JP2008521912A - 健康な皮膚を維持するための抗酸化栄養補助食品組成物及び方法 - Google Patents
健康な皮膚を維持するための抗酸化栄養補助食品組成物及び方法 Download PDFInfo
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- JP2008521912A JP2008521912A JP2007544460A JP2007544460A JP2008521912A JP 2008521912 A JP2008521912 A JP 2008521912A JP 2007544460 A JP2007544460 A JP 2007544460A JP 2007544460 A JP2007544460 A JP 2007544460A JP 2008521912 A JP2008521912 A JP 2008521912A
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- lycopene
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Abstract
【選択図】なし
Description
本願は、2004年12月2日に出願された、Chomczynskiの米国特許仮出願第60/632,481号及び2005年8月16日に出願された、Chomczynskiの米国特許仮出願第60/708,498号(共に参照により本明細書中に援用される)に関し、その優先権を主張する。
適切な食事は、健康な皮膚を維持する要因である。ヒトの皮膚状態に影響を与え得る種々の既知の栄養補助食品が存在する。(International Cosmetic Ingredient Dictionary and Handbook, 2004;及びU.S. Pharmacopoeia Dietary Supplement Monographs)。
本発明は、座瘡、酒さ、及び炎症に関連することの多い発赤、吹き出物、及び紅潮を含む皮膚状態の症状の緩和のために使用される経口投与組成物に関する。組成物は、リコピン、没食子酸、及びアスコルビン酸を含む抗酸化物質を含む。
本発明は、健康な皮膚を維持すると共に、炎症、刺激、及び皮膚老化等の皮膚疾患に関連する多数の皮膚状態(皮膚の発赤及び炎症が含まれる)を緩和するための抗酸化栄養補助食品組成物及び方法に関する。本発明から恩恵を受ける皮膚疾患の例には、座瘡及び酒さが含まれる。
以下の経口補助食品を、単独で又はシクロヘキサノール誘導体を含む局所組成物と組み合わせて使用する。局所組成物を、皮膚の発赤領域に朝と晩の1日2回適用する。局所組成物は、0.5%のカルボマー940(Spectrum Quality Products, Gardena, CA)、1%の1,4−シクロヘキサンジオール(シス/トランス)、0.3%のグリセリン、及び水(100%に合わせる)を含む。溶液を、水酸化ナトリウムでpH7.0に調整する。
(トマトジュース補助食品)
300mgのビタミンC/リットルを含み、20mgのパントテノール/リットルを補足したトマトジュース(Tomato Drink, Cinna Health Products, Molecular Research Center, Inc., Cincinnati, OH)。250mlのジュースを、1日に1回消費する。
(トマトペースト補助食品)
36mgのビタミンC及び300IUのビタミンAを含む200gのトマトペースト(HUNT’S(登録商標)トマトペースト、ConAgra Dietaries, Irvine,CA)を、1000mlの水と混合する。250mlの混合物を、1日に1回消費する。
(リコピン錠剤補助食品)
ダイズ油に溶解した5mgのリコピンを含むリコピンの錠剤(Nature's Bounty, Inc., Bohemia, N.Y)を、経口投与する(5錠を、1日に1回消費する)。
(水抽出補助食品)
340gのトマトペースト(HUNT’S(登録商標)トマトペースト)を、660mlの水と混合し、混合物を室温で保存する。6時間の保存後、混合物は沈殿し、リコピン含有ペレットを再度660mlの水で抽出する。得られた水抽出ペレットを、660mlの水に懸濁する。200mlの懸濁液を、1日に1回消費する。
(酸性水抽出補助食品)
340gのトマトペースト(HUNT’S(登録商標)トマトペースト)を、660mlの水と混合する。混合物を、HClでpH3に酸性化し、室温で保存する。6時間の保存後、混合物は沈殿し、リコピン含有ペレットを再度660mlのpH3の水で抽出する。得られた酸性抽出ペレットを、660mlの水に懸濁する。混合物のpHを、水酸化ナトリウムでpH4に調整する。200mlの懸濁液を、0.5mlのトウモロコシ油(ACH Dietary Companies, Inc., Memphis,TN)と混合し、1日に1回消費する。
