JP2013067901A - Method for imparting allergen-reducing function - Google Patents
Method for imparting allergen-reducing function Download PDFInfo
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- JP2013067901A JP2013067901A JP2011206705A JP2011206705A JP2013067901A JP 2013067901 A JP2013067901 A JP 2013067901A JP 2011206705 A JP2011206705 A JP 2011206705A JP 2011206705 A JP2011206705 A JP 2011206705A JP 2013067901 A JP2013067901 A JP 2013067901A
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- JP
- Japan
- Prior art keywords
- allergen
- fiber
- tannic acid
- reducing
- urethane resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Landscapes
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Abstract
Description
本発明は、ダニや花粉等のアレルゲンのアレルゲン性を低減化させるため、あるいは不織布、繊維または繊維製品にアレルゲン性を低減化させる機能を付与するための、耐水性を有するアレルゲン低減化剤の加工方法に関する。 The present invention relates to processing of an allergen reducing agent having water resistance for reducing the allergenicity of allergens such as mites and pollen, or for imparting a function of reducing allergenicity to nonwoven fabrics, fibers or fiber products. Regarding the method.
喘息やアトピー性皮膚炎、アレルギー性鼻炎等のアレルギー性疾患は多くの人が悩まされているものであり、特に近年では増加する傾向となっている。これらのアレルギー性疾患の原因となっているのは環境中に存在する種々のアレルゲンであり、それらの中でも屋内に棲息するダニやペットの毛、花粉、カビは代表的な吸入性のアレルゲンとして、良く知られている。特に家屋内に生息する塵性ダニであるヒョウヒダニ類はアレルゲンの発生源として大きな問題となっている。ヒョウヒダニ類は畳、絨毯、寝具、カーテン等の家屋内の繊維製品、あるいは屋外においても電車や自動車等の移動車両の座席シート生地等が生育の温床となる。 Allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis are plagued by many people, and in recent years, the tendency has been increasing. The causes of these allergic diseases are various allergens present in the environment. Among them, mites, pet hair, pollen, and mold that inhabit indoors are typical inhalable allergens. Well known. In particular, leopard mites, which are dust mites that live in the house, are a major problem as a source of allergens. Leopard mites are a hotbed for growing textile products in the house such as tatami mats, carpets, bedding, curtains, etc., or seat sheet fabrics of moving vehicles such as trains and cars outdoors.
ヒョウヒダニ類の中でも、コナヒョウヒダニ(Dermatophagoides farinae)とヤケヒョウヒダニ(Dermatophagoides pteronyssinus)は代表的な種であり、これらのダニの死骸や糞が強いアレルゲン物質となる。また春先に飛散するスギ(Cryptomeria japonica)の花粉を初め、多種の植物の花粉もアレルゲンとなるものであり、特にアレルギー性鼻炎を発症させる原因となっている。飛散する花粉は春先のスギ花粉だけでなく、ヒノキ、ヨモギ、ブタクサ、カモガヤ等、多くの種類があり一年を通じて何らかの花粉が飛散している状態であり、いつの時期でも花粉によるアレルギーを引き起こす危険性があると考えられる。 Among the leopard mites, Dermatophagoides farinae and Dermatophagoides pteronysinsinus are typical species, and the dead bodies and feces of these mites are strong allergen substances. In addition, pollen of various plants including cedar ( Cryptomeria japonica ) pollen scattered in early spring is also an allergen, and causes allergic rhinitis in particular. The pollen that scatters is not only cedar pollen in the early spring, but also many kinds of cypress, mugwort, ragweed, camo, etc. There is a state that some kind of pollen is scattered throughout the year, and there is a risk of causing pollen allergies at any time It is thought that there is.
このようなダニや花粉等のアレルゲンを除去するためには、エアコンや空気清浄機を用いて空気をフィルターに通じる方法があるが、除去できるのは空気中に舞うアレルゲンのみであり、フィルターにアレルゲン物質を集める結果となり、フィルターを交換する際にはアレルゲンが再飛散する危険性がある。また、マスクはスギ等の花粉を吸入するのを防ぐために用いられているが、マスクに付着した花粉はアレルゲン性が消失するわけではないので、再飛散することによって吸収してしまう危険性がある。電気掃除機はアレルゲン除去の方法として有効であるが、吸引したゴミに含まれる多量のアレルゲンは集塵袋に貯蔵されるだけであり、集塵袋の廃棄時にアレルゲンが再飛散する危険性が考えられる。 In order to remove such allergens such as mites and pollen, there is a method of passing air to the filter using an air conditioner or an air purifier, but only allergens flying in the air can be removed, and allergens in the filter can be removed. As a result of collecting the material, there is a risk of allergen re-entrainment when changing the filter. Also, the mask is used to prevent inhalation of cedar pollen, but the pollen attached to the mask does not lose allergenicity, so there is a risk that it will be absorbed by re-scattering. . A vacuum cleaner is an effective method for removing allergens, but a large amount of allergens contained in the sucked garbage is only stored in the dust bag, and there is a risk that the allergen will re-scatter when the dust bag is discarded. It is done.
アレルゲン物質のアレルギー性を低減あるいは除去するための薬剤に関しては、タンニン酸が古くから知られており、タンニン酸等のポリフェノール類化合物を応用する方法が提案されてきた。例えば、タンニン酸をアレルゲンの不活性化剤として使用する方法(特許文献1)、茶抽出物、ハイドロキシアパタイト、エピカテキン、エピガロカテキン、エピカテキンガレート、エピガロカテキンガレート、没食子酸および没食子酸と炭素数1から4までのアルコールとのエステルをアレルゲンの不活性化剤として使用する方法(特許文献2)が開示されている。タンニン酸は褐色に呈色しており、さらに経時的に着色が進行することで用途が制限される短所があったが、安全性の高い天然物であること、優れたアレルゲン低減化効果を有していることから、着色が問題とならない用途では優秀な剤であった。しかしタンニン酸は水溶性であるため、耐水性を要求される用途では依然として使用に適していないという問題があった。 With regard to drugs for reducing or eliminating allergenicity of allergen substances, tannic acid has been known for a long time, and a method of applying a polyphenol compound such as tannic acid has been proposed. For example, a method of using tannic acid as an allergen inactivating agent (Patent Document 1), tea extract, hydroxyapatite, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, gallic acid and gallic acid A method of using an ester with an alcohol having 1 to 4 carbon atoms as an allergen inactivating agent (Patent Document 2) is disclosed. Tannic acid has a brown color and has the disadvantage that its use is limited by the progress of coloring over time, but it is a highly safe natural product and has an excellent allergen-reducing effect. Therefore, it was an excellent agent in applications where coloring is not a problem. However, since tannic acid is water-soluble, there is a problem that it is still unsuitable for use in applications requiring water resistance.
