JP2013541013A - ある液体量を部分量に配分するためのマイクロ流体試験担体 - Google Patents
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Abstract
【選択図】図2
Description
EP0626071B1
WO2007/042219A1
WO01/46465A2
WO95/33986
米国特許第5,160,702号
WO93/19827
により知られている。
本発明によるマイクロ流体試験担体は、基板を有し、この基板に毛細管構造が形成される。毛細管構造は、基板および被覆層によって囲まれる。毛細管構造は、ある分量の試料流体を受け入れる受容チャンバと、受容チャンバより小さい容積を有する少なくとも1つの試料チャンバと、受容チャンバと試料チャンバの間に延びる接続流路とを備える。受容チャンバ、接続流路および試料チャンバの組み合わせは、上記分量の試料流体を元の分量の流体より小さい1つまたは複数の部分量に配分するように働く。
Claims (14)
- 基板(4)および被覆層(21)を有すると共に、前記基板(4)および前記被覆層(21)によって囲まれる前記基板(4)に形成された毛細管構造(3)を有する、ある分量の流体を部分量に配分するためのマイクロ流体試験担体であって、
− 前記毛細管構造(3)が、受容チャンバ(6)、試料チャンバ(8、10、11)、および前記受容チャンバ(6)と前記試料チャンバ(8、10、11)の間の接続流路(9)を備え、
− 前記受容チャンバ(6)が、2つの向かい合う境界面(22、23)、および側壁(27)を有し、前記境界面(22、23)の一方が入口部(7)を有し、前記境界面のうちの一方の境界面(22)が前記受容チャンバ(6)の床部(24)であり、他方の境界面(23)が前記受容チャンバ(6)の覆い(25)であり、
− 前記受容チャンバ(6)が、円周状の排出流路(16)、および前記受容チャンバ(6)と前記排出流路(16)の間に配置された円周状の堰(18)を有し、前記堰(18)が、前記排出流路(16)よりも前記入口部(7)に近く、
− 前記堰(18)が、幾何的弁(28)を形成する毛細管栓が、前記堰(18)および前記排出流路(16)によって形成されるように設計され、前記毛細管栓を通じて空気が、前記排出流路(16)から逃れることができ、
− 前記接続流路(9)が、前記排出流路(16)の流出孔(26)と前記試料チャンバ(8、10、11)の入口孔(35)の間に延び、流体輸送が、前記受容チャンバ(6)から前記試料チャンバ(8、10、11)の中へと可能となっており、
− 前記弁(28)が、前記受容チャンバ(6)からの自動的な流体輸送が防がれるように設計される、マイクロ流体試験担体。 - 前記受容チャンバ(6)の前記境界面(22、23)の一方が湾曲しており、好ましくは他方の境界面(22、23)が前記被覆層(21)によって形成されることを特徴とする請求項1に記載のマイクロ流体試験担体。
- 前記湾曲した境界面(23)が、前記受容チャンバ(6)の前記覆い(25)であることを特徴とする請求項2に記載のマイクロ流体試験担体。
- 前記湾曲した境界面(22)が、前記受容チャンバ(6)の前記床部(24)であり、好ましくは、前記床部(24)は、前記床部(24)が前記受容チャンバ(6)の前記堰(18)に向かって上向きに傾斜されるように湾曲していることを特徴とする請求項2に記載のマイクロ流体試験担体。
- 前記試験担体(1)が、前記試験担体(1)を通じて延びる回転軸(5)、好ましくは前記試験担体(1)の中心点または重心を通じて延びる回転軸(5)を中心にして回転することを特徴とする請求項1乃至4のいずれか一項に記載のマイクロ流体試験担体。
- 前記受容チャンバ(6)が、前記回転軸(5)が前記入口部(7)を通じて延びるように前記試験担体(1)に対して配置されることを特徴とする請求項5に記載のマイクロ流体試験担体。
- 前記受容チャンバ(6)が、前記回転軸(5)が前記受容チャンバ(6)の前記中心点または前記重心を通じて延びるように前記試験担体に配置されることを特徴とする請求項5または6に記載のマイクロ流体試験担体。
- 前記受容チャンバ(6)が、前記試験担体(1)の前記中心点または前記試験担体(1)の前記重心から偏心して配置されることを特徴とする請求項5または6に記載のマイクロ流体試験担体。
- 前記受容チャンバ(6)の前記床部(24)が、前記流体が流れ込む前記流出孔(26)に近い収集領域(42)に凹み(43)が形成されるように凹まされることを特徴とする請求項1乃至8のいずれか一項に記載のマイクロ流体試験担体。
- 前記覆い(25)中の前記入口部(7)に向き合って配置され、好ましくは前記回転軸(5)と一直線に並べられる好ましくは円錐形の突起部(40)が、前記受容チャンバ(6)の前記床部(24)に形成されることを特徴とする請求項1乃至9のいずれか一項に記載のマイクロ流体試験担体。
- 前記受容チャンバ(6)から離れるように延びる接続流路(9)とそれぞれ流体連通する複数の流出孔(26)が、前記排出流路(16)に配置され、好ましくは、前記流出孔(26)が、等距離を隔てて円周に分散されることを特徴とする請求項1乃至10のいずれか一項に記載のマイクロ流体試験担体。
- 前記試料チャンバ(8、10、11)が、流体が前記試料チャンバ(8、10、11)から流れることができるように出口流路(34)と流体連通する出口孔(33)を備えることを特徴とする請求項1乃至11のいずれか一項に記載のマイクロ流体試験担体。
- 入口孔(39)を有するさらなる流体チャンバ(38)が、前記出口流路(34)と接続し、流体チャンバ(38)が、前記出口流路(34)によって前記試料チャンバ(8、10、11)と流体連通することを特徴とする請求項12に記載のマイクロ流体試験担体。
- 前記側壁が、前記受容チャンバ(6)の中心点から離れるように延在する窪み(44)を備え、前記流出孔(26)が、前記窪み(44)に配置されることを特徴とする請求項1乃至13のいずれか一項に記載のマイクロ流体試験担体。
