JP2014005218A - Harmful-insect repellent aerosol-agent for human body, and method of harmful-insect repelling and giving cool feeling using the same - Google Patents
Harmful-insect repellent aerosol-agent for human body, and method of harmful-insect repelling and giving cool feeling using the same Download PDFInfo
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Abstract
Description
本発明は、蚊、ブヨ、サシバエ、イエダニ、ナンキンムシ等の害虫から人体を守るための人体用害虫忌避エアゾール剤、及びこれを用いた害虫忌避並びに冷感の付与方法に関する。更に詳しくは、害虫忌避効果や人体への安全性にすぐれることはもちろん、さらさら感だけでなく、冷感をも付与させた人体用害虫忌避エアゾール剤に関するものである。 The present invention relates to a pest repellent aerosol agent for protecting a human body from pests such as mosquitoes, gnats, sand flies, house dust mites, bed bugs, and the like, and a pest repellent and a method for imparting a cool feeling using the pest repellent aerosol. More specifically, the present invention relates to a pest repellent aerosol agent for human body which is not only excellent in pest repellent effect and safety to human body, but also has a cool feeling.
人体用害虫忌避剤について、従来より、刺激性の軽減、使用感の改善を目的とした様々な特許が出願されている。人体用害虫忌避剤は基本的に腕、足、首筋等、人体の露出した肌、即ち、外的な刺激を受けやすい部分に塗布するものであり、近年、アレルギー性物質や刺激性物質に対し過敏な反応を起こす人が増加している社会的状況を鑑み、従来一般的に配合していた紫外線吸収剤や紫外線散乱剤、タール色素等の刺激やアレルギーの原因となりやすい原料の配合を減らしたり、皮膚の乾燥を防ぐ保湿剤等を配合したりして、刺激性軽減に重点を置いた処方を指向する動きが活発になっている。
また、組成物中に皮膚に優しい水を配合した水性害虫忌避剤の特許も出願され、例えば、特開２００３−１９２５０３号公報（特許文献１）は、害虫忌避成分、水溶性溶剤及び水を配合し、水溶性溶剤と水の配合比率を規定することにより、皮膚感触と臭気を改善する試みを開示している。
Various patents have been filed for pest repellents for the human body with the aim of reducing irritation and improving the feeling of use. The pest repellent for human body is basically applied to the exposed skin of the human body, such as arms, legs, neck, etc., i.e., areas that are susceptible to external irritation. In light of the social situation in which the number of people with hypersensitive reactions is increasing, the formulation of ingredients that are likely to cause irritation or allergies such as UV absorbers, UV scattering agents, and tar dyes that have been generally added in the past has been reduced. There are active movements to formulate prescriptions with emphasis on reducing irritation, such as by adding moisturizers to prevent skin dryness.
In addition, a patent for an aqueous pest repellent containing skin-friendly water in the composition has been filed. For example, Japanese Patent Application Laid-Open No. 2003-192503 (Patent Document 1) contains a pest repellent component, a water-soluble solvent and water. In addition, an attempt to improve the skin feel and odor by disposing the mixing ratio of the water-soluble solvent and water is disclosed.
ところで、使用感を改善する方向性としては、（１）さらさら感の付与、（２）清涼感（冷感）の付与があげられる。（１）さらさら感を付与するための一般的な方法として、無機又は有機粉体の配合が有効で、例えば、特開平９−１５７１０７号公報（特許文献２）は吸油量が２５０ミリリットル／１００ｇ以下である無水ケイ酸の配合を開示し、また、本発明者らも特開２００６−１９９６５４号公報（特許文献３）の水性害虫忌避エアゾール組成物において、水ベースであれば相応の（１）さらさら感を有するものの、平均粒子径が０．５〜２０μｍの無機又は有機粉末を添加することによって、さっぱりした使用感を一層向上させ得ることを述べている。 By the way, directions for improving the feeling of use include (1) imparting a smooth feeling and (2) imparting a cool feeling (cool feeling). (1) As a general method for imparting a smooth feeling, blending of inorganic or organic powders is effective. For example, JP-A-9-157107 (Patent Document 2) has an oil absorption of 250 ml / 100 g or less. In addition, the present inventors have disclosed an appropriate water-based pest repellent aerosol composition disclosed in Japanese Patent Application Laid-Open No. 2006-199654 (Patent Document 3). Although it has a feeling, it is described that the refreshing feeling of use can be further improved by adding an inorganic or organic powder having an average particle diameter of 0.5 to 20 μm.
