295F/A339S/E345R,
(27)M9L/G149A/M202T/Y295F/A339S/E345R,
(28)M9L/G149A/M202I/V214T/Y295F/N299Y/M323T/A339S/E345R,
(29)M9L/G149A/M202L/V214I/Y295F/M323T/A339S/E345R/M382Y,
(30)M9L/G149A/G182T/G186A/M202I/V214I/Y295F/N299Y/M323T/A339S,
(31)M9L/G149A/G182T/G186A/M202L/T257I/Y295F/N299Y/M323T/A339S/E345R,
(32)M9L/G149A/M202L/V214T/Y295F/N299Y/M323T/A339S/E345R,
(33)M9L/G149A/M202I/V214I/Y295F/M323T/A339S/E345R/M382Y,
(34)M9L/G149A/G182T/G186A/M202L/V214I/Y295F/N299Y/M323T/A339S,
(35)M9L/G149A/G182T/G186A/M202I/T257I/Y295F/N299Y/M323T/A339S/E345R,
(36)M9L/G149A/M202I/V214T/Y295F/N299Y/M323T/A339S/E345R/N471E,
(37)M9L/G149A/M202L/V214I/Y295F/M323T/A339S/E345R/M382Y/N471E,
(38)M9L/G149A/G182T/G186A/M202I/V214I/Y295F/N299Y/M323T/A339S/N471E,
(39)M9L/G149A/G182T/G186A/M202L/T257I/Y295F/N299Y/M323T/A339S/E345R/N471E,
(40)M202L/M105F/M208F,
(42)G133E/M202L/R444E,
(43)M202L/Y295F,
(44)M202L/A339S,
(45)M202L/M323T,
(46)M202L/M323T/M309L,
(47)M202L/M323T/M430I,
(48)M202L/V214T/R444Y,
(49)M202L/N283D/Q361E,
(50)M202L/M382Y/K383R,
(51)M202L/K446R/N484Q,
(52)M202I/Y295F,
(53)M202I/A339S,
(54)M202I/M105F/M208F,
(55)G133E/M202I/Q361E,
(56)G133E/M202I/R444E,
(57)M202I/M323T,
(58)M202I/M323T/M309L,
(59)M202I/M323T/M430I,
(60)M202I/V214T/R444Y,
(62)M202I/M382Y/K383R,
(63)M202I/K446R/N484Q,
(64)M202V/M105F/M208F,
(65)G133E/M202V/Q361E,
(66)G133E/M202V/R444E,
(67)M202V/M323T,
(68)M202V/M323T/M309L,
(69)M202V/M323T/M430I,
(70)M202V/M323T/M9L,
(71)M202V/V214T/R444Y,
(72)M202V/N283D/Q361E,
(73)M202V/M382Y/K383R,
(74)M202V/K446R/N484Q,
(75)M202T/M105F/M208F,
(76)G133E/M202T/Q361E,
(77)G133E/M202T/R444E,
(78)M202T/Y295F,
(79)M202T/A339S,
(80)M202T/M323T,
(81)M202T/M323T/M309L,
(82)M202T/M323T/M430I,
(83)M202T/M323T/M9L,
(84)M202T/V214T/R444Y,
(85)M202T/N283D/Q361E,
(86)M202T/A339S,
(87)M202T/Y295F
(88)M202T/N299F,Y,
(89)M202T/M382Y/K383Rまたは
(90)M202T/K446R/N484Q。
(10)M9L/M202L,
