JP2013010799A - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP2013010799A JP2013010799A JP2012229225A JP2012229225A JP2013010799A JP 2013010799 A JP2013010799 A JP 2013010799A JP 2012229225 A JP2012229225 A JP 2012229225A JP 2012229225 A JP2012229225 A JP 2012229225A JP 2013010799 A JP2013010799 A JP 2013010799A
- Authority
- JP
- Japan
- Prior art keywords
- psyllium
- taurine
- oral composition
- texture
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title abstract description 23
- 235000003421 Plantago ovata Nutrition 0.000 claims abstract description 59
- 239000009223 Psyllium Substances 0.000 claims abstract description 57
- 229940070687 psyllium Drugs 0.000 claims abstract description 57
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 57
- 229960003080 taurine Drugs 0.000 claims abstract description 28
- 235000013361 beverage Nutrition 0.000 claims abstract description 13
- 239000000725 suspension Substances 0.000 claims abstract description 12
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- 239000000796 flavoring agent Substances 0.000 abstract description 20
- 235000019634 flavors Nutrition 0.000 abstract description 18
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- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
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- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
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- 235000003805 Musa ABB Group Nutrition 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
本発明は、サイリウムが呈する不快な風味やテクスチャが低減された経口用組成物に関する。 The present invention relates to an oral composition with reduced unpleasant flavor and texture exhibited by psyllium.
サイリウムは、インド原産のオオバコ科に属するプランタゴオバタ（Ｐｌａｎｔａｇｏ Ｏｖａｔａ Ｆｏｒｓｋａｌ）の種子の皮に含まれる食物繊維の一種である。 Psyllium is a kind of dietary fiber contained in the seed peel of Plantago Ovata Forskal, which belongs to the plantain family native to India.
サイリウムは水溶性サイリウムと非水溶性サイリウムの混合物であるが、水溶性サイリウムには、糖分や有害な物質を吸着して体外へ***する作用があるといわれている。また非水溶性サイリウムは、胃腸内における水分を吸収し蓄える性質（保水性）と、これによって３０〜５０倍の大きさに膨潤する性質（膨潤性）を有しており、その結果少量のサイリウムの摂取によって満腹感を得られることから、いわゆるダイエット効果があるとも言われている。さらに、サイリウムの保水性と膨潤性は、便の質を改善し、同時に便量を増加させることで腸の運動を活発にし、便***をスムーズにさせる機能も有している。 Psyllium is a mixture of water-soluble psyllium and water-insoluble psyllium, and it is said that water-soluble psyllium has the action of adsorbing sugars and harmful substances and excreting them outside the body. Water-insoluble psyllium has the property of absorbing and storing water in the gastrointestinal tract (water retention) and the property of swelling to 30 to 50 times the size (swelling property), resulting in a small amount of psyllium. It is also said that there is a so-called diet effect because a fullness can be obtained by ingestion. Furthermore, the water retention and swellability of psyllium has the function of improving the quality of stool and at the same time increasing the amount of stool to activate intestinal movement and smooth stool excretion.
この様なダイエット効果や便秘解消効果を享受するために、サイリウムを含む食品の開発が注目されてきている。 In order to enjoy such diet effects and constipation relieving effects, development of foods containing psyllium has been attracting attention.
しかしながら、サイリウムは、独特の不快な風味ならびに粘り等のテクスチャという問題を有している。上記の各種効果を確実にあげるためには、相当量、例えば１日あたり４〜６ｇのサイリウムの摂取が必要であると考えられているが、不快な風味やテクスチャがサイリウムの摂取を妨げる原因となっている。 However, psyllium has the problem of a unique unpleasant flavor and texture such as stickiness. In order to ensure the above-mentioned various effects, it is considered that a considerable amount, for example, 4 to 6 g of psyllium is ingested per day. However, unpleasant flavors and textures may hinder psyllium ingestion. It has become.
本発明は、サイリウムの不快な風味やテクスチャを改善し、日常的に無理なくサイリウムを多量に摂取することのできるサイリウム含有食品を提供することを目的とする。 An object of the present invention is to provide a psyllium-containing food that can improve the unpleasant flavor and texture of psyllium and can ingest a large amount of psyllium without difficulty on a daily basis.