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EP10189261A EP2486978A1 (de) | 2010-10-28 | 2010-10-28 | Mikrofluidischer Testträger zum Aufteilen einer Flüssigkeitsmenge in Teilmengen |
EP10189261.0 | 2010-10-28 | ||
PCT/EP2011/067929 WO2012055707A1 (de) | 2010-10-28 | 2011-10-13 | Mikrofluidischer testträger zum aufteilen einer flüssigkeitsmenge in teilmengen |
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EP (2) | EP2486978A1 (ja) |
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---|---|---|---|---|
JP2015121493A (ja) * | 2013-12-24 | 2015-07-02 | 凸版印刷株式会社 | 試料分析チップ |
JP2016507065A (ja) * | 2013-02-07 | 2016-03-07 | サンドストーン ダイアグノスティックス インコーポレイテッドSandstone Diagnostics,Inc. | 自動化された試料処理、流体分配、及び沈降検定 |
JP2018081084A (ja) * | 2016-11-16 | 2018-05-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 複数の測定チャンバを備える回転可能カートリッジ |
US10197480B2 (en) | 2012-11-07 | 2019-02-05 | Sandstone Diagnostics, Inc. | Methods and devices for processing samples and counting cells |
JP2019144260A (ja) * | 2014-05-15 | 2019-08-29 | タカノ株式会社 | 分析チップ及び試料分析装置 |
US11714034B2 (en) | 2012-11-07 | 2023-08-01 | Laboratory Corporation Of America Holdings | Methods and devices for processing samples and counting cells |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20150307927A1 (en) * | 2012-12-15 | 2015-10-29 | Tangen Biosciences, Inc. | Apparatus for centrifuge mountable manifold for processing fluidic assays |
US10195607B2 (en) * | 2013-03-21 | 2019-02-05 | Nec Corporation | Microchip, DNA analysis method and DNA analysis system |
US20150093838A1 (en) * | 2013-10-01 | 2015-04-02 | James P. Landers | Microfluidic valve systems |
EP2952257A1 (en) | 2014-06-06 | 2015-12-09 | Roche Diagnostics GmbH | Rotatable cartridge for processing and analyzing a biological sample |
KR101859860B1 (ko) * | 2014-06-06 | 2018-05-18 | 에프. 호프만-라 로슈 아게 | 생물학적 샘플을 분석하기 위한 계측 챔버를 갖는 회전 가능한 카트리지 |
EP2952258A1 (en) * | 2014-06-06 | 2015-12-09 | Roche Diagnostics GmbH | Rotatable cartridge for analyzing a biological sample |
EP2957890A1 (en) * | 2014-06-16 | 2015-12-23 | Roche Diagnostics GmbH | Cartridge with a rotatable lid |
EP3215260B1 (en) | 2014-11-03 | 2020-01-15 | Tangen Biosciences Inc. | Apparatus and method for cell, spore, or virus capture and disruption |
DE102014019526B4 (de) * | 2014-12-23 | 2016-10-27 | Testo Ag | Untersuchungsverfahren, scheibenförmiger Probenträger und Verwendung eines Probenträgers |
KR20160114494A (ko) * | 2015-03-24 | 2016-10-05 | 삼성전자주식회사 | 미세유동 장치 및 이를 포함하는 시료 분석장치 |
TWI581862B (zh) * | 2015-06-16 | 2017-05-11 | 亞諾法生技股份有限公司 | 微流道裝置的夾持載具 |