(28)M9L/G149A/M202I/V214T/Y295F/N299Y/M323T/A339S/E345R,
(31)M9L/G149A/G182T/G186A/M202L/T257I/Y295F/N299Y/M323T/A339S/E345R,
(35)M9L/G149A/G182T/G186A/M202I/T257I/Y295F/N299Y/M323T/
(38)M9L/G149A/G182T/G186A/M202I/V214I/Y295F/N299Y/M323T/
(39)M9L/G149A/G182T/G186A/M202L/T257I/Y295F/N299Y/M323T/A339S/E345R/N471E,
(45)M202L/M323T,
(46)M202L/M323T/M309L,
(62)M202I/M382Y/K383R,
(68)M202V/M323T/M309L,
(73)M202V/M382Y/K383R,
(82)M202T/M323T/M430Iまたは
(84)M202T/V214T/R444Y。
(a)酵素相:
ビルダー 15.0〜20.0
糖アルコール 8.0〜12.0
非イオン性界面活性剤(22EO含有C8〜C10
脂肪アルコールエトキシレート) 3.0〜5.0
アルカリ化合物(塩基) 3.0〜4.0
ホウ酸 2.5〜3.5
ホスホネート(HEDP) 1.5〜2.5
アミラーゼ 1.0〜2.0
プロテアーゼ 後の記載を参照
Ca塩 0.8〜1.2
Zn塩 0.15〜0.25
増粘剤 0.8〜1.2
染料、香料、防腐剤 0.25〜0.5
水 100まで
(b)アルカリ性相:
ビルダー 7.5〜12.5
炭酸ナトリウム 7.5〜12.5
スルホポリマー 5.0〜8.0
アルカリ化合物(塩基) 3.0〜5.0
モノエタノールアミン 2.0〜4.0
ホスホネート(HEDP) 2.0〜5.0
増粘剤 0.8〜1.2
染料、香料、防腐剤 0.25〜0.5
水 100まで
i)アニオンおよび/またはポリアニオン物質、および/または
ii)カチオンおよび/またはポリカチオン物質、および/または
iii)ヒドロキシルおよび/またはポリヒドロキシル基含有物質。
−R4は、H、−(CH2)nOH、−C(O)OR5、−C(O)SR5、−(CH2)n−C(O)NR6R7、−O−C(O)−O−R6、アミノ酸またはペプチドである。ここで、nは0〜4の数である。
−R5はHである。
−R6は、−C(R7)−(CH2)n−O−C(O)−R8、−(CH2)n−C(R7)−O−C(O)R8、−(CH2)n−C(R7)−O−C(O)−O−R8、または−C(R7)−(CH2)n−O−C(O)−O−R8である。ここで、nは0〜4の数である。
−R7およびR8は、それぞれの場合において、H、アルキル、置換アルキル、アリール、置換アリール、アルケニル、置換アルケニル、アルキニル、置換アルキニル、複素環、置換複素環、アルキルアリール、置換アルキルアリール、シクロアルキル、置換シクロアルキル、またはCH2CO2アルキルであって、R7およびR8は同じであるか、または異なっていてよい。
(i)例えば、Aculyn(登録商標)、Acusol(登録商標)またはTego(登録商標)Polymerの商品名で市販されている、アクリル酸、メタクリル酸および(好ましくはC1〜4アルカノールを用いて生成された)それらの単純エステルからなる群から選択される2種以上のモノマーからなるコポリマー(INCI:アクリレートコポリマー);
(ii)例えば、スクロースまたはペンタエリトリトールのアリルエーテルにより架橋されたC10〜30アルキルアクリレートと、アクリル酸、メタクリル酸および(好ましくはC1〜4アルカノールを用いて生成された)それらの単純エステルからなる群からの1種以上のモノマーとのコポリマー(INCIはアクリレート/C10−30アルキルアクリレートクロスポリマーであって、例えばCarbopol(登録商標)の商品名で市販されている)を包含する、架橋高分子量アクリル酸コポリマー。更に適当なポリマーは、Sokalan(登録商標)タイプの(メタ)アクリル酸(コ)ポリマーである。
基本製剤は、下記組成を有するアミラーゼ含有二相液状自動食器洗い機用洗剤である(全ての値は、重量%単位で記載)。
酵素相:
ビルダー 18.0
糖アルコール 12.0
非イオン性界面活性剤(22EO含有C8〜C10
脂肪アルコールエトキシレート) 5.0
アルカリ化合物(塩基) 3.5