本発明者らは、それ自体は無味無臭であるタウリンを配合することにより、サイリウムの不快な風味やテクスチャが改善され、より服用し易い経口用組成物が得られることを見いだし、下記の各発明を完成した。 The present inventors have found that by adding taurine, which is itself tasteless and odorless, the unpleasant flavor and texture of psyllium is improved, and an oral composition that is easier to take can be obtained. Was completed.
（１）０．１〜１０重量％のタウリンならびにサイリウムを含有する経口用組成物。 (1) An oral composition containing 0.1 to 10% by weight of taurine and psyllium.
（２）サイリウム１重量部に対してタウリンを１〜１０重量部含む、（１）に記載の経口用組成物。 (2) The oral composition according to (1), comprising 1 to 10 parts by weight of taurine with respect to 1 part by weight of psyllium.
（３）懸濁飲料である、（１）又は（２）に記載の経口用組成物。 (3) The oral composition according to (1) or (2), which is a suspension beverage.
（４）ｐＨが２．５〜７である、（３）に記載の経口用組成物。 (4) The oral composition according to (3), wherein the pH is 2.5-7.
本発明の組成物は、従来問題とされていたサイリウムの不快な風味やテクスチャが改良された、極めて服用しやすい経口用組成物を提供することができる。特に、タウリン自体は無味無臭であるため、別途適当な香料や矯味剤を利用することで、サイリウムの不快な風味をマスキングする一方で様々なフレーバーを持つ経口用組成物を提供することができる。 The composition of the present invention can provide an oral composition which is improved in the unpleasant flavor and texture of psyllium, which has been regarded as a problem, and is easy to take. In particular, since taurine itself is tasteless and odorless, an oral composition having various flavors can be provided by masking the unpleasant flavor of psyllium by separately using an appropriate fragrance or flavoring agent.
また、サイリウムの生理作用、例えば脂質の消化吸収阻害作用、血清コレステロール濃度上昇抑制作用、便通改善、ダイエット効果等を享受するには、サイリウムの摂取量を増やすことが重要であるが、サイリウムを多量に摂取することは、同時にその不快な風味やテクスチャをより長く又は強く感じることを意味する。本発明は、このサイリウムの大量服用時に感じやすい不快な風味やテクスチャを、タウリンというそれ自体が人の健康に対して種々の利益をもたらす物質によって低減することができるので、サイリウムの大量摂取による恩恵とタウリンに由来する効果を同時に享受することを可能にするものである。 In addition, in order to enjoy the physiological effects of psyllium, such as lipid digestion and absorption inhibitory effect, serum cholesterol level increase inhibitory effect, stool improvement, diet effect, etc., it is important to increase the intake of psyllium. Ingestion means that the unpleasant flavor and texture are felt longer or stronger at the same time. The present invention is able to reduce the unpleasant flavor and texture that is easily felt when taking a large amount of psyllium by means of taurine, a substance that itself has various benefits on human health. It is possible to simultaneously enjoy the effects derived from taurine.
本発明で使用するサイリウムは、例えばインドのラジャスタン州及びグラジャード州で栽培されるオオバコの１種であるＰｌａｎｔａｇｏ種植物のｐｌａｎｔａｇｏ ｏｖａｔａ Ｆｏｒｓｋａｌなどの種子の外側を包む外皮から回収、精製したものを利用することができる。また、不快な風味等を有するサイリウムを含んでいる限り、サイリウムの精製の度合いに制限はなく、未精製品あるいは部分精製品であってもよい。 The psyllium used in the present invention is obtained by collecting and purifying from the hulls enveloping the outside of seeds such as Plantago ovata Forskal of Plantago seed plant which is a kind of psyllium cultivated in Rajasthan and Grajard in India. be able to. In addition, as long as psyllium having an unpleasant flavor or the like is included, the degree of purification of psyllium is not limited, and may be an unpurified product or a partially purified product.
