JP2010202269A - Reaction card manufacturing device - Google Patents

Reaction card manufacturing device Download PDF

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Publication number
JP2010202269A
JP2010202269A JP2009052539A JP2009052539A JP2010202269A JP 2010202269 A JP2010202269 A JP 2010202269A JP 2009052539 A JP2009052539 A JP 2009052539A JP 2009052539 A JP2009052539 A JP 2009052539A JP 2010202269 A JP2010202269 A JP 2010202269A
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Prior art keywords
carrier
reaction
card
container
dispensing
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Shinya Matsuyama
真也 松山
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Beckman Coulter Inc
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Beckman Coulter Inc
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Priority to JP2009052539A priority Critical patent/JP2010202269A/en
Priority to PCT/JP2010/053347 priority patent/WO2010101151A1/en
Publication of JP2010202269A publication Critical patent/JP2010202269A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00—Mixers with rotating receptacles
    • B01F29/30—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles
    • B01F29/31—Mixing the contents of individual packages or containers, e.g. by rotating tins or bottles the containers being supported by driving means, e.g. by rotating rollers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/28—Moving reactors, e.g. rotary drums
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00038—Processes in parallel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0429—Sample carriers adapted for special purposes
    • G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes

Abstract

<P>PROBLEM TO BE SOLVED: To provide a reaction card manufacturing device for manufacturing a reaction card for improving a precision of analysis. <P>SOLUTION: A reaction card manufacturing device 1 includes a holding part 15 for rotating carrier holding containers 18 for holding carriers accommodated in reaction containers 31 to stir the carrier accommodated in the carrier holding containers 18, a deaeration piping 181 for reducing a pressure in an internal space of the carrier holding containers 18, and a dispensing mechanism 17 for dispensing the carrier into the reaction containers 31 while stirring the carrier and reducing the pressure. Because the carrier is dispensed into the reaction containers 31 of reaction cards 3 while stirring the carrier and reducing the pressure, the reaction card 3 where no bubble is mixed into the carrier can be created, and the reaction card 3 that can perform a high-precision analysis can be manufactured. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

本発明は、免疫学的凝集反応を行う複数の反応容器を有する反応カードの製造方法に関するものである。   The present invention relates to a method for producing a reaction card having a plurality of reaction vessels for performing an immunological agglutination reaction.

従来、血漿、血球または血清などの検体を免疫学的に分析する分析方法においては、検査内容に対応した試薬を専用の反応カード内の反応容器で検体と混和して反応させ、必要に応じてインキュベーションを行った後、その反応カードを遠心器で遠心することによって生じる反応像から凝集の有無を確認し、検体と試薬との凝集反応パターンをもとに検体が抗体または抗原に対して陰性であるか陽性であるかを判定する。   Conventionally, in an analysis method for immunologically analyzing a sample such as plasma, blood cells, or serum, a reagent corresponding to the test content is mixed with the sample in a reaction container in a dedicated reaction card and reacted. After incubation, the presence or absence of agglutination is confirmed from the reaction image generated by centrifuging the reaction card with a centrifuge. The sample is negative for antibody or antigen based on the agglutination pattern of the sample and reagent. Determine if it is positive or negative.

ところで、上述した反応カードの反応容器は、検体と試薬とを混合させて免疫学的凝集反応を行なわせる反応部と、反応部下部に連結され、免疫学的凝集反応を行なわせた反応液を、反応液の大きさに応じて移動度を変化させる担体を収容した分析部とを有している。分析部に収容する担体において、担体内に気泡が混入すると、気泡を凝集と誤判定する、または反応液の担体内へ移動度が変化する等、分析の結果に影響を及ぼすという問題があり、反応容器内に収容された担体内に気泡が混入していないことが望まれている。この問題に対し、気泡の混入を防ぐ方法として、混合物を収容した容器内を陰圧に設定して、脱気を行う製造方法が開示されている（例えば、特許文献１参照）。   By the way, the reaction container of the above-mentioned reaction card includes a reaction part that mixes a sample and a reagent to perform an immunological agglutination reaction, and a reaction solution that is connected to the lower part of the reaction part and that performs the immunological agglutination reaction. And an analysis unit containing a carrier whose mobility is changed according to the size of the reaction solution. In the carrier housed in the analysis unit, if bubbles are mixed in the carrier, there is a problem that the analysis results are affected, such as misjudging the bubbles as aggregation or the mobility of the reaction solution changes into the carrier, It is desired that bubbles are not mixed in the carrier accommodated in the reaction vessel. In order to prevent this problem, a manufacturing method is disclosed in which degassing is performed by setting the inside of the container containing the mixture to a negative pressure as a method for preventing the mixture of bubbles (for example, see Patent Document 1).

特開２００８−１４２０４８号公報JP 2008-144208 A

しかしながら、特許文献１に示す製造方法では、脱気処理を行いながら分注処理を行なう機構がないため、数時間を要する担体の分注においては、分注時に担体内に気泡が混入するおそれがあった。   However, in the manufacturing method shown in Patent Document 1, there is no mechanism for performing a dispensing process while performing a deaeration process. Therefore, in the dispensing of a carrier that requires several hours, there is a possibility that bubbles are mixed in the carrier at the time of dispensing. there were.

本発明は、上記に鑑みてなされたものであって、分析精度を向上させる反応カードの製造を行う反応カード製造装置を提供することを目的とする。   This invention is made | formed in view of the above, Comprising: It aims at providing the reaction card manufacturing apparatus which manufactures the reaction card which improves analysis accuracy.

上述した課題を解決し、目的を達成するために、本発明は、担体を収容する反応容器を少なくとも１つ以上有する反応カードを製造する反応カード製造装置において、前記反応容器に収容される前記担体を保持する担体保持容器を回転させ、該担体保持容器に収容された前記担体の攪拌を行なう攪拌手段と、前記担体保持容器の内部空間を減圧する減圧手段と、前記攪拌手段による攪拌と前記減圧手段よる減圧とを行ないつつ、前記担体を前記反応容器に分注する分注手段と、を備えたことを特徴とする。   In order to solve the above-described problems and achieve the object, the present invention provides a reaction card manufacturing apparatus for manufacturing a reaction card having at least one reaction container for storing a carrier, and the carrier accommodated in the reaction container. A carrier holding container for holding the carrier, stirring means for stirring the carrier housed in the carrier holding container, pressure reducing means for reducing the internal space of the carrier holding container, stirring by the stirring means and the pressure reduction Dispensing means for dispensing the carrier into the reaction vessel while performing pressure reduction by the means.