US10797567B2 (en) * | 2015-07-23 | 2020-10-06 | Life Technologies Corporation | Rotor assembly including a housing for a sensor array component and methods for using same |
USD841186S1 (en) * | 2015-12-23 | 2019-02-19 | Tunghai University | Biochip |
WO2018183744A1 (en) | 2017-03-29 | 2018-10-04 | The Research Foundation For The State University Of New York | Microfluidic device and methods |
EP3615220A4 (en) * | 2017-04-28 | 2020-12-30 | Neofluidics, LLC | FLUIDIC REACTION WELL DEVICES, AND ASSOCIATED USES |
US20200171490A1 (en) * | 2017-05-31 | 2020-06-04 | Biosurfit, S.A. | Liquid handling, in particular metering |
WO2019032690A1 (en) | 2017-08-09 | 2019-02-14 | Neofluidics, Llc | DEVICES AND METHODS FOR BIOLOGICAL TESTING |
US11305279B2 (en) | 2017-11-10 | 2022-04-19 | Neofluidics, Llc | Integrated fluidic circuit and device for droplet manipulation and methods thereof |
WO2019157170A1 (en) * | 2018-02-07 | 2019-08-15 | The Trustees Of The University Of Pennsylvania | High throughput microfluidic device |
WO2020087032A2 (en) | 2018-10-26 | 2020-04-30 | Neofluidics, Llc | Fluidic devices with reaction wells and constriction channels and uses thereof |
DE102022109766A1 (de) | 2022-04-22 | 2023-10-26 | Endress+Hauser BioSense GmbH | Mikrofluidische Kartusche zur Durchführung wenigstens eines Verarbeitungsschrittes |
DE102023101481A1 (de) | 2023-01-20 | 2024-07-25 | Testo bioAnalytics GmbH | Zentrifugierbarer Probenträger |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5433090A (en) * | 1977-08-18 | 1979-03-10 | Guigan Jean | Apparatus for inspecting liquid sample for analysis |
US4154793A (en) * | 1977-08-18 | 1979-05-15 | Jean Guigan | Device for conditioning a sample of liquid for analyzing |
WO2007116909A1 (ja) * | 2006-04-04 | 2007-10-18 | Panasonic Corporation | 試料液分析用パネル |
US20090155925A1 (en) * | 2007-12-13 | 2009-06-18 | Roche Diagnostics Operations, Inc. | Microfluidic element for thoroughly mixing a liquid with a reagent |
US20090227041A1 (en) * | 2008-02-04 | 2009-09-10 | Micropoint Biosciences, Inc. | Centrifugal fluid analyzer rotor |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4426451A (en) | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
US5160702A (en) | 1989-01-17 | 1992-11-03 | Molecular Devices Corporation | Analyzer with improved rotor structure |
US5061381A (en) * | 1990-06-04 | 1991-10-29 | Abaxis, Inc. | Apparatus and method for separating cells from biological fluids |
US5304348A (en) | 1992-02-11 | 1994-04-19 | Abaxis, Inc. | Reagent container for analytical rotor |
AU4047493A (en) | 1992-04-02 | 1993-11-08 | Abaxis, Inc. | Analytical rotor with dye mixing chamber |