一方、液化石油ガスのような液化噴射ガスやイソペンタン等は、特開昭６２−３３１１５号公報（特許文献４）や特開平３−２０９３１５号公報（特許文献５）に記載されているように、皮膚に付着すると蒸発に際して皮膚から多量の潜熱を奪うので、その強度を調節することにより（２）清涼感（冷感）を付与できるとされる。しかしながら、液化噴射ガスは瞬間的に蒸発するため、この冷感効果は到底持続しない。 On the other hand, liquefied propellant gas such as liquefied petroleum gas, isopentane, etc., as described in JP-A-62-233115 (Patent Document 4) and JP-A-3-209315 (Patent Document 5), When it adheres to the skin, it takes a large amount of latent heat from the skin during evaporation, and (2) a refreshing feeling (cool feeling) can be imparted by adjusting its strength. However, since the liquefied propellant gas evaporates instantaneously, this cooling effect is not sustained at all.
本発明者らは、先に、（２）清涼感（冷感）を持続して付与させるには、液化噴射ガスの蒸発作用よりも水の気化熱を利用するのが効果的であると考え、検討を重ねた。その結果、特開２００６−１９９６５４号公報（特許文献３）の水性害虫忌避エアゾール組成物で配合した無機又は有機粉末は、（１）さらさら感をより改善させるには有効であるものの、（２）清涼感（冷感）の付与にはむしろ逆効果であることを見出し、この知見に基づいて、冷感付与に効果的な水性害虫忌避エアゾール組成物に係る特許を出願した（特願２０１１−１７３４９１）。 The present inventors consider that it is more effective to use the heat of vaporization of water than to evaporate the liquefied propellant gas in order to continuously impart (2) a cool feeling (cool feeling). , Repeated examination. As a result, the inorganic or organic powder blended with the aqueous pest repellent aerosol composition of JP-A-2006-199654 (Patent Document 3) is effective in (1) further improving the dry feeling, (2) It was found that it was rather counterproductive for imparting a refreshing feeling (cool feeling), and based on this finding, a patent was filed for an aqueous pest repellent aerosol composition effective for imparting a cool feeling (Japanese Patent Application No. 2011-173491). ).
その後、本発明者らは更に試験を繰り返した結果、水の気化熱を利用しなくても、エアゾール原液と液化石油ガスを主体とする噴射ガスの配合比率や、液化石油ガスの２０℃における蒸気圧を特定し、好ましくは、更にバルブステム口の断面積とボタン噴射口先端の断面積の比率を特定することによって実用的に十分な冷感が付与されうることを知見し、本発明を完成するに至ったものである。 Thereafter, as a result of further repeating the test, the present inventors have determined that the mixing ratio of the injection gas mainly composed of the aerosol stock solution and the liquefied petroleum gas and the vapor of the liquefied petroleum gas at 20 ° C. without using the heat of vaporization of water. Knowing that the pressure is sufficient, and preferably, by identifying the ratio of the cross-sectional area of the valve stem port and the cross-sectional area of the button injection port tip, a practically sufficient cooling sensation can be provided, and the present invention is completed. It has come to be.
本発明は、害虫忌避効果や人体への安全性にすぐれることはもちろん、水の気化熱を利用しなくても持続した冷感を付与させた人体用害虫忌避エアゾール剤を提供しようとするものである。 The present invention is intended to provide a pest repellent aerosol agent for human body which is not only excellent in pest repellent effect and safety to human body, but also gives sustained cooling feeling without using heat of vaporization of water. It is.
本発明は、上記目的を達成するため、以下の構成が優れた効果を奏することを見出したものである。
（１）エアゾール原液全体量に対して害虫忌避成分を１〜２０質量％とエタノールを５０質量％以上含有し、かつ無機又は有機粉末を含まないエアゾール原液と、液化石油ガスを主体とする噴射ガスとを１０／９０〜５０／５０の配合比率でエアゾール容器に充填してなる人体用害虫忌避エアゾール剤であって、
前記液化石油ガスの２０℃における蒸気圧が０．３ＭＰａ以下であり、人体の皮膚表面に噴霧塗布したときに、前記エタノールと液化石油ガスの蒸発作用に基づき持続した冷感を付与するものである人体用害虫忌避エアゾール剤。
（２）人体の皮膚表面に１５ｃｍ離れた距離から３秒間噴霧塗布したときに、その施用面の皮膚表面温度を１分間以上にわたり１５〜９０％低下させるものである（１）に記載の人体用害虫忌避エアゾール剤。
（３）平均噴霧粒子径が、３０〜１００μｍである（１）又は（２）に記載の人体用害虫忌避エアゾール剤。
（４）前記エアゾール容器に装填されるバルブステム口の断面積とボタン噴射口先端の断面積の比率が、１／１〜１／１０である（１）ないし（３）のいずれか１に記載の人体用害虫忌避エアゾール剤。
（５）前記害虫忌避成分が、ディート、フェノトリン、３−（Ｎ−ｎ−ブチル−Ｎ−アセチル）アミノプロピオン酸エチルエステル、及びｐ−メンタン−３，８−ジオールから選ばれる１種又は２種である（１）ないし（４）のいずれか１に記載の人体用害虫忌避エアゾール剤。
（６）（１）ないし（５）のいずれか１に記載の人体用害虫忌避エアゾール剤を、人体の皮膚表面に噴霧塗布する害虫忌避並びに冷感の付与方法。
In order to achieve the above object, the present invention has been found that the following configuration has an excellent effect.
