JP2012005501A - 促進される吸収および生物学的利用のための全てが天然の多種ビタミンおよび多種ミネラル食事補助調合物 - Google Patents
促進される吸収および生物学的利用のための全てが天然の多種ビタミンおよび多種ミネラル食事補助調合物 Download PDFInfo
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- JP2012005501A JP2012005501A JP2011191993A JP2011191993A JP2012005501A JP 2012005501 A JP2012005501 A JP 2012005501A JP 2011191993 A JP2011191993 A JP 2011191993A JP 2011191993 A JP2011191993 A JP 2011191993A JP 2012005501 A JP2012005501 A JP 2012005501A
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- 150000002266 vitamin A derivatives Chemical class 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 150000003712 vitamin E derivatives Chemical class 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
- 238000003911 water pollution Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 235000009529 zinc sulphate Nutrition 0.000 description 1
- 239000011686 zinc sulphate Substances 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
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Abstract
【解決手段】植物−由来ミネラル類の規格化された原料、1種もしくはそれ以上の天然ビタミン類またはプロビタミン類および1種もしくはそれ以上の天然植物抽出物を含有する食事補助調合物を作成した。
【選択図】なし
Description
本発明は、一般的には人間および動物接取用の組成物、そしてより特に栄養素の促進される吸収および生物学的利用性を有する全てが天然の多種ビタミン、多種ミネラル食事補助調合物、に関する。
本発明の範囲を限定するものではないが、その背景を栄養補助剤に関連して記述する。
阻害的であることが現在までわかっていないかまたは吸収を負に調整する組み合わせを包含するため、それらは逆効果がある。従って、消化問題を減じながら吸収を最大化し且つ骨などの補強を与える毎日の食品補助剤に関する要望が当該技術にある。
本発明は、一般的には天然ビタミン原料、植物−由来ミネラル原料、および植物をベースとした組成物(例えば、抽出物、脱水された植物物質、ガム、など)と規格化された植物化学物質との組み合わせを包含する人間および動物接取用の食事補助組成物に関する。これらの組成物は特定栄養素の分配を最大化しおよび/または最適化し、そして広範囲の薬用量形態で入手可能でありうる。
、ブラシカ・ジュンセア、メジカゴ・サチバ、およびオリザエ・サチバ種子などの実生よりなる群から選択されうる。当業者は植物をベースとしたミネラル類の同等なまたはより良好な分配を与えうる他の植物を発見、開発または操作しうることを認識するであろうし、それらの全ては同等物として本発明の内容となる。骨の健康を維持するための植物−由来ミネラル類は、鉄、セレン、クロム、バナジウム、銅、マンガン、モリブデン、ヨウ素、およびそれらの組み合わせから選択されるミネラル類の1種もしくはそれ以上を包含しうる。骨の健康を維持するための1種もしくはそれ以上の天然ビタミンは、ビタミンA、チアミン、リボフラビン、ナイアシン、ビタミンB−6、葉酸塩、ビタミンB−12、パントテン酸、ビタミンC、ビタミンD、ビタミンE、トコフェロール類、トコトリエネオール類、およびそれらの組み合わせから選択されうる。