またタンニン酸等のポリフェノール化合物以外のアレルゲン低減化剤として、非水溶性亜鉛化合物あるいは非水溶性亜鉛・金属酸化物の複合粒子を用いたアレルゲン不活化剤が提案され(特許文献3)、さらに二酸化ケイ素、酸化亜鉛、酸化アルミニウムを用いたアレルゲン不活化剤が提案されているが(特許文献4)、耐水性やアレルゲン不活化性能は満足できるものではなかった。またこれらのアレルゲン低減化剤は水溶性ではないが、不織布、繊維、繊維製品、プラスチック製品、木質材料にバインダーとしてアクリルエマルジョン等の樹脂エマルジョンを用いて加工した場合、バインダー量が十分な場合はアレルゲン低減化剤を覆ってしまい、流脱を防ぐもののアレルゲン低減化性能そのものが発揮されず、バインダー量が少ないと流脱を防ぐことができずに効力を維持できないことが多かった。またタンニン酸をポリカルボン酸と架橋剤を用いて繊維に固着させる方法が開示されている(特許文献5)。しかし、反応が煩雑で架橋剤の刺激性が高く、十分な効果を発揮できないという問題点があった。 Further, as an allergen reducing agent other than a polyphenol compound such as tannic acid, an allergen inactivating agent using a water-insoluble zinc compound or a water-insoluble zinc / metal oxide composite particle has been proposed (Patent Document 3). Although an allergen inactivating agent using silicon, zinc oxide, and aluminum oxide has been proposed (Patent Document 4), water resistance and allergen inactivating performance have not been satisfactory. These allergen reducing agents are not water-soluble, but when processed with a resin emulsion such as an acrylic emulsion as a binder to nonwoven fabrics, fibers, textile products, plastic products, and wood materials, allergens are used when the amount of binder is sufficient. Although the reducing agent is covered to prevent the outflow, the allergen reducing performance itself is not exhibited, and when the amount of the binder is small, the outflow cannot be prevented and the effect cannot often be maintained. Also disclosed is a method of fixing tannic acid to fibers using a polycarboxylic acid and a crosslinking agent (Patent Document 5). However, there are problems that the reaction is complicated, the crosslinking agent is highly irritating, and sufficient effects cannot be exhibited.
タンニン酸を用いて、ダニやスギ花粉等のアレルゲンのアレルゲン性を低減化させること、さらに不織布、繊維または繊維製品にアレルゲン性を低減化させる機能を付与し、容易に流脱することのない加工方法およびこれらのアレルゲン低減化剤を加工した不織布、繊維または繊維製品を提供することが、本発明の課題である。 Uses tannic acid to reduce the allergenicity of allergens such as mites and cedar pollen, and to add a function to reduce allergenicity to non-woven fabrics, fibers or textiles, and does not easily flow out It is an object of the present invention to provide methods and nonwovens, fibers or textiles processed with these allergen reducing agents.
本発明者は、このような課題を解決するため鋭意研究を行った結果、高いアレルゲン低減化性能を持つタンニン酸と、ウレタン樹脂バインダーを併用することによって、耐水性のあるアレルゲン低減化効果を付与することが可能であることを見出した。すなわち本発明は、(1)タンニン酸とウレタン樹脂を、不織布、繊維または繊維製品に加工することによってアレルゲン低減化機能を付与する方法であり、(2)そのウレタン樹脂が、水性ウレタン樹脂エマルジョンであるアレルゲン低減化機能を付与する方法であり、(3)アレルゲン低減化機能を付与する方法によって加工した不織布、繊維または繊維製品である。 As a result of earnest research to solve such problems, the present inventor has given water-resistant allergen reduction effect by using tannic acid having high allergen reduction performance and urethane resin binder in combination. Found that it is possible to do. That is, the present invention is (1) a method for imparting an allergen-reducing function by processing tannic acid and urethane resin into a nonwoven fabric, fiber or textile product, and (2) the urethane resin is an aqueous urethane resin emulsion. It is a method of imparting a certain allergen reducing function, and (3) a non-woven fabric, fiber or fiber product processed by a method of imparting an allergen reducing function.
本発明の加工方法を用いることにより、不織布、繊維または繊維製品にダニやスギ花粉等のアレルゲンのアレルゲン性を低減化させる機能、さらにその機能に耐水性を持たせ、アレルゲン性を低減化させる機能を持ったフィルター材、マスク等の不織布、繊維または繊維製品を提供することができる。 By using the processing method of the present invention, the function of reducing the allergenicity of allergens such as mites and cedar pollen in non-woven fabrics, fibers or fiber products, and the function of making the functions water resistant and reducing the allergenicity It is possible to provide a non-woven fabric such as a filter material, a mask or the like, a fiber or a fiber product.
本発明におけるタンニン酸は、植物から抽出される収れん性の多価フェノール成分で、縮合型タンニン酸あるいは加水分解型タンニン酸のいずれでもよく、タンニン酸、ガロタンニン、エピカテキンガレート、エピカテキン、エピガロカテキン、エピガロカテキンガレート等のポリフェノール類が含まれる。これらのポリフェノール類化合物の二種類以上を混合して使用しても差し支えない。タンニン酸は、一般に試薬や工業用原料として市販されているものを使用することができる。 The tannic acid in the present invention is an astringent polyphenol component extracted from a plant, and may be either condensed tannic acid or hydrolyzed tannic acid. Tannic acid, gallotannin, epicatechin gallate, epicatechin, epigallo Polyphenols such as catechin and epigallocatechin gallate are included. A mixture of two or more of these polyphenol compounds may be used. As the tannic acid, those commercially available as reagents and industrial raw materials can be used.
