JP2012520143A - ガスクラスターイオンビーム技術の適用により生物学的材料の表面の湿潤性及び/又はその他の生体適合性特性を改質する方法と製造された生物学的材料 - Google Patents
ガスクラスターイオンビーム技術の適用により生物学的材料の表面の湿潤性及び/又はその他の生体適合性特性を改質する方法と製造された生物学的材料 Download PDFInfo
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Abstract
【選択図】図1
Description
GCIB照射を除いて、靱帯組織標本(試験標本及び対照の両方)の引き続く処理は、同一であった。脱細胞化組織は、一晩中PBS中に保存された。その後、脱細胞化組織標本は、PBSから取り出され、GCIB処理システムの処理チャンバに個別に導入された。処理チャンバは、約100ミリトールの低真空まで排気された(低真空を実現するための排気時間は、靱帯標本に対し約2分であった)。低真空を実現後、標本は、引き続き、高真空に導入され、高真空(約6×10−5トール)に暴露された。脱細胞化靱帯組織の試験標本は、その後、GCIB照射によって高真空中で処理された。対照標本は、照射されなかったが、同じ真空条件及び持続期間に晒された。GCIB照射は、30kV加速電位で1cm2当たり5×1014個のアルゴンクラスターの表面照射量を被照射表面に加えることからなる。照射時間及び対応する高真空暴露持続時間は、両方の脱細胞化靱帯組織標本(照射及び対照)に対して約3分20秒であった。
Claims (17)
- ドナーから移植片組織を外移植することと、
前記移植片組織の少なくとも第1の部分にイオンビームを照射することと、
前記移植片組織をレシピエントに外科的移植することと、
を含む、組織の外科的移植方法。 - 前記ドナーは、哺乳類種又は鳥類種であり、前記レシピエントは、哺乳類である、請求項1に記載の方法。
- 前記移植片組織は、同種移植片、自家移植片、又は、異種移植片である、請求項2に記載の方法。
- 前記移植片組織は、靱帯組織又は腱組織である、請求項1に記載の方法。
- 前記照射することの前に前記移植片組織を凍結乾燥することをさらに含む、請求項1に記載の方法。
- 前記照射することの前に前記移植片組織の少なくとも第2の部分を脱細胞化することをさらに含み、前記第1の部分は、前記第2の部分のうちの少なくとも一部を含む、請求項1に記載の方法。
- 前記凍結乾燥することの前に前記移植片組織の少なくとも第2の部分を脱細胞化することをさらに含み、前記第1の部分は、前記第2の部分のうちの少なくとも一部を含む、請求項5に記載の方法。
- シードするため細胞を採取することと、
前記外科的移植することの前に、採取された細胞を用いて前記少なくとも第1の部分のうちの少なくとも第3の部分をシードすることと、
をさらに含む、請求項1に記載の方法。 - 前記採取された細胞は、前記レシピエントから採取された細胞である、請求項8に記載の方法。
- 前記凍結乾燥すること及び前記照射することの後に、かつ、前記外科的移植することの前に、前記移植片組織を再建することをさらに含む、請求項5に記載の方法。
- 前記凍結乾燥すること及び前記照射することの後に、かつ、前記シードすることの前に、前記移植片組織を再建することをさらに含む、請求項8に記載の方法。
- 前記外科的移植することにおいて、in situ再建又はシードのため、前記少なくとも第2の部分を前記レシピエントからの体液又は細胞と接触させる、請求項6に記載の方法。
- 前記外科的移植することの前に、前記外科的移植のため、前記移植片組織を離れた場所へ輸送することをさらに含む、請求項5に記載の方法。
- 前記イオンビームはガスクラスターイオンビームである、請求項1に記載の方法。
- ドナーから移植片組織を外移植することと、
前記移植片組織の少なくとも第1の部分を脱細胞化することと、
前記移植片組織の前記第1の部分のうちの少なくとも第2の部分を凍結乾燥することと、
前記移植片組織の前記第2の部分のうちの少なくとも第3の部分に照射することと、
将来の使用のため前記移植片組織を任意的に保存することと、
外科的移植のため前記移植片組織を離れた場所へ任意的に輸送することと、
前記移植片組織の前記少なくとも第3の部分の少なくとも表面に細胞を任意的にシードすることと、
前記移植片組織の上又は中に、前記細胞を所望の程度、任意的に付着及び増殖させることと、
前記移植片組織をレシピエントに外科的移植することと、
を含む、外科的移植方法。 - 前記第1の部分、前記第2の部分、又は、前記第3の部分は、少なくとも共通表面部分を有している、請求項15に記載の方法。
- 成長因子と、
サイトカインと、
分化因子と、
脱灰骨粉と、
幹細胞と、
からなる群より選択された成分を含有する組成物を前記移植片組織に暴露することをさらに含む、請求項15に記載の方法。
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