.03〜3.5mg)、クロム(0.03〜3.5mg)、銅(0.03〜3.5mg)、セレン(0.03〜3.5mg)、バナジウム(0.03〜3.5mg)、モリブデン(0.03〜3.5mg)、ホウ素(0.03〜3.5mg)、ヨウ素(0.03〜3.5mg)を包含するInBミネラル・ブレンド(125mg);アクアミンズ(100mg)、例えば、30%Ca(2.5〜30mg)および/または2.5%Mg(2.5〜30mg);ブロッコシノレート(20〜160mg)、例えば6%グルコシノレート類(1.2〜20mg);ルチンNF(1.2〜20mg);クランベリー抽出物(35%有機酸類)(1.2〜20mg);グレープ・パミス抽出物(50%ポリ)(1.2〜20mg);およびアロエゲル粉末(200x)(1.2〜20mg)を包含する植物ペクチン調合物のものである。さらに、組成物は酵母ビタミン複合体(0.038〜4mg)、チアミン(0.038〜4mg)、リボフラビン(0.038〜4mg)、ナイアシン(0.038〜4mg)、ピリドキシン(0.038〜4mg)、パントテン酸(0.038〜4mg)、葉酸(0.038〜4mg)、ビオチン(0.038〜4mg);並びに以下のビタミン類:混合カロテノイド粉末(35,000IU/gのビタミンA同等物)、1%ビタミンB12(酵母由来)(15mcg)、アセロラ・チェリー(15%ビタミンC)(0.15〜100mg)、ビタミンD(100KIU/g)(0.15〜100mg)、ビタミンE(350IU/g)(0.15〜100mg)、またはそれらの組み合わせの1種もしくはそれ以上を包含しうる。小児形態用に提供される時には、組成物は以上で挙げられた合計量の半分以下を、または調合物が小児用途に許容可能である寸法および形態で提供される限り挙げられた範囲により生ずる重量対重量比を基準として、包含することができる。患者がここに記述された天然ビタミン類およびミネラル類のあるものを多少とも必要とする場合には、具体的な調合物は当業者に既知であるようにして製造することができる。
本発明の種々の態様の製造および使用を以下で詳細に論ずるが、本発明は広範囲の具体的な概念で具体化されうる多くの適用可能な発明概念を提供することを認識すべきである。ここで論じられる具体的な態様は本発明を製造しそして使用するための具体的な方法の単なる説明でありそして発明の範囲を限定するものではない。
ば「a」、「an」、および「the」の如き用語は単数物体だけをさすが、具体例が説明用に使用できるものの全般的な種類を包含する。ここで使用される用語法は本発明の具体的な態様を記述するために使用されるが、それらの用法は特許請求の範囲に概略記述されることを除いて、本発明を制限するものではない。
響を最少にするために局部的栽培および地域とのバランスも維持すべきである。
avid Ganderton,Trevor Jones,James McGinity,Eds.,1995);Aqueous Polymeric Coatings
for Pharmaceutical Dosage Forms(Drugs and the Pharmaceutical Sciences,Series 36(James McGinity,Ed.,1989);Pharmaceutical
Particulate Carriers:Therapeutic Applications:Drugs and the Pharmaceutical Sciences,Vol 61(Alain Rolland,Ed.,1993);Drug
Delivery to the Gastrointestinal Tract(Ellis Horwood Books in the Biological Scineces.Series in Pharmaceutical Technology;J.G.Hardy,S.S.Davis,Clive G.Wilson,Eds.);Modern Pharmaceutics Drugs and the Pharmaceutical Sciences,Vol 40(Gilbert S.Banker,Christopher T.Rhodes,Eds.)など。
合体、ポリエプシロンカプロラクトン、ポリヒドロキシ酪酸、ポリオルトエステル類、ポリアセタール類、ポリジヒドロピラン類、ポリシアノアシレート類、並びにヒドロゲル類の架橋結合されたまたは両親媒性ブロック共重合体を包含する。
ド状二酸化珪素、5ミリグラムのステアリン酸マグネシウム、50−275ミリグラムの微結晶性セルロース、11ミリグラムの澱粉および98.8ミリグラムのラクトースであるような多数の錠剤を普遍的工程により製造する。適するコーティングを適用して飲み易さを高めそして吸収を遅延させることができる。
れない物質および条件もそれらが本発明の利点が実現するのを妨げない限り除外されないことを理解すべきである。
栄養素にとって重要であるイオンを包含するある種のイオンとの選択的な結合および放出特徴を示す。このイオン交換機構の例は、カルシウム、亜鉛、銅およびカリウムイオンと緑藻であるMougeotia scalarisの多糖マトリックスとの選択的結合で示される。Tretyn,et al.(1996)。イオン交換マトリックスとして機能する天然多糖類の使用による食事補助調合物からのミネラルイオンの選択的なおよび/または延長された放出が本発明で特に有用である。
