JP2008508338A - 口腔乾燥症用新規組成物 - Google Patents
口腔乾燥症用新規組成物 Download PDFInfo
- Publication number
- JP2008508338A JP2008508338A JP2007524259A JP2007524259A JP2008508338A JP 2008508338 A JP2008508338 A JP 2008508338A JP 2007524259 A JP2007524259 A JP 2007524259A JP 2007524259 A JP2007524259 A JP 2007524259A JP 2008508338 A JP2008508338 A JP 2008508338A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- gum
- pvp
- composition according
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010013781 dry mouth Diseases 0.000 title claims abstract description 20
- 239000000203 mixture Substances 0.000 title claims description 49
- 208000005946 Xerostomia Diseases 0.000 title claims description 15
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 35
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 35
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 35
- 229920002807 Thiomer Polymers 0.000 claims abstract description 15
- 125000000129 anionic group Chemical group 0.000 claims abstract description 13
- 208000024891 symptom Diseases 0.000 claims abstract description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 4
- 210000000214 mouth Anatomy 0.000 claims description 24
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 23
- 229920001285 xanthan gum Polymers 0.000 claims description 22
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 21
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 20
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 18
- 229920000642 polymer Polymers 0.000 claims description 13
- 235000010493 xanthan gum Nutrition 0.000 claims description 9
- 239000000230 xanthan gum Substances 0.000 claims description 9
- 229940082509 xanthan gum Drugs 0.000 claims description 9
- 229920002125 Sokalan® Polymers 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 6
- 150000001720 carbohydrates Chemical class 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 claims description 3
- 229920006037 cross link polymer Polymers 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 244000215068 Acacia senegal Species 0.000 claims description 2
- 241000416162 Astragalus gummifer Species 0.000 claims description 2
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims description 2
- 229920002907 Guar gum Polymers 0.000 claims description 2
- 229920000084 Gum arabic Polymers 0.000 claims description 2
- 229920000569 Gum karaya Polymers 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 2
- 229920000148 Polycarbophil calcium Polymers 0.000 claims description 2
- 241000934878 Sterculia Species 0.000 claims description 2
- 229920001615 Tragacanth Polymers 0.000 claims description 2
- 235000010489 acacia gum Nutrition 0.000 claims description 2
- 239000000205 acacia gum Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- FYUWIEKAVLOHSE-UHFFFAOYSA-N ethenyl acetate;1-ethenylpyrrolidin-2-one Chemical compound CC(=O)OC=C.C=CN1CCCC1=O FYUWIEKAVLOHSE-UHFFFAOYSA-N 0.000 claims description 2
- 239000000665 guar gum Substances 0.000 claims description 2
- 235000010417 guar gum Nutrition 0.000 claims description 2