ポリウレタン樹脂は、高分子ジオール成分とイソシアネート基を有する有機イソシアネート化合物からなり、ジオール成分の種類によって、ポリエーテル系、ポリエステル系,ポリカーボネート系およびこれらの混合系等、種々のものがある。本発明に使用するポリウレタン樹脂はこれらのポリエーテル系、ポリエステル系,ポリカーボネート系等のいずれを使用しても差し支えなく、また二種類以上を混合して使用することも可能である。また溶剤系のポリウレタン樹脂とポリウレタン樹脂エマルジョンのいずれも使用可能である。ポリウレタン樹脂エマルジョンのイオン性はアニオン性または非イオン性であることが望ましく、カチオン性の場合はタンニン酸と混合したときに凝集を起こす懸念がある。ポリウレタン樹脂のエマルジョンには自己乳化型または強制乳化型があるがいずれの型のものを使用しても差し支えなく、各々の型のものを混合して使用しても差し支えない。 The polyurethane resin is composed of a polymer diol component and an organic isocyanate compound having an isocyanate group, and there are various types such as a polyether type, a polyester type, a polycarbonate type and a mixed type thereof depending on the kind of the diol component. The polyurethane resin used in the present invention may be any of these polyether-based, polyester-based, polycarbonate-based, etc., and two or more types may be mixed and used. Both solvent-based polyurethane resins and polyurethane resin emulsions can be used. The ionicity of the polyurethane resin emulsion is desirably anionic or nonionic. In the case of a cationic resin, there is a concern that aggregation occurs when mixed with tannic acid. The polyurethane resin emulsion includes a self-emulsifying type and a forced emulsifying type, but any type may be used, and each type may be mixed and used.
ポリウレタン樹脂の分子量に特に制限はないが、分子量3000以上であることが好ましく、5000以上であることがさらに好ましい。 Although there is no restriction | limiting in particular in the molecular weight of a polyurethane resin, It is preferable that it is 3000 or more molecular weight, and it is further more preferable that it is 5000 or more.
タンニン酸とポリウレタン樹脂は、両方を含有する一液の製剤を調製し、この製剤を適宜必要に応じて希釈して使用することができる。またタンニン酸の製剤と、ポリウレタン樹脂の製剤あるいはエマルジョンを別々で希釈しておいてから混合し、使用することも可能である。 Tannic acid and polyurethane resin can be used by preparing a one-part preparation containing both, and appropriately diluting this preparation as necessary. It is also possible to dilute and mix the tannic acid preparation and the polyurethane resin preparation or emulsion before use.
タンニン酸とウレタン樹脂を含有する製剤を調製する場合、製剤中のタンニン酸およびウレタン樹脂の含有率はそれぞれ0.01〜30%、好ましくは0.1〜10%、さらに好ましくは0.5〜5%の範囲とすることができる。30%より高濃度とした場合、製剤中でタンニン酸とウレタン樹脂が凝集を起こす可能性がある。またタンニン酸とウレタン樹脂の希釈液を別々に調製しておき、加工時にそれぞれの希釈液を混合し、加工する方が凝集の危険性を避けることができる。希釈するには水を用いるのが適しているが、アルコール類やグリコールエーテル類等の極性溶剤を使用あるいは併用することもできる。 When preparing a preparation containing tannic acid and urethane resin, the contents of tannic acid and urethane resin in the preparation are each 0.01 to 30%, preferably 0.1 to 10%, more preferably 0.5 to It can be in the range of 5%. If the concentration is higher than 30%, tannic acid and urethane resin may aggregate in the preparation. Moreover, the danger of agglomeration can be avoided by preparing dilute solutions of tannic acid and urethane resin separately, mixing each dilute solution during processing, and processing. Water is suitable for dilution, but polar solvents such as alcohols and glycol ethers can be used or used together.
このような極性溶剤の例としては、エタノール、プロピルアルコール、イソプロピルアルコール、ブタノール、ジエチレングリコールモノメチルエーテル、ジエチレングリコールモノエチルエーテル、ジエチレングリコールモノプロピルエーテル、N−メチルピロリドン、γ−ブチロラクトン、ジメチルスルホキシド、エチレングリコール、プロピレングリコール、ブチレングリコール、ジエチレングリコール、トリエチレングリコール、ポリエチレングリコール(分子量1000以下)、ポリプロピレングリコール(分子量1000以下)等が挙げられる。これらの溶剤は2種類以上を混合して使用しても差し支えない。 Examples of such polar solvents are ethanol, propyl alcohol, isopropyl alcohol, butanol, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, N-methylpyrrolidone, γ-butyrolactone, dimethyl sulfoxide, ethylene glycol, propylene. Examples include glycol, butylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol (molecular weight 1000 or less), polypropylene glycol (molecular weight 1000 or less), and the like. These solvents may be used in combination of two or more.
ポリウレタン樹脂を用いる場合、さらに架橋剤を添加することによって耐水性をさらに向上させることが可能で、このような架橋剤としてエポキシ系やメラミン系のものがある。架橋剤は必ずしも必要ではないが、使用しても差し支えない。 In the case of using a polyurethane resin, it is possible to further improve the water resistance by adding a crosslinking agent, and there are epoxy and melamine type as such a crosslinking agent. A cross-linking agent is not always necessary, but may be used.
加工を行うときのタンニン酸とポリウレタン樹脂の比率は、重量比でタンニン酸1に対してポリウレタン樹脂が0.1〜2で使用することができ、さらに好ましくは0.2〜1.5、またよりさらに望ましくは0.5〜1.0で使用することができる。タンニン酸1に対してポリウレタン樹脂の使用量が0.1より小さくなるとバインダーによる耐水化効果が低くなり、また2より大きくなるとウレタン樹脂がタンニン酸を覆いすぎる結果となり返って効力が低下する危険性がある。耐水性あるいは効力の発揮に影響のない範囲で、他の樹脂バインダー、例えばアクリル系バインダー等を混合して使用しても差し支えない。 The ratio of the tannic acid and the polyurethane resin when processing is such that the polyurethane resin can be used in a weight ratio of 0.1 to 2 with respect to tannic acid 1, more preferably 0.2 to 1.5, More desirably, it can be used at 0.5 to 1.0. If the amount of polyurethane resin used is less than 0.1 with respect to tannic acid 1, the water-resistant effect of the binder will be reduced, and if it is greater than 2, the urethane resin will cover the tannic acid too much and the risk of reduced efficacy There is. Other resin binders such as acrylic binders may be mixed and used within a range that does not affect water resistance or effectiveness.