(グレープフルーツジュースと混合した酸抽出トマト補助食品)
340gのトマトペースト(HUNT’S(登録商標)トマトペースト)を、660mlの水と混合する。混合物を、HClでpH3に酸性化し、室温で保存する。6時間の保存後、混合物は沈殿し、リコピン含有ペレットを再度660mlのpH3の水で抽出する。得られた酸抽出ペレットを、300mg/リットルのビタミンC及び0.4mg/リットルのチアミンを含む660mlのルビーレッドグレープフルーツジュース(Citrus World, Inc., Lake Wales, FL)に懸濁する。混合物のpHを、水酸化ナトリウムでpH4に調整する。200mlの懸濁液を、1日に1回消費する。
(アップルピューレと混合した酸抽出トマト補助食品)
340gのトマトペースト(HUNT’S(登録商標)トマトペースト)を、660mlの水と混合する。混合物を、HClでpH3に酸性化し、室温で保存する。6時間の保存後、混合物は沈殿し、リコピン含有ペレットを再度660mlのpH3の水で抽出する。得られた酸抽出ペレットを、48mgのビタミンCを含む450gのアップルソース(Mott's Inc., Stamford, CT)と混合する。混合物のpHを、水酸化ナトリウムでpH4に調整する。90gの混合物を、1日に1回消費する。
(ビタミンを強化した酸抽出トマト/リンゴ補助食品)
340gのトマトペースト(HUNT’S(登録商標)トマトペースト)を、660mlの水と混合する。6時間の保存後、混合物は沈殿し、リコピン含有ペレットを再度660mlのpH3の水で抽出する。得られた酸抽出ペレットを、450gのリンゴピューレに懸濁する。混合物のpHを、水酸化ナトリウムでpH4に調整する。90gの混合物を、砕いたマルチビタミン錠剤(CENTRUM(登録商標)、Wyeth Consumer Healthcare, Madison, NJ)と混合し、1日に1回消費する。マルチビタミン錠剤は、ビタミンA 3500IU、ビタミンC 60mg、ビタミンD 400IU、ビタミンE 45IU、ビタミンK 0.01mg、チアミン1.5mg、リボフラビン1.7mg、ナイアシン20mg、ビタミンB6 3mg、葉酸0.4mg、ビタミンB12 0.025mg、ビオチン0.03mg、パントテン酸10mg、カルシウム0.2g、リン 48mg、ヨウ素0.15mg、マグネシウム0.1g、亜鉛15mg、セレン0.02mg、銅2mg、クロム0.15mg、モリブデン0.075mg、塩化物0.075mg、カリウム80mg、ホウ素0.15mg、ニッケル0.005mg、ケイ素2mg、バナジウム0.01mg、ルテイン0.25mg、及びリコピン0.3mgを含む。
(没食子酸補助食品を含むトマトジュース)
トマトペースト、トウモロコシ油、塩、及びアスコルビン酸(400mg/l)を含む1lのトマト飲料(Cinna Health Products, MRC, Inc., Cincinnati, OH)に、800mgの没食子酸及び200mgのルチン(Spectrum Quality Products, Inc.)(pH=4.7)を補足する。200mlの飲料を、1日に1回消費する。
(没食子酸補助食品を含むパイナップルジュース)
678mgのビタミンCを含む1lのパイナップルジュース(Dole Packaged Foods Corp., Westlake Village, CA)に、1gの没食子酸(Spectrum Quality Products, Inc.)を補足する。200mgのジュースを、1日に2回消費する。
(没食子酸錠剤)
200gmの没食子酸(Spectrum Quality Products, Inc.)を、植物性カプセル(Capsuline, FL)に封入する。毎日朝食前と夕食前に2錠を消費する。
(ビタミンC錠剤)
1gのアスコルビン酸(Spectrum Quality Products, Inc.)を、植物性カプセル(Capsuline, FL)に封入する。毎日朝食前及び夕食前に2錠を消費する。
Deming, D. M. and Erdman, J.W., Mammalian Carotenoid Absorption and Metabolism, Pure Appl Chem, 71, 2213-2223.
Felter H.W., Lloyd J.U. Acidum Gallicum-Gallic Acid in King's American Dispensatory.
Friedman, M. and Jurgens, H.S., Effect of pH on the Stability of Plant Phenolic Compounds, J Agri Chem, 2000, 2101-2110.
