JP2011530346A - 骨インプラントのための医療機器およびその機器の製造方法 - Google Patents
骨インプラントのための医療機器およびその機器の製造方法 Download PDFInfo
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- JP2011530346A JP2011530346A JP2011522265A JP2011522265A JP2011530346A JP 2011530346 A JP2011530346 A JP 2011530346A JP 2011522265 A JP2011522265 A JP 2011522265A JP 2011522265 A JP2011522265 A JP 2011522265A JP 2011530346 A JP2011530346 A JP 2011530346A
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- therapeutic agent
- medical device
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- bone
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Abstract
【選択図】図1
Description
チタニアまたはジルコニアは、骨形成誘発剤で塗布された後、イオンビーム(好ましくはGCIB)照射によって処理されて骨形成誘発剤が注入される面を形成する。
Claims (28)
- 骨に埋入可能な医療機器の表面を改変する方法であって、
前記医療機器の前記表面の少なくとも第一の部分を骨形成誘発剤で被覆して被覆面領域を形成するステップと、
前記被覆面領域の少なくとも一部分に第一のイオンビームを照射する第一の照射ステップと、
を備えていることを特徴とする方法。 - 前記第一の照射ステップは、前記骨形成誘発剤の埋込み分子および/または解離生成物を備える浅面および内面層を形成することを特徴とする請求項1に記載の方法。
- 前記第一のイオンビームは第一のガスクラスタイオンビームであり、さらに前記浅面および内面層が注入面層であることを特徴とする請求項2に記載の方法。
- 前記骨形成誘発剤は、栄養材料、リン酸三カルシウム、ヒドロキシアパタイト、バイオガラス45S5、バイオガラス58S、骨成長刺激剤、成長因子、サイトカイン、TGF−βタンパク質、BMP、GPIアンカーシグナルタンパク質、RGM、および増殖調整タンパク質から成る群からの材料のいずれかを個々に、または組み合わせて含むことを特徴とする請求項1乃至3のいずれか一項に記載の方法。
- 前記骨に埋入可能な医療機器の前記表面は、金属、酸化物、またはセラミックのいずれかを個々にまたは組み合わせて含むことを特徴とする請求項1乃至4のいずれか一項に記載の方法。
- 前記表面はチタン、チタニア、またはジルコニアを含むことを特徴とする請求項5に記載の方法。
- 前記被覆ステップの前に、
ガスクラスタイオンビームである第二のイオンビームを形成するステップと、
前記医療機器の前記表面の少なくとも第二の部分を照射して、前記表面の少なくとも前記第二の部分を清掃する第二の照射ステップと、
をさらに備えることを特徴とする請求項1乃至6のいずれか一項に記載の方法。 - 前記第一の照射ステップは、照射される前記被覆面領域の前記少なくとも一部分を制御するために遮蔽手段を採用することをさらに備えることを特徴とする請求項1乃至7のいずれか一項に記載の方法。
- 前記第一の照射ステップは、照射される前記被覆面領域の前記少なくとも一部分を制御するために前記第一のイオンビームを向けることをさらに備えるを特徴とする請求項1に記載の方法。
- 前記医療機器の前記表面に一または複数の穴を形成するステップと、
前記一または複数の穴のうち少なくとも一つの穴に治療薬を装填するステップと、
一以上の前記装填済みの穴の中の前記治療薬の露出面に第三のイオンビームを照射して、前記露出面に障壁層を形成する第三の照射ステップと、
をさらに備えることを特徴とする請求項1に記載の方法。 - 前記第三のイオンビームはガスクラスタイオンビームであることを特徴とする請求項10に記載の方法。
- 前記障壁層は治療薬の溶出速度を制御することを特徴とする請求項10または11のいずれかに記載の方法。
- 前記障壁層は前記穴への、流体の内部への拡散速度を制御することを特徴とする請求項10または11のいずれか一項に記載の方法。
- 骨に埋入可能な医療機器の表面を改変する方法であって、
前記医療機器の前記表面に一以上の穴を形成するステップと、
