JP2013194008A - 細胞賦活剤およびその用途 - Google Patents
細胞賦活剤およびその用途 Download PDFInfo
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- JP2013194008A JP2013194008A JP2012064301A JP2012064301A JP2013194008A JP 2013194008 A JP2013194008 A JP 2013194008A JP 2012064301 A JP2012064301 A JP 2012064301A JP 2012064301 A JP2012064301 A JP 2012064301A JP 2013194008 A JP2013194008 A JP 2013194008A
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- food
- cell activator
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- drink
- cell
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Abstract
【解決手段】明細書に記載の化合物1〜4の少なくとも1種を有効成分として含有する細胞賦活剤と、これを含有する薬剤組成物や皮膚外用剤組成物(化粧品など)、飲食品により、上記課題は解決されうる。
【選択図】なし
Description
乾燥させたアーティチョークの可食部600 gに酢酸エチル2300 mLを加え、80℃にて2時間抽出した。抽出液をろ過した後、溶媒を減圧除去し、アーティチョークの酢酸エチル抽出物17.5 gを得た。同様の抽出を再度行い、合計32.3 gの抽出物を得た。得られた抽出物32.3 gを酢酸エチル10 mLに溶解後、シルカゲル30 gを加え、エバポレーターで減圧乾燥し、試料層を調製した。シリカゲル700 gをクロマト管に詰め、先に調製した試料層を積層し、乾式カラムクロマトを作製した。ヘキサン:酢酸エチル混合溶媒(混合比率、2:3)で溶出を開始し、1画分当たり1400 mLずつ溶出液を捕集し、4個の画分に分離した。続いて2番目の画分を乾式カラムクロマトにて、ヘキサン:酢酸エチル:酢酸混合溶媒(混合比率、80:20:1)、ヘキサン:アセトン:メタノール(混合比率、40:8:1)で順次分画し、粗分画物300 mgを得た。続いて、得られた粗分画物約300 mgをジクロロメタン2.0 mLに溶解し、次いでアセトニトリル2.0 mLを加えた。溶液を0.45μmメンブランフィルターにてろ過し、以下のHPLCによる分離操作に付した。
カラム:Capcell Pak C18カラム(UG80, 250 × 10 mm i.d., 株式会社資生堂)
溶媒:アセトニトリル−0.1%ギ酸 70:30
流速:4.0 mL/min
温度:40℃
検出波長:254 nm
負荷量:0.4 mg
本条件で得られたクロマトグラムを図1に示す。図1に示すように、粗分画物には主要ピークが3本観察された。以下、これらをそれぞれピーク1(Rt 10.9)、ピーク2(Rt 11.8)およびピーク3(Rt 12.5)と称する。
カラム:Cosmosil cholester(250 × 10 mm i.d., ナカライテスク株式会社)
溶媒:メタノール−アセトニトリル−0.1%ギ酸 65 : 12 : 23
流速:3.5 mL/min
温度:40℃
検出波長:254 nm
負荷量:1.0 mg
本条件で得られたクロマトグラムを図2に示す。図2から明らかなように、ピーク1は混合物であることが判明し、主要ピークが2本観察された。以下、これらをそれぞれピーク1−1(Rt 19.8)およびピーク1−2(Rt 22.1)と称する。
ヒト正常真皮線維芽細胞を1%ウシ胎児血清(FBS)含有DMEMを用いて、1ウェル当たり2×104個となるように96ウェルプレートに播種した。24時間後、試験試料(上記で単離された各ピークの化合物(計4種))を最終濃度が20μMとなるように添加した。また、コントロールとしては溶媒であるDMSOのみを添加した。試料添加から24時間後、Premix WST-1 Cell Proliferation Assay System(タカラバイオ株式会社製)を用いて、細胞増殖活性を評価した。コントロールの細胞賦活活性(細胞増殖促進作用)を100%としたときの結果を下記の表1に示す。
上記で優れた細胞賦活活性(細胞増殖促進作用)を示した各ピークの化合物(計4種)を、以下のとおり機器分析により同定した。
Claims (9)
- 下記の化合物1〜4の少なくとも1種:
- 線維芽細胞に対して賦活作用を有する、請求項1に記載の細胞賦活剤。
- 請求項1または2に記載の細胞賦活剤と、製薬上許容されうる担体とを含有する、薬剤組成物。
- 請求項3に記載の薬剤組成物からなる、創傷治癒促進剤。
- 請求項1または2に記載の細胞賦活剤と、製薬上許容されうる担体とを含有する、皮膚外用剤組成物。
- 請求項5に記載の皮膚外用剤組成物からなる、化粧品。
- 請求項1または2に記載の細胞賦活剤を含有する、飲食品。
- 請求項1または2に記載の細胞賦活剤を有効量含有する飲食品であって、
創傷治癒の促進および/または老化防止の機能を有し、その機能表示が付された、飲食品。 - 健康食品、機能性食品、特定保健用食品、栄養補助食品、疾病リスク低減表示が付された食品、または病者用食品である、請求項8に記載の飲食品。
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JP2011037739A (ja) * | 2009-08-10 | 2011-02-24 | Pola Chemical Industries Inc | 組成物 |
JP2011184411A (ja) * | 2010-03-11 | 2011-09-22 | Kyoto Univ | トマト抽出物を含有する生活習慣病改善剤 |
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JP2008525446A (ja) * | 2004-12-22 | 2008-07-17 | エイボン プロダクツ インコーポレーテッド | 化粧品組成物における植物抽出物の使用 |
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JP2011184411A (ja) * | 2010-03-11 | 2011-09-22 | Kyoto Univ | トマト抽出物を含有する生活習慣病改善剤 |
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WO2020246468A1 (ja) | 2019-06-06 | 2020-12-10 | ビタミンC60バイオリサーチ株式会社 | 動物細胞の細胞賦活剤 |
KR20220003051A (ko) | 2019-06-06 | 2022-01-07 | 비타민 씨60 바이오리서치 가부시키가이샤 | 동물 세포의 세포 부활제 |
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