製剤を行なう上で必ずしも配合されるべきものではないが、安定性の向上等の目的のために界面活性剤を添加することが可能である。界面活性剤は特に限定されず、非イオン性界面活性剤、アニオン性界面活性剤、カチオン性界面活性剤、両性界面活性剤を挙げることができるが、非イオン性またはアニオン性が好ましい。非イオン性界面活性剤の種類は特に限定されるものではないが、例えばポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンスチリルフェニルエーテル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルケニルエーテル、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステルなどが挙げられる。アニオン性界面活性剤にはアルキルベンゼンスルホネート、ポリオキシエチレンアルキルフェニルエーテルサルフェート、ジアルキルスルホサクシネート等が挙げられる。カチオン性界面活性剤では脂肪族アミン塩およびその4級アンモニウム塩などが挙げられ、両イオン性界面活性剤ではベタイン型界面活性剤、アミノカルボン酸塩などが挙げられる。また、これらの非イオン性界面活性剤、アニオン性界面活性剤、カチオン性界面活性剤および両イオン性界面活性剤は一種を単独に用いても二種以上を併用してもよい。 Although not necessarily blended in preparation, a surfactant can be added for the purpose of improving stability. The surfactant is not particularly limited, and examples thereof include a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant, and nonionic or anionic is preferable. The type of nonionic surfactant is not particularly limited. For example, polyoxyethylene alkyl phenyl ether, polyoxyethylene styryl phenyl ether, polyoxyethylene alkyl ether, polyoxyethylene alkenyl ether, sorbitan fatty acid ester, Examples thereof include oxyethylene sorbitan fatty acid esters. Examples of the anionic surfactant include alkyl benzene sulfonate, polyoxyethylene alkyl phenyl ether sulfate, and dialkyl sulfosuccinate. Cationic surfactants include aliphatic amine salts and quaternary ammonium salts thereof, and amphoteric surfactants include betaine surfactants and aminocarboxylates. These nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants may be used alone or in combination of two or more.
本発明のアレルゲン低減化剤に公知となっているアレルゲン低減化成分をさらに添加することも可能である。アレルゲン低減化成分としては、ジヒドロキシ安息香酸や2,4,6−トリヒドロキシ安息香酸等のヒドロキシ安息香酸系化合物またはその塩、パラヒドロキシポリスチレンやポリスチレンスルホン酸塩等のポリスチレン系化合物、柿渋等の天然抽出物、カルシウム塩やストロンチウム塩や希土類塩等の無機塩系化合物が挙げられる。 It is also possible to add a known allergen-reducing component to the allergen-reducing agent of the present invention. Examples of allergen-reducing components include hydroxybenzoic acid compounds such as dihydroxybenzoic acid and 2,4,6-trihydroxybenzoic acid or salts thereof, polystyrene compounds such as parahydroxypolystyrene and polystyrenesulfonate, Examples include extracts, inorganic salt compounds such as calcium salts, strontium salts, and rare earth salts.
本発明のアレルゲン低減化剤は、屋内塵性ダニのアレルゲン除去を目的に使用する場合、殺ダニ剤と同時に加工することにより、そのアレルゲン低減化効果をさらに持続させることも可能である。使用する殺ダニ剤は、屋内塵性ダニに対して致死効果や忌避効果のあるものであれば特に限定はなく、例えば、ベンジルアルコール、ベンジルベンゾエート、サリチル酸フェニル、シンナムアルデヒド、ヒソップ油、ニンジン種子油等を用いることができ、また天然ピレトリン、フェノトリン、ペルメトリン等のピレスロイド系化合物、フェニトロチオン、マラチオン、フェンチオン、ダイアジノン等の有機リン系化合物、ジコホル、クロルベンジレート、ヘキシチアゾクス、テブフェンピラド、ピリダベン、アミドフルメト等を用いることができる。 When the allergen reducing agent of the present invention is used for the purpose of removing allergens from indoor dust mites, the allergen reducing effect can be further maintained by processing simultaneously with the acaricide. The acaricide used is not particularly limited as long as it has a lethal and repellent effect on indoor dust mites. For example, benzyl alcohol, benzyl benzoate, phenyl salicylate, cinnamaldehyde, hyssop oil, carrot seed oil In addition, pyrethroid compounds such as natural pyrethrin, phenothrin, and permethrin, organophosphorus compounds such as fenitrothion, malathion, fenthion, and diazinon, dicofol, chlorbenzilate, hexityazox, tebufenpyrad, pyridaben, and amidoflumet are used. be able to.
本発明のアレルゲン低減化剤は、カビあるいは菌の増殖が懸念される場合がある。そのために防カビ剤または抗菌剤を同時に併用することが可能である。防カビ剤または抗菌剤の種類は、防カビまたは抗菌効果を有するものであれば特に限定されないが、例えば、5−クロロ−N−メチルイソチアゾロン、メチレンビスチオシアネート、2−ブロモ−2−ニトロプロパン−1,3−ジオール、グルタルアルデヒド、ヨードプロピニルブチルカーバメート、ピリジンチオール−N−オキシドの亜鉛塩、1,2−ベンゾイソチアゾロン、1,2−ジブロモ−2,4−ジシアノブタン、グルコン酸クロルヘキシジン、2−イソプロピル−5−メチルフェノール、3−メチル−4−イソプロピルフェノール、オルトフェニルフェノール、パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチル、パラクロロメタキシレノール、パラクロロメタクレゾール、ポリリジン、塩化ベンザルコニウム、塩化ジデシルジメチルアンモニウム、N−n−ブチルベンゾイソチアゾロン、N−オクチルイソチアゾロン、2−(4−チアゾリル)ベンズイミダゾール、2−ベンズイミダゾリルカルバミン酸メチル、テトラクロロイソフタロニトリル、ジヨードメチルパラトリルスルホン、パラクロロフェニル−3−ヨードプロパギルホルマール、2,3,5,6−テトラクロロ−4−(メチルスルホニル)ピリジン、脂肪酸グリセリンエステル、ヒノキチオール等を用いることができる。 The allergen-reducing agent of the present invention may cause mold or fungus growth. Therefore, it is possible to use a fungicide or an antibacterial agent at the same time. The type of the fungicide or antibacterial agent is not particularly limited as long as it has a fungicide or antibacterial effect. For example, 5-chloro-N-methylisothiazolone, methylenebisthiocyanate, 2-bromo-2-nitropropane- 1,3-diol, glutaraldehyde, iodopropynyl butyl carbamate, zinc salt of pyridinethiol-N-oxide, 1,2-benzisothiazolone, 1,2-dibromo-2,4-dicyanobutane, chlorhexidine gluconate, 2- Isopropyl-5-methylphenol, 3-methyl-4-isopropylphenol, orthophenylphenol, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, parachlorometaxylenol, parachlorometac Sol, polylysine, benzalkonium chloride, didecyldimethylammonium chloride, Nn-butylbenzisothiazolone, N-octylisothiazolone, 2- (4-thiazolyl) benzimidazole, methyl 2-benzimidazolylcarbamate, tetrachloroisophthalo Nitrile, diiodomethyl paratolyl sulfone, parachlorophenyl-3-iodopropargyl formal, 2,3,5,6-tetrachloro-4- (methylsulfonyl) pyridine, fatty acid glycerin ester, hinokitiol and the like can be used.
