JP2015086152A - カプセル充填用組成物 - Google Patents
カプセル充填用組成物 Download PDFInfo
- Publication number
- JP2015086152A JP2015086152A JP2013224495A JP2013224495A JP2015086152A JP 2015086152 A JP2015086152 A JP 2015086152A JP 2013224495 A JP2013224495 A JP 2013224495A JP 2013224495 A JP2013224495 A JP 2013224495A JP 2015086152 A JP2015086152 A JP 2015086152A
- Authority
- JP
- Japan
- Prior art keywords
- mass
- rice bran
- powder
- bran extract
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 235000009566 rice Nutrition 0.000 claims abstract description 52
- 239000000284 extract Substances 0.000 claims abstract description 42
- 239000000843 powder Substances 0.000 claims abstract description 23
- 229930182558 Sterol Natural products 0.000 claims abstract description 16
- 235000003702 sterols Nutrition 0.000 claims abstract description 16
- -1 sterol glycoside Chemical class 0.000 claims abstract description 13
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Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
一方、油性溶剤に植物由来のワックス類を配合してなる基剤に、粉末成分又は水溶性成分を均一に分散してなる軟カプセル剤充填用組成物が知られている(特許文献1:特開2002−161029号公報)。
(1)アシル化ステロール配糖体を2.7〜4.1質量%、γ−オリザノールを1.4〜2.1質量%、ステアロ・オレオ・レシチン換算で、リン脂質を18〜28質量%含有し、加水分解したときに、加水分解前の質量に対して20〜30質量%のリノール酸、24〜37質量%のオレイン酸、11〜17質量%のパルミチン酸、1.7〜2.6質量%の植物ステロールを含有する米糠抽出物と
ワックス類と
粉体を
含有することを特徴とするカプセル充填用の組成物。
(2)ワックス類がミツロウである(1)に記載の組成物。
(3)粉体がβクリプトキサンチンである(1)に記載の組成物。
(4)(1)〜(3)のいずれかに記載の組成物を内包するカプセル製剤。
また構成ステロールはβ−シトステロール、スチグマステロール、カンペステロール等である。アシル化は主にグルコースの6位が、脂肪酸によってアシル化されており、構成脂肪酸は主にリノール酸、オレイン酸、パルミチン酸であることが明らかになっている(帯大研報,10,(1977)507〜514)。
(1)米糠抽出物を適量秤取し、クロロホルム/メタノール混液(クロロホルム:メタノール=2:1)を加え、メスフラスコにてメスアップする。
(2)(1)で得られた溶液は成分濃度に応じて適宜希釈し、分析用試料溶液とする。
(3)標品はEsterified Steryl Glucoside(フナコシ)とし、高速液体クロマトグラフ法によりアシル化ステロール配糖体の濃度を算出する。
(4)高速液体クロマトグラフ法による分析条件
分析装置:HPLC
移動相A:メタノール:水 = 95:5(v/v)
移動相B:クロロホルム = 100(v/v)
ポンプ:Model 582
solvent delivery system
分析カラム:LiChrospher Si60(5μm)
HPLC−Cartridge(MERCK)
検出器:荷電化粒子検出器(コロナ ダイオネクス社)
Injection Volume:20μL
カラムオーブン:40℃(FLO社 model 502)
分析時間:40min
脱泡装置:uniflows Degasys Ultimate
DV3003
流速:1mL/min
グラジェント条件
以下に示すとおり
0−15分
移動相A:1% → 25%、移動相B: 99% → 75%
15−20分
