JP2012532681A - 皮膚を介した侵襲装置のための抗菌被覆 - Google Patents
皮膚を介した侵襲装置のための抗菌被覆 Download PDFInfo
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- JP2012532681A JP2012532681A JP2012519725A JP2012519725A JP2012532681A JP 2012532681 A JP2012532681 A JP 2012532681A JP 2012519725 A JP2012519725 A JP 2012519725A JP 2012519725 A JP2012519725 A JP 2012519725A JP 2012532681 A JP2012532681 A JP 2012532681A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/442—Colorants, dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0056—Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (21)
- 先端、基端およびそれらの間の延在部を有するカテーテルであって、経皮表面および血管内表面をを含む外表面をさらに有するカテーテルと、
前記カテーテルの患者への挿入後に前記経皮表面と前記患者の皮膚との間に介在するよう、前記外表面の前記経皮表面に適用される抗菌物質と、
を具えたことを特徴とする抗菌カテーテル装置。 - 前記抗菌物質は、水溶性被覆、不溶性被覆、粘性ゲル被覆、成形可能なマトリックスおよび固体被覆の少なくとも1つを含むことを特徴とする請求項1に記載の装置。
- ポリマー成分と、
不安定溶媒成分と、
アルコール成分と、
殺生物質と、
を含むことを特徴とする抗菌組成物。 - 前記殺生物物質が非アルコール性殺生物物質であることを特徴とする請求項3に記載の組成物。
- 前記ポリマー成分がカチオン性ポリマー成分であることを特徴とする請求項3に記載の組成物。
- 前記ポリマー成分が非水溶性であることを特徴とする請求項3に記載の組成物。
- 前記ポリマー成分が水溶性であることを特徴とする請求項3に記載の組成物。
- 前記殺生物物質が存在する量が、約0.01%(重量/体積)から約10.0%(重量/体積)であることを特徴とする請求項3に記載の組成物。
- 前記殺生物質が存在する量が、約0.01%(重量/体積)から約5.0%(重量/体積)であることを特徴とする請求項3に記載の組成物。
- 前記ポリマー成分が存在する量が、約0.001%(重量/体積)から約5.0%(重量/体積)であることを特徴とする請求項3に記載の組成物。
- 前記ポリマー成分がセルロース系ポリマー、キトサン、ポリビニル・アルコール、ポリビニル・ピロリドン、、ポリビニル・アセテート、ポリウレタンの少なくとも1つであることを特徴とする請求項6に記載の組成物。
- 前記殺生物物質がクロルヘキシジン二塩酸塩、グルコン酸クロルヘキシジン、クロルヘキシジン・アセテート、クロルヘキシジン・ジアセテート、トリクロサン、クロロキシレノール、塩化デカリニウム、塩化ベンゼトニウム、塩化ベンザルコニウムの少なくとも1つであることを特徴とする請求項3に記載の組成物。
- 前記アルコール成分が1および6の間の炭素原子を有する低級アルコールを含むことを特徴とする請求項3に記載の組成物。
- 前記抗菌物質内に前記アルコール成分が存在する量が、20%(重量/体積)にほぼ等しいことを特徴とする請求項3に記載の組成物。
- 前記アルコール成分はイソプロピル・アルコールおよびエタノールの混合物であり、前記抗菌物質内に存在する量が約40%(重量/体積)から約95%(重量/体積)であることを特徴とする請求項3に記載の組成物。
- 前記不安定溶媒は、前記抗菌物質内に約20%(重量/体積)から約95%(重量/体積)の量だけ存在する有機溶媒を含むことを特徴とする請求項3に記載の組成物。
- 前記ポリマー成分はカチオン性ポリマーを含むことを特徴とする請求項3に記載の組成物。
- 抗菌カテーテル装置を製造するための方法であって、
外表面を有するカテーテルを準備し、
前記外表面の経皮表面を決定し、
前記外表面の血管内表面を決定し、および
前記経皮表面を抗菌物質で被覆する、
ことを特徴とする方法。 - 前記血管内表面を抗血栓物質で被覆する工程をさらに具えたことを特徴とする請求項18に記載の方法。
- 前記抗菌物質は生体適合性のあるバクテリア・インジケータ染料を含むことを特徴とする請求項18に記載の方法。
- 前記血管内表面を不溶性の抗菌物質で被覆する工程をさらに具えたことを特徴とする請求項18に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22416809P | 2009-07-09 | 2009-07-09 | |
US61/224,168 | 2009-07-09 | ||
US12/831,880 US8821455B2 (en) | 2009-07-09 | 2010-07-07 | Antimicrobial coating for dermally invasive devices |
US12/831,880 | 2010-07-07 | ||
PCT/US2010/041358 WO2011005951A2 (en) | 2009-07-09 | 2010-07-08 | Antimicrobial coating for dermally invasive devices |