本発明のアレルゲン低減化剤の使用方法としては、不織布、繊維または繊維製品に浸漬、塗布、スプレー等の方法によって加工することができる。繊維または繊維製品としては、衣料品、カーペット、ソファー、壁紙、カーテン等のインテリア類、布団側地、布団カバー、布団中綿、シーツ、枕カバー、マット等の寝具類、カーシート、カーマット、天井材および床材等の自動車部品類、ぬいぐるみ等が挙げられ、不織布としては掃除用ウェットワイパー、マスク、フィルター材料、電気掃除機の集塵袋等があげられる。 As a method for using the allergen reducing agent of the present invention, it can be processed by a method such as dipping, coating, spraying, etc. on a nonwoven fabric, fiber or fiber product. Textiles or textile products include clothing, carpets, sofas, wallpaper, curtains and other interior items, futon sides, futon covers, futon batting, sheets, pillowcases, mats and other bedding, car seats, car mats, and ceiling materials And automobile parts such as flooring materials, stuffed animals, etc., and non-woven fabrics include wet wipers for cleaning, masks, filter materials, dust collection bags for vacuum cleaners, and the like.
本発明のアレルゲン低減化剤を加工することができる不織布や繊維には種々のものがあるが、たとえばナイロン、綿、ポリエステル、羊毛等が挙げられ、これらの繊維を2種類以上使用した複合繊維であっても差し支えない。またポリエチレンやポリプロピレンを用いた不織布にも使用することが可能である。本発明のアレルゲン低減化剤の不織布、繊維または繊維製品への加工方法は特に限定されるものではないが、浸漬処理、スプレー処理、吸尽加工等を行うことが可能である。繊維への加工量は、不織布、繊維または繊維製品の重量に対して、タンニン酸量として0.01〜30%であり、好ましくは0.1〜20%であり、さらに好ましくは0.5〜10%である。 There are various non-woven fabrics and fibers that can process the allergen reducing agent of the present invention, and examples thereof include nylon, cotton, polyester, wool, etc., and these are composite fibers using two or more of these fibers. There is no problem. It can also be used for non-woven fabrics using polyethylene or polypropylene. The method for processing the allergen reducing agent of the present invention into a non-woven fabric, fiber, or fiber product is not particularly limited, and immersion treatment, spray treatment, exhaustion processing, and the like can be performed. The amount of processing into fibers is 0.01 to 30%, preferably 0.1 to 20%, more preferably 0.5 to tannic acid based on the weight of the nonwoven fabric, fiber or fiber product. 10%.
本発明のアレルゲン低減化剤を不織布や繊維または繊維製品に処理し乾燥する場合には180℃以下とするのが望ましい。高温で乾燥を行なうとタンニン酸による着色が促進される可能性がある。 When the allergen reducing agent of the present invention is processed into a non-woven fabric, fiber, or fiber product and dried, the temperature is preferably 180 ° C. or lower. When drying at a high temperature, coloring with tannic acid may be promoted.
本発明のアレルゲン低減化剤の製剤化に際しては、前述の界面活性剤、防ダニ剤、抗菌剤の他に、必要に応じてキレート剤、防錆剤、香料、スケール防止剤、消泡剤、帯電防止剤、増粘剤、柔軟加工剤等を添加することも可能である。 In formulating the allergen reducing agent of the present invention, in addition to the above-mentioned surfactant, anti-mite agent, antibacterial agent, if necessary, chelating agent, anti-rust agent, perfume, scale inhibitor, antifoaming agent, It is also possible to add an antistatic agent, a thickener, a softening agent and the like.
本発明のアレルゲン低減化剤の使用形態としては主に加工剤用途が挙げられる。また洗濯耐久性を要求される繊維または繊維製品以外にも、環境中で人が接触する可能性のある組成物、たとえば柔軟剤、消臭剤、防カビ剤、除菌剤、殺虫剤、塗料、接着剤等に添加することによって環境中のアレルゲンを低減化させることも可能であり、環境中で人が接触する可能性のある材料、たとえば木材、コンクリート、金属、石、ガラス等の建材等、ゴム、紙、樹脂、プラスチックのよる成型品等に加工することによって環境中のアレルゲンを低減化させることも可能である。 The usage form of the allergen reducing agent of the present invention mainly includes use as a processing agent. In addition to fibers or textile products that require washing durability, compositions that may come into contact with people in the environment, such as softeners, deodorants, fungicides, disinfectants, insecticides, paints It is also possible to reduce allergens in the environment by adding them to adhesives, etc., and materials that may come into contact with people in the environment, such as building materials such as wood, concrete, metal, stone, glass, etc. It is also possible to reduce allergens in the environment by processing into molded products made of rubber, paper, resin, plastic, or the like.