(1) An aerosol stock solution containing 1 to 20% by mass of pest repellent components and 50% by mass or more of ethanol with respect to the total amount of the aerosol stock solution, and a propellant gas mainly composed of liquefied petroleum gas. A pest repellent aerosol agent for human body, which is filled in an aerosol container at a blending ratio of 10/90 to 50/50,
The vapor pressure of the liquefied petroleum gas at 20 ° C. is 0.3 MPa or less, and when sprayed onto the skin surface of the human body, it imparts a continuous cooling feeling based on the evaporation action of the ethanol and liquefied petroleum gas. Pest repellent aerosol for human body.
(2) When applied to the human skin surface by spraying from a distance of 15 cm for 3 seconds, the skin surface temperature of the application surface is reduced by 15 to 90% over 1 minute or more. Pest repellent aerosol.
(3) The pest repellent aerosol for human body according to (1) or (2), wherein the average spray particle size is 30 to 100 μm.
(4) The ratio of the cross-sectional area of the valve stem port loaded in the aerosol container to the cross-sectional area of the button injection port tip is 1/1 to 1/10, according to any one of (1) to (3) Pest repellent aerosol for human body.
(5) The pest repellent component is one or two selected from diet, phenothrin, 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester, and p-menthane-3,8-diol The pest repellent aerosol agent for human body according to any one of (1) to (4).
(6) A method for repelling pests and imparting a cool feeling, wherein the pest repellent aerosol for human body according to any one of (1) to (5) is spray-applied to the skin surface of the human body.
本発明の人体用害虫忌避エアゾール剤は、害虫忌避効果や人体への安全性にすぐれることはもちろん、水の気化熱を利用しなくても持続した冷感を付与させたのでその実用性は極めて高い。 The pest repellent aerosol agent for human body of the present invention is not only excellent in pest repellent effect and safety to human body, but also has a practical feeling because it gives a sustained cooling feeling without using the heat of vaporization of water. Extremely expensive.
本発明で用いる害虫忌避成分としては、害虫に対して忌避作用あるいは吸血阻害作用を有する合成あるいは天然の各種化合物が挙げられる。例えば、ディート、フェノトリン、３−（Ｎ−ｎ−ブチル−Ｎ−アセチル）アミノプロピオン酸エチルエステル、ｐ−メンタン−３，８−ジオール、シトロネラール、シトロネロール、シトラール、リナロール、テルピネオール、メントール、α―ピネン、カンファー、ゲラニオール、カランー３，４−ジオールなどを例示できる。更に天然物としては、桂皮、シトロネラ、レモングラス、クローバ、ベルガモット、月桂樹、ユーカリなどから採れる精油、抽出液などを例示でき、これらの１種または２種以上を選択して用いることができる。上記化合物及び天然物のなかでは、ディート、フェノトリン、３−（Ｎ−ｎ−ブチル−Ｎ−アセチル）アミノプロピオン酸エチルエステル、ならびにｐ−メンタン−３，８−ジオールが好ましい。ディートは長年にわたる使用実績があり、一方、３−（Ｎ−ｎ−ブチル−Ｎ−アセチル）アミノプロピオン酸エチルエステルは、ディートとほぼ同等の忌避効果を有し、本発明で用いる内容組成物に適した害虫忌避成分といえる。
害虫忌避成分はその忌避効力等にもよるが、本発明で用いるエアゾール原液全体量に対して１〜２０質量％、好ましくは３〜１２質量％配合される。
Examples of the pest repellent component used in the present invention include various synthetic or natural compounds having a repellent action or blood sucking inhibitory action against pests. For example, diet, phenothrin, 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester, p-menthane-3,8-diol, citronellal, citronellol, citral, linalool, terpineol, menthol, α-pinene , Camphor, geraniol, caran-3,4-diol, and the like. Furthermore, examples of natural products include essential oils and extracts from cinnamon bark, citronella, lemongrass, clover, bergamot, laurel, eucalyptus, etc., and one or more of these can be selected and used. Of the above compounds and natural products, diet, phenothrin, 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester, and p-menthane-3,8-diol are preferred. Diet has been used for many years, while 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester has a repellent effect almost equivalent to that of diet, and is used as a content composition for use in the present invention. It can be said to be a suitable pest repellent component.