US5591643A (en) | 1993-09-01 | 1997-01-07 | Abaxis, Inc. | Simplified inlet channels |
JPH10501340A (ja) | 1994-06-06 | 1998-02-03 | アバクシス,インコーポレイテッド | 測定精度を改善するための改良サイホン |
US6143248A (en) | 1996-08-12 | 2000-11-07 | Gamera Bioscience Corp. | Capillary microvalve |
US6162400A (en) | 1998-08-12 | 2000-12-19 | Agilent Technologies, Inc. | Apparatus for controlling reactions |
US6601613B2 (en) | 1998-10-13 | 2003-08-05 | Biomicro Systems, Inc. | Fluid circuit components based upon passive fluid dynamics |
SE0001779D0 (sv) | 2000-05-12 | 2000-05-12 | Gyros Ab | Microanalysis device |
US6919058B2 (en) | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
FR2841158B1 (fr) | 2002-06-24 | 2007-02-23 | Bio Merieux | Dispositif fluidique permettant de maniere thermo-pneumatique l'isolement et eventuellement l'agitation du contenu d'une cavite operatoire |
US7125711B2 (en) | 2002-12-19 | 2006-10-24 | Bayer Healthcare Llc | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device |
DE10302720A1 (de) | 2003-01-23 | 2004-08-05 | Steag Microparts Gmbh | Mikrofluidischer Schalter zum Anhalten des Flüssigkeitsstroms während eines Zeitintervalls |
EP1525916A1 (en) | 2003-10-23 | 2005-04-27 | F. Hoffmann-La Roche Ag | Flow triggering device |
DE10360220A1 (de) * | 2003-12-20 | 2005-07-21 | Steag Microparts Gmbh | Mikrostrukturierte Anordnung zur blasenfreien Befüllung zumindest eines Systems zur Ableitung von Flüssigkeiten, Vorrichtung mit einer solchen Anordnung und Befüllungsverfahren |
KR100540143B1 (ko) | 2003-12-22 | 2006-01-10 | 한국전자통신연구원 | 미소 유체 제어소자 및 미소 유체의 제어 방법 |
DE102004027422A1 (de) * | 2004-06-04 | 2005-12-29 | Boehringer Ingelheim Microparts Gmbh | Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen |
DE102005048260A1 (de) | 2005-10-07 | 2007-04-12 | Albert-Ludwigs-Universität Freiburg | Verfahren und Vorrichtung zum Handhaben einer flüssigen Probe unter Verwendung einer Rotation mit einem zeitlich veränderlichen Drehvektor |
EP1977829A1 (en) * | 2007-03-29 | 2008-10-08 | Roche Diagnostics GmbH | Device for performing multiple analyses in parallel |
EP1977830A1 (en) | 2007-03-30 | 2008-10-08 | Roche Diagnostics GmbH | Micro-fluidic temperature driven valve |
CN101850231B (zh) * | 2009-07-03 | 2012-08-29 | 中国科学院上海微***与信息技术研究所 | 一种微流体反应器、使用方法及其应用 |
-
2010
- 2010-10-28 EP EP10189261A patent/EP2486978A1/de not_active Withdrawn
-
2011
- 2011-10-13 EP EP11771105.1A patent/EP2632590B1/de active Active
- 2011-10-13 WO PCT/EP2011/067929 patent/WO2012055707A1/de active Application Filing
- 2011-10-13 JP JP2013535352A patent/JP5908917B2/ja active Active
- 2011-10-13 KR KR20137010846A patent/KR101495563B1/ko active IP Right Grant