前記一以上の穴のうち少なくとも一つの穴に、第一の治療薬を装填する第一の装填ステップと、
一以上の装填済みの穴の中の前記第一の治療薬の露出面に、第一のイオンビームを照射して、前記一以上の装填済みの穴の中の前記治療薬の前記露出面に第一の障壁層を形成する第一の照射ステップと、
を備えることを特徴とする方法。 - 前記一以上の穴は、所定の分布計画に従い前記表面上に前記第一の治療薬を分布させるために所定のパターンで前記表面に配置されることを特徴とする請求項14に記載の方法。
- 二以上の穴があり、前記穴のうち一以上の穴に第一の治療薬が装填され、一以上の穴に前記第一の治療薬とは異なる第二の治療薬が装填されることを特徴とする請求項14に記載の方法。
- 前記一以上の穴のうち少なくとも一つの穴は第一の量の前記第一の治療薬を装填されており、この第一の量は前記一以上の穴のうち少なくとも別の穴に装填される前記第一の治療薬の第二の量とは異なっていることを特徴とする請求項15に記載の方法。
- 前記第一の装填ステップは前記少なくとも一つの穴を完全には充填せず、前記第一の照射ステップの後に、
前記少なくとも一つの不完全に充填された穴に、前記第一の障壁層を覆う追加の治療薬を装填する第二の装填ステップと、
少なくとも一つの第二の装填済みの穴内の前記追加の治療薬の露出面に第二のイオンビームを照射して、前記少なくとも一つの装填済みの穴の前記露出面に追加の障壁層を形成する第二の照射ステップと、
をさらに備えることを特徴とする請求項14乃至17のいずれか一項に記載の方法。 - 前記第一の障壁層および前記追加の障壁層は、前記第一の治療薬および第二の治療薬の溶出速度を制御する異なる特性を有することを特徴とする請求項18に記載の方法。
- 前記第一のイオンビームは第一のガスクラスタイオンビームであることを特徴とする請求項14に記載の方法。
- 前記第一のイオンビームは第一のガスクラスタイオンビームであり、さらに前記第二のイオンビームが第二のガスクラスタイオンビームであることを特徴とする請求項18に記載の方法。
- 表面を有している、骨に埋入可能な医療機器であって、前記表面の少なくとも一部分が、前記表面の前記少なくとも一部分に埋め込まれた骨形成誘発剤の分子および/または解離生成物を含む浅い層を備えることを特徴とする骨に埋入可能な医療機器。
- 前記浅い層がGCIB注入面層であることを特徴とする請求項22に記載の医療機器。
- 前記医療機器の前記表面は、チタン、チタニア、およびジルコニアからなる群から選択される材料を含むことを特徴とする請求項23に記載の医療機器。
- 前記医療機器の前記表面に治療薬を含有する一以上の穴と、
前記一以上の穴に含まれる前記治療薬の一以上の表面の、少なくとも一以上の障壁層と、
をさらに備えており、
前記少なくとも一以上の障壁層が治療薬の少なくとも一つの溶出速度を制御するように構成されていることを特徴とする請求項22または23に記載の医療機器。 - 表面を有している、骨に埋入可能な医療機器であって、前記表面の少なくとも一部分が、
前記医療機器の前記表面に治療薬を含有する一以上の穴と、
前記一以上の穴に含まれる前記治療薬の一以上の表面の、少なくとも一以上の障壁層と、
を備えており、
少なくとも一以上の障壁層が治療薬の少なくとも一つの溶出速度を制御するように構成されていることを特徴とする骨に埋入可能な医療機器。 - 前記医療機器の前記表面は、チタン、チタニア、およびジルコニアから成る群から選択される材料を含んでいることを特徴とする請求項26に記載の医療機器。
- 前記一以上の穴は、所定の分布計画に従って前記表面上に前記治療薬を分布させるために、所定のパターンで前記表面に配置されていることを特徴とする請求項26または27に記載の医療機器。
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US20100036502A1 (en) | 2010-02-11 |
EP2326356B1 (en) | 2017-10-11 |
WO2010017451A2 (en) | 2010-02-11 |
EP2326356A2 (en) | 2011-06-01 |
US20130138213A1 (en) | 2013-05-30 |
US20130138212A1 (en) | 2013-05-30 |
JP5878369B2 (ja) | 2016-03-08 |
US9005696B2 (en) | 2015-04-14 |
EP2326356A4 (en) | 2013-12-04 |
WO2010017451A3 (en) | 2010-07-01 |
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