- 229960002154 guar gum Drugs 0.000 claims description 2
- 235000010494 karaya gum Nutrition 0.000 claims description 2
- 239000000231 karaya gum Substances 0.000 claims description 2
- 229940039371 karaya gum Drugs 0.000 claims description 2
- 235000010420 locust bean gum Nutrition 0.000 claims description 2
- 239000000711 locust bean gum Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000001814 pectin Substances 0.000 claims description 2
- 229920001277 pectin Polymers 0.000 claims description 2
- 235000010987 pectin Nutrition 0.000 claims description 2
- 235000010487 tragacanth Nutrition 0.000 claims description 2
- 239000000196 tragacanth Substances 0.000 claims description 2
- 229940116362 tragacanth Drugs 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 230000036571 hydration Effects 0.000 claims 1
- 238000006703 hydration reaction Methods 0.000 claims 1
- 229950005134 polycarbophil Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 description 20
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 13
- 230000001953 sensory effect Effects 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- -1 citric acid Chemical class 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 229940051866 mouthwash Drugs 0.000 description 5
- 230000035807 sensation Effects 0.000 description 5
- 235000019615 sensations Nutrition 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000007937 lozenge Substances 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000002199 base oil Substances 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- 229940008099 dimethicone Drugs 0.000 description 3
- 239000004205 dimethyl polysiloxane Substances 0.000 description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 239000004599 antimicrobial Substances 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 230000003232 mucoadhesive effect Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- 150000003751 zinc Chemical class 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 206010013647 Drowning Diseases 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 244000024873 Mentha crispa Species 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- DAOANAATJZWTSJ-UHFFFAOYSA-N N-Decanoylmorpholine Chemical compound CCCCCCCCCC(=O)N1CCOCC1 DAOANAATJZWTSJ-UHFFFAOYSA-N 0.000 description 1
- 208000007027 Oral Candidiasis Diseases 0.000 description 1
- 206010048685 Oral infection Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008369 fruit flavor Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 229940092969 oral strip Drugs 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 229940096978 oral tablet Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229960000502 poloxamer Drugs 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 229920000428 triblock copolymer Polymers 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Confectionery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
【選択図】 なし
Description
口腔乾燥症用に使用するポリマーの最適化のための官能試験を、小規模パネルテストを用いて行った。官能試験結果としては、以下が挙げられる。
口腔乾燥症用に使用するポリマーの最適化のためのさらなる官能試験を、6人のパネリストから成る小規模パネルテストによって行った。