また、本発明にかかる反応カード製造装置は、上記の発明において、前記担体保持容器は、密閉可能な筒状であって、上端開口部に開閉可能な蓋と、底部に設けられた管状の、前記担体を取り出す取出管と、を有し、前記攪拌手段は、前記担体保持容器を収納し、底部に前記取出管を貫通させる孔を有する収納部と、前記収納部の側面に設けられた歯合部と、前記歯合部と歯合するギアを有する駆動部と、を備え、前記駆動部の駆動によるギアの駆動によって、該ギアが歯合している前記歯合部に動力を伝達させることで前記収納部を回転させ、前記担体保持容器に収容された前記担体を攪拌することを特徴とする。   Further, in the reaction card manufacturing apparatus according to the present invention, in the above invention, the carrier holding container has a cylindrical shape that can be sealed, a lid that can be opened and closed at an upper end opening, and a tubular shape provided at the bottom. A take-out pipe for taking out the carrier, and the stirring means contains the carrier holding container and has a housing part having a hole through which the take-out pipe penetrates, and a tooth provided on a side surface of the storage part And a drive unit having a gear meshing with the meshing part, and driving the gear by driving the drive part transmits power to the meshing part meshed with the gear. Thus, the storage portion is rotated to stir the carrier accommodated in the carrier holding container.

また、本発明にかかる反応カード製造装置は、上記の発明において、前記担体保持容器は、密閉可能な筒状であって、上端開口部に開閉可能な蓋と、底部に設けられた管状の、前記担体を取り出す取出管と、前記担体保持容器外周に形成された歯合部と、を備え、前記攪拌手段は、前記歯合部に動力を伝達させることで、該担体保持容器に収容された前記担体を攪拌することを特徴とする。   Further, in the reaction card manufacturing apparatus according to the present invention, in the above invention, the carrier holding container has a cylindrical shape that can be sealed, a lid that can be opened and closed at an upper end opening, and a tubular shape provided at the bottom. An extraction tube for taking out the carrier; and a meshing portion formed on the outer periphery of the carrier holding container; and the stirring means is accommodated in the carrier holding container by transmitting power to the meshing portion. The carrier is stirred.

また、本発明にかかる反応カード製造装置は、上記の発明において、前記減圧手段は、前記蓋に配置された脱気配管を介して前記担体保持容器内の脱気を行なうことを特徴とする。   In the reaction card manufacturing apparatus according to the present invention as set forth in the invention described above, the decompression means performs deaeration in the carrier holding container through a deaeration pipe disposed on the lid.

また、本発明にかかる反応カード製造装置は、上記の発明において、前記分注手段は、前記担体保持容器の前記取出管に接続された分注配管を介して前記反応容器に分注することを特徴とする。   In the reaction card manufacturing apparatus according to the present invention, in the above invention, the dispensing means dispenses the reaction container via the dispensing pipe connected to the take-out pipe of the carrier holding container. Features.

また、本発明にかかる反応カード製造装置は、上記の発明において、前記担体保持容器は、前記反応容器に収容する前記担体の種別に対応して設けられ、前記分注手段は、各担体保持容器に対応して接続された前記分注配管によって各反応容器に前記担体の分注を行なうことを特徴とする。   Further, in the reaction card manufacturing apparatus according to the present invention, in the above invention, the carrier holding container is provided corresponding to a type of the carrier accommodated in the reaction container, and the dispensing means includes each carrier holding container. The carrier is dispensed to each reaction vessel by the dispensing pipe connected corresponding to the above.

また、本発明にかかる反応カード製造装置は、上記の発明において、担体収容前の反応カードを収容し、前記反応カードを供給するカード供給部と、前記分注手段による前記担体の分注が終了した前記反応カードに対して、前記反応容器を封止する封止部材および前記反応カードに関する情報が記載されたシールを貼付する貼付部と、前記貼付部によって前記封止部材および前記シールが貼付された前記反応カードを梱包する梱包部と、前記カード供給部と前記梱包部との間の前記反応カードの搬送を行なうカード搬送手段と、をさらに備えたことを特徴とする。   In the reaction card manufacturing apparatus according to the present invention, in the above invention, the reaction card before receiving the carrier is stored, the card supply unit for supplying the reaction card, and the dispensing of the carrier by the dispensing means is completed. The sealing member and the seal are affixed to the reaction card, the affixing part for affixing the sealing member that seals the reaction container and the information on the reaction card, and the affixing part. The apparatus further comprises a packing section for packing the reaction card, and a card transfer means for transferring the reaction card between the card supply section and the packing section.

本発明によれば、反応容器に収容された担体内に気泡が混入しないようにしたため、分析精度を向上させ、安定した分析を行うことが可能となるという効果を奏する。   According to the present invention, since bubbles are not mixed in the carrier accommodated in the reaction container, the analysis accuracy is improved and stable analysis can be performed.

以下、図面を参照して、この発明の実施の形態である反応カードについて説明する。なお、この実施の形態によりこの発明が限定されるものではない。また、図面の記載において、同一部分には同一の符号を付している。なお、以下の説明で参照する図面は模式的なものであって、同じ物体を異なる図面で示す場合には、寸法や縮尺等が異なる場合もある。   A reaction card according to an embodiment of the present invention will be described below with reference to the drawings. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals. Note that the drawings referred to in the following description are schematic, and when the same object is shown in different drawings, dimensions, scales, and the like may be different.