The pest repellent component is blended in an amount of 1 to 20% by mass, preferably 3 to 12% by mass, based on the total amount of the aerosol stock solution used in the present invention, depending on its repellent efficacy.
本発明では、持続した冷感を付与させるため、エアゾール原液中にエタノールを５０質量％以上含有するとともに、エアゾール原液と液化石油ガスを主体とする噴射ガスの配合比率、ならびに液化石油ガスの２０℃における蒸気圧を特定することを必須とする。
即ち、液化石油ガスのような液化噴射ガスは、皮膚に付着すると蒸発に際して皮膚から多量の潜熱を奪うことが知られているが、これを含む油性の人体用害虫忌避エアゾール剤においては、液化噴射ガスが瞬間的に蒸発するため冷感効果はほとんど持続しないものと考えられてきた。
しかるに、本発明者らは、エアゾール原液中にエタノールを５０質量％以上含有するとともに、エアゾール原液と液化石油ガスを主体とする噴射ガスの配合比率、ならびに液化石油ガスの２０℃における蒸気圧を特定することによって、エタノールと液化石油ガスの作用が協働し、水による気化熱を利用しなくても冷感を持続して付与させ得ることを認め、本発明を完成するに至ったものである。
ここで、持続した冷感とは、人体の皮膚表面に１５ｃｍ離れた距離から３秒間噴霧塗布したときに、その施用面の皮膚表面温度を１分間以上にわたり１５〜９０％低下させる性能を言う。
この発明において、皮膚表面温度を低下させる性能とは、使用前の体温と０℃との差を１００％とした場合の使用後における温度低下の比率の数値を表わす。
In the present invention, in order to give a sustained cooling sensation, the aerosol stock solution contains 50% by mass or more of ethanol, the blending ratio of the injection gas mainly composed of the aerosol stock solution and liquefied petroleum gas, and 20 ° C. of the liquefied petroleum gas. It is essential to specify the vapor pressure at.
That is, it is known that a liquefied propellant gas such as liquefied petroleum gas takes a large amount of latent heat from the skin upon evaporation when it adheres to the skin, but in oily human pest repellent aerosols containing this, It has been considered that the cooling effect hardly lasts because the gas evaporates instantaneously.
However, the present inventors specify 50% by mass or more of ethanol in the aerosol stock solution, specify the blending ratio of the injection gas mainly composed of the aerosol stock solution and liquefied petroleum gas, and the vapor pressure at 20 ° C. of the liquefied petroleum gas. By doing so, it was recognized that the action of ethanol and liquefied petroleum gas cooperated, and a cool feeling could be continuously imparted without using the heat of vaporization by water, and the present invention was completed. .
Here, the sustained cooling sensation refers to the ability to reduce the skin surface temperature of the application surface by 15 to 90% over 1 minute when spray applied for 3 seconds from a distance of 15 cm away from the human skin surface.
In the present invention, the ability to reduce the skin surface temperature represents a numerical value of the ratio of temperature decrease after use when the difference between body temperature before use and 0 ° C. is 100%.
本発明では、冷感付与、ならびに害虫忌避成分の溶解とエアゾール原液の安定性向上のためにエタノールを含有するが、その目的に支障を来たさない量である限り、炭素数が２〜５の低級アルコール（エタノールを除く）及び／又はグリコールを配合してもよい。かかる低級アルコールとしてはイソプロパノール、また、グリコールとしてはジエチレングリコール、プロピレングリコール、ジプロピレングリコール、１，３−ブチレングリコール等が挙げられ、これらを単独、又は混合して使用することができる。 In the present invention, ethanol is contained for imparting a cooling sensation and improving the stability of the pest repellent component and the aerosol stock solution. However, as long as the amount does not hinder the purpose, the number of carbon atoms is 2-5. Lower alcohol (excluding ethanol) and / or glycol may be blended. Examples of such lower alcohol include isopropanol, and examples of glycol include diethylene glycol, propylene glycol, dipropylene glycol, and 1,3-butylene glycol. These can be used alone or in combination.