CMC溶液にPVPを加えることで、ポリマー溶液の官能特性が向上した。PVPはCMC溶液の粘着性を顕著に(p=0.01)減少させ、口腔での質感をより滑らかにした。CMC+PVP溶液の口の感触および後味はより心地よいものであった。口はさらに潤った。両方のポリマー溶液は適度に粘着性を有していると知覚された。CMC+PVP溶液は、CMC溶液と比較してより粘性がありゲル状(よりねばねばしている)であると知覚される傾向があった。このことは、溶液の粘度を増すポリマー全体がさらに多く存在するという事実からも説明される。
この小規模パネルテストでは、キサンタン溶液と、キサンタンおよびPVPの混合物との官能特性の間に顕著な差は見られなかった。PVPをキサンタン溶液に加えると、ねばねばした感覚が増すために、溶液の口の感触の心地よさおよび口腔での質感の滑らかさがわずかに減少する傾向があり、これはこの系でポリマー全体が増加したことで説明することができる。しかしながら、PVPを加えると口をコートする能力が高まった。両方のポリマーの溶液は、口を適度に潤し滑らかにすると受け取られた。重要なことに、PVPを加えるとキサンタン溶液の粘着性が減少した。
PVPをキサンタン+CMC溶液に加えると、溶液の口腔での質感の滑らかさが顕著に(p=0.03)向上した。PVPにはキサンタン+CMC溶液の粘着性を減少させ、より心地よい口の感触をもたらし、口を潤し滑らかにする傾向があった。キサンタン+CMC+PVP溶液は、溶液の粘度を増すポリマー全体がさらに多く存在するという事実ゆえに、さらに粘着性を有していると知覚された。
Claims (16)
- ポリビニルピロリドン(PVP)またはその誘導体、アニオン性粘膜付着性ポリマーおよび口腔で許容される担体または賦形剤を含んでなる口腔ケア組成物。
- 該ポリビニルピロリドンの誘導体がビニルピロリドン/ビニルアセテート(VP/VA)コポリマー、またはビニルピロリドン/ビニルアルコール(VP/VOH)コポリマーである、請求項1記載の組成物。
- PVPまたはVP/VAコポリマーを含む請求項1または2に記載の組成物。
- 該PVPまたはその誘導体が0.1〜20重量%の量で存在する、請求項1〜3のいずれか1項に記載の組成物。
- 該アニオン性粘膜付着性ポリマーが、セルロースガム、サッカリドガム、もしくはポリアクリル酸ポリマー、またはこれらの混合物から選択される、請求項1〜4のいずれか1項に記載の組成物。
- 該セルロースポリマーがカルボキシメチルセルロースガムである、請求項5に記載の組成物。
- 該サッカリドガムがキサンタンガム、グアーガム、アラビアゴム、トラガカント、カラヤゴム、ローカストビーンガムおよびペクチン、またはこれらの混合物から選択される請求項5に記載の組成物。
- 該サッカリドがキサンタンガムである請求項7に記載の組成物。
- 該ポリアクリル酸ポリマーがカルボマー、アクリレート/C10-30アルキルアクリレートクロスポリマー、またはポリカルボフィルである請求項5に記載の組成物。
- 該粘膜付着性ポリマーがカルボキシメチルセルロースナトリウムとキサンタンガムの組み合わせである請求項5に記載の組成物。
- 該アニオン性粘膜付着性ポリマーが0.02〜20重量%の範囲で存在する、請求項1〜10のいずれか1項に記載の組成物。
- 該PVPまたはその誘導体と該アニオン性粘膜付着性ポリマーとの比が5:1〜1:1である、請求項1〜11のいずれか1項に記載の組成物。
- 口腔内で潤滑剤として使用するための、請求項1〜12のいずれか1項に記載の組成物。
- 口腔内の水分補給に使用される、請求項1〜13のいずれか1項に記載の組成物。
- 口腔乾燥症の症状を治療するための、請求項1〜14のいずれか1項に記載の組成物。
- 治療に有効な量の請求項1〜12のいずれか1項に記載の組成物を投与することを含んでなる、口腔乾燥症の症状の治療する方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0417193A GB0417193D0 (en) | 2004-08-02 | 2004-08-02 | Novel compositions |
GB0417193.0 | 2004-08-02 | ||
GB0502077.1 | 2005-02-01 | ||
GB0502077A GB0502077D0 (en) | 2005-02-01 | 2005-02-01 | Novel composition |
PCT/EP2005/008327 WO2006013081A1 (en) | 2004-08-02 | 2005-07-29 | Novel composition for xerostomia |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008508338A true JP2008508338A (ja) | 2008-03-21 |
JP4919957B2 JP4919957B2 (ja) | 2012-04-18 |
Family
ID=35079153
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007524259A Active JP4919957B2 (ja) | 2004-08-02 | 2005-07-29 | 口腔乾燥症用新規組成物 |
Country Status (14)
Country | Link |
---|---|
US (2) | US9044500B2 (ja) |
EP (2) | EP1793799B1 (ja) |
JP (1) | JP4919957B2 (ja) |
AT (1) | ATE466566T1 (ja) |
AU (1) | AU2005268926B2 (ja) |
BR (1) | BRPI0514037B8 (ja) |
CA (1) | CA2575605C (ja) |
DE (1) | DE602005021126D1 (ja) |
ES (1) | ES2344911T3 (ja) |
GC (1) | GC0001377A (ja) |
MX (1) | MX2007001384A (ja) |
PT (1) | PT1793799E (ja) |
WO (1) | WO2006013081A1 (ja) |
ZA (1) | ZA200700965B (ja) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010114005A1 (ja) * | 2009-03-31 | 2010-10-07 | 小林製薬株式会社 | 歯磨組成物 |
JP2010538074A (ja) * | 2007-09-06 | 2010-12-09 | コルゲート・パーモリブ・カンパニー | 口腔乾燥症を治療するための歯磨剤組成物 |
JP2011511793A (ja) * | 2008-02-08 | 2011-04-14 | コルゲート・パーモリブ・カンパニー | 口内乾燥の処置のための組成物および方法 |
JP2012511507A (ja) * | 2008-12-09 | 2012-05-24 | グラクソ グループ リミテッド | 新規の使用 |