（実施の形態１）
図１は、本発明の実施の形態１にかかる反応カード製造装置１を示す模式図である。図１に示す反応カード製造装置１は、大別して、反応カード３を複数枚収容し、カード搬送ライン１０に反応カード３を供給するカード供給部１１と、搬送された反応カード３の反応容器３１に単体を分注する分注部１２と、反応カード３の各反応容器３１の開口部を封止する封止部材および識別用のバーコードやロット番号、有効年月日等が印刷されているとともに、検体の情報や反応結果の記載欄を有する情報シートを反応カード３に貼付する貼付部１３と、貼付部１３から搬送された反応カード３の梱包を行なうカード梱包部１４とを有する製造部１ａと、製造部１ａを含む反応カード製造装置１全体の制御を行なう制御部１ｂとで構成される。 (Embodiment 1)
FIG. 1 is a schematic diagram showing a reaction card manufacturing apparatus 1 according to a first embodiment of the present invention. The reaction card manufacturing apparatus 1 shown in FIG. 1 is roughly divided into a plurality of reaction cards 3, a card supply unit 11 that supplies the reaction card 3 to the card transport line 10, and a reaction container 31 of the transported reaction card 3. A dispensing part 12 for dispensing a single substance, a sealing member for sealing the opening of each reaction container 31 of the reaction card 3, a barcode for identification, a lot number, an effective date, etc. are printed. In addition, a manufacturing unit having an affixing unit 13 for affixing an information sheet having a description column of sample information and reaction results to the reaction card 3 and a card packing unit 14 for packing the reaction card 3 conveyed from the affixing unit 13 1a and a control unit 1b that controls the entire reaction card manufacturing apparatus 1 including the manufacturing unit 1a.

カード供給部１１は、反応カード３を複数枚整列して収容され、順次カード搬送ライン１０に反応カード３を送り込む。反応カード３は、図示しない駆動部によってカード供給部１１内を移動して、カード搬送ライン１０まで移送される。   The card supply unit 11 accommodates a plurality of reaction cards 3 in an aligned manner, and sequentially sends the reaction cards 3 to the card transport line 10. The reaction card 3 moves through the card supply unit 11 by a drive unit (not shown) and is transferred to the card transport line 10.

分注部１２は、担体を収容する担体保持容器１８を保持する保持部１５と、各担体保持容器１８底部に接続された分注配管１６を連結し、反応カード３の各反応容器３１内に担体の分注を行なう分注機構１７とを備える。また、各担体保持容器１８は、保持部１５に列をなして設けられた各容器収納部１５２に収納され、容器収納部１５２側面には、歯合部１５３が形成されている。容器収納部１５２が、モータの回転駆動によるギア１９１の回転によって歯合部１５３に動力が伝達されて回転することで、収納している担体保持容器１８を回転させ、担体保持容器１８内に収容されている担体の攪拌を行なう。ここで、各担体保持容器１８上部には脱気配管１８１が接続され、ポンプ２０による吸気によって担体保持容器１８内部の減圧を行なう。   The dispensing unit 12 connects the holding unit 15 that holds the carrier holding container 18 that stores the carrier and the dispensing pipe 16 connected to the bottom of each carrier holding container 18, and is connected to each reaction container 31 of the reaction card 3. And a dispensing mechanism 17 for dispensing the carrier. In addition, each carrier holding container 18 is stored in each container storage unit 152 provided in a row in the holding unit 15, and an engagement portion 153 is formed on the side surface of the container storage unit 152. The container storage unit 152 rotates when the power is transmitted to the meshing unit 153 by the rotation of the gear 191 driven by the rotation of the motor, so that the stored carrier holding container 18 is rotated and stored in the carrier holding container 18. Stir the supported carrier. Here, a deaeration pipe 181 is connected to the upper part of each carrier holding container 18, and the inside of the carrier holding container 18 is depressurized by suction by the pump 20.

貼付部１３は、カード搬送ライン１０によって搬送される担体を収容した反応カード３の各反応容器３１の上部開口部を封止する封止部材を貼付する。また、反応カード３の本体部に、識別用のバーコードやロット番号、有効年月日等が印刷されているとともに、検体の情報や反応結果の記載欄を有する情報シートを貼付する。   The affixing unit 13 affixes a sealing member that seals the upper opening of each reaction container 31 of the reaction card 3 containing the carrier conveyed by the card conveyance line 10. In addition, an identification sheet, a lot number, an effective date, and the like are printed on the main body of the reaction card 3 and an information sheet having a column for sample information and reaction results is pasted.

カード梱包部１４は、カード搬送ライン１０によって搬送される封止部材および情報シートが貼付された反応カード３を、所定数毎にまとめ、梱包する。梱包された反応カード３は、図示しない保管庫へと送られる。   The card packing unit 14 collects and packs the reaction cards 3 to which a sealing member and an information sheet conveyed by the card conveying line 10 are attached every predetermined number. The packed reaction card 3 is sent to a storage (not shown).

以上のように構成された反応カード製造装置１では、制御部１ｂの制御のもと、列をなして順次搬送される複数の反応カード３に対して、分注部１２が反応カード３の各反応容器３１に担体を分注した後、貼付部１３が反応カード３の各反応容器３１を封止する封止部材を貼付して反応容器３１を密閉し、カード梱包部１４が各反応カード３を梱包することで反応カードの製造が自動的に行なわれる。   In the reaction card manufacturing apparatus 1 configured as described above, the dispensing unit 12 is provided for each of the reaction cards 3 with respect to the plurality of reaction cards 3 that are sequentially conveyed in a row under the control of the control unit 1b. After dispensing the carrier into the reaction container 31, the affixing unit 13 affixes a sealing member that seals each reaction container 31 of the reaction card 3 to seal the reaction container 31, and the card packing unit 14 provides each reaction card 3. The reaction card is automatically manufactured by packing the card.