本発明において上記サイリウムの苦味や風味を改善する作用を示すタウリン（アミノエチルスルホン酸）は、分子量１２５．１５の単純な化学構造をもつ含硫アミノ酸である。タウリンは化学構造的にはアミノ酸に属するが、タンパク質を構成するアミノ酸とは異なり、ビタミン類やホルモンのような作用、さらには脳神経系、循環系、肝胆系をはじめとして様々な薬理作用を示すことが知られている。この様に、タウリンは生理活性物質として注目され、利用されてきたが、その性状は無色または白色の結晶の粉末で臭いも味もないことから、矯味成分として、また特に嗜好性を形成するほどの強い苦味に対してのマスキング成分としては利用されていない。 In the present invention, taurine (aminoethylsulfonic acid), which has an action to improve the bitterness and flavor of the above-mentioned psyllium, is a sulfur-containing amino acid having a simple chemical structure with a molecular weight of 125.15. Taurine belongs to amino acids in terms of chemical structure, but unlike amino acids that constitute proteins, taurine has actions like vitamins and hormones, as well as various pharmacological actions including cranial nervous system, circulatory system, and hepatobiliary system. It has been known. Thus, taurine has attracted attention and has been used as a physiologically active substance, but its properties are colorless or white crystalline powder, and it has no odor or taste. It is not used as a masking ingredient for strong bitterness.
一般にサイリウムの有効量は、健康成人で一日で４〜６ｇであり、本発明では、サイリウム１重量部に対してタウリンを１〜１０重量部配合して利用することができる。 In general, the effective amount of psyllium is 4 to 6 g per day for healthy adults. In the present invention, 1 to 10 parts by weight of taurine can be used in combination with 1 part by weight of psyllium.
この組み合わせによって、サイリウムが呈する不快な風味やテクスチャを無味無臭のタウリンによって低減することができる。 By this combination, unpleasant flavor and texture exhibited by psyllium can be reduced by tasteless and odorless taurine.
サイリウムは水を加えると容易にゲル化し、またタウリンは水溶液中で比較的安定な化合物であることから、本発明における好適な形態は懸濁飲料であり、特にｐＨが２．５〜７、好ましくは４．５〜６．５に調整されている、容器詰の飲料である。 Psyllium easily gels when water is added, and taurine is a relatively stable compound in an aqueous solution. Therefore, the preferred form in the present invention is a suspension beverage, and preferably has a pH of 2.5-7. Is a packaged beverage adjusted to 4.5-6.5.
ｐＨは適当なｐＨ調節剤を用いて調整すればよい。ｐＨ調整剤としては、有機及び無機の食用酸を用いることができる。酸はそれらの非解離形で、あるいはそれらの各塩、例えばリン酸水素カリウム又はナトリウム、リン酸二水素カリウム又はナトリウム塩のような形態で用いてもよい。好ましい酸は、クエン酸、リンゴ酸、フマル酸、アジピン酸、リン酸、グルコン酸、酒石酸、アスコルビン酸、酢酸、リン酸又はそれらの混合物を含めた食用有機酸である。また、重炭酸塩類を用いることもできる。 The pH may be adjusted using an appropriate pH adjuster. As the pH adjuster, organic and inorganic edible acids can be used. The acids may be used in their undissociated form or in the form of their respective salts, such as potassium or sodium hydrogen phosphate, potassium dihydrogen phosphate or sodium salt. Preferred acids are edible organic acids including citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid or mixtures thereof. Bicarbonates can also be used.
この様にｐＨが調整された飲料として本発明にかかる経口用組成物を製造するには、同飲料は容器詰の形態で製造されることが好ましい。容器の種類に特に制限はないが、ポリエチレンテレフタレートを主成分とする成形容器（いわゆるＰＥＴボトル）、金属缶、金属箔やプラスチックフィルムと複合された紙容器、瓶など、いずれの容器も利用することができる。 In order to produce the oral composition according to the present invention as a beverage whose pH is adjusted in this way, the beverage is preferably produced in a container form. There are no particular restrictions on the type of container, but any container such as a molded container (so-called PET bottle) mainly composed of polyethylene terephthalate, a metal can, a paper container combined with a metal foil or plastic film, or a bottle should be used. Can do.
また、本発明の経口用組成物において、特に生理電解質であるナトリウムイオンやカリウムイオンを配合することによって、いわゆるスポーツ飲料やアイソトニック飲料とすることも有益である。ナトリウムイオンやカリウムイオンの他にも、ミネラル類としてカルシウム、クロム、銅、鉄、マグネシウム、マンガン、リン、セレン、ケイ素、モリブデンまたは亜鉛等を添加することもできる。 In addition, in the oral composition of the present invention, it is also advantageous to make so-called sports drinks and isotonic drinks by blending sodium ions and potassium ions, which are physiological electrolytes. In addition to sodium ions and potassium ions, calcium, chromium, copper, iron, magnesium, manganese, phosphorus, selenium, silicon, molybdenum, zinc, or the like can be added as minerals.