本発明組成物、および本発明組成物を加工した不織布、繊維または繊維製品の使用により、ハウスダスト中のダニ由来のアレルゲン、イヌやネコなどのペットの毛や上皮、ゴキブリ、羽毛、カビ由来のアレルゲン、およびスギ、ヨモギ、ハルガヤ、ヒノキ、ブタクサ等の花粉、天然ゴムラテックス等の植物アレルゲンを低減化することができ、多種のアレルゲンを実質的になくすことができる。よって本発明は、環境中のアレルゲンがハウスダスト中のダニアレルゲンや植物アレルゲンの場合に特に効果的に作用するものである。 By using the composition of the present invention and non-woven fabrics, fibers or fiber products processed from the composition of the present invention, allergens derived from ticks in house dust, pet hair and epithelium such as dogs and cats, cockroaches, feathers and molds Allergens and pollen such as cedar, mugwort, hargaya, cypress, ragweed, and other plant allergens such as natural rubber latex can be reduced, and various allergens can be substantially eliminated. Therefore, the present invention works particularly effectively when the allergen in the environment is a mite allergen or a plant allergen in house dust.
本発明を実施例、試験例により更に詳しく説明するが、本発明がこれらによって限定されるものではない。なお、下記に示す%はすべて重量%である。 The present invention will be described in more detail with reference to examples and test examples, but the present invention is not limited thereto. In addition, all% shown below are weight%.
[実施例1]
10%のタンニン酸(和光純薬工業株式会社製)水溶液1.5gをイオン交換水で29gに希釈し、ポリカーボネート系ウレタンバインダー(株式会社ADEKA製水系ウレタン樹脂エマルジョン:HUX−386[固形分30%])の25%水溶液1gを混合した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた(加工量はタンニン酸として1g/m2、ウレタン樹脂として0.5g/m2)。
[Example 1]
A 1.5% aqueous solution of 10% tannic acid (manufactured by Wako Pure Chemical Industries, Ltd.) was diluted to 29 g with ion-exchanged water, and a polycarbonate-based urethane binder (ADEKA water-based urethane resin emulsion: HUX-386 [solid content 30%) ] 1% of 25% aqueous solution was mixed. A 20 cm × 15 cm polypropylene non-woven fabric (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and dried at 110 ° C. (the processing amount was 1 g / m 2 as tannic acid, 0 as urethane resin) .5 g / m 2 ).
[実施例2]
実施例1のポリカーボネート系ウレタンバインダーの代わりにエステル系ウレタンバインダー(株式会社ADEKA製水系ウレタン樹脂:HUX−822[固形分40%])を用い、実施例1と同様に不織布に処理を行った。
[Example 2]
The nonwoven fabric was treated in the same manner as in Example 1 using an ester urethane binder (ADEKA Corporation water-based urethane resin: HUX-822 [solid content 40%]) instead of the polycarbonate urethane binder of Example 1.
[実施例3]
実施例1のポリカーボネート系ウレタンバインダーの代わりにエーテル系ウレタンバインダー(株式会社ADEKA製水系ウレタン樹脂:HUX−350[固形分30%])を用い、実施例1と同様に不織布に処理を行った。
[Example 3]
The nonwoven fabric was treated in the same manner as in Example 1 using an ether urethane binder (ADEKA Corporation water-based urethane resin: HUX-350 [solid content 30%]) instead of the polycarbonate urethane binder of Example 1.
[実施例4]
10%のタンニン酸水溶液1.5gをイオン交換水で28gに希釈し、ポリカーボネート系ウレタンバインダーの25%水溶液2gを混合した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた(加工量はタンニン酸として1g/m2、ウレタン樹脂として1g/m2)。
[Example 4]
1.5 g of 10% tannic acid aqueous solution was diluted to 28 g with ion-exchanged water, and 2 g of 25% aqueous solution of polycarbonate urethane binder was mixed. A 20 cm × 15 cm non-woven fabric made of polypropylene (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and then dried at 110 ° C. (the processing amount was 1 g / m 2 as tannic acid and 1 g as urethane resin) / M 2 ).
[実施例5]
10%のタンニン酸水溶液1.5gをイオン交換水で26gに希釈し、ポリカーボネート系ウレタンバインダーの25%水溶液4gを混合した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた(加工量はタンニン酸として1g/m2、ウレタン樹脂として2g/m2)。
[Example 5]
1.5 g of 10% tannic acid aqueous solution was diluted to 26 g with ion-exchanged water, and 4 g of 25% aqueous solution of polycarbonate urethane binder was mixed. A 20 cm × 15 cm non-woven fabric made of polypropylene (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and then dried at 110 ° C. (the processing amount was 1 g / m 2 as tannic acid and 2 g as a urethane resin). / M 2 ).
[実施例6]
10%のタンニン酸水溶液1.5gをイオン交換水で28gに希釈し、ポリカーボネート系ウレタンバインダー2gを混合した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた(加工量はタンニン酸として1g/m2、ウレタン樹脂として4g/m2)。
[Example 6]
1.5 g of 10% tannic acid aqueous solution was diluted to 28 g with ion-exchanged water, and 2 g of polycarbonate urethane binder was mixed. A 20 cm × 15 cm non-woven fabric made of polypropylene (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and then dried at 110 ° C. (the processing amount was 1 g / m 2 as tannic acid, and 4 g as a urethane resin). / M 2 ).
[比較例1]
10%のタンニン酸水溶液1.5gをイオン交換水で30gに希釈した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた(加工量はタンニン酸として1g/m2)。
[Comparative Example 1]
1.5 g of 10% tannic acid aqueous solution was diluted to 30 g with ion-exchanged water. A 20 cm × 15 cm polypropylene non-woven fabric (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and then dried at 110 ° C. (the processing amount was 1 g / m 2 as tannic acid).
[比較例2]
10%のタンニン酸水溶液1.5gをイオン交換水で29gに希釈し、アクリルバインダー(山陽色素株式会社製水系アクリル樹脂:エマコール CTバインダーASC)の25%水溶液1gを混合した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた(加工量はタンニン酸として1g/m2)。
[Comparative Example 2]
1.5 g of 10% tannic acid aqueous solution was diluted to 29 g with ion-exchanged water, and 1 g of 25% aqueous solution of an acrylic binder (Sanyo Dye Co., Ltd. water-based acrylic resin: Emacol CT Binder ASC) was mixed. A 20 cm × 15 cm polypropylene non-woven fabric (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and then dried at 110 ° C. (the processing amount was 1 g / m 2 as tannic acid).
[比較例3]
水系ウレタン樹脂HUX−386の25%水溶液4gをイオン交換水で30gに希釈した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた。
[Comparative Example 3]
4 g of a 25% aqueous solution of an aqueous urethane resin HUX-386 was diluted to 30 g with ion-exchanged water. A 20 cm × 15 cm non-woven fabric made of polypropylene (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and dried at 110 ° C.
