JP2009504748A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009504748A5 JP2009504748A5 JP2008527061A JP2008527061A JP2009504748A5 JP 2009504748 A5 JP2009504748 A5 JP 2009504748A5 JP 2008527061 A JP2008527061 A JP 2008527061A JP 2008527061 A JP2008527061 A JP 2008527061A JP 2009504748 A5 JP2009504748 A5 JP 2009504748A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- tetrahydrobenzathiazole
- administration
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- FASDKYOPVNHBLU-ZETCQYMHSA-N pramipexole Chemical compound C1[C@@H](NCCC)CCC2=C1SC(N)=N2 FASDKYOPVNHBLU-ZETCQYMHSA-N 0.000 claims 2
- 229960003089 pramipexole Drugs 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000004165 myocardium Anatomy 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 210000003699 striated muscle Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Claims (8)
- R(+)エナンチオマーのエナンチオマー過剰が99%より大きい、請求項1に記載の薬学的組成物。
- 前記テトラヒドロベンザチアゾールが、プラミペキソールのR(+)エナンチオマーである、請求項1または2に記載の薬学的組成物。
- 局所投与、経皮投与、経腸投与、または非経口投与に適する、請求項1〜3のいずれか一項に記載の薬学的組成物。
- 前記テトラヒドロベンザチアゾールまたはその薬学的に受容可能な塩が、10mgと100mgとの間の単回投薬量の経腸投与のための投薬処方物で提供される、請求項4に記載の薬学的組成物。
- 前記テトラヒドロベンザチアゾールまたはその薬学的に受容可能な塩が、10mg/日と500mg/日との間の連続静脈内注入による単回投薬量の非経口投与のための投薬処方物で提供される、請求項4に記載の薬学的組成物。
- 前記投薬処方物が30mgのプラミペキソールを含む、請求項5に記載の薬学的組成物。
- 前記神経変性疾患が、アルツハイマー病、パーキンソン病または筋萎縮性側索硬化症である、請求項1〜7のいずれか一項に記載の薬学的組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70821305P | 2005-08-15 | 2005-08-15 | |
PCT/US2006/031831 WO2007022182A1 (en) | 2005-08-15 | 2006-08-15 | Neurorestoration with r(+) pramipexole |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012233610A Division JP2013014629A (ja) | 2005-08-15 | 2012-10-23 | R(+)プラミペキソールを用いた神経回復 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009504748A JP2009504748A (ja) | 2009-02-05 |
JP2009504748A5 true JP2009504748A5 (ja) | 2009-10-01 |
Family
ID=37428609
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008527061A Withdrawn JP2009504748A (ja) | 2005-08-15 | 2006-08-15 | R(+)プラミペキソールを用いた神経回復 |
JP2012233610A Pending JP2013014629A (ja) | 2005-08-15 | 2012-10-23 | R(+)プラミペキソールを用いた神経回復 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012233610A Pending JP2013014629A (ja) | 2005-08-15 | 2012-10-23 | R(+)プラミペキソールを用いた神経回復 |
Country Status (10)
Country | Link |
---|---|
US (3) | US20080234338A1 (ja) |
EP (1) | EP1917014B1 (ja) |
JP (2) | JP2009504748A (ja) |
AT (1) | ATE444750T1 (ja) |
AU (1) | AU2006279643B2 (ja) |
CA (1) | CA2619217A1 (ja) |
DE (1) | DE602006009670D1 (ja) |
ES (1) | ES2334061T3 (ja) |
IL (1) | IL189512A (ja) |
WO (1) | WO2007022182A1 (ja) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2004121177A (ru) * | 2001-12-11 | 2005-03-10 | Юниверсити Оф Вирджиния Пэйтент Фаундейшн (Us) | Применение прамипексола для лечения бокового амитрофического склероза |
US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
US20050226926A1 (en) | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
EA201001083A1 (ru) | 2004-08-13 | 2011-08-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Композиция таблетки пролонгированного высвобождения, содержащая прамипексол или его фармацевтически приемлемую соль, способ ее изготовления и ее применение |
SG164375A1 (en) | 2004-08-13 | 2010-09-29 | Boehringer Ingelheim Int | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
DE602006009670D1 (de) * | 2005-08-15 | 2009-11-19 | Univ Virginia | Neurorestauration mit r(+) pramipexol |
WO2007090882A2 (en) * | 2006-02-10 | 2007-08-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical extended release compositions comprising pramipexole |
US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
