JP2013226413A - 血液凝固基質および医療デバイス - Google Patents
血液凝固基質および医療デバイス Download PDFInfo
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
- B29C59/14—Surface shaping of articles, e.g. embossing; Apparatus therefor by plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00463—Plasters use haemostatic
- A61F2013/00472—Plasters use haemostatic with chemical means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2023/00—Use of polyalkenes or derivatives thereof as moulding material
- B29K2023/10—Polymers of propylene
- B29K2023/12—PP, i.e. polypropylene
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
【解決手段】ポリプロピレンフィルムの表面から伸びる酸素プラズマ処理した複数のポリプロピレンピラーを有する血液凝固基質およびデバイス、およびフィルムの表面から伸びる酸素プラズマ処理した複数のポリプロピレンピラーを有するポリプロピレンフィルムを含む血液凝固医療デバイスと血液を接触させることを含む、血液凝固を促進する方法。前記ピラーが直径約0.8〜約3μmであり、約0.5〜約40のアスペクト比であり、前記ピラーの表面酸含量が約21%である血液凝固基質。
【選択図】なし
Description
この実施例は、高アスペクト比を有するポリプロピレンの密に充填された表面構造体を酸素プラズマ処理して、表面により高い表面積とより高い酸素含量を生じさせることができ、このようにしてより速い全血凝固時間をもたらすことができることを示す。ポリカーボネート膜をモールドとして使用し、以下のようなインプリンティングプロセスを用いて、直径1ミクロンおよび高さ20ミクロンのポリプロピレンピラーを製造した。
・直径1ミクロンの細孔および2.5cmの円直径を有する厚さ20ミクロンの市販のトラックエッチポリカーボネート膜をMillipore Corporation of Billerica,MA,USAから入手した。
・該膜を鋳型として使用し、Ethicon,Inc.of Somerville,NJ,USAから入手した厚さ300ミクロンの耐溶媒性のポリプロピレン高分子フィルムをインプリントした。ポリプロピレンフィルムを高温および高圧下(180℃、600kPa(6バール))で20分間、ポリカーボネート膜鋳型にプレスして、ポリプロピレンを融解した。
・ポリプロピレン高分子と膜を175℃に冷却した後、圧を解除し、その後、膜をジクロロメタンに溶解することによって高分子構造体を型から取り離して解放した。
・マイクロ波プラズマ処理装置を100Wで30秒間用いて、一部のフィルムを酸素プラズマ処理した。
ポリジオキサノン(PDO)フィルムを使用して、実施例1で述べたのと同様の方法で、高アスペクト比のピラーを製造した。高さ20μmで直径1μmのピラー(アスペクト比20)のSEM画像を図3に示す。実施例1で概説したように静止時の水接触角測定を実施した。平均接触角を以下の表3に示す。
Claims (18)
- ポリプロピレンフィルムの表面から伸びる酸素プラズマ処理した複数のポリプロピレンピラーを含む血液凝固基質。
- 前記ピラーが直径約0.8μm〜約3μmであり、約0.5〜約40のアスペクト比を有する請求項1に記載の血液凝固基質。
- 静止時の水接触角が約15°未満である請求項1に記載の血液凝固基質。
- 前記ポリプロピレンフィルムおよび前記ピラーの表面の酸素含量が、酸素プラズマ処理していないポリプロピレンフィルムおよびピラーよりも高い、請求項1に記載の血液凝固基質。
- 前記ポリプロピレンフィルムおよび前記ピラーが約21%の酸素含量を有する請求項1に記載の血液凝固基質。
- 前記酸素プラズマ処理したポリプロピレンフィルムおよびピラーが、未処理フィルムの0.9の標準化凝固時間と比較して0.2の標準化凝固時間を示す、請求項1に記載の血液凝固基質。
- 前記ピラーが約1μmの直径および約20μmの高さを有する請求項2に記載の血液凝固基質。
- ポリプロピレンフィルムの表面から伸びる酸素プラズマ処理した複数のポリプロピレンピラーを有するポリプロピレンフィルムを含む血液凝固医療デバイス。
- 前記ポリプロピレンフィルムが酸素プラズマ処理を有する請求項8に記載の血液凝固医療デバイス。
- 前記ピラーが直径約0.8μm〜約3μmであり、約0.5〜約40のアスペクト比を有する請求項8に記載の血液凝固医療デバイス。
- 静止時の水接触角が約15°未満である請求項8に記載の血液凝固医療デバイス。
- 前記ポリプロピレンフィルムおよび前記ピラーの表面の酸素含量が、酸素プラズマ処理していないポリプロピレンフィルムおよびピラーよりも高い、請求項8に記載の血液凝固医療デバイス。
- 前記ポリプロピレンフィルムおよび前記ピラーが約21%の酸素含量を有する請求項8に記載の血液凝固医療デバイス。
- 前記酸素プラズマ処理したポリプロピレンフィルムおよびピラーが、未処理フィルムの0.9の標準化凝固時間と比較して0.2の標準化凝固時間を示す、請求項8に記載の血液凝固医療デバイス。