さらに、嗜好性を高めるために、適宜甘味料を選択して配合してもよい。例えば、ステビアなどの天然甘味料、アスパルテーム等の人工甘味料類、蔗糖等の炭水化物類、ソルビトール、エリスリトール、キシリトール等の糖アルコール、グリセリン等のグリセロール類を利用することができる。 Furthermore, in order to improve palatability, you may select and mix | blend a sweetener suitably. For example, natural sweeteners such as stevia, artificial sweeteners such as aspartame, carbohydrates such as sucrose, sugar alcohols such as sorbitol, erythritol, and xylitol, and glycerols such as glycerin can be used.
本発明の経口用組成物の調製に際しては、特別な界面活性剤等の添加物は必須ではないが、必要に応じて他の公知の添加剤、賦形剤その他を加えて適当な剤型へと加工してもよい。例えば液剤であれば、抗酸化剤、着色剤、矯味矯臭剤、界面活性剤、可塑剤、ｐＨ調整剤などを混合して常法により、ドライシロップ剤、液剤などの経口物とすることができる。また固形剤であれば、賦形剤、崩壊剤、結合剤、滑沢剤、抗酸化剤、コーティング剤、着色剤、矯味矯臭剤、界面活性剤、可塑剤などを混合して常法により、顆粒剤、散剤、カプセル剤、錠剤などを製造することができる。 In the preparation of the oral composition of the present invention, special additives such as surfactants are not essential, but other known additives, excipients, etc. may be added to an appropriate dosage form as necessary. And may be processed. For example, in the case of a liquid agent, an antioxidant, a colorant, a flavoring agent, a surfactant, a plasticizer, a pH adjuster, etc. can be mixed to obtain an oral product such as a dry syrup agent or a liquid agent. If it is a solid agent, an excipient, a disintegrant, a binder, a lubricant, an antioxidant, a coating agent, a coloring agent, a corrigent, a surfactant, a plasticizer, etc. are mixed in a conventional manner. Granules, powders, capsules, tablets and the like can be produced.
抗酸化剤としては、例えばビタミンＣ、ジブチルヒドロキシトルエン（ＢＨＴ）、没食子酸プロピル、ブチルヒドロキシアニソール（ＢＨＴ）、α−トコフェロール、クエン酸などが挙げられる。 Examples of the antioxidant include vitamin C, dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHT), α-tocopherol, and citric acid.
着色剤としては、例えばタール色素、酸化チタンなどが挙げられる。 Examples of the colorant include tar dyes and titanium oxide.
界面活性剤としては、例えばポリグリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、モノステアリン酸ソルビタン、モノパルミチン酸ソルビタン、モノラウリン酸ソルビタン、ポリオキシエチレンポリオキシプロピレンブロックコポリマー、ポリソルベート類、ラウリル硫酸ナトリウム、マクロゴール類、ショ糖脂肪酸エステルなどが挙げられる。 Examples of the surfactant include polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, polyoxyethylene polyoxypropylene block copolymer, polysorbates, sodium lauryl sulfate, macro Examples include galls and sucrose fatty acid esters.
また、必要に応じてタウリンあるいはサイリウムの他に各種の生理活性成分、例えばビタミン類などを混合することもできる。好ましいビタミン類としては、ビタミンＡ、ビタミンＢ、ビタミンＣ、ビタミンＤ及びビタミンＥもしくはそれらの各種誘導体を挙げることができる。 In addition to taurine or psyllium, various physiologically active ingredients such as vitamins can be mixed as necessary. Preferable vitamins include vitamin A, vitamin B, vitamin C, vitamin D, vitamin E or various derivatives thereof.
また、本発明の組成物に嗜好性を持たせるために、各種の香料等を添加しても良い。 Moreover, in order to give palatability to the composition of this invention, you may add various fragrance | flavors.