移動相A:25% → 90%、移動相B: 75% → 10%
20−25分
移動相A:90%、 移動相B: 10%
25−30分
移動相A:90% → 1%、 移動相B: 10% → 99%
30−40分
移動相A:1%、 移動相B: 99%
γ−オリザノールは、米糠の脂質に含有されるフェルラ酸とステロールのエステルを意味し、フェルラ酸24−メチレンシクロアルテニル、フェルラ酸シクロアルテニル、フェルラ酸カンペステリル、フェルラ酸β−シトステリル等の混合物である。
また、具体的な抽出操作を以下に示す。
市場に流通している米糠を選別した後に、ノルマルヘキサンなどの溶媒を用いて脱脂する。得られた油、脱脂糠等の粗原料を蒸留装置により脱溶媒し、さらにノルマルヘキサン、アセトン、エタノール、水などの溶媒によって抽出する。かくして得られた抽出液を、脱溶剤装置を用いて再度脱溶剤することで米糠抽出物を得ることができる。
市場に流通している米糠を選別し胚乳や異物を除いた米糠を得た。得られた選別済みの米糠10kgに対して50Lのノルマルヘキサンを用い脱脂した。この脱脂作業を1回繰り返し、脱脂米糠を得た。得られた脱脂米糠から蒸留装置により溶媒を除去した。得られた脱脂米糠8kgに対し、50Lの割合でエタノールを用いて70±3℃にて1時間還流しながら抽出した。これを3回繰り返し、得られた抽出液について、脱溶剤装置を用いてエタノールを除去した。米糠抽出物中のアシル化ステロール配糖体、γ−オリザノール、ステアロ・オレオ・レシチン換算のリン脂質の濃度並びに、加水分解前の質量に対する、加水分解後のリノール酸、オレイン酸、パルミチン酸、植物ステロールの濃度を表1に示す。
市場に流通している米糠を選別し胚乳や異物を除いた米糠を得た。得られた選別済みの米糠10kgに対して50Lのノルマルヘキサンを用い脱脂した。この脱脂作業を3回繰り返し、脱脂米糠を得た。得られた脱脂米糠から蒸留装置により溶媒を除去した。得られた脱脂米糠8kgに対し、50Lの割合でアセトンを用いて50±3℃にて1時間還流しながら抽出した。これを3回繰り返し、得られた抽出液について、脱溶剤装置を用いてアセトンを除去した。米糠抽出物中のアシル化ステロール配糖体、γ−オリザノール、ステアロ・オレオ・レシチン換算のリン脂質の濃度並びに、加水分解前の質量に対する、加水分解後のリノール酸、オレイン酸、パルミチン酸、植物ステロールの濃度を表1に示す。
粉体としてβクリプトキサンチンを15質量%配合した米糠抽出物を調製し、粉体の分散安定性を確認した。
表2の処方の通り、各原料を秤量後、70℃以上で加温溶解・撹拌し、均一になったのちに、直径10mmのマイクロチューブに1.0ml分注した。
マイクロチューブを40℃条件下に1日静置し、油分と固形分の分離の様子を目視観察した。均一に混合しているものを「○」、分離傾向が見られたものを「△」、分離したものを「×」と評価した。
したがって、参考例1の米糠抽出物とミツロウの組み合わせは、カプセルに均一な組成で粉体を分散させた液体を充填する目的に適していることが明らかとなった。
なお、ミツロウの配合量を10%を超えて配合させた場合は、カプセルへの充填に際し、粘度が高くなりすぎて不適であった。
Claims (4)
- アシル化ステロール配糖体を2.7〜4.1質量%、γ−オリザノールを1.4〜2.1質量%、ステアロ・オレオ・レシチン換算で、リン脂質を18〜28質量%含有し、加水分解したときに、加水分解前の質量に対して20〜30質量%のリノール酸、24〜37質量%のオレイン酸、11〜17質量%のパルミチン酸、1.7〜2.6質量%の植物ステロールを含有する米糠抽出物と
ワックス類と
粉体を
含有することを特徴とするカプセル充填用の組成物。 - ワックス類がミツロウである請求項1に記載の組成物。
- 粉体がβクリプトキサンチンである請求項1に記載の組成物。
- 請求項1〜3のいずれかに記載の組成物を内包するカプセル製剤。
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KR102064242B1 (ko) * | 2018-04-26 | 2020-01-09 | 주식회사 서흥 | 천연 소재에 기반한 정제 조성물, 정제 및 정제 제조방법 |
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JP2015086151A (ja) * | 2013-10-29 | 2015-05-07 | 株式会社ファンケル | 米糠抽出物 |
KR102064242B1 (ko) * | 2018-04-26 | 2020-01-09 | 주식회사 서흥 | 천연 소재에 기반한 정제 조성물, 정제 및 정제 제조방법 |
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