ホウ酸 3.0
ホスホネート(HEDP) 1.5
アミラーゼ 1.2
Ca塩 1.2
Zn塩 0.2
増粘剤 1.0
染料、香料、防腐剤 0.3
水 97まで
アルカリ性相:
ビルダー 12.0
炭酸ナトリウム 10.0
スルホポリマー 7.0
アルカリ化合物(塩基) 4.0
モノエタノールアミン 3.5
ホスホネート(HEDP) 4.0
増粘剤 1.0
染料、香料、防腐剤 0.3
水 100まで
バッチ2:SEQ ID no.2に従ったプロテアーゼ(SEQ ID no.1+S3T+V4I+R99E+V199I)。
Claims (14)
- (a)SEQ ID no.1で示されるアミノ酸配列とその全長にわたって少なくとも70%同一であって、SEQ ID no.1のナンバリングにおいてS3T、V4IおよびV199Iからなる群から選択される少なくとも2つのアミノ酸置換と組み合わせて更なるアミノ酸置換R99EまたはR99Dを有するアミノ酸配列を含んでなるプロテアーゼ、および
(b)アミラーゼ
を含んでなる液状洗剤または洗浄剤。 - プロテアーゼは、SEQ ID no.1で示されるアミノ酸配列とその全長にわたって少なくとも71%、72%、73%、74%、75%、76%、77%、78%、79%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、90.5%、91%、91.5%、92%、92.5%、93%、93.5%、94%、94.5%、95%、95.5%、96%、96.5%、97%、97.5%、98%および98.5%同一であって、SEQ ID no.1のナンバリングにおいてアミノ酸置換S3T、V4IおよびV199Iと組み合わせてアミノ酸置換R99Eを有するアミノ酸配列を含んでなり、具体的には、SEQ ID no.2に従ったアミノ酸配列を有するプロテアーゼを含んでなることを特徴とする、請求項1に記載の洗剤または洗浄剤。
- プロテアーゼは、SEQ ID no.1で示されるアミノ酸配列とその全長にわたって少なくとも71%、72%、73%、74%、75%、76%、77%、78%、79%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、90.5%、91%、91.5%、92%、92.5%、93%、93.5%、94%、94.5%、95%、95.5%、96%、96.5%、97%、97.5%、98%および98.5%同一であって、SEQ ID no.1のナンバリングにおいてアミノ酸置換S3T、V4IおよびV199Iと組み合わせてアミノ酸置換R99Dを有するアミノ酸配列を含んでなり、具体的には、SEQ ID no.3に従ったアミノ酸配列を有するプロテアーゼを含んでなることを特徴とする、請求項1に記載の洗剤または洗浄剤。
- アミラーゼは、α−アミラーゼAA560のナンバリングにおいて1個、2個、3個、4個、5個または6個の下記配列修飾:R118K、D183*(欠失)、G184*(欠失)、N195F、R320K、R458Kを有するSEQ ID no.4に従ったα−アミラーゼAA560のα−アミラーゼ変異体であることを特徴とする、請求項1〜3のいずれかに記載の洗剤または洗浄剤。
- アミラーゼは活性タンパク質に関して1×10−8〜5重量%の量で存在し、および/またはプロテアーゼは活性タンパク質に関して1×10−8〜5重量%の量で存在することを特徴とする、請求項1〜4のいずれかに記載の洗剤または洗浄剤。
- i)アニオン性および/またはポリアニオン性物質、および/または
ii)カチオン性および/またはポリカチオン性物質、および/または
iii)ヒドロキシル基および/またはポリヒドロキシル基含有物質
から選択される成分を更に含んでなることを特徴とする、請求項1〜5のいずれかに記載の洗剤または洗浄剤。 - 少なくとも1種の更なる成分、特に、ホスホネート、界面活性剤、ビルダー、非水溶媒、酸、水溶性塩、増粘剤およびそれらの組み合わせからなる群から選択される成分を含んでなることを特徴とする、請求項1〜6のいずれかに記載の洗剤または洗浄剤。
- 少なくとも1種の更なる酵素、特に、プロテアーゼ、アミラーゼ、セルラーゼ、ヘミセルラーゼ、マンナナーゼ、タンナーゼ、キシラナーゼ、キサンタナーゼ、キシログルカナーゼ、β−グルコシダーゼ、ペクチナーゼ、カラギナーゼ、ペルヒドロラーゼ、オキシダーゼ、オキシドレダクターゼまたはリパーゼ、およびそれらの組み合わせを含有することを特徴とする、請求項1〜7のいずれかに記載の洗剤または洗浄剤。