JP2012527485A (ja) * | 2009-05-22 | 2012-11-08 | ルブリス,エルエルシー. | Prg4及びその治療調節作用の応用及び使用 |
JP2014501259A (ja) * | 2010-12-23 | 2014-01-20 | コルゲート・パーモリブ・カンパニー | ポリマー系 |
JP2014501257A (ja) * | 2010-12-23 | 2014-01-20 | コルゲート・パーモリブ・カンパニー | 水性オーラルケア組成物 |
JP2017081951A (ja) * | 2011-04-19 | 2017-05-18 | アームズ ファーマシューティカル エルエルシーArms Pharmaceutical Llc. | 有害な微生物を阻害する方法及びそのためのバリア形成組成物 |
JP2017537983A (ja) * | 2014-12-10 | 2017-12-21 | エレべイト オーラル ケア、エルエルシー | 口渇の軽減のための組成物 |
US11478435B2 (en) | 2017-02-22 | 2022-10-25 | Smilesonica Inc. | Artificial saliva, related methods, and uses |
US11890355B2 (en) | 2016-01-10 | 2024-02-06 | Smilesonica Inc. | Viscosity and stability modified ultrasound gel |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6669929B1 (en) | 2002-12-30 | 2003-12-30 | Colgate Palmolive Company | Dentifrice containing functional film flakes |
MX2007001384A (es) | 2004-08-02 | 2007-04-19 | Glaxo Group Ltd | Novedosa composicion para xerostomia. |
US20070148213A1 (en) * | 2005-12-22 | 2007-06-28 | Sayed Ibrahim | Film containing compositions |
US9161909B2 (en) | 2007-08-24 | 2015-10-20 | Axiomedic Ltd. | Adhesive compositions for the treatment of xerostomia |
US20090053309A1 (en) * | 2007-08-24 | 2009-02-26 | Axiomedic Ltd., Gibraltar | Adhesive compositions for the treatment of xerostomia |
US8568697B2 (en) | 2008-03-21 | 2013-10-29 | Colgate-Palmolive Company | High fluoride ion recovery compositions |
WO2010129795A1 (en) * | 2009-05-08 | 2010-11-11 | 3M Innovative Properties Company | Oral care method and kit |
RU2523900C2 (ru) | 2009-10-29 | 2014-07-27 | Колгейт-Палмолив Компани | Средство для чистки зубов, содержащее фторид двухвалентного олова и цитрат цинка и небольшие количества воды |
US20110104081A1 (en) * | 2009-11-03 | 2011-05-05 | Douglas Craig Scott | Oral Compositions for Treatment of Dry Mouth |
US20110104080A1 (en) * | 2009-11-03 | 2011-05-05 | David Salloum Salloum | Oral Compositions for Treatment of Dry Mouth |
BR112013016210A2 (pt) * | 2010-12-23 | 2019-09-24 | Colgate Palmolive Co | composições fluidas compreendendo um agente estruturador. |
GB201105408D0 (en) | 2011-03-30 | 2011-05-11 | Glaxo Group Ltd | Composition |
US10426761B2 (en) | 2011-04-19 | 2019-10-01 | Arms Pharmaceutical, Llc | Method for treatment of disease caused or aggravated by microorganisms or relieving symptoms thereof |
US9675542B2 (en) | 2011-05-16 | 2017-06-13 | Colgate-Palmolive Company | Oral care compositions |
GB201121300D0 (en) | 2011-12-12 | 2012-01-25 | Glaxo Group Ltd | Novel composition |
MX342833B (es) * | 2011-12-15 | 2016-10-14 | Colgate Palmolive Co | Composiciones de cuidado oral acuosas. |
ITMI20120883A1 (it) * | 2012-05-22 | 2013-11-23 | Brux S R L | Nuova formulazione per la prevenzione della carie dentale |
US10314771B2 (en) * | 2013-02-28 | 2019-06-11 | University Of Tennessee Research Foundation | Methods and compositions for preventing and treating tooth erosion |
AU2014243929B2 (en) | 2013-03-14 | 2019-01-17 | 3 In 1 Dental Pllc | Compositions for treatment of xerostomia and for tooth treatment |