また、本発明で用いるエアゾール原液には、上記成分以外に内容組成物の安定性を一層高めるために界面活性剤を配合することができる。界面活性剤としては、特にＨＬＢが１１〜１６のノニオン系界面活性剤が好ましく、ポリオキシエチレン（１０モル）オレイルエーテル｛ＨＬＢ＝１２．４｝、ポリオキシエチレン（２０モル）オレイルエーテル｛ＨＬＢ＝１５．１｝、ポリオキシエチレン（９モル）ラウリルエーテル｛ＨＬＢ＝１３．６｝、ポリオキシエチレン（１０モル）セチルエーテル｛ＨＬＢ＝１２．９｝、ポリオキシエチレン（１５モル）ステアリルエーテル｛ＨＬＢ＝１４．２｝、ポリオキシエチレン（１５モル）イソステアリルエーテル｛ＨＬＢ＝１４．２｝等のポリオキシエチレンアルキルエーテル類、ポリオキシエチレン（２０モル）ソルビタンモノオレエート｛ＨＬＢ＝１５．７｝、ポリオキシエチレン（１０モル）ソルビタンモノラウレート｛ＨＬＢ＝１４．９｝、ポリオキシエチレン（２０モル）ソルビタンモノステアレート｛ＨＬＢ＝１５．７｝等のポリオキシエチレンソルビタン脂肪酸エステル類、ポリオキシエチレン（１４モル）モノオレエート｛ＨＬＢ＝１３．７｝、ポリオキシエチレン（９モル）モノラウレート｛ＨＬＢ＝１３．３｝、ポリオキシエチレン（１４モル）ミリステート｛ＨＬＢ＝１４．６｝等のポリオキシエチレンアルキルエステル類等が挙げられ、これらを単独、又は混合して使用することができる。界面活性剤は肌への刺激性を考えると極力低減するのが好ましいが、ＨＬＢが１１〜１６のノニオン系界面活性剤は少量の配合で内容組成物の安定化に効果がある。 In addition to the above components, a surfactant may be added to the aerosol stock solution used in the present invention in order to further enhance the stability of the content composition. As the surfactant, nonionic surfactants having HLB of 11 to 16 are particularly preferable, and polyoxyethylene (10 mol) oleyl ether {HLB = 12.4}, polyoxyethylene (20 mol) oleyl ether {HLB = 15.1}, polyoxyethylene (9 mol) lauryl ether {HLB = 13.6}, polyoxyethylene (10 mol) cetyl ether {HLB = 12.9}, polyoxyethylene (15 mol) stearyl ether {HLB = 14.2}, polyoxyethylene alkyl ethers such as polyoxyethylene (15 mol) isostearyl ether {HLB = 14.2}, polyoxyethylene (20 mol) sorbitan monooleate {HLB = 15.7} , Polyoxyethylene (10 mol) sorbitan monolaurate {HLB 14.9}, polyoxyethylene (20 mol) sorbitan monostearate {HLB = 15.7} and other polyoxyethylene sorbitan fatty acid esters, polyoxyethylene (14 mol) monooleate {HLB = 13.7}, poly And polyoxyethylene alkyl esters such as oxyethylene (9 mol) monolaurate {HLB = 13.3}, polyoxyethylene (14 mol) myristate {HLB = 14.6}, and the like. Or it can be mixed and used. The surfactant is preferably reduced as much as possible in consideration of irritation to the skin, but the nonionic surfactant having an HLB of 11 to 16 is effective in stabilizing the content composition in a small amount.
市販されている油性の人体用害虫忌避エアゾール剤には、さらさら感を付与するために無機又は有機粉末を配合しているものが多いが、本発明では配合しない。これは、試験の結果、無機又は有機粉末を配合することによって冷感作用が低減する傾向が見出されたためである。 Many commercially available oil-based pest repellent aerosols for human body contain inorganic or organic powders to impart a smooth feeling, but are not blended in the present invention. This is because, as a result of the test, it was found that the cooling effect tends to be reduced by blending inorganic or organic powders.
更に、本発明のエアゾール原液には、グリチルリチン酸ジカリウム、アラントイン、塩化アルキルトリメチルアンモニウム、酢酸トコフェロール、カンフル等の消炎剤、パラアミノ安息香酸、アミルサリシネート、オクチルシンナメート、メトキシ桂皮酸オクチル、２,４−ジヒドロキシベンゾフェノン等の紫外線吸収剤や紫外線散乱剤、あるいは硫酸アルミニウム、クロルヒドロキシアルミニウム、フェノールスルホン酸亜鉛等の制汗剤、安定剤、香料等を内容組成物の安定性に影響のない範囲で配合することも可能である。 Further, the aerosol solution of the present invention includes dipotassium glycyrrhizinate, allantoin, alkyltrimethylammonium chloride, tocopherol acetate, camphor and other anti-inflammatory agents, paraaminobenzoic acid, amylsalicynate, octylcinnamate, octyl methoxycinnamate, 2, UV absorbers such as 4-dihydroxybenzophenone and UV scattering agents, or antiperspirants such as aluminum sulfate, chlorohydroxyaluminum, and zinc phenolsulfonate, stabilizers, and fragrances in a range that does not affect the stability of the composition. It is also possible to mix.