[比較例4]
水系ウレタン樹脂HUX−822の25%水溶液4gをイオン交換水で30gに希釈した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた。
[Comparative Example 4]
4 g of a 25% aqueous solution of an aqueous urethane resin HUX-822 was diluted to 30 g with ion-exchanged water. A 20 cm × 15 cm non-woven fabric made of polypropylene (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and dried at 110 ° C.
[比較例5]
水系ウレタン樹脂HUX−350の25%水溶液4gをイオン交換水で30gに希釈した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた。
[Comparative Example 5]
4 g of a 25% aqueous solution of an aqueous urethane resin HUX-350 was diluted to 30 g with ion-exchanged water. A 20 cm × 15 cm non-woven fabric made of polypropylene (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and dried at 110 ° C.
[比較例6]
アナタース型酸化チタン粉末(石原テクノ株式会社製:ST−01)0.15gをイオン交換水で29gに分散させ、ポリカーボネート系ウレタンバインダー(株式会社ADEKA製水系ウレタン樹脂:HUX−386)の25%水溶液1gを混合した。この液に20cm×15cmのポリプロピレン製不織布(80g/m2)を浸漬し、絞り率250%で処理後、110℃で乾燥させた(加工量は酸化チタンとして1g/m2)。
[Comparative Example 6]
Anatase-type titanium oxide powder (Ishihara Techno Co., Ltd .: ST-01) 0.15 g is dispersed in 29 g with ion-exchanged water, and a 25% aqueous solution of polycarbonate urethane binder (ADEKA Corporation water-based urethane resin: HUX-386). 1 g was mixed. A 20 cm × 15 cm polypropylene non-woven fabric (80 g / m 2 ) was immersed in this solution, treated at a drawing rate of 250%, and then dried at 110 ° C. (the processing amount was 1 g / m 2 as titanium oxide).
[不織布の水洗]
実施例1〜3および比較例1〜6の不織布を等分に切断し(10cm×15cm)、一方を4Lのイオン交換水に浸漬して30分間攪拌し、取り出して室温で風乾し水洗後の試料とした。
[Washing of non-woven fabric]
The non-woven fabrics of Examples 1 to 3 and Comparative Examples 1 to 6 were cut equally (10 cm × 15 cm), one was immersed in 4 L of ion exchange water, stirred for 30 minutes, taken out, air-dried at room temperature, and washed with water. A sample was used.
[評価試験1](加工不織布のダニアレルゲンの低減化効果の測定)
実施例1〜3、比較例1〜6の不織布、および水洗を行ったこれらの不織布を5cm×5cmに切り取り、チャック付きポリ袋に投入し標準ダニアレルゲン懸濁液(アレルゲン量1200ng/mL)1mLを加え、試料とアレルゲンを接触させた。1時間後にチャック付きポリ袋からアレルゲン液を搾り出し、遠心分離後のこれら試料について Der f2酵素免疫測定法(ELISA)のサンドイッチ法にてダニアレルゲン低減化効果の測定を行った。まず、リン酸緩衝液(pH7.4、0.1重量%NaN3含有)で2μg/mLに希釈したDer f2 モノクローナル抗体15E11を、F16 MAXISORP NUNC−IMMUNO MODULEプレート(NUNC社製)の1ウェルあたり200μLずつ添加し、4℃にて3日以上感作させた。感作後、液を捨て、ブロッキング試薬{1重量%牛血清アルブミン+リン酸緩衝液(pH7.2、0.1重量%NaN3含有)}を1ウェルあたり200μLずつ添加し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。
[Evaluation Test 1] (Measurement of reduction effect of mite allergen in processed nonwoven fabric)
The nonwoven fabrics of Examples 1 to 3 and Comparative Examples 1 to 6 and these washed nonwoven fabrics were cut into 5 cm × 5 cm, put into a plastic bag with a chuck, and a standard mite allergen suspension (allergen amount 1200 ng / mL) 1 mL And the sample was brought into contact with the allergen. One hour later, the allergen solution was squeezed out of the plastic bag with the chuck, and the mite allergen reducing effect was measured on these samples after centrifugation by the sandwich method of Der f2 enzyme immunoassay (ELISA). First, Der f2 monoclonal antibody 15E11 diluted to 2 μg / mL with a phosphate buffer (pH 7.4, containing 0.1 wt% NaN 3 ) was added per well of F16 MAXISORP NUNC-IMMUNO MODULE plate (manufactured by NUNC). 200 μL each was added and sensitized at 4 ° C. for 3 days or more. After sensitization, the solution was discarded, and a blocking reagent {1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 )} was added in an amount of 200 μL per well. Reacted for 1 minute. After the reaction, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate).
次に、加工不織布と接触させたダニアレルゲン抽出液試料を1ウェルあたり100μLずつ滴下し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。ペルオキシダーゼ標識したDer f2モノクローナル抗体を蒸留水で200μg/mLに溶解し、それをリン酸緩衝液{pH7.2、1重量%牛血清アルブミンおよび0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}で1000倍希釈した液を、1ウェルあたり100μLずつ添加した。37℃、60分間反応させた後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}で、次いで蒸留水でプレートを洗浄した。0.1mol/Lリン酸緩衝液(pH6.2)13mLにオルト−フェニレンジアミンジヒドロクロライド(SIGMA CHEMICAL CO.製:26mg Tablet)と過酸化水素水13μLを加えたものを1ウェルあたり100μLずつ添加し、37℃、5分間反応させた。その後直ちに、2mol/L H2SO4を50μLずつ入れて反応を停止させ、マイクロプレート用分光光度計(テカンジャパン株式会社製)で吸光度(OD490nm)を測定した。結果を表1に示した。 Next, 100 μL of the mite allergen extract solution contacted with the processed non-woven fabric was added dropwise per well and reacted at 37 ° C. for 60 minutes. After the reaction, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate). The peroxidase-labeled Der f2 monoclonal antibody was dissolved in distilled water at 200 μg / mL, and was dissolved in phosphate buffer {pH 7.2, 1% by weight bovine serum albumin and 0.1% by weight polyoxyethylene (20) sorbitan monolaur. A solution diluted 1000 times with a rate containing} was added at 100 μL per well. After reacting at 37 ° C. for 60 minutes, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate) and then with distilled water. Add 100 μL per well of 13 mol of 0.1 mol / L phosphate buffer (pH 6.2) plus ortho-phenylenediamine dihydrochloride (manufactured by SIGMA CHEMICAL CO .: 26 mg Table) and 13 μL of hydrogen peroxide. And allowed to react at 37 ° C. for 5 minutes. Immediately thereafter, 50 μL of 2 mol / L H 2 SO 4 was added to stop the reaction, and the absorbance (OD 490 nm) was measured with a spectrophotometer for microplate (Tecan Japan Co., Ltd.). The results are shown in Table 1.