WO2015023773A2 (en) | 2013-08-14 | 2015-02-19 | University Of Tennessee Research Foundation | Tooth remineralization compositions and methods |
FR3010635B1 (fr) * | 2013-09-13 | 2017-01-20 | Pf Medicament | Compositions pharmaceutiques a base d'agent filmogene pour le traitement de l'hyposialie |
FR3010634A1 (fr) * | 2013-09-13 | 2015-03-20 | Pf Medicament | Compositions pharmaceutiques a base de tensioactif vegetal pour le traitement de l'hyposialie |
EP3157639B1 (en) * | 2014-06-20 | 2018-12-26 | Colgate-Palmolive Company | Oral compositions containing metal ions |
US9782333B2 (en) | 2015-01-21 | 2017-10-10 | Chattem Inc. | Oral composition for xerostomia |
US10524993B2 (en) | 2015-11-19 | 2020-01-07 | Fantarella & Harewood, Llc | Mouthwash composition |
AU2017286544B2 (en) * | 2016-06-13 | 2022-10-20 | Meharry Medical College | Modulation of the nitric oxide synthase pathway for oral health |
Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63179823A (ja) * | 1987-01-19 | 1988-07-23 | Sunstar Inc | 歯周疾患治療用外用剤 |
JPH0558866A (ja) * | 1991-08-28 | 1993-03-09 | Lion Corp | 口腔用組成物 |
JPH0710757A (ja) * | 1993-06-23 | 1995-01-13 | Dai Ichi Seiyaku Co Ltd | 口腔用組成物 |
JPH07101856A (ja) * | 1993-03-02 | 1995-04-18 | Block Drug Co Inc | 口腔乾燥症状軽減の為の固形調剤形態製造物 |
JPH07126163A (ja) * | 1993-10-08 | 1995-05-16 | Theratech Inc | 制御放出性ピロカルピン送達システム |
JPH08333226A (ja) * | 1995-06-02 | 1996-12-17 | Lion Corp | 泡状口腔用組成物 |
US5741805A (en) * | 1992-07-02 | 1998-04-21 | Oramed, Inc. | Controlled release pilocarpine delivery system |
WO2000059423A1 (en) * | 1999-04-01 | 2000-10-12 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
JP2002226315A (ja) * | 2001-02-02 | 2002-08-14 | Tendan Hino | 義歯用口腔湿潤剤 |
JP2002322088A (ja) * | 2001-04-24 | 2002-11-08 | Kakunai Juyotai Kenkyusho:Kk | 口腔貼付用製剤 |
JP2004136102A (ja) * | 2003-11-27 | 2004-05-13 | Tendan Hino | 義歯用口腔湿潤剤 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5262629A (en) | 1975-11-20 | 1977-05-24 | Matsushita Electric Ind Co Ltd | Alkaline battery |
JPS5562012A (en) | 1978-11-06 | 1980-05-10 | Teijin Ltd | Slow-releasing preparation |
US4262299A (en) * | 1979-01-29 | 1981-04-14 | Rca Corporation | Semiconductor-on-insulator device and method for its manufacture |
JPS60215622A (ja) * | 1984-04-09 | 1985-10-29 | Toyobo Co Ltd | 口腔粘膜適用徐放性製剤 |
JPS6117510A (ja) * | 1984-07-03 | 1986-01-25 | Toyobo Co Ltd | 口腔粘膜適用徐放性ニフエジピン製剤 |
IE58858B1 (en) * | 1986-08-25 | 1993-11-17 | Catchgate Ltd | Saliva replacement formulations |
JPH0259513A (ja) | 1988-08-24 | 1990-02-28 | Kiyuukiyuu Yakuhin Kogyo Kk | 口腔粘膜貼付型口臭防止剤 |
JPH0334928A (ja) * | 1989-06-29 | 1991-02-14 | Teikoku Seiyaku Kk | 潰瘍性大腸炎およびクローン病治療用経口投与製剤 |
US5077051A (en) | 1990-04-10 | 1991-12-31 | Warner-Lambert Company | Sustained release of active agents from bioadhesive microcapsules |
DE69119217T2 (de) | 1990-08-21 | 1996-10-31 | Theratech Inc | Zusammensetzungen zur kontrollierten freigabe |
JPH05262629A (ja) | 1992-03-17 | 1993-10-12 | Lion Corp | 口腔用組成物 |
US5612207A (en) | 1993-03-23 | 1997-03-18 | Cbr Laboratories, Inc. | Method and apparatus for encapsulation of biologically-active substances in cells |