Hof, K.H. et al., Carotenoid Bioavailability in Humans from Tomatoes Processed in Different Ways Determined from the Carotenoid Response in the Triglyceride-Rich Lipoprotein Fraction of Plasma after Single Consumption and in Plasma after Four Days of Consumption, J.Nutr, 2000, 130, 1189-1196.
Khachik, F. et al., Chemistry, Distribution, and Metabolism of Tomato Carotenoids and Their Impact on Human Health, Exp Biol Med 2002, 227, 845-851.
Ki et al., Cocoa Has More Phenolic Phytochemicals and a Higher Antioxidant Capacity than Teas and Red Wine, J. Agric. Food Chem., 51(25):7292-7295 (2003).
Ow, Y.Y., Stupans, J., Gallic Acid and Gallic Acid Derivatives: Effect on Drug Metabolizing Enzymes, Curr. Drug Metab., 2003, 4, 241-248.
Shahrzad S., Aoyagi K., Winter A., Koyama A. and Bitsch I, Pharmacokinetics of Gallic Acid and Its relative Bioavailability from Tea in Healthy Humans, J.Nutr. 2001, 131, 1207-1210.
Tyssandier, V. et al., Processing of Vegetable-Borne Carotenoids in the Human Stomach and Duodenum, A.J. Pyhysiol Gastroinest Liver Physiol, 284, G913-G923.
H.J. Heinz Company, sponsor, www.lycopene.org.
National Rosacea Society, www.rosacea.org.
Claims (39)
- 水で抽出されたリコピン含有材料を含む経口消費のための組成物。
- トマト、スイカ、グレープフルーツ、グアバ、パパイヤ、及びそれらの混合物から選択される果物由来の材料を含む、請求項1に記載の組成物。
- 非リコピン植物材料をさらに含む、請求項1に記載の組成物。
- ビタミン、抗酸化剤、微量元素、天然抽出物、食品添加物、ホルモン、タンパク質、脂肪酸、オイル、アルコール、炭水化物、及びそれらの混合物から選択される補助材料をさらに含む、請求項1に記載の組成物。
- 前記水抽出はpH約6未満で行われる、請求項1に記載の組成物。
- 前記抽出はpH約1.5〜pH約4で行われる、請求項5に記載の組成物。
- トマト、スイカ、グレープフルーツ、グアバ、パパイヤ、及びそれらの混合物から選択される果物由来の材料を含む、請求項5に記載の組成物。
- 非リコピン植物材料をさらに含む、請求項5に記載の組成物。
- ビタミン、抗酸化剤、微量元素、天然抽出物、植物材料、食品添加物、ホルモン、タンパク質、脂肪酸、オイル、アルコール、炭水化物、及びそれらの混合物から選択される補助材料を含む、請求項8に記載の組成物。
- 実質的に純粋な没食子酸、没食子酸エステルを除く没食子酸誘導体、及びそれらの混合物から選択される材料を補足した植物由来材料を含む経口消費のための組成物。
- ショウガ、ショウガ抽出物、ルチン、及びそれらの混合物から選択される有効量の材料をさらに含む、請求項10に記載の組成物。
- アスコルビン酸及びその誘導体を除く、実質的に純粋な抗酸化剤から選択される材料、並びに/又は、フェノール系、ポリフェノール系、カロテノイド系及びフラボノイド系の抗酸化剤及びそれらの誘導体から選択される抗酸化剤を豊富に含む植物由来材料、並びに、それらの混合物を補足したリコピン含有材料を含む経口消費のための組成物。
- 前記抗酸化剤は、没食子酸、ルチン、ヒドロキシチロゾール、オレウロペイン、及びそれらの混合物を含む、請求項12に記載の組成物。
- 前記植物由来材料は、1gの乾燥重量あたり少なくとも約40mgの没食子酸又は没食子酸等価物を含む、請求項12に記載の組成物。
- ショウガ、ショウガ抽出物、及びそれらの混合物から選択される有効量の材料をさらに含む、請求項14に記載の組成物。
- 水抽出されたリコピン含有植物材料の作製プロセスであって、該水抽出を行って、水不溶性植物マトリックス中に分散した親水性化合物を含む水不溶性残渣が得られることを特徴とする、水抽出されたリコピン含有植物材料の作製プロセス。
- 前記抽出はpH約6未満の水で行われる、請求項16に記載の作製プロセス。
- 前記抽出はpH約1.5〜pH約4の水で行われる、請求項17に記載の作製プロセス。