EP2497473A1 (en) * | 2006-05-16 | 2012-09-12 | Knopp Neurosciences, Inc. | Therapeutically effective amounts of R(+) and S(-) pramipexole for use in the treatment of Parkinson's disease and pharmaceutical compositions thereof |
CN101448498B (zh) | 2006-05-16 | 2011-04-27 | 诺普神经科学股份有限公司 | R(+)和s(-)普拉克索的组合物以及使用该组合物的方法 |
CN102772404A (zh) * | 2006-12-14 | 2012-11-14 | 诺普神经科学股份有限公司 | (r)-普拉克索的组合物以及使用该组合物的方法 |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
WO2008113003A1 (en) * | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Modified release formulations of (6r)-4,5,6,7-tetrahydro-n6-propyl-2,6-benzothiazole-diamine and methods of using the same |
US8519148B2 (en) | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
US20100130569A1 (en) * | 2007-05-11 | 2010-05-27 | Saten Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for posterior ocular disease comprising non-ergot selective d2 receptor agonist as active ingredient |
GB0721333D0 (en) * | 2007-10-31 | 2007-12-12 | Motac Neuroscience Ltd | Medicaments |
CN102186350A (zh) | 2008-08-19 | 2011-09-14 | 诺普神经科学股份有限公司 | 使用(r)-普拉克索的组合物与方法 |
AU2010234244A1 (en) * | 2009-04-09 | 2011-10-13 | Purdue Pharma | Once-daily oral IR/CR pramipexole formulation |
CA2765876A1 (en) * | 2009-06-19 | 2010-12-23 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
KR101799429B1 (ko) | 2010-05-03 | 2017-11-21 | 에스케이바이오팜 주식회사 | 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물 |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
EP3838271A1 (en) | 2013-07-12 | 2021-06-23 | Knopp Biosciences LLC | Treating elevated levels of eosinophils and/or basophils |
CA2921378A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
DK3033081T3 (da) | 2013-08-13 | 2021-05-31 | Knopp Biosciences Llc | Sammensætninger og fremgangsmåder til behandling af kronisk urticaria |
WO2016194015A2 (en) * | 2015-06-04 | 2016-12-08 | Chiarugi Alberto | Use of r(+)-pramipexole (dexpramipexole) for the treatment of cerebral ischemia of the focal type |
JP2020512390A (ja) * | 2017-03-27 | 2020-04-23 | チェイス セラピューティクス コーポレイション | シヌクレイノパチーを処置するための組成物および方法 |
IL312486A (en) | 2017-04-10 | 2024-07-01 | Chase Therapeutics Corp | NK1 antagonist combination and a method for the treatment of synucleinopathies |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3572485D1 (en) * | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
DE3937271A1 (de) * | 1989-11-09 | 1991-05-16 | Boehringer Ingelheim Kg | Transdermale applikation von 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazol |
US5650420A (en) * | 1994-12-15 | 1997-07-22 | Pharmacia & Upjohn Company | Pramipexole as a neuroprotective agent |
US6156777A (en) * | 1994-12-15 | 2000-12-05 | Pharmacia & Upjohn Company | Use of pramipexole as a neuroprotective agent |
CZ293360B6 (cs) * | 1995-10-26 | 2004-04-14 | Sanofi-Synthelabo | Léčivo pro léčení amyotrofické laterální sklerózy |
GB9705428D0 (en) * | 1997-03-15 | 1997-04-30 | Knoll Ag | Therapeutic agents |
US6197339B1 (en) * | 1997-09-30 | 2001-03-06 | Pharmacia & Upjohn Company | Sustained release tablet formulation to treat Parkinson's disease |
PE20000728A1 (es) * | 1998-06-26 | 2000-08-21 | Cocensys Inc | Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda |
DE19830201A1 (de) * | 1998-07-07 | 2000-01-13 | Boehringer Ingelheim Pharma | Mittel mit antidepressiver Wirkung |
CA2301899C (en) * | 1998-07-27 | 2008-11-18 | Boehringer Ingelheim Pharma Kg | Agent with an antidepressant activity |
WO2000025752A1 (en) * | 1998-11-02 | 2000-05-11 | Church, Marla, J. | Multiparticulate modified release composition |