1個の薬用量形態当たり1日値の〜25%(%DV)のビタミン類、例えば、天然原料ビタミンB複合体(チアミン、リボフラビン、ナイアシン、ビタミンB6、パントテン酸、葉酸塩、ビタミンB12);天然原料ビタミンA(レチノール、ベータ−カロテン、混合カロテノイド類);天然ビタミンC(アスコルビン酸、ビタミン−C複合体)、天然ビタミンD;および/または天然ビタミンE(混合トコフェロール類);
規格化された植物化学物質である6.0%グルコシノレート類に規格化されたブロッコリ(Broccoli)抽出物−20mg/カプセル;10%に規格化されたリコペン−20mg/カプセル;3または10%に規格化されたベータ−カロテン(混合カロテノイド類)−40mg/カプセル;10%に規格化されたルテイン−25mg/カプセル;50%ポリフェノール類に規格化されたブドウ搾り滓抽出物−20mg/カプセル;35%有機酸に規格化されたクランベリー抽出物−20mg/カプセル;95%ポリフェノール類および50%ECGCに規格化された緑茶抽出物;ルチンNF10mg/カプセル;アロエゲル200x20mgおよび/またはアクアミン類並びに他のミネラル類、例えば、CaおよびMg
も包含する。
g/gのマンガン、200mcg/gのバナジウム、200mcg/gのモリブデン、2mg/gのホウ素、300mcg/gのヨウ素、および2mg/gのストロンチウムを含有する1個のカプセル剤当たり125ミリグラムのブラシカ・ジュンセア(インディアン・マスタード);並びに1個の薬用量形態当たり1日値の〜25%(%DV)のビタミン類、例えば、天然原料ビタミンB複合体(チアミン、リボフラビン、ナイアシン、ビタミンB6、パントテン酸、葉酸塩、ビタミンB12);天然原料ビタミンA(レチノール、混合カロテノイド類);天然ビタミンC(アスコルビン酸、ビタミンC複合体)、天然ビタミンD;および/または天然ビタミンE(混合トコフェロール類);並びに/または1種もしくはそれ以上の規格化された植物化学物質、例えば、6.0%グルコシノレート類に規格化されたブロッコリ抽出物−20mg/カプセル;および/または3−10%に規格化されたベータ−カロテン−40mg/カプセル;アロエゲル200x20mgおよび/またはアクアミン類並びに他のミネラル類、例えば、CaおよびMg、を包含する丸剤、散剤、カプセル剤、カプレット剤、ゲルキャップ剤、微小錠剤およびそれらの組み合わせである。
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Claims (15)
- 植物由来ミネラル類の規格化された原料、1種若しくはそれ以上の天然ビタミン類又はプロビタミン類、及び1種若しくはそれ以上の植物抽出物を含む食事補助調合物であって、前記1種若しくはそれ以上の天然ビタミン類が、ビタミンA、ベータ−カロテン単独、カロテノイド類、リコペン、ルテイン、ゼアキサンチン、クリプトキサンチン、チアミン(ビタミンB1)、リボフラビン(ビタミンB2)、ナイアシン(ビタミンB3)、パントテン酸(ビタミンB5)、ピリドキシン(ビタミンB1)、葉酸塩(ビタミンB9)、シアノコバラミン(ビタミンB12)、ビタミンC−複合体、ビタミンD、ビタミンE、トコフェロール類、トコトリエネオール類、及びそれらの組合せから選択される、食事補助調合物。
- 植物由来亜鉛の規格化された原料、ビタミンA、ベータ−カロテン、カロテノイド類、リコペン、ルテイン、ゼアキサンチン、クリプトキサンチン、チアミン(ビタミンB1)、リボフラビン(ビタミンB2)、ナイアシン(ビタミンB3)、パントテン酸(ビタミンB5)、ピリドキシン(ビタミンB1)、葉酸塩(ビタミンB9)、シアノコバラミン(ビタミンB12)、ビタミンC−複合体、ビタミンD、ビタミンE、トコフェロール類、トコトリエネオール類を含む規格化された植物抽出物、並びにビタミンD、ビタミンC、カルシウム、マグネシウム、ストロンチウム、及びホウ素を含む1種若しくはそれ以上の追加栄養素を含む、骨の健康を維持するための食事補助調合物であって、組成物が、バルク散剤、咀嚼可能な形態を含むか又は子供による使用に適する、食事補助調合物。
- 1種若しくはそれ以上の規格化された植物化学物質が、スルフォラファン類、イソチオシアネート類、グルコシノレート類、グルコラファニン、グルコナスツルチイン、グルコブラシシン、グルコエルシン、S−メチルシステインスルホキシド、インドール−3−カルビノール、エルシン、キサントフィル類、カロテノイド類、リコペン、ルテイン、クリプトキサンチン、ベータ−カロテン、ポリフェノール類、フラボノイド類、アピゲニン、ルチン、クエルセチン、クリシン、ヘスペリジン、ビオフラボノイド類、イソフラボン類、アントシアニン類、クロロゲン酸、ECGC、エラグ酸、カテキン類、エスシン、レスベラトロール、クルクミン、リグニン類、カルノシン酸(carnosic acid)、ロセマリン酸(roesmarinic acid)、ギンゲロール、オレウロペイン、シリマリン、シニグリン、キナ酸、及びそれらの組合せを含む、請求項2記載の食事補助調合物。