Publications (2)
Publication Number | Publication Date |
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JP2012532681A true JP2012532681A (ja) | 2012-12-20 |
JP5998051B2 JP5998051B2 (ja) | 2016-09-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2012519725A Active JP5998051B2 (ja) | 2009-07-09 | 2010-07-08 | 皮膚を介した侵襲装置のための抗菌被覆 |
Country Status (8)
Country | Link |
---|---|
US (1) | US8821455B2 (ja) |
EP (1) | EP2451495A2 (ja) |
JP (1) | JP5998051B2 (ja) |
CN (1) | CN102481391B (ja) |
AU (1) | AU2010271415B2 (ja) |
BR (1) | BR112012000469B1 (ja) |
IN (1) | IN2012DN00272A (ja) |
WO (1) | WO2011005951A2 (ja) |
Cited By (10)
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JP2013505062A (ja) * | 2009-09-17 | 2013-02-14 | ベクトン・ディキンソン・アンド・カンパニー | 医療装置用の抗感染性潤滑剤およびその調製方法 |
JP2016517300A (ja) * | 2013-03-11 | 2016-06-16 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 針の抗菌性の潤滑剤を備えた血液制御カテーテル |
JP2017519604A (ja) * | 2014-07-08 | 2017-07-20 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 耐キンク性特徴を血管アクセスデバイス上に形成する抗菌コーティング |
JP2017520341A (ja) * | 2014-07-08 | 2017-07-27 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | ポート付きカテーテルのサイドポートを開くための抗菌性作動器 |
US9750927B2 (en) | 2013-03-11 | 2017-09-05 | Becton, Dickinson And Company | Blood control catheter with antimicrobial needle lube |
US9789279B2 (en) | 2014-04-23 | 2017-10-17 | Becton, Dickinson And Company | Antimicrobial obturator for use with vascular access devices |
JP2017533001A (ja) * | 2014-09-11 | 2017-11-09 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 採血成功を改善するための、および、溶血を低減させるための血液サンプリングシステム |
US9956379B2 (en) | 2014-04-23 | 2018-05-01 | Becton, Dickinson And Company | Catheter tubing with extraluminal antimicrobial coating |
US10376686B2 (en) | 2014-04-23 | 2019-08-13 | Becton, Dickinson And Company | Antimicrobial caps for medical connectors |
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BR112012000469B1 (pt) | 2018-07-31 |
US8821455B2 (en) | 2014-09-02 |
WO2011005951A2 (en) | 2011-01-13 |
WO2011005951A3 (en) | 2011-04-28 |
EP2451495A2 (en) | 2012-05-16 |
BR112012000469A2 (pt) | 2016-02-16 |
US20110009831A1 (en) | 2011-01-13 |
AU2010271415A1 (en) | 2012-02-02 |
CN102481391A (zh) | 2012-05-30 |
JP5998051B2 (ja) | 2016-09-28 |
CN102481391B (zh) | 2015-04-08 |
IN2012DN00272A (ja) | 2015-05-08 |
AU2010271415B2 (en) | 2015-02-05 |
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