ここで、分注部１２について、図２を参照して説明する。図２は、分注部１２を模式的に示す模式図である。図２に示す分注部１２は、担体保持容器１８を収納し、モータ１９を有するブロック１５１で構成される保持部１５と、反応カード３が有する反応容器３１の数に応じて設けられた分注ノズル１７２を有する分注機構１７と、担体保持容器１８底部に連結され、分注機構１７と接続された分注配管１６とを有する。分注配管１６は、電磁弁１６ａ，１６ｂと、シリンジポンプ１６１とを有し、このシリンジポンプ１６１によって担体保持容器１８内の担体を吸引して、分注ノズル１７２に送り込み、分注機構１７は、所定位置に搬送された反応カード３の各反応容器３１に担体を所定量分注する。電磁弁１６ａは、シリンジポンプ１６１が各担体保持容器１８内の担体を吸引する場合に開放され、シリンジポンプ１６１が吸引した担体を分注ノズル１７２から吐出する場合に閉鎖される。また、電磁弁１６ｂは、シリンジポンプ１６１が各担体保持容器１８内の担体を吸引する場合に閉鎖され、シリンジポンプ１６１が吸引した担体を分注ノズル１７２から吐出する場合に開放される。電磁弁１６ａ，１６ｂは、図１に示す制御部１ｂの制御によって切り替えられ、各担体保持容器１８内の担体を各反応容器３１に分注する。この電磁弁の切り替えによって、担体保持容器１８内を減圧しながら反応容器３１への分注を行なうことが可能となる。また、各担体保持容器１８上部には脱気配管１８１が接続され、図示しない制御部の制御のもと、ポンプ２０による吸気によって担体保持容器１８内部の減圧を行なう。   Here, the dispensing unit 12 will be described with reference to FIG. FIG. 2 is a schematic diagram schematically showing the dispensing unit 12. The dispensing unit 12 shown in FIG. 2 accommodates the carrier holding container 18 and is provided in accordance with the number of the holding unit 15 configured by the block 151 having the motor 19 and the number of reaction containers 31 included in the reaction card 3. It has a dispensing mechanism 17 having a dispensing nozzle 172 and a dispensing pipe 16 connected to the bottom of the carrier holding container 18 and connected to the dispensing mechanism 17. The dispensing pipe 16 includes electromagnetic valves 16a and 16b and a syringe pump 161. The syringe pump 161 sucks the carrier in the carrier holding container 18 and sends it to the dispensing nozzle 172. The dispensing mechanism 17 Then, a predetermined amount of carrier is dispensed into each reaction vessel 31 of the reaction card 3 conveyed to a predetermined position. The electromagnetic valve 16a is opened when the syringe pump 161 sucks the carrier in each carrier holding container 18, and is closed when the carrier sucked by the syringe pump 161 is discharged from the dispensing nozzle 172. The electromagnetic valve 16 b is closed when the syringe pump 161 sucks the carrier in each carrier holding container 18 and is opened when the carrier sucked by the syringe pump 161 is discharged from the dispensing nozzle 172. The electromagnetic valves 16 a and 16 b are switched by the control of the control unit 1 b shown in FIG. 1 and dispense the carrier in each carrier holding container 18 into each reaction vessel 31. By switching the electromagnetic valve, it is possible to dispense the reaction container 31 while reducing the pressure inside the carrier holding container 18. In addition, a deaeration pipe 181 is connected to the upper part of each carrier holding container 18, and the inside of the carrier holding container 18 is depressurized by intake of the pump 20 under the control of a control unit (not shown).

図２において、担体保持容器１８が容器収納部１５２に収納され、分注配管１６と脱気配管１８１とが接続されると、図示しない駆動部によってモータ１９が駆動し、ギア１９１が回転する。ギア１９１の回転によって、隣接して歯合された歯合部１５３に動力が伝達され、歯合部１５３が回転し、この回転に従って容器収納部１５２が回転する。なお、歯合部１５３を隣接して配置することによって隣り合う容器収納部１５２を回転させることが可能となる。容器収納部１５２が回転すると、内部に収納されている担体保持容器１８が回転し、担体保持容器１８の内部に収容されている担体が回転攪拌され、担体を均一に攪拌することができる。また、各容器収納部１５２の回転は、隣接するギアまたは容器収納部と逆方向に回転する。ここで、担体保持容器１８は、底部に分注配管１６を接続し、シリンジポンプ１６１における図示しない駆動部によるピストン１６３の駆動によってシリンジ１６２の内部圧力が変化し、分注配管１６を介して担体保持容器１８内部の担体を吸引することができる。その後、分注配管１６を接続し、分注ノズル１７２に担体を送り込む接続部１７１を支持する板状部材１７３が、図示しない駆動部によって昇降されることで、各分注ノズル１７２が、各反応容器３１内部に挿入されて、反応容器３１に担体の分注を行なう。   In FIG. 2, when the carrier holding container 18 is stored in the container storage unit 152 and the dispensing pipe 16 and the deaeration pipe 181 are connected, the motor 19 is driven by the driving unit (not shown) and the gear 191 is rotated. By the rotation of the gear 191, power is transmitted to the adjacent meshing portion 153, the meshing portion 153 rotates, and the container storage portion 152 rotates according to this rotation. In addition, it becomes possible to rotate the adjacent container accommodating part 152 by arrange | positioning the meshing part 153 adjacent. When the container storage unit 152 rotates, the carrier holding container 18 housed therein rotates, and the carrier housed inside the carrier holding container 18 is rotated and stirred, so that the carrier can be stirred uniformly. Further, the rotation of each container storage unit 152 rotates in the opposite direction to the adjacent gear or container storage unit. Here, the carrier holding container 18 is connected to the dispensing pipe 16 at the bottom, and the internal pressure of the syringe 162 is changed by the driving of the piston 163 by the drive unit (not shown) in the syringe pump 161, and the carrier holding container 18 is connected to the carrier via the dispensing pipe 16. The carrier inside the holding container 18 can be sucked. Thereafter, the plate-like member 173 supporting the connecting portion 171 that connects the dispensing pipe 16 and feeds the carrier to the dispensing nozzle 172 is moved up and down by a drive unit (not shown), so that each dispensing nozzle 172 has each reaction. The carrier is inserted into the container 31 and the carrier is dispensed into the reaction container 31.