本発明は、かかるエアゾール原液と液化石油ガス（ＬＰＧ）を主体とする噴射ガスをエアゾール容器に充填して人体用害虫忌避エアゾール剤を製する。ここで、ＬＰＧは、冷感付与の観点から、２０℃における蒸気圧が０．３ＭＰａ以下のものを用いる必要がある。
ＬＰＧ以外の噴射ガスとしては、ジメチルエーテル（ＤＭＥ）や圧縮ガス（窒素ガス、炭酸ガス等）があげられ、必要に応じてその若干量を加えてもよいことはもちろんである。
In the present invention, a pest-repellent aerosol agent for the human body is produced by filling an aerosol container with a spray gas mainly composed of the aerosol stock solution and liquefied petroleum gas (LPG). Here, it is necessary to use LPG having a vapor pressure of 0.3 MPa or less at 20 ° C. from the viewpoint of imparting a cool feeling.
Examples of the injection gas other than LPG include dimethyl ether (DME) and compressed gas (nitrogen gas, carbon dioxide gas, etc.), and it is needless to say that a slight amount may be added as necessary.
本発明の人体用害虫忌避エアゾール剤は、その平均噴霧粒子径が３０〜１００μｍであることが好ましく、噴霧粒子が過度に飛散しないというメリットを有する。
また、エアゾール容器に充填されるエアゾール原液と噴射ガスの配合比率は、１０／９０〜５０／５０（容量）が適当であり、その内圧はＬＰＧの蒸気圧と同じく、２０℃において０．３ＭＰａ以下に調整される。
The pest repellent aerosol for human body of the present invention preferably has an average spray particle size of 30 to 100 μm, and has an advantage that spray particles are not excessively scattered.
The mixing ratio of the aerosol stock solution and the injection gas filled in the aerosol container is suitably 10/90 to 50/50 (volume), and the internal pressure is 0.3 MPa or less at 20 ° C., similar to the vapor pressure of LPG. Adjusted to
エアゾール容器に装填される各パーツの仕様も適宜決定すればよいが、所定の性能を奏するために、例えば、バルブステム口の断面積とボタン噴射口先端の断面積の比率を１／１〜１／１０の範囲とし、噴霧液の舞い散りを低減させ、皮膚への付着量を高めるように設計するのが好ましい。なお、１／１０を超えると噴射時にボタンからの液だれを生じる恐れがあり好ましくない。 The specification of each part loaded in the aerosol container may be determined as appropriate. In order to achieve a predetermined performance, for example, the ratio of the cross-sectional area of the valve stem port to the cross-sectional area of the button injection port tip is 1/1 to 1. / 10 range, and it is preferable to design to reduce the scattering of the spray liquid and increase the amount of adhesion to the skin. In addition, when it exceeds 1/10, there is a possibility of causing dripping from the button during injection, which is not preferable.
こうして得られた本発明の人体用害虫忌避エアゾール剤は、人に対する安全性が高く、人体への刺激性をほとんど有さない。しかも、持続した冷感を奏するので、蚊、ブヨ、サシバエ、イエダニ、ナンキンムシ等の刺咬被害防除に対して極めて有用なものである。 The thus obtained pest repellent aerosol for human body according to the present invention is highly safe for humans and has little irritation to the human body. Moreover, since it has a sustained cooling sensation, it is extremely useful for controlling bite damage such as mosquitoes, gnats, sand flies, house dust mites and bed bugs.
次に具体的な実施例ならびに試験例に基づき、本発明の人体用害虫忌避エアゾール剤について更に詳細に説明する。 Next, the pest repellent aerosol for human body of the present invention will be described in more detail based on specific examples and test examples.
害虫忌避成分としてディート３．０ｇ、微量のメントール、及び９５％エタノール２１．６ｇ（２７ｍＬ）を加え、全量を２４．６ｇ（３０ｍＬ）として本発明で用いるエアゾール原液を調製した。
このエアゾール原液をエアゾール容器に封入後、その上部にバルブ部分（ステム口断面積／ボタン噴射口先端の断面積：１／６）を取り付け、該バルブ部分を通じてＬＰＧ７０ｍＬを加圧充填（内圧：０．２８ＭＰａ；２０℃に調整）して本発明の人体用害虫忌避エアゾール剤を得た。
As an insect repellent component, 3.0 g of diet, a small amount of menthol, and 21.6 g (27 mL) of 95% ethanol were added to prepare an aerosol stock solution used in the present invention with a total amount of 24.6 g (30 mL).