[評価試験2](アレルゲン低減化剤によるスギ花粉アレルゲンCry j1の低減化効果の測定)
実施例1〜6または比較例1〜6の不織布、および水洗を行ったこれらの不織布を5cm×5cmに切り取り、チャック付きポリ袋に投入し標準スギ花粉アレルゲン液(アレルゲン量 12.5ng/mL)1mLを加え、試料とアレルゲンを接触させた。1時間後にチャック付きポリ袋からアレルゲン液を搾り出し、遠心分離後のこれら試料について Cry j1酵素免疫測定法(ELISA)のサンドイッチ法にてスギ花粉アレルゲン低減化効果の測定を行った。まず、リン酸緩衝液(pH7.4、0.1重量%NaN3含有)で2μg/mLに希釈したCry j1 モノクローナル抗体013を、F16 MAXISORP NUNC−IMMUNO MODULEプレート(NUNC社製)の1ウェルあたり100μLずつ添加し、4℃にて1日以上感作させた。感作後、液を捨て、ブロッキング試薬{1重量%牛血清アルブミン+リン酸緩衝液(pH7.2、0.1重量%NaN3含有)}を1ウェルあたり200μLずつ添加し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。
[Evaluation Test 2] (Measurement of reduction effect of cedar pollen allergen Cry j1 by allergen reducing agent)
The nonwoven fabrics of Examples 1 to 6 or Comparative Examples 1 to 6 and these washed nonwoven fabrics were cut into 5 cm × 5 cm, put into a plastic bag with a chuck, and a standard cedar pollen allergen solution (allergen amount 12.5 ng / mL) 1 mL was added to bring the sample into contact with the allergen. After 1 hour, the allergen solution was squeezed out of the plastic bag with a chuck, and the cedar pollen allergen reducing effect was measured by the sandwich method of Cry j1 enzyme immunoassay (ELISA) for these samples after centrifugation. First, Cry j1 monoclonal antibody 013 diluted to 2 μg / mL with phosphate buffer (pH 7.4, containing 0.1 wt% NaN 3 ) was added per well of F16 MAXISORP NUNC-IMMUNO MODULE plate (manufactured by NUNC). 100 μL each was added and sensitized at 4 ° C. for 1 day or longer. After sensitization, the solution was discarded, and a blocking reagent {1% by weight bovine serum albumin + phosphate buffer (pH 7.2, containing 0.1% by weight NaN 3 )} was added in an amount of 200 μL per well. Reacted for 1 minute. After the reaction, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate).
次に、加工不織布と接触させたスギ花粉アレルゲン抽出液試料を1ウェルあたり100μLずつ滴下し、37℃、60分間反応させた。反応後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}にてプレートを洗浄した。ペルオキシダーゼ標識したCry j1モノクローナル抗体053を蒸留水で200μg/mLに溶解し、それをリン酸緩衝液{pH7.2、1重量%牛血清アルブミンおよび0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}で1200倍希釈した液を、1ウェルあたり100μLずつ添加した。37℃、60分間反応させた後、リン酸緩衝液{pH7.2、0.1重量%ポリオキシエチレン(20)ソルビタンモノラウレート含有}でプレートを洗浄した。0.1mol/Lリン酸緩衝液(pH6.2)13mLにオルト−フェニレンジアミンジヒドロクロライド(SIGMA CHEMICAL CO.製:26mg Tablet)と過酸化水素水13μLを加えたものを1ウェルあたり100μLずつ添加し、37℃、5分間反応させた。その後直ちに、2mol/L H2SO4を50μLずつ入れて反応を停止させ、マイクロプレート用分光光度計(テカンジャパン株式会社製)で吸光度(OD490nm)を測定した。結果を表2および表3に示した。 Next, 100 μL of a cedar pollen allergen extract solution contacted with the processed non-woven fabric was added dropwise per well and reacted at 37 ° C. for 60 minutes. After the reaction, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate). Peroxidase-labeled Cry j1 monoclonal antibody 053 was dissolved in distilled water to 200 μg / mL, and then dissolved in phosphate buffer {pH 7.2, 1 wt% bovine serum albumin and 0.1 wt% polyoxyethylene (20) sorbitan mono A solution diluted 1200 times with laurate contained} was added at 100 μL per well. After reacting at 37 ° C. for 60 minutes, the plate was washed with a phosphate buffer (pH 7.2, containing 0.1 wt% polyoxyethylene (20) sorbitan monolaurate). Add 100 μL per well of 13 mol of 0.1 mol / L phosphate buffer (pH 6.2) plus ortho-phenylenediamine dihydrochloride (manufactured by SIGMA CHEMICAL CO .: 26 mg Table) and 13 μL of hydrogen peroxide. And allowed to react at 37 ° C. for 5 minutes. Immediately thereafter, 50 μL of 2 mol / L H 2 SO 4 was added to stop the reaction, and the absorbance (OD 490 nm) was measured with a spectrophotometer for microplate (Tecan Japan Co., Ltd.). The results are shown in Tables 2 and 3.
本発明により、ダニや花粉等のアレルゲンのアレルゲン性を低減化させることができ、また不織布、繊維または繊維製品に洗濯耐久性のある、アレルゲン性を低減化させる機能を付与するためのアレルゲン低減化剤、およびアレルゲンを低減化できる不織布、繊維または繊維製品を提供することができる。
According to the present invention, allergens of allergens such as mites and pollen can be reduced, and allergens can be reduced to impart a function of reducing the allergenicity of a nonwoven fabric, fiber or textile product with durability to washing. An agent and a non-woven fabric, fiber or fiber product capable of reducing allergens can be provided.
Claims (3)
A nonwoven fabric, a fiber, or a fiber product processed by the method for imparting an allergen-reducing function according to claim 1.
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