- 自動食器洗い機用洗剤であることを特徴とする、請求項1〜8のいずれかに記載の洗剤または洗浄剤。
- 布地または硬質表面からプロテアーゼ感受性汚れを除去するための、請求項1〜9のいずれかに記載の洗剤または洗浄剤の使用。
- 請求項1〜9のいずれかに記載の洗剤または洗浄剤を、方法の少なくとも一工程で使用することを特徴とする、布地または硬質表面の洗浄方法。
- アミラーゼは1×10−10〜0.2重量%の濃度で洗浄液中に存在し、および/またはプロテアーゼは1×10−10〜0.2重量%の濃度で洗浄液中に存在することを特徴とする、請求項11に記載の方法。
- 10℃〜60℃、好ましくは20℃〜50℃、より好ましくは30℃〜50℃の温度で実施することを特徴とする、請求項11または12に記載の方法。
- アミラーゼ含有液状洗剤または洗浄剤においてタンパク質分解活性を提供するための、SEQ ID no.1で示されるアミノ酸配列とその全長にわたって少なくとも70%同一であって、SEQ ID no.1のナンバリングにおいてS3T、V4IおよびV199Iからなる群から選択される少なくとも2つのアミノ酸置換と組み合わせて更なるアミノ酸置換R99EまたはR99Dを有するアミノ酸配列を含んでなるプロテアーゼの使用。
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DE102011088751A DE102011088751A1 (de) | 2011-12-15 | 2011-12-15 | Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Amylase |
PCT/EP2012/074883 WO2013087545A1 (de) | 2011-12-15 | 2012-12-10 | Lagerstabiles flüssiges wasch- oder reinigungsmittel enthaltend protease und amylase |
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JP2020143288A (ja) * | 2016-05-03 | 2020-09-10 | ザ プロクター アンド ギャンブル カンパニーThe Procter & Gamble Company | 自動食器洗浄洗剤組成物 |
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EP2791331A1 (de) | 2014-10-22 |
ES2630877T3 (es) | 2017-08-25 |
RU2617406C2 (ru) | 2017-04-25 |
DE102011088751A1 (de) | 2013-06-20 |
US20140295522A1 (en) | 2014-10-02 |
HUE033241T2 (en) | 2017-11-28 |
PL2791331T3 (pl) | 2017-09-29 |
CN103987845A (zh) | 2014-08-13 |
KR101929610B1 (ko) | 2019-03-14 |
MX350254B (es) | 2017-08-31 |
KR20140105006A (ko) | 2014-08-29 |
CN103987845B (zh) | 2020-08-04 |
BR112014014039A2 (pt) | 2020-11-03 |
EP2791331B1 (de) | 2017-03-15 |
RU2014128801A (ru) | 2016-02-10 |
US9752102B2 (en) | 2017-09-05 |
JP6154822B2 (ja) | 2017-06-28 |
BR112014014039B1 (pt) | 2021-11-30 |
MX2014007116A (es) | 2014-09-08 |
WO2013087545A1 (de) | 2013-06-20 |
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