After this aerosol stock solution is sealed in an aerosol container, a valve part (stem port cross-sectional area / button injection port tip cross-sectional area: 1/6) is attached to the upper part, and LPG 70 mL is pressurized and filled through the valve part (internal pressure: 0. 0). 28 MPa; adjusted to 20 ° C.) to obtain a pest repellent aerosol agent for human body of the present invention.
このエアゾール剤を１５ｃｍ離れた距離から腕の皮膚表面に３秒間噴霧したところ、平均噴霧粒子径は４０μｍであり、また、皮膚表面温度の推移をみると、処理前の３５．１℃が数十秒後に最低温度の１７．４℃（低下率：５０．４％）となり、１分後においても２７．８℃（低下率：２０．８％）で冷感が持続した。このさっぱりとした冷感に加え、屋外での実使用では蚊に対して８時間以上にわたり忌避効果を奏し、極めて有用な人体用害虫忌避エアゾール剤であることが認められた。 When this aerosol was sprayed on the skin surface of the arm for 3 seconds from a distance of 15 cm, the average sprayed particle size was 40 μm, and the transition of the skin surface temperature showed that 35.1 ° C. before treatment was several tens of degrees Celsius. After 2 seconds, the minimum temperature was 17.4 ° C. (reduction rate: 50.4%), and the cooling sensation was maintained at 27.8 ° C. (reduction rate: 20.8%) even after 1 minute. In addition to this refreshing cooling sensation, it was confirmed that this was a very useful pest repellent aerosol agent for human bodies, having a repellent effect for 8 hours or more when actually used outdoors.
実施例１に準じ、害虫忌避成分として３−（Ｎ−ｎ−ブチル−Ｎ−アセチル）アミノプロピオン酸エチルエステル３．８ｇ、及び９５％エタノール３７ｇ（４６．２ｍＬ）を加え、全量を４０．８ｇ（５０ｍＬ）として本発明で用いるエアゾール原液を調製した。
このエアゾール原液をエアゾール容器に封入後、その上部にバルブ部分（ステム口断面積／ボタン噴射口先端の断面積：１／４）を取り付け、該バルブ部分を通じて混合噴射ガス（ＬＰＧ／ＤＭＥ＝９／１）５０ｍＬを加圧充填（内圧：０．２６ＭＰａに調整）して本発明の人体用害虫忌避エアゾール剤を得た。
本エアゾール剤の平均噴霧粒子径は６３μｍで、実施例１の場合と同様、火気に対する安全性や忌避効果はもちろん、冷感の持続性［処理前：３４．９℃、数十秒後の最低温度：１５．７℃（低下率：５５．８％）、１分後：２６．５℃（低下率：２４．１％）］にすぐれ実用性の高いものであった。
According to Example 1, 3.8 g of 3- (Nn-butyl-N-acetyl) aminopropionic acid ethyl ester and 37 g (46.2 mL) of 95% ethanol were added as pest repellent components, and the total amount was 40.8 g. An aerosol stock solution used in the present invention was prepared as (50 mL).
After the aerosol stock solution is sealed in an aerosol container, a valve part (stem cross-sectional area / cross-sectional area at the tip of the button injection port: 1/4) is attached to the upper part, and a mixed injection gas (LPG / DME = 9 / 1) 50 mL was pressurized and filled (internal pressure: adjusted to 0.26 MPa) to obtain a pest repellent aerosol agent for human body of the present invention.
The average spray particle size of this aerosol agent is 63 μm, and in the same manner as in Example 1, not only the safety against fire and repellent effect, but also the persistence of cooling feeling [before treatment: 34.9 ° C., minimum after several tens of seconds. Temperature: 15.7 ° C. (reduction rate: 55.8%), 1 minute later: 26.5 ° C. (reduction rate: 24.1%)] and excellent practicality.
実施例１に準じて表１に示す各種人体用害虫忌避エアゾール剤を調製し、下記に示す試験を行った。結果を表２に示す。
（１） 平均噴霧粒子径
レーザー光を利用する噴霧粒子測定装置を用いて測定した。
（２）冷感の持続性
人体用害虫忌避エアゾール剤を１５ｃｍ離れた距離から腕の皮膚表面に３秒間噴霧し、皮膚表面温度を経時的［処理前、最低温度記録時、及び１分後］に測定し、処理前の皮膚表面温度に対する温度低下率も求めた。また、冷感を下記基準により併せて評価した。
◎：心地よい冷感あり、 ○：やや冷感あり、 △：殆ど冷感なし、 ×：冷感なし。
According to Example 1, various human insect pest repellent aerosols shown in Table 1 were prepared, and the tests shown below were conducted. The results are shown in Table 2.
(1) Average spray particle diameter It measured using the spray particle | grain measuring apparatus using a laser beam.