また、図３は、図１，２に示す反応カード３を模式的に示す斜視図である。反応カード３は、カード状をなす本体部３０と、本体部の上端平面部に開口を有する反応容器３１と、本体部３０に貼付され、識別用のバーコードやロット番号、有効年月日等が印刷されているとともに、検体の情報や反応結果の記載欄を有するシール３４とを有する。反応容器３１は、略円筒形状をなし、検体と試薬とを反応させる反応部３２と、反応部３２の底部に連通して設けられ、反応の結果に応じた凝集の有無を判定するための反応像を生じさせる担体としてゲル、ガラスビーズまたはプラスチックビーズが充填されて、検体と試薬との抗原抗体反応による反応液を遠心器によって遠心したものを保持する分析部３３とを有する。反応カード３は、半透明の樹脂を用いて形成されている。分析部３３における凝集像は、目視または撮像によって確認される。また、本体部３０の上部平面は、封止部材３５によって各反応容器３１の上部開口部を封止され、各反応容器３１内部の密閉性が保たれている。反応カード３を使用する場合は、封止部材３５を剥がすか、若しくは開口部分を穿孔することによって、反応容器３１内に検体及び試薬を分注して使用する。   FIG. 3 is a perspective view schematically showing the reaction card 3 shown in FIGS. The reaction card 3 is a card-shaped main body 30, a reaction container 31 having an opening in the upper flat surface of the main body, and a sticker attached to the main body 30. An identification barcode, lot number, effective date, etc. Is printed, and a seal 34 having a column for describing specimen information and reaction results. The reaction container 31 has a substantially cylindrical shape and is provided in communication with a reaction part 32 for reacting a specimen and a reagent and a bottom part of the reaction part 32, and a reaction for determining the presence or absence of aggregation according to the result of the reaction. It has an analysis section 33 that holds gel, glass beads, or plastic beads as a carrier for generating an image, and holds a reaction solution obtained by antigen-antibody reaction between a specimen and a reagent, which is centrifuged by a centrifuge. The reaction card 3 is formed using a translucent resin. The aggregated image in the analysis unit 33 is confirmed by visual observation or imaging. Further, the upper flat surface of the main body 30 is sealed at the upper opening of each reaction vessel 31 by the sealing member 35, and the hermeticity inside each reaction vessel 31 is maintained. When the reaction card 3 is used, the specimen and reagent are dispensed into the reaction container 31 by peeling off the sealing member 35 or perforating the opening.

ここで、保持部１５について、図４を参照して説明する。図４は、図１，２に示す分注部１２の保持部１５を模式的に示す模式図である。図４において、ブロック１５１の一方の端部側下方にはモータ１９が設けられ、モータ１９は、モータ１９上部に接続され、ブロック１５１を貫通してギア１９１を支持してモータ１９の回転動力をギア１９１に伝達する棒状部材１９２を有する。また、ブロック１５１には、円筒状の孔が形成され、ブロック１５１の上部平面であって、孔の外周近傍に環状のベアリング１５４が設けられている。さらに、ベアリング１５４上部には、内部に空間領域を形成し、空間領域に担体保持容器１８を収納する、円筒状の容器収納部１５２が配置され、容器収納部１５２外周には歯合部１５３が形成されている。   Here, the holding | maintenance part 15 is demonstrated with reference to FIG. FIG. 4 is a schematic diagram schematically showing the holding unit 15 of the dispensing unit 12 shown in FIGS. In FIG. 4, a motor 19 is provided below one end of the block 151, and the motor 19 is connected to the upper part of the motor 19, and passes through the block 151 to support the gear 191, thereby rotating the motor 19. A rod-shaped member 192 that transmits to the gear 191 is provided. In addition, a cylindrical hole is formed in the block 151, and an annular bearing 154 is provided on the upper plane of the block 151 and in the vicinity of the outer periphery of the hole. Further, a cylindrical container storage portion 152 that forms a space region inside and stores the carrier holding container 18 in the space region is disposed above the bearing 154, and a meshing portion 153 is provided on the outer periphery of the container storage portion 152. Is formed.

また、担体保持容器１８は、大別して、上部に開口部を有し、担体Ｃを収容する担体収容部１８２と、担体収容部１８２の上部開口部を密閉する蓋１８３とで構成される。ここで、担体収容部１８２底部中央部には、送液管１８５が接続されており、送液管１８５外周と担体収容部１８２との間はベアリング１８４によって接続されている。同様に、蓋１８３においても、蓋１８３中央部に排気管１８６が接続され、排気管１８６外周は、ベアリング１８４を介して蓋１８３と接続されている。なお、送液管１８５は、担体保持容器１８が容器収納部１５２に収納された場合に、容器収納部１５２およびブロック１５１に形成された孔に挿入される。上述した構成が、担体保持容器１８に対応して複数設けられ、ギア１９１と歯合した歯合部１５３が、モータ１９の駆動によるギア１９１の回転動力を受けて回転することで、隣接する歯合部１５３に動力を伝達する。歯合部１５３の回転に従って容器収納部１５２が回転することによって、担体保持容器１８も回転し、担体保持容器１８内に収容された担体Ｃが攪拌される。なお、容器収納部１５２の回転動力は、ベアリング１５４によってブロック１５１に伝達されない。   The carrier holding container 18 is roughly divided into a carrier accommodating portion 182 that has an opening in the upper portion and that accommodates the carrier C, and a lid 183 that seals the upper opening of the carrier accommodating portion 182. Here, a liquid feeding pipe 185 is connected to the bottom central part of the carrier accommodating part 182, and the outer periphery of the liquid feeding pipe 185 and the carrier accommodating part 182 are connected by a bearing 184. Similarly, in the lid 183, an exhaust pipe 186 is connected to the center of the lid 183, and the outer periphery of the exhaust pipe 186 is connected to the lid 183 via a bearing 184. In addition, when the carrier holding container 18 is stored in the container storage unit 152, the liquid feeding tube 185 is inserted into the holes formed in the container storage unit 152 and the block 151. A plurality of the above-described configurations are provided corresponding to the carrier holding container 18, and the meshing portion 153 that meshes with the gear 191 rotates by receiving the rotational power of the gear 191 driven by the motor 19, so that adjacent teeth Power is transmitted to the joint portion 153. As the container storage unit 152 rotates in accordance with the rotation of the meshing unit 153, the carrier holding container 18 also rotates, and the carrier C stored in the carrier holding container 18 is stirred. In addition, the rotational power of the container storage unit 152 is not transmitted to the block 151 by the bearing 154.