- 植物由来ミネラル類がブラシカ・ナプス(Brassica napus)、ブラシカ・ラパ(Brassica rapa)、ブラシカ・ジュンセア(Brassica juncea)、メジカゴ・サチバ(Medicago sativa)、及びオリザエ・サチバ(Oryzae sativa)種子の実生よりなる群から選択され、前記植物由来ミネラル類が、鉄、セレン、クロム、バナジウム、銅、マンガン、モリブデン、ヨウ素、ホウ素、亜鉛、及びそれらの組合せからなる群から選択される1種若しくはそれ以上のミネラルをさらに含む、請求項1〜3のいずれかに記載の食事補助調合物。
- カルシウム、マグネシウム、鉄、亜鉛、セレン、クロム、バナジウム、銅、マンガン、モリブデン、ホウ素、ヨウ素、及びストロンチウムを含む植物由来ミネラル類の規格化された原料;ビタミンA、カロテノイド類、リコペン、ルテイン、ゼアキサンチン、クリプトキサンチン、チアミン(ビタミンB1)、リボフラビン(ビタミンB2)、ナイアシン(ビタミンB3)、パントテン酸(ビタミンB5)、ピリドキシン(ビタミンB1)、葉酸塩(ビタミンB9)、シアノコバラミン(ビタミンB12)、ビタミンC、ビタミンD、ビタミンE、トコフェロール類、トコトリエネオール類を含む1種若しくはそれ以上の天然ビタミン類又はプロビタミン類;並びに植物フェノール系化合物、ポリフェノール類、フラボノイド類、アピゲニン、ルチン、クエルセチン、クリシン、ヘスペリジン、ビオフラボノイド類、イソフラボン類、アントシアニン類、クロロゲン酸、ECGC、エラグ酸、カテキン類、エスシン、レスベラトロール、クルクミン、リグニン類、タンニン類、タンニン酸、ギンゲロール、及びオレウロペインを含む1種若しくはそれ以上の規格化された植物抽出物を含む、腸グルクロニド化の抑制により促進されるビタミン吸収用の食事補助調合物。
- カルシウム、マグネシウム、鉄、亜鉛、セレン、クロム、バナジウム、銅、マンガン、モリブデン、ホウ素、ヨウ素、及びストロンチウムを含む植物由来ミネラル類の規格化された原料;ビタミンA、カロテノイド類、リコペン、ルテイン、ゼアキサンチン、クリプトキサンチン、チアミン、リボフラビン、ナイアシン、ビタミンB−6、葉酸塩、ビタミンB−12、ビタミンC、ビタミンD、ビタミンE、トコフェロール類、トコトリエネオール類を含む1種若しくはそれ以上の天然ビタミン類又はプロビタミン類;並びに植物フェノール系化合物、ポリフェノール類、フラボノイド類、アピゲニン、ルチン、クエルセチン、クリシン、ヘスペリジン、ビオフラボノイド類、イソフラボン類、アントシアニン類、クロロゲン酸、ECGC、エラグ酸、カテキン類、エスシン、レスベラトロール、クルクミン、リグニン類、タンニン類、タンニン酸、ギンゲロール、及びオレウロペインを含む1種若しくはそれ以上の規格化された植物抽出物を含有する、調整されたミネラル吸収用の食事補助調合物。
- カルシウム、マグネシウム、鉄、亜鉛、セレン、クロム、バナジウム、銅、マンガン、モリブデン、ホウ素、ヨウ素、及びストロンチウムを含む植物由来ミネラル類の規格化された原料;並びにビタミンA、カロテノイド類、リコペン、ルテイン、ゼアキサンチン、クリプトキサンチン、チアミン(ビタミンB1)、リボフラビン(ビタミンB2)、ナイアシン(ビタミンB3)、パントテン酸(ビタミンB5)、ピリドキシン(ビタミンB1)、葉酸塩(ビタミンB9)、シアノコバラミン(ビタミンB12)、ビタミンC、ビタミンD、ビタミンE、トコフェロール類、トコトリエネオール類を含む1種若しくはそれ以上の天然ビタミン類又はプロビタミン類;並びにスルフォラファン類、イソチオシアネート類、グルコシノレート類、グルコラファニン、グルコナスツルチイン、グルコブラシシン、グルコエルシン、シニグリン、S−メチルシステインスルホキシド、インドール−3−カルビノール、エルシン、及びそれらの組合せの1種若しくはそれ以上を含む1種若しくはそれ以上の規格化された植物抽出物を含有する、ビタミンA又はEによるグルタチオン・トランスフェラーゼの抑制を克服するための食事補助調合物。
- 植物多糖、藻多糖、菌・カビ多糖、細菌多糖、植物ゴム、アロエ多糖、及びそれらの組合せを含む天然多糖成分をさらに含む、請求項1〜7のいずれかに記載の食事補助調合物。
- 補助剤が外側カプセル、植物カプセル又は硬質ゼラチンカプセルの内部に置かれている、請求項1〜8のいずれかに記載の食事補助調合物。
- 補助剤が2,000psiより大きい圧力で圧縮される、請求項1〜9のいずれかに記載の食事補助調合物。