CA2415815A1 (en) * | 2000-07-06 | 2002-01-17 | Nigel H. Greig | Tetrahydrobenzothiazole analogues as neuroprotective agents |
DE10037619A1 (de) * | 2000-08-02 | 2002-02-14 | Daimler Chrysler Ag | Anordnung von Bedienelementen |
ES2187249B1 (es) * | 2000-09-18 | 2004-09-16 | Synthon Bv | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
US20020151526A1 (en) * | 2000-10-06 | 2002-10-17 | Gallop Mark A. | Bile-acid prodrugs of L-dopa and their use in the sustained treatment of parkinsonism |
DE10137082A1 (de) * | 2001-07-28 | 2003-02-13 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
RU2004121177A (ru) * | 2001-12-11 | 2005-03-10 | Юниверсити Оф Вирджиния Пэйтент Фаундейшн (Us) | Применение прамипексола для лечения бокового амитрофического склероза |
US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
AU2002316231A1 (en) * | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
AU2003225837B2 (en) * | 2002-03-15 | 2008-11-06 | Forest Laboratories Holdings Limited | NE and 5-HT reuptake inhibitors for treating visceral pain syndromes |
US20050226926A1 (en) * | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
US20040121010A1 (en) * | 2002-10-25 | 2004-06-24 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
KR101152183B1 (ko) * | 2003-03-31 | 2012-06-15 | 타이탄 파머슈티컬즈 인코퍼레이티드 | 도파민 아고니스트의 지속 방출을 위한 이식가능한 폴리머디바이스 |
US7662987B2 (en) * | 2003-07-15 | 2010-02-16 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl compounds |
DE10333393A1 (de) * | 2003-07-23 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit dem Wirkstoff Pramipexol |
SG164375A1 (en) * | 2004-08-13 | 2010-09-29 | Boehringer Ingelheim Int | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
TW200616604A (en) * | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
DE602006009670D1 (de) * | 2005-08-15 | 2009-11-19 | Univ Virginia | Neurorestauration mit r(+) pramipexol |
-
2006
- 2006-08-15 DE DE602006009670T patent/DE602006009670D1/de active Active
- 2006-08-15 WO PCT/US2006/031831 patent/WO2007022182A1/en active Application Filing
- 2006-08-15 AT AT06801521T patent/ATE444750T1/de not_active IP Right Cessation
- 2006-08-15 JP JP2008527061A patent/JP2009504748A/ja not_active Withdrawn
- 2006-08-15 US US12/063,943 patent/US20080234338A1/en not_active Abandoned
- 2006-08-15 CA CA002619217A patent/CA2619217A1/en not_active Abandoned
- 2006-08-15 EP EP06801521A patent/EP1917014B1/en not_active Not-in-force
- 2006-08-15 AU AU2006279643A patent/AU2006279643B2/en not_active Ceased
- 2006-08-15 ES ES06801521T patent/ES2334061T3/es active Active
-
2008
- 2008-02-13 IL IL189512A patent/IL189512A/en not_active IP Right Cessation
-
2011
- 2011-05-06 US US13/102,757 patent/US20110218222A1/en not_active Abandoned
-
2012
- 2012-10-23 JP JP2012233610A patent/JP2013014629A/ja active Pending
- 2012-12-27 US US13/728,504 patent/US20130116292A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2009504748A5 (ja) | ||
JP2008545793A5 (ja) | ||
JP2003509349A5 (ja) | ||
JP2020512337A5 (ja) | ||
JP2008536844A5 (ja) | ||
JP2015505296A5 (ja) | ||
JP2013542247A5 (ja) | ||
JP2013508279A5 (ja) | ||
JP2016534063A5 (ja) | ||
JP2013510885A5 (ja) | ||
JP2009535352A5 (ja) | ||
JP2012530779A5 (ja) | ||
JP2014517050A5 (ja) | ||
JP2020505423A5 (ja) | ||
JP2007519649A5 (ja) | ||
JP2019515908A5 (ja) | ||
JP2011051993A5 (ja) | ||
JP2017511339A5 (ja) | ||
WO2008092072A3 (en) | Modulators of the metabotropic glutamate receptor subtype 5 and uses thereof | |
JP2010521417A5 (ja) | ||
JP2019516739A5 (ja) | ||
JP2007530703A5 (ja) | ||
CA2589744A1 (en) | Pyrrolinidium derivatives as m3 muscarinic receptors | |
JP2013514980A5 (ja) | ||
JP2013536833A5 (ja) |