- 2011-10-13 CN CN201180052524.XA patent/CN103167911B/zh active Active
-
2013
- 2013-04-26 US US13/871,720 patent/US9186671B2/en active Active
- 2013-08-15 HK HK13109544.7A patent/HK1182048A1/zh not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5433090A (en) * | 1977-08-18 | 1979-03-10 | Guigan Jean | Apparatus for inspecting liquid sample for analysis |
US4154793A (en) * | 1977-08-18 | 1979-05-15 | Jean Guigan | Device for conditioning a sample of liquid for analyzing |
WO2007116909A1 (ja) * | 2006-04-04 | 2007-10-18 | Panasonic Corporation | 試料液分析用パネル |
US20090155925A1 (en) * | 2007-12-13 | 2009-06-18 | Roche Diagnostics Operations, Inc. | Microfluidic element for thoroughly mixing a liquid with a reagent |
JP2009150880A (ja) * | 2007-12-13 | 2009-07-09 | F Hoffmann La Roche Ag | 液体を試薬と十分に混合するためのマイクロ流体エレメント |
US20090227041A1 (en) * | 2008-02-04 | 2009-09-10 | Micropoint Biosciences, Inc. | Centrifugal fluid analyzer rotor |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10197480B2 (en) | 2012-11-07 | 2019-02-05 | Sandstone Diagnostics, Inc. | Methods and devices for processing samples and counting cells |
US11714034B2 (en) | 2012-11-07 | 2023-08-01 | Laboratory Corporation Of America Holdings | Methods and devices for processing samples and counting cells |
JP2016507065A (ja) * | 2013-02-07 | 2016-03-07 | サンドストーン ダイアグノスティックス インコーポレイテッドSandstone Diagnostics,Inc. | 自動化された試料処理、流体分配、及び沈降検定 |
US10376877B2 (en) | 2013-02-07 | 2019-08-13 | Sandstone Diagnostics, Inc. | Automated sample processing, fluid distribution, and sedimentation assay |
US11471881B2 (en) | 2013-02-07 | 2022-10-18 | Laboratory Corporation Of America Holdings | Automated sample processing, fluid distribution, and sedimentation assay |
JP2015121493A (ja) * | 2013-12-24 | 2015-07-02 | 凸版印刷株式会社 | 試料分析チップ |
JP2019144260A (ja) * | 2014-05-15 | 2019-08-29 | タカノ株式会社 | 分析チップ及び試料分析装置 |
JP2018081084A (ja) * | 2016-11-16 | 2018-05-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 複数の測定チャンバを備える回転可能カートリッジ |
JP7045158B2 (ja) | 2016-11-16 | 2022-03-31 | エフ.ホフマン-ラ ロシュ アーゲー | 複数の測定チャンバを備える回転可能カートリッジ |
Also Published As
Publication number | Publication date |
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EP2632590A1 (de) | 2013-09-04 |
KR20130099122A (ko) | 2013-09-05 |
KR101495563B1 (ko) | 2015-02-25 |
CN103167911A (zh) | 2013-06-19 |
WO2012055707A1 (de) | 2012-05-03 |
EP2486978A1 (de) | 2012-08-15 |
EP2632590B1 (de) | 2020-03-04 |
CN103167911B (zh) | 2015-08-19 |
US9186671B2 (en) | 2015-11-17 |
HK1182048A1 (zh) | 2013-11-22 |
US20130236376A1 (en) | 2013-09-12 |
JP5908917B2 (ja) | 2016-04-26 |
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