NL9400160A (nl) | 1994-02-02 | 1995-09-01 | Stichting Tech Wetenschapp | Therapeutische samenstelling voor het vervangen en/of aanvullen van lichaamsvloeistoffen. |
EP0691124A1 (en) | 1994-07-07 | 1996-01-10 | Sara Lee/DE N.V. | Mouth care products |
US5541165A (en) | 1994-09-27 | 1996-07-30 | Turgeon; Jean A. | Saliva substitute |
DE19522750A1 (de) * | 1995-06-22 | 1997-01-02 | Henkel Kgaa | Flüssige Zahnreinigungsmittel |
FR2742989B1 (fr) * | 1995-12-29 | 1998-01-23 | Adir | Composition pharmaceutique bioadhesive pour la liberation controlee de principes actifs |
EP1021204B1 (en) | 1997-09-26 | 2005-12-28 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
US7544348B2 (en) | 2001-02-15 | 2009-06-09 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
CA2441352C (en) | 2001-02-15 | 2010-05-25 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
US6585997B2 (en) * | 2001-08-16 | 2003-07-01 | Access Pharmaceuticals, Inc. | Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds |
US6682722B2 (en) * | 2001-09-19 | 2004-01-27 | The Procter & Gamble Company | Oral compositions providing enhanced overall cleaning |
US6696058B2 (en) * | 2002-01-29 | 2004-02-24 | Laclede, Inc. | Aqueous enzymatic denture adhesives |
AUPS303202A0 (en) | 2002-06-20 | 2002-07-11 | Pacific Biolink Pty Limited | Protein based oral lubricant |
US6800295B2 (en) * | 2002-10-09 | 2004-10-05 | The Dial Corporation | Water soluble sheet composition |
US20040101494A1 (en) | 2002-11-26 | 2004-05-27 | Scott Douglas Craig | Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth |
MX2007001384A (es) | 2004-08-02 | 2007-04-19 | Glaxo Group Ltd | Novedosa composicion para xerostomia. |
JP5262629B2 (ja) | 2008-12-01 | 2013-08-14 | コニカミノルタビジネステクノロジーズ株式会社 | 画像形成装置及びプログラム |
-
2005
- 2005-07-29 MX MX2007001384A patent/MX2007001384A/es active IP Right Grant
- 2005-07-29 AU AU2005268926A patent/AU2005268926B2/en active Active
- 2005-07-29 ES ES05766797T patent/ES2344911T3/es active Active
- 2005-07-29 JP JP2007524259A patent/JP4919957B2/ja active Active
- 2005-07-29 CA CA2575605A patent/CA2575605C/en active Active
- 2005-07-29 PT PT05766797T patent/PT1793799E/pt unknown
- 2005-07-29 EP EP05766797A patent/EP1793799B1/en active Active
- 2005-07-29 AT AT05766797T patent/ATE466566T1/de active
- 2005-07-29 DE DE602005021126T patent/DE602005021126D1/de active Active
- 2005-07-29 US US11/572,751 patent/US9044500B2/en active Active
- 2005-07-29 EP EP10161489A patent/EP2263644A2/en not_active Withdrawn
- 2005-07-29 BR BRPI0514037A patent/BRPI0514037B8/pt active IP Right Grant
- 2005-07-29 WO PCT/EP2005/008327 patent/WO2006013081A1/en active Application Filing
- 2005-07-30 GC GCP200504976 patent/GC0001377A/xx active
-
2007
- 2007-02-01 ZA ZA2007/00965A patent/ZA200700965B/en unknown
-
2013
- 2013-07-01 US US13/932,088 patent/US10350238B2/en active Active
Patent Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63179823A (ja) * | 1987-01-19 | 1988-07-23 | Sunstar Inc | 歯周疾患治療用外用剤 |
JPH0558866A (ja) * | 1991-08-28 | 1993-03-09 | Lion Corp | 口腔用組成物 |