- 前記ピラーが約1μmの直径および約20μmの高さを有する請求項10に記載の血液凝固医療デバイス。
- ポリプロピレンフィルムの表面から伸びる酸素プラズマ処理した複数のポリプロピレンピラーを含む血液凝固基質と血液を接触させることを含む、血液凝固を促進する方法。
- ポリプロピレンフィルムの表面から伸びる酸素プラズマ処理した複数のポリプロピレンピラーを有するポリプロピレンフィルムを含む血液凝固医療デバイスと血液を接触させることを含む、血液凝固を促進する方法。
- 血液凝固基質を形成する方法であって、
a)窪み部を備えた溶媒に可溶なモールドを準備するステップと、
b)ポリプロピレンフィルムをモールドに供給し、前記モールドの前記窪み部にポリプロピレンを充填するステップと、
c)ステップb)の前記ポリプロピレンおよび前記モールドを処理し、前記ポリプロピレンを実質的に凝固させるステップと、
d)前記溶媒(ポリプロピレンは溶解せず、モールドを溶解するように選択される)に前記モールドおよび前記ポリプロピレンを暴露し、前記モールドを溶解させ、ピラー化した基質を得るステップと、および
e)前記ピラー化した基質を酸素プラズマ処理するステップ
を含む方法。
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Application Number | Priority Date | Filing Date | Title |
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US13/441,539 | 2012-04-06 | ||
US13/441,539 US8969648B2 (en) | 2012-04-06 | 2012-04-06 | Blood clotting substrate and medical device |
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JP2013226413A true JP2013226413A (ja) | 2013-11-07 |
JP6185738B2 JP6185738B2 (ja) | 2017-08-23 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US8926881B2 (en) | 2012-04-06 | 2015-01-06 | DePuy Synthes Products, LLC | Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them |
US8969648B2 (en) | 2012-04-06 | 2015-03-03 | Ethicon, Inc. | Blood clotting substrate and medical device |
US9211176B2 (en) | 2010-08-30 | 2015-12-15 | Ethicon Endo-Surgery, Inc. | Adhesive structure with stiff protrusions on adhesive surface |
US9492952B2 (en) | 2010-08-30 | 2016-11-15 | Endo-Surgery, Inc. | Super-hydrophilic structures |
US10278701B2 (en) | 2011-12-29 | 2019-05-07 | Ethicon, Inc. | Adhesive structure with tissue piercing protrusions on its surface |
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WO2015021192A1 (en) * | 2013-08-07 | 2015-02-12 | Hassan Tarek | Medical devices and instruments with non-coated superhydrophobic or superoleophobic surfaces |
EP3660108A1 (en) * | 2018-11-30 | 2020-06-03 | SABIC Global Technologies B.V. | Compositions including a laser marking additive and systems and methods of laser marking the compositions |
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US8969648B2 (en) | 2012-04-06 | 2015-03-03 | Ethicon, Inc. | Blood clotting substrate and medical device |
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US20130267880A1 (en) | 2013-10-10 |
US8969648B2 (en) | 2015-03-03 |
JP6185738B2 (ja) | 2017-08-23 |
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