(2) Persistence of cold sensation Pest repellent aerosol for human body is sprayed on the skin surface of the arm for 3 seconds from a distance of 15 cm, and the skin surface temperature is changed over time [before treatment, when recording the minimum temperature, and after 1 minute] The temperature decrease rate relative to the skin surface temperature before treatment was also determined. Moreover, the cool feeling was also evaluated according to the following criteria.
A: There is a pleasant cooling sensation, ○: Some cooling sensation, Δ: Almost no cooling sensation, ×: No cooling sensation
本発明の人体用害虫忌避エアゾール剤は、べたつきが無くさっぱりとした冷感が持続し、人体用害虫忌避エアゾール剤として高い実用性が認められた。なお、バルブステム口の断面積とボタン噴射口先端の断面積の比率としては、１／１〜１／１０の範囲がより好適であった。
これに対し、比較例１のように、２０℃における蒸気圧が０．３ＭＰａを超えるＬＰＧを用いたり、エアゾール原液と噴射ガスの配合比率が１０／９０〜５０／５０（容量）の範囲を外れる場合（比較例２）、エアゾール剤による冷感は長続きしなかった。また、比較例３の如く、無機粉体を配合することによって冷感作用が低減され、所定量のエタノールを含有しない比較例４も冷感作用が劣った。更に、液化噴射ガスでなく圧縮ガスを用いた比較例５は十分な冷感作用を奏せず、非エアゾールでスプレータイプの比較例６についても冷感作用が幾分劣ったことから、ＬＰＧがエタノールと協働して冷感作用に寄与することが明らかとなった。
The pest repellent aerosol agent for human body of the present invention has no stickiness and maintains a refreshing cooling sensation, and is highly practical as a pest repellent aerosol agent for human body. In addition, as a ratio of the cross-sectional area of the valve stem port and the cross-sectional area of the button injection port tip, a range of 1/1 to 1/10 was more preferable.
On the other hand, as in Comparative Example 1, LPG having a vapor pressure at 20 ° C. exceeding 0.3 MPa is used, or the mixing ratio of the aerosol stock solution and the injection gas is out of the range of 10/90 to 50/50 (volume). In the case (Comparative Example 2), the cooling sensation by the aerosol agent did not last long. Further, as in Comparative Example 3, the cooling effect was reduced by blending the inorganic powder, and Comparative Example 4 not containing a predetermined amount of ethanol was inferior in cooling effect. Furthermore, Comparative Example 5 using compressed gas instead of liquefied propellant gas did not provide sufficient cooling sensation, and the non-aerosol spray type Comparative Example 6 was somewhat inferior in cooling sensation. It became clear that it contributed to the cool feeling effect in cooperation with ethanol.
本発明の人体用害虫忌避エアゾール剤は、人体用の害虫忌避用途だけでなく、殺虫・殺ダニ用や殺菌・抗菌用、あるいは消臭・防臭用途等にも利用できる可能性がある。 The pest repellent aerosol for human body of the present invention may be used not only for pest repellent use for human body, but also for insecticidal / miticidal use, sterilization / antibacterial use, deodorization / deodorization use, and the like.
Claims (6)
前記液化石油ガスの２０℃における蒸気圧が０．３ＭＰａ以下であり、人体の皮膚表面に噴霧塗布したときに、前記エタノールと液化石油ガスの蒸発作用に基づき持続した冷感を付与するものであることを特徴とする人体用害虫忌避エアゾール剤。 10 to 20% by mass of a pest repellent component and 50% by mass or more of ethanol and no inorganic or organic powder, and a jet gas mainly composed of liquefied petroleum gas with respect to the total amount of aerosol solution A pest repellent aerosol agent for human body, which is filled in an aerosol container at a blending ratio of / 90 to 50/50,
The vapor pressure of the liquefied petroleum gas at 20 ° C. is 0.3 MPa or less, and when sprayed onto the skin surface of the human body, it imparts a continuous cooling feeling based on the evaporation action of the ethanol and liquefied petroleum gas. A pest repellent aerosol agent for the human body characterized by that.
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| JP2018177792A (en) * | 2017-04-17 | 2018-11-15 | 大日本除蟲菊株式会社 | Pest repellent composition, and pest repellent liquid |
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| JP2018177792A (en) * | 2017-04-17 | 2018-11-15 | 大日本除蟲菊株式会社 | Pest repellent composition, and pest repellent liquid |
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| JP2022078226A (en) * | 2017-04-17 | 2022-05-24 | 大日本除蟲菊株式会社 | Spray product |
| JP7293434B2 (en) | 2017-04-17 | 2023-06-19 | 大日本除蟲菊株式会社 | spray products |
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