上述した構成によって、モータ１９の動力をギア１９１が担体保持容器１８の歯合部１５３に伝達することによる担体Ｃの回転攪拌と、排気管１８６による減圧処理と、送液管１８５による分注処理とを同時に行なうことで、気泡を除去した担体Ｃを安定して反応容器に供給することができる。   With the configuration described above, the gear C 191 transmits the power of the motor 19 to the meshing portion 153 of the carrier holding container 18, rotational stirring of the carrier C, decompression processing using the exhaust pipe 186, and dispensing processing using the liquid feeding pipe 185. The carrier C from which bubbles have been removed can be stably supplied to the reaction vessel.

つづいて、図５は、担体保持容器１８が容器収納部１５２に収容された場合を示す模式図である。容器収納部１５２に収納された担体保持容器１８には、送液管１８５に分注配管１６が接続され、排気管１８６に脱気配管１８１が接続される。送液管１８５に連結された分注配管１６は、容器収納部１５２およびブロック１５１に形成された孔を介してブロック１５１底部から図１，２に示す分注機構１７まで延伸される。また、脱気配管１８１は、図１，２に示すように、一方がポンプ２０に連結され、担体保持容器１８内部の減圧を行なう。また、ベアリング１８４によって、担体保持容器１８が回転した場合でも送液管１８５および排気管１８６は回転しないため、分注配管１６および脱気配管１８１へ回転の動力が伝達されない。   FIG. 5 is a schematic diagram showing a case where the carrier holding container 18 is accommodated in the container accommodating portion 152. In the carrier holding container 18 stored in the container storage unit 152, the dispensing pipe 16 is connected to the liquid feeding pipe 185, and the deaeration pipe 181 is connected to the exhaust pipe 186. Dispensing pipe 16 connected to liquid feeding pipe 185 extends from the bottom of block 151 to dispensing mechanism 17 shown in FIGS. 1 and 2 through a hole formed in container storage section 152 and block 151. As shown in FIGS. 1 and 2, one of the deaeration pipes 181 is connected to the pump 20 to reduce the pressure inside the carrier holding container 18. Further, even when the carrier holding container 18 is rotated by the bearing 184, the liquid supply pipe 185 and the exhaust pipe 186 do not rotate, so that the rotational power is not transmitted to the dispensing pipe 16 and the deaeration pipe 181.

ここで、図２に示すポンプ２０とシリンジポンプ１６１との各圧力は、ポンプ２０の圧力が、シリンジポンプ１６１の圧力と比して低いことが好ましい。特に、ポンプ２０の吸引圧力が−４０ｋＰａ〜−８０ｋＰａであって、シリンジポンプ１６１の吸引圧力が−１００ｋＰａ〜−１５０ｋＰａであることが好ましい。なお、上記範囲内であれば、ポンプ２０とシリンジポンプ１６１との各吸引圧力は、如何なる組み合わせでもよい。また、分注時以外に送液管１８５による分注配管１６または外部への担体Ｃの流出を防ぐため、送液管１８５に、圧力変化によって開閉する蓋を設けることが好ましく、分注配管１６が接続された場合に開放可能な開閉機構を送液管１８５の外部側先端に設けてもよい。ここで、開閉機構は、分注配管１６が接続されて送液管１８５が開放された場合であっても、分注配管１６の内部圧力によって担体Ｃの流出を防止し、シリンジポンプ１６１の駆動によってのみ担体Ｃが放出されることが好ましい。   Here, each pressure of the pump 20 and the syringe pump 161 shown in FIG. 2 is preferably lower than the pressure of the syringe pump 161. In particular, the suction pressure of the pump 20 is preferably −40 kPa to −80 kPa, and the suction pressure of the syringe pump 161 is preferably −100 kPa to −150 kPa. In addition, if it is in the said range, each suction pressure of the pump 20 and the syringe pump 161 may be any combination. Further, in order to prevent the dispensing pipe 16 through the liquid feeding pipe 185 or outflow of the carrier C to the outside other than at the time of dispensing, the liquid feeding pipe 185 is preferably provided with a lid that opens and closes due to pressure change. An open / close mechanism that can be opened when is connected may be provided at the outer end of the liquid feeding pipe 185. Here, the opening / closing mechanism prevents the carrier C from flowing out by the internal pressure of the dispensing pipe 16 even when the dispensing pipe 16 is connected and the liquid feeding pipe 185 is opened, and the syringe pump 161 is driven. It is preferred that the carrier C is released only by

また、攪拌の効率を向上させるために加温する場合は、担体Ｃ中の内容物の活性が失活しない温度以下であれば加温してもよい。各容器収納部１５２に加温機構を設けることで温度調節を行なうことが可能となる。   Moreover, when heating in order to improve the efficiency of stirring, as long as it is below the temperature which the activity of the content in the support | carrier C does not deactivate, you may heat. Temperature adjustment can be performed by providing a heating mechanism in each container storage unit 152.

上述した実施の形態１にかかる反応カード製造装置は、攪拌処理、減圧処理および分注処理を同時に行なうことで、担体中の気泡を除去して反応容器内に分注することができるため、分析結果の安定した精度の高い分析を行うことが可能となる。   The reaction card manufacturing apparatus according to the first embodiment described above can remove bubbles in the carrier and dispense into the reaction container by simultaneously performing the stirring process, the decompression process, and the dispensing process. It is possible to perform a stable and accurate analysis of the results.

（実施の形態２）
図６，７は、実施の形態２にかかる反応カード製造装置の保持部を示す模式図である。図６，７に示す保持部１５において、担体保持容器１８は、担体収容部１８２側面に歯合部１８７を有し、ベアリング１５４の上部の形状に対応した凹部１８８が底部に形成されている。担体保持容器１８の凹部１８８がベアリング１５４と嵌合することによって、担体保持容器１８がブロック１５１に支持され、歯合部１８７がギア１９１若しくは隣接する担体保持容器１８の歯合部と歯合して、ギア１９１を介してモータ１９の動力が伝達され、担体保持容器１８を回転させることができる。 (Embodiment 2)
6 and 7 are schematic diagrams illustrating a holding unit of the reaction card manufacturing apparatus according to the second embodiment. In the holding part 15 shown in FIGS. 6 and 7, the carrier holding container 18 has a meshing part 187 on the side surface of the carrier accommodating part 182, and a concave part 188 corresponding to the shape of the upper part of the bearing 154 is formed in the bottom part. By fitting the recess 188 of the carrier holding container 18 with the bearing 154, the carrier holding container 18 is supported by the block 151, and the meshing portion 187 meshes with the gear 191 or the meshing portion of the adjacent carrier holding container 18. Thus, the power of the motor 19 is transmitted through the gear 191 and the carrier holding container 18 can be rotated.