- 健康な皮膚を維持すると共に、座瘡、酒さ、炎症、刺激、及び皮膚老化に関連する状態を含む皮膚状態を緩和する方法であって、(a)該皮膚状態の部位での該状態の局所治療を、(b)有効量の1つ又は複数の抗酸化剤を含む組成物のヒトへの経口投与と共にこのような治療を必要とする前記ヒトに施すことを含むことを特徴とする、健康な皮膚を維持すると共に、皮膚状態を緩和する方法。
- 有効量のショウガ又はショウガ抽出物を、前記ヒトにさらに投与する、請求項19に記載の方法。
- 前記化合物を、約0.001mg/cm2〜約10mg/cm2の量で皮膚に適用する、請求項21に記載の方法。
- 前記化合物を含む局所キャリアを皮膚に適用する、請求項21に記載の方法。
- 前記化合物は、シクロヘキサノール、2−シクロヘキシルエタノール、シクロヘキシルメタノール、3−シクロヘキシル−1−プロパノール、1,4−シクロヘキサンジオール、1,3−シクロヘキサンジオール、1,2−シクロヘキサンジオール、4−シクロヘキシルシクロヘキサノール、4−メチルシクロヘキサノール、1,2,3−シクロヘキサントリオール、1,3,5−シクロヘキサントリオール、1,4,5−シクロヘキサントリオール、及びそれらの混合物から選択される、請求項21に記載の方法。
- 前記化合物は、1,2−シクロヘキサンジオール、1,3−シクロヘキサンジオール、1,4−シクロヘキサンジオール、1,2,3−シクロヘキサントリオール、1,3,5−シクロヘキサントリオール及びそれらの混合物から選択される、請求項24に記載の方法。
- 前記局所組成物は、ビタミン、抗酸化剤、微量元素、天然抽出物、植物材料、ホルモン、タンパク質、脂肪酸、炭水化物、オイル、及びそれらの混合物から選択される選択される補助材料を含む、請求項19に記載の方法。
- 前記経口組成物は、水で抽出したリコピン含有材料を含む、請求項19に記載の方法。
- 前記水抽出はpH約6未満で行われる、請求項27に記載の方法。
- 前記水抽出はpH約1.5〜pH約4で行われる、請求項28に記載の方法。
- 前記経口組成物は、非リコピン植物由来材料をさらに含む、請求項27に記載の方法。
- 前記経口組成物は、ビタミン、抗酸化剤、微量元素、天然抽出物、植物材料、食品添加物、ホルモン、タンパク質、脂肪酸、炭水化物、オイル、及びそれらの混合物から選択される選択される材料を含む、請求項19に記載の方法。
- 没食子酸、アスコルビン酸、没食子酸及びアスコルビン酸の薬学的に活性な誘導体、並びにそれらの混合物から選択される抗酸化剤を含む、請求項31に記載の方法。
- 有効量のショウガ又はショウガ抽出物を、前記ヒトにさらに投与する、請求項32に記載の方法。
- 前記抗酸化剤を、約1mg/kg体重〜約200mg/kg体重の1日量で投与する、請求項32に記載の方法。
- 前記抗酸化剤は、アスコルビン酸及びその誘導体から選択され、約3mg/kg体重〜約200mg/kg体重の範囲の1日量で投与する、請求項32に記載の方法。
- 前記抗酸化剤は、没食子酸、ルチン、及びそれらの誘導体から選択される、請求項32に記載の方法。
- 前記経口組成物は、ビタミン、微量元素、天然抽出物、植物材料、食品添加物、ホルモン、タンパク質、脂肪酸、炭水化物、オイル、及びそれらの混合物を含む群から選択される補助材料をさらに含む、請求項31に記載の方法。
- 前記抗酸化剤を含む前記経口組成物を、固体、溶液、又は懸濁液として投与する、請求項31に記載の方法。
- アスコルビン酸、没食子酸、ルチン、及びそれらの誘導体から選択される1つ又は複数の抗酸化剤と共にショウガ又はショウガ抽出物を含む経口投与のための組成物。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63248104P | 2004-12-02 | 2004-12-02 | |
US60/632,481 | 2004-12-02 | ||
US70849805P | 2005-08-16 | 2005-08-16 | |
US60/708,498 | 2005-08-16 | ||
US11/273,514 | 2005-11-14 | ||
US11/273,514 US9579298B2 (en) | 2004-12-02 | 2005-11-14 | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
PCT/US2005/043301 WO2006060470A1 (en) | 2004-12-02 | 2005-11-29 | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
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JP5084512B2 JP5084512B2 (ja) | 2012-11-28 |
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US (3) | US9579298B2 (ja) |
EP (2) | EP3213759A1 (ja) |
JP (1) | JP5084512B2 (ja) |
CA (1) | CA2586865C (ja) |
ES (1) | ES2637891T3 (ja) |
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JP2010509352A (ja) * | 2006-11-13 | 2010-03-25 | モレキュラー リサーチ センター インコーポレイテッド | 抗酸化性の食物サプリメントの組成物および健康な皮膚を維持するための方法 |