- 栄養補助剤の85%が1〜8時間の間に放出される、請求項1〜10のいずれかに記載の食事補助調合物。
- 栄養補助剤が液体、半固体、固体、ゴム状、ゴム、カプセル化された、又は平板形態である、請求項1〜11のいずれかに記載の食事補助調合物。
- 補助剤が1種若しくはそれ以上の賦形剤をさらに含む、請求項1〜12のいずれか記載の食事補助調合物。
- 補助剤の1つ若しくはそれ以上の成分がバイオアベイラビリティーにより測定して相乗的であるように、植物由来ミネラル類の1種若しくはそれ以上の規格化された原料、1種若しくはそれ以上のビタミン類又はプロビタミン類、及び1種若しくはそれ以上の植物抽出物を選択する段階を含む、バランスのとれた栄養補助剤を提供する方法。
- 組成物が、カルシウム、マグネシウム、鉄、亜鉛、セレン、クロム、バナジウム、銅、マンガン、モリブデン、ホウ素、ヨウ素、及びストロンチウムを含む植物由来ミネラル類の規格化された原料;ビタミンA、カロテノイド類、リコペン、ルテイン、ゼアキサンチン、クリプトキサンチン、チアミン(ビタミンB1)、リボフラビン(ビタミンB2)、ナイアシン(ビタミンB3)、パントテン酸(ビタミンB5)、ピリドキシン(ビタミンB1)、葉酸塩(ビタミンB9)、シアノコバラミン(ビタミンB12)、ビタミンC、ビタミンD、ビタミンE、トコフェロール類、トコトリエネオール類を含む1種若しくはそれ以上の天然ビタミン類又はプロビタミン類;並びに植物フェノール系化合物、ポリフェノール類、フラボノイド類、アピゲニン、ルチン、クエルセチン、クリシン、ヘスペリジン、ビオフラボノイド類、イソフラボン類、アントシアニン類、クロロゲン酸、ECGC、エラグ酸、カテキン類、エスシン、レスベラトロール、クルクミン、リグニン類、タンニン類、タンニン酸、ギンゲロール、オレウロペイン、及びそれらの組合せを含む1種若しくはそれ以上の規格化された植物抽出物を含む方法であって、補助剤が外側カプセル、植物カプセル又は硬質ゼラチンカプセルの内部に置かれるか、補助剤が2,000psiより大きい圧力で圧縮されるか、栄養補助剤の85%が1〜8時間の間に放出されるか、前記栄養補助剤が液体、半固体、固体、ゴム状、ゴム、カプセル化された、若しくは平板形態であるか、又は前記補助剤が1種若しくはそれ以上の賦形剤をさらに含む、請求項14に記載の方法。
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JP5643166B2 (ja) | 2014-12-17 |
KR101464500B1 (ko) | 2014-12-04 |
MY161865A (en) | 2017-05-15 |
KR101661246B1 (ko) | 2016-09-29 |
KR20130133087A (ko) | 2013-12-05 |
KR20150090270A (ko) | 2015-08-05 |
EP1993382A4 (en) | 2011-08-17 |
BRPI0621321A2 (pt) | 2011-12-06 |
US20070190209A1 (en) | 2007-08-16 |
EP1993382A2 (en) | 2008-11-26 |
JP2009528818A (ja) | 2009-08-13 |
NZ594596A (en) | 2011-10-28 |
SG10201700744YA (en) | 2017-03-30 |
WO2007094827A2 (en) | 2007-08-23 |
KR20080095276A (ko) | 2008-10-28 |
IL193307A0 (en) | 2011-08-01 |
NZ570704A (en) | 2011-09-30 |
WO2007094827A3 (en) | 2009-05-07 |
AU2006338273A1 (en) | 2007-08-23 |
MY166532A (en) | 2018-07-10 |
KR101563528B1 (ko) | 2015-10-27 |
CN101553134A (zh) | 2009-10-07 |
KR101716128B1 (ko) | 2017-03-14 |
ZA200807423B (en) | 2009-09-30 |
CA2641950A1 (en) | 2007-08-23 |
MX2008010127A (es) | 2009-03-05 |
KR20160116023A (ko) | 2016-10-06 |
AU2006338273B2 (en) | 2011-10-13 |
SG10201700743PA (en) | 2017-03-30 |
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