また、図７に示すように、担体保持容器１８の凹部１８８がベアリング１５４と嵌合すると、送液管１８５に分注配管１６を接続し、排気管１８６に脱気配管１８１を接続する。実施の形態１と同様に、担体保持容器１８の回転動力は、ベアリング１５４，１８４によってブロック１５１、送液管１８５および排気管１８６には伝達しない。上述した構成によって、モータ１９の動力をギア１９１が担体保持容器１８の歯合部１８７に伝達することによる担体Ｃの回転攪拌と、排気管１８６による減圧処理と、送液管１８５による分注処理とを同時に行なうことで、気泡を除去した担体Ｃを安定して反応容器に供給することができる。   Further, as shown in FIG. 7, when the concave portion 188 of the carrier holding container 18 is fitted with the bearing 154, the dispensing pipe 16 is connected to the liquid feeding pipe 185 and the degassing pipe 181 is connected to the exhaust pipe 186. As in the first embodiment, the rotational power of the carrier holding container 18 is not transmitted to the block 151, the liquid feeding pipe 185 and the exhaust pipe 186 by the bearings 154 and 184. With the configuration described above, the gear C 191 transmits the power of the motor 19 to the meshing portion 187 of the carrier holding container 18, rotational stirring of the carrier C, decompression processing using the exhaust pipe 186, and dispensing processing using the liquid feeding pipe 185. The carrier C from which bubbles have been removed can be stably supplied to the reaction vessel.

実施の形態２にかかる反応カード製造装置は、担体保持容器の外周に歯合部を設けたため、簡易な構成で攪拌処理を行うことが可能となる。   Since the reaction card manufacturing apparatus according to the second embodiment is provided with the engagement portion on the outer periphery of the carrier holding container, it is possible to perform the stirring process with a simple configuration.

なお、ブロックにおける容器収納部またはベアリングの配置は、行と列との二次元の配置でもよい。また、分注配管は、金属等の剛性の高い部材を用いてもよく、ゴム等の剛性の低い部材を用いてもよい。   The arrangement of the container storage portion or the bearing in the block may be a two-dimensional arrangement of rows and columns. In addition, the dispensing pipe may be made of a highly rigid member such as metal, or may be made of a less rigid member such as rubber.

上述した実施の形態１，２にかかる反応カード製造装置は、攪拌処理および減圧処理を行いながら分注処理が可能なため、反応容器に分注した担体内に気泡が混入することを防止し、安定して精度の高い分析を行うことができる反応カードを製造することが可能となる。また、均一に攪拌された担体を反応容器に分注することができるため、内容物に試薬等が混合されている場合でも、各反応容器に均一に分注することが可能となる。   The reaction card manufacturing apparatus according to the first and second embodiments described above is capable of dispensing while performing a stirring process and a decompression process, thus preventing bubbles from being mixed into the carrier dispensed in the reaction vessel, It becomes possible to manufacture a reaction card capable of performing a stable and highly accurate analysis. In addition, since the uniformly stirred carrier can be dispensed into the reaction container, even when a reagent or the like is mixed in the contents, it can be evenly dispensed into each reaction container.

本発明の実施の形態１にかかる反応カード製造装置を示す模式図である。It is a schematic diagram which shows the reaction card manufacturing apparatus concerning Embodiment 1 of this invention. 本発明の実施の形態１にかかる分注部を模式的に示す模式図である。It is a schematic diagram which shows typically the dispensing part concerning Embodiment 1 of this invention. 図１，２に示す反応カードを模式的に示す斜視図である。It is a perspective view which shows typically the reaction card | curd shown in FIG. 図１，２に示す分注部の保持部を模式的に示す模式図である。It is a schematic diagram which shows typically the holding | maintenance part of the dispensing part shown to FIG. 本発明の実施の形態１にかかる担体保持容器が容器収納部に収容された場合を示す模式図である。It is a schematic diagram which shows the case where the carrier holding container concerning Embodiment 1 of this invention is accommodated in the container accommodating part. 実施の形態２にかかる反応カード製造装置の保持部を示す模式図である。It is a schematic diagram which shows the holding part of the reaction card manufacturing apparatus concerning Embodiment 2. 本発明の実施の形態２にかかる担体保持容器が容器収納部に収容された場合を示す模式図である。It is a schematic diagram which shows the case where the carrier holding container concerning Embodiment 2 of this invention is accommodated in the container accommodating part.

１ 反応カード製造装置
１ａ 製造部
１ｂ 制御部
３ 反応カード
１０ カード搬送ライン
１１ カード供給部
１２ 分注部
１３ 貼付部
１４ カード梱包部
１５ 保持部
１６ 分注配管
１６ａ，１６ｂ 電磁弁
１７ 分注機構
１８ 担体保持容器
１９ モータ
２０ ポンプ
３０ 本体部
３１ 反応容器
３２ 反応部
３３ 分析部
３４ シール
３５ 封止部材
１５１ ブロック
１５２ 容器収納部
１５３，１８７ 歯合部
１５４，１８４ ベアリング
１６１ シリンジポンプ
１６２ シリンジ
１６３ ピストン
１７１ 接続部
１７２ 分注ノズル
１７３ 板状部材
１８１ 脱気配管
１８２ 担体収容部
１８３ 蓋
１８５ 送液管
１８６ 排気管
１９１ ギア
１９２ 棒状部材
Ｃ 担体 DESCRIPTION OF SYMBOLS 1 Reaction card manufacturing apparatus 1a Manufacturing part 1b Control part 3 Reaction card 10 Card conveyance line 11 Card supply part 12 Dispensing part 13 Pasting part 14 Card packing part 15 Holding part 16 Dispensing piping 16a, 16b Electromagnetic valve 17 Dispensing mechanism 18 Carrier holding container 19 Motor 20 Pump 30 Body part 31 Reaction container 32 Reaction part 33 Analysis part 34 Seal 35 Sealing member 151 Block 152 Container storage part 153,187 Intersection part 154,184 Bearing 161 Syringe pump 162 Syringe 163 Piston 171 Connection Portion 172 Dispensing nozzle 173 Plate member 181 Deaeration pipe 182 Carrier housing portion 183 Lid 185 Liquid feed pipe 186 Exhaust pipe 191 Gear 192 Rod member C Carrier