以下に実施例を挙げて本発明をさらに詳細に説明するが、本発明はこれらの実施例に限定されるものではない。 EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these examples.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）５ｇとタウリン１０ｇを精製水に溶解して全量を１０００ｍｌとし、飲料懸濁液を得た。この懸濁液のｐＨは５．７である。 5 g of commercially available psyllium (Sanei Pharmaceutical Trading Co., Ltd., trade name psyllium husk powder) and 10 g of taurine were dissolved in purified water to make a total volume of 1000 ml to obtain a beverage suspension. The pH of this suspension is 5.7.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）５ｇとタウリン３０ｇを精製水に溶解して全量を１０００ｍｌとし、飲料懸濁液を得た。この懸濁液のｐＨは５．８である。 5 g of commercially available psyllium (Sanei Pharmaceutical Trading Co., Ltd., trade name psyllium husk powder) and 30 g of taurine were dissolved in purified water to make a total volume of 1000 ml to obtain a beverage suspension. The pH of this suspension is 5.8.
＜試験例＞
実施例１、２で調製した懸濁液、ならびに実施例１からタウリンを除いた組成からなるコントロ−ルの風味について、20歳代〜50歳代の健常な成人男性６名からなるパネラーによる調査を行った。
<Test example>
The panel prepared by six healthy adult males in their 20s to 50s with respect to the suspensions prepared in Examples 1 and 2 and the flavor of the control composed of the composition excluding taurine from Example 1 Went.
実施例１、２の懸濁液ならびにコントロールをそれぞれ前記パネラーに飲用させた後、各飲料の風味（紙っぽさ）とテクスチャ（粘り）について、「感じない」：５点、「僅かに感じる」：４点、「少し感じる」：３点、「感じる」：２点、「強く感じる」：１点から選択させ、その合計点で判定した。 After each of the suspensions and controls of Examples 1 and 2 was drunk to the paneler, the taste (paperiness) and texture (stickiness) of each beverage were “not felt”: 5 points, “slightly felt” ”: 4 points,“ feel a little ”: 3 points,“ feel ”: 2 points,“ feel strongly ”: 1 point was selected, and the total was determined.
なお、検体の服用はダブルブラインドで行い、パネラーは、中味が解らない状況で検体を服用した。データ解析には、ＳＤ法による絶対評価法を用いた。この各飲料についてのスコアを表１に示す。 The sample was taken with double blinds, and the paneler took the sample in a situation where the contents were not understood. For data analysis, an absolute evaluation method by the SD method was used. The score for each beverage is shown in Table 1.
この様に、タウリンを添加することで、コントロールで認められている風味やテクスチャが改善されることが確認された。 Thus, it was confirmed that the flavor and texture recognized by the control were improved by adding taurine.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）１２５ｇ、タウリン２５０ｇ、乳糖２１．４ｇ、軽質無水ケイ酸０．６ｇを混合したものを、ヒドロキシプロピルセルロース２．５ｇを精製水３７．５ｇに溶解した結合液を用いて流動層造粒した後、軽質無水ケイ酸０．５ｇを添加して、固形組成物を得た。 A mixture of 125 g of commercially available psyllium (Sanei Pharmaceutical Co., Ltd., trade name Psyllium Husque powder), 250 g of taurine, 21.4 g of lactose, and 0.6 g of light anhydrous silicic acid, 2.5 g of hydroxypropyl cellulose and purified water 37 After fluid bed granulation using a binding solution dissolved in 0.5 g, 0.5 g of light anhydrous silicic acid was added to obtain a solid composition.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）１７５ｇ、タウリン５０ｇ、乳糖１７０．５ｇ、軽質無水ケイ酸０．８ｇを混合したものを、ヒドロキシプロピルセルロース３ｇを精製水３７．５ｇに溶解した結合液を用いて流動層造粒した後、軽質無水ケイ酸０．７ｇを添加して、固形組成物を得た。 175 g of commercial psyllium (Sanei Pharmaceutical Trading Co., Ltd., trade name psyllium husk powder), 50 g of taurine, 170.5 g of lactose, and 0.8 g of light anhydrous silicic acid, 3 g of hydroxypropyl cellulose and 37.5 g of purified water After fluidized bed granulation using the binding solution dissolved in 0.7, 0.7 g of light anhydrous silicic acid was added to obtain a solid composition.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）１７５ｇ、タウリン１５０ｇ、乳糖７０．５ｇ、軽質無水ケイ酸０．８ｇを混合したものを、ヒドロキシプロピルセルロース３ｇを精製水３７．