JP2010513348A (ja) * | 2006-12-20 | 2010-04-30 | ディーエスエム アイピー アセッツ ビー.ブイ. | Egcgおよびリコペン含有経口組成物 |
JP2015505676A (ja) * | 2011-12-14 | 2015-02-26 | アイピー サイエンス リミテッド | 脂肪ベース食品 |
JP2015205882A (ja) * | 2009-01-19 | 2015-11-19 | ライコード・リミテツド | カロテノイドとポリフェノールとの相乗的組み合わせ |
WO2017119797A1 (ko) * | 2016-01-08 | 2017-07-13 | 주식회사 위즈바이오 | 농축산물의 생산효율 향상을 위한 생육 보조제 및 기능성 식품 조성물 |
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2005
- 2005-11-14 US US11/273,514 patent/US9579298B2/en active Active
- 2005-11-29 ES ES05852519.7T patent/ES2637891T3/es active Active
- 2005-11-29 PL PL05852519T patent/PL1817017T3/pl unknown
- 2005-11-29 WO PCT/US2005/043301 patent/WO2006060470A1/en active Application Filing
- 2005-11-29 EP EP17162870.4A patent/EP3213759A1/en not_active Withdrawn
- 2005-11-29 EP EP05852519.7A patent/EP1817017B1/en active Active
- 2005-11-29 JP JP2007544460A patent/JP5084512B2/ja not_active Expired - Fee Related
- 2005-11-29 CA CA2586865A patent/CA2586865C/en active Active
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2017
- 2017-02-01 US US15/421,947 patent/US9827208B2/en active Active
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010509352A (ja) * | 2006-11-13 | 2010-03-25 | モレキュラー リサーチ センター インコーポレイテッド | 抗酸化性の食物サプリメントの組成物および健康な皮膚を維持するための方法 |
JP2010513348A (ja) * | 2006-12-20 | 2010-04-30 | ディーエスエム アイピー アセッツ ビー.ブイ. | Egcgおよびリコペン含有経口組成物 |
JP2015205882A (ja) * | 2009-01-19 | 2015-11-19 | ライコード・リミテツド | カロテノイドとポリフェノールとの相乗的組み合わせ |
JP2015505676A (ja) * | 2011-12-14 | 2015-02-26 | アイピー サイエンス リミテッド | 脂肪ベース食品 |
JP2018038407A (ja) * | 2011-12-14 | 2018-03-15 | アイピー サイエンス リミテッド | 脂肪ベース食品 |
WO2017119797A1 (ko) * | 2016-01-08 | 2017-07-13 | 주식회사 위즈바이오 | 농축산물의 생산효율 향상을 위한 생육 보조제 및 기능성 식품 조성물 |
Also Published As
Publication number | Publication date |
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US20170157063A1 (en) | 2017-06-08 |
US20180042862A1 (en) | 2018-02-15 |
WO2006060470A1 (en) | 2006-06-08 |
US9827208B2 (en) | 2017-11-28 |
CA2586865C (en) | 2016-09-27 |
JP5084512B2 (ja) | 2012-11-28 |
EP1817017A1 (en) | 2007-08-15 |
US9579298B2 (en) | 2017-02-28 |
EP1817017B1 (en) | 2017-05-31 |
CA2586865A1 (en) | 2006-06-08 |
PL1817017T3 (pl) | 2017-11-30 |
ES2637891T3 (es) | 2017-10-17 |
US20060121133A1 (en) | 2006-06-08 |
EP3213759A1 (en) | 2017-09-06 |
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