Claims (7)

担体を収容する反応容器を少なくとも１つ以上有する反応カードを製造する反応カード製造装置において、
前記反応容器に収容される前記担体を保持する担体保持容器を回転させ、該担体保持容器に収容された前記担体の攪拌を行なう攪拌手段と、
前記担体保持容器の内部空間を減圧する減圧手段と、
前記攪拌手段による攪拌と前記減圧手段よる減圧とを行ないつつ、前記担体を前記反応容器に分注する分注手段と、
を備えたことを特徴とする反応カード製造装置。 In a reaction card manufacturing apparatus for manufacturing a reaction card having at least one reaction container containing a carrier,
A stirring means for rotating the carrier holding container for holding the carrier contained in the reaction vessel and stirring the carrier contained in the carrier holding container;
Decompression means for decompressing the internal space of the carrier holding container;
Dispensing means for dispensing the carrier into the reaction vessel while performing stirring by the stirring means and pressure reduction by the pressure reducing means;
A reaction card manufacturing apparatus comprising: 前記担体保持容器は、密閉可能な筒状であって、
上端開口部に開閉可能な蓋と、
底部に設けられた管状の、前記担体を取り出す取出管と、
を有し、
前記攪拌手段は、
前記担体保持容器を収納し、底部に前記取出管を貫通させる孔を有する収納部と、
前記収納部の側面に設けられた歯合部と、
前記歯合部と歯合するギアを有する駆動部と、
を備え、前記駆動部の駆動によるギアの駆動によって、該ギアが歯合している前記歯合部に動力を伝達させることで前記収納部を回転させ、前記担体保持容器に収容された前記担体を攪拌することを特徴とする請求項１に記載の反応カード製造装置。 The carrier holding container has a cylindrical shape that can be sealed,
A lid that can be opened and closed at the upper end opening;
A tube provided at the bottom, and an extraction tube for taking out the carrier;
Have
The stirring means includes
A storage portion for storing the carrier holding container and having a hole through which the take-out pipe penetrates at the bottom;
A meshing portion provided on a side surface of the storage portion;
A drive unit having a gear that meshes with the meshing part;
The carrier housed in the carrier holding container by rotating the housing portion by transmitting power to the meshing portion engaged with the gear by driving the gear by driving the driving portion. The reaction card manufacturing apparatus according to claim 1, wherein the reaction card is stirred. 前記担体保持容器は、密閉可能な筒状であって、
上端開口部に開閉可能な蓋と、
底部に設けられた管状の、前記担体を取り出す取出管と、
前記担体保持容器外周に形成された歯合部と、
を備え、
前記攪拌手段は、前記歯合部に動力を伝達させることで、該担体保持容器に収容された前記担体を攪拌することを特徴とする請求項１に記載の反応カード製造装置。 The carrier holding container has a cylindrical shape that can be sealed,
A lid that can be opened and closed at the upper end opening;
A tube provided at the bottom, and an extraction tube for taking out the carrier;
A meshing portion formed on the outer periphery of the carrier holding container;
With
The reaction card manufacturing apparatus according to claim 1, wherein the agitation unit agitates the carrier contained in the carrier holding container by transmitting power to the meshing portion. 前記減圧手段は、前記蓋に配置された脱気配管を介して前記担体保持容器内の脱気を行なうことを特徴とする請求項１〜３のいずれか一つに記載の反応カード製造装置。   The reaction card manufacturing apparatus according to any one of claims 1 to 3, wherein the decompression unit performs deaeration in the carrier holding container via a deaeration pipe disposed on the lid. 前記分注手段は、前記担体保持容器の前記取出管に接続された分注配管を介して前記反応容器に分注することを特徴とする請求項１〜４のいずれか一つに記載の反応カード製造装置。   The reaction according to any one of claims 1 to 4, wherein the dispensing means dispenses the reaction container through a dispensing pipe connected to the take-out pipe of the carrier holding container. Card manufacturing equipment. 前記担体保持容器は、前記反応容器に収容する前記担体の種別に対応して設けられ、
前記分注手段は、各担体保持容器に対応して接続された前記分注配管によって各反応容器に前記担体の分注を行なうことを特徴とする請求項１〜５のいずれか一つに記載の反応カード製造装置。 The carrier holding container is provided corresponding to the type of the carrier accommodated in the reaction container,
The said dispensing means dispenses the said support | carrier to each reaction container by the said dispensing piping connected corresponding to each support | carrier holding | maintenance container. Reaction card manufacturing equipment. 担体収容前の反応カードを収容し、前記反応カードを供給するカード供給部と、
前記分注手段による前記担体の分注が終了した前記反応カードに対して、前記反応容器を封止する封止部材および前記反応カードに関する情報が記載されたシールを貼付する貼付部と、
前記貼付部によって前記封止部材および前記シールが貼付された前記反応カードを梱包する梱包部と、
前記カード供給部と前記梱包部との間の前記反応カードの搬送を行なうカード搬送手段と、
をさらに備えたことを特徴とする請求項１〜６のいずれか一つに記載の反応カード製造装置。 A card supply unit for storing the reaction card before receiving the carrier and supplying the reaction card;
An affixing unit for affixing a seal on which the information on the reaction card and the sealing member that seals the reaction container is written to the reaction card after the dispensing of the carrier by the dispensing unit is completed,
A packing portion for packing the reaction card to which the sealing member and the seal are attached by the attaching portion;
Card conveying means for conveying the reaction card between the card supply unit and the packing unit;
The reaction card manufacturing apparatus according to claim 1, further comprising:
JP2009052539A 2009-03-05 2009-03-05 Reaction card manufacturing device Withdrawn JP2010202269A (en)

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