５ｇに溶解した結合液を用いて流動層造粒した後、軽質無水ケイ酸０．７ｇを添加して、固形組成物を得た。 175 g of commercial psyllium (Sanei Pharmaceutical Trading Co., Ltd., trade name psyllium husk powder), 150 g of taurine, 70.5 g of lactose and 0.8 g of light anhydrous silicic acid, 3 g of hydroxypropylcellulose and 37.5 g of purified water After fluidized bed granulation using the binding solution dissolved in 0.7, 0.7 g of light anhydrous silicic acid was added to obtain a solid composition.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）１７５ｇ、タウリン２５０ｇ、乳糖２０．５ｇ、軽質無水ケイ酸０．８ｇを混合したものを、ヒドロキシプロピルセルロース３ｇを精製水４２．５ｇに溶解した結合液を用いて流動層造粒した後、軽質無水ケイ酸１．２ｇを添加して、固形組成物を得た。 A mixture of 175 g of commercially available psyllium (Sanei Pharmaceutical Trading Co., Ltd., trade name Psyllium Husque powder), 250 g of taurine, 20.5 g of lactose and 0.8 g of light anhydrous silicic acid, 3 g of hydroxypropyl cellulose and 42.5 g of purified water After fluidized bed granulation using the binder solution dissolved in 1, 1.2 g of light anhydrous silicic acid was added to obtain a solid composition.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）２６２．５ｇ、タウリン２５ｇ、乳糖１５６ｇ、軽質無水ケイ酸１．２５ｇを混合したものを、ヒドロキシプロピルセルロース４．２ｇを精製水４５ｇに溶解した結合液を用いて流動層造粒した後、軽質無水ケイ酸１．２ｇを添加して、固形組成物を得た。 A mixture of 262.5 g of commercial psyllium (Sanei Pharmaceutical Trading Co., Ltd., trade name Psyllium Husque powder), 25 g of taurine, 156 g of lactose and 1.25 g of light anhydrous silicic acid, 4.2 g of hydroxypropyl cellulose and 45 g of purified water After fluidized bed granulation using the binder solution dissolved in 1, 1.2 g of light anhydrous silicic acid was added to obtain a solid composition.
市販のサイリウム（三栄薬品貿易（株）、商品名サイリウムハスク末）２６２．５ｇ、タウリン１２５ｇ、乳糖５６ｇ、軽質無水ケイ酸１．２５ｇを混合したものを、ヒドロキシプロピルセルロース４．２ｇを精製水４５ｇに溶解した結合液を用いて流動層造粒した後、軽質無水ケイ酸１．２ｇを添加して、固形組成物を得た。 Commercially available psyllium (Sanei Pharmaceutical Trading Co., Ltd., trade name psyllium husk powder) 262.5g, taurine 125g, lactose 56g, light anhydrous silicic acid 1.25g, hydroxypropylcellulose 4.2g purified water 45g After fluidized bed granulation using the binder solution dissolved in 1, 1.2 g of light anhydrous silicic acid was added to obtain a solid composition.
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| JP2001057869A (en) * | 1999-08-24 | 2001-03-06 | Itoham Foods Inc | Material for ameliorating obesity and dieting, and diet food |
| JP2006016356A (en) * | 2004-07-02 | 2006-01-19 | Dai Ichi Seiyaku Co Ltd | Composition for hypercholesterolemia |
| JP2006182654A (en) * | 2004-12-24 | 2006-07-13 | Toyo Shinyaku:Kk | Body fat accumulation suppressing or reducing agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001057869A (en) * | 1999-08-24 | 2001-03-06 | Itoham Foods Inc | Material for ameliorating obesity and dieting, and diet food |
| JP2006016356A (en) * | 2004-07-02 | 2006-01-19 | Dai Ichi Seiyaku Co Ltd | Composition for hypercholesterolemia |
| JP2006182654A (en) * | 2004-12-24 | 2006-07-13 | Toyo Shinyaku:Kk | Body fat accumulation suppressing or reducing agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2021192360A1 (en) * | 2020-03-25 | 2021-09-30 | 日清食品ホールディングス株式会社 | Psyllium seed coat granules, method for producing same, and powdered beverage including psyllium seed coat granules |
| JP7516281B2 (en) | 2020-03-25 | 2024-07-16 | 日清食品ホールディングス株式会社 | Psyllium husk granules, manufacturing method thereof, and powdered beverage containing psyllium husk granules |
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