US5741805A (en) * | 1992-07-02 | 1998-04-21 | Oramed, Inc. | Controlled release pilocarpine delivery system |
JPH07101856A (ja) * | 1993-03-02 | 1995-04-18 | Block Drug Co Inc | 口腔乾燥症状軽減の為の固形調剤形態製造物 |
JPH0710757A (ja) * | 1993-06-23 | 1995-01-13 | Dai Ichi Seiyaku Co Ltd | 口腔用組成物 |
JPH07126163A (ja) * | 1993-10-08 | 1995-05-16 | Theratech Inc | 制御放出性ピロカルピン送達システム |
JPH08333226A (ja) * | 1995-06-02 | 1996-12-17 | Lion Corp | 泡状口腔用組成物 |
WO2000059423A1 (en) * | 1999-04-01 | 2000-10-12 | Watson Pharmaceuticals, Inc. | Oral transmucosal delivery of drugs or any other ingredients via the inner buccal cavity |
JP2002226315A (ja) * | 2001-02-02 | 2002-08-14 | Tendan Hino | 義歯用口腔湿潤剤 |
JP2002322088A (ja) * | 2001-04-24 | 2002-11-08 | Kakunai Juyotai Kenkyusho:Kk | 口腔貼付用製剤 |
JP2004136102A (ja) * | 2003-11-27 | 2004-05-13 | Tendan Hino | 義歯用口腔湿潤剤 |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010538074A (ja) * | 2007-09-06 | 2010-12-09 | コルゲート・パーモリブ・カンパニー | 口腔乾燥症を治療するための歯磨剤組成物 |
JP2011511793A (ja) * | 2008-02-08 | 2011-04-14 | コルゲート・パーモリブ・カンパニー | 口内乾燥の処置のための組成物および方法 |
JP2012511507A (ja) * | 2008-12-09 | 2012-05-24 | グラクソ グループ リミテッド | 新規の使用 |
JP2010235573A (ja) * | 2009-03-31 | 2010-10-21 | Kobayashi Pharmaceutical Co Ltd | 歯磨組成物 |
WO2010114005A1 (ja) * | 2009-03-31 | 2010-10-07 | 小林製薬株式会社 | 歯磨組成物 |
JP2015129115A (ja) * | 2009-05-22 | 2015-07-16 | ルブリス,エルエルシー. | Prg4及びその治療調節作用の応用及び使用 |
JP2012527485A (ja) * | 2009-05-22 | 2012-11-08 | ルブリス,エルエルシー. | Prg4及びその治療調節作用の応用及び使用 |
JP2014501259A (ja) * | 2010-12-23 | 2014-01-20 | コルゲート・パーモリブ・カンパニー | ポリマー系 |
JP2014501257A (ja) * | 2010-12-23 | 2014-01-20 | コルゲート・パーモリブ・カンパニー | 水性オーラルケア組成物 |
JP2017081951A (ja) * | 2011-04-19 | 2017-05-18 | アームズ ファーマシューティカル エルエルシーArms Pharmaceutical Llc. | 有害な微生物を阻害する方法及びそのためのバリア形成組成物 |
JP2017537983A (ja) * | 2014-12-10 | 2017-12-21 | エレべイト オーラル ケア、エルエルシー | 口渇の軽減のための組成物 |
US10772908B2 (en) | 2014-12-10 | 2020-09-15 | Elevate Oral Care, Llc | Composition for the relief of dry mouth |
US11890355B2 (en) | 2016-01-10 | 2024-02-06 | Smilesonica Inc. | Viscosity and stability modified ultrasound gel |
US11478435B2 (en) | 2017-02-22 | 2022-10-25 | Smilesonica Inc. | Artificial saliva, related methods, and uses |
Also Published As
Publication number | Publication date |
---|---|
PT1793799E (pt) | 2010-07-29 |
AU2005268926B2 (en) | 2011-10-13 |
BRPI0514037B1 (pt) | 2018-05-22 |
EP1793799B1 (en) | 2010-05-05 |
BRPI0514037B8 (pt) | 2021-05-25 |
ATE466566T1 (de) | 2010-05-15 |
US9044500B2 (en) | 2015-06-02 |
MX2007001384A (es) | 2007-04-19 |
ZA200700965B (en) | 2017-09-27 |
AU2005268926A1 (en) | 2006-02-09 |
US10350238B2 (en) | 2019-07-16 |
US20130295041A1 (en) | 2013-11-07 |
CA2575605A1 (en) | 2006-02-09 |
JP4919957B2 (ja) | 2012-04-18 |
EP1793799A1 (en) | 2007-06-13 |
WO2006013081A1 (en) | 2006-02-09 |
EP2263644A2 (en) | 2010-12-22 |
DE602005021126D1 (de) | 2010-06-17 |
CA2575605C (en) | 2014-05-20 |
ES2344911T3 (es) | 2010-09-09 |
US20080317703A1 (en) | 2008-12-25 |
GC0001377A (en) | 2011-03-31 |
BRPI0514037A (pt) | 2008-05-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4919957B2 (ja) | 口腔乾燥症用新規組成物 | |
TWI477269B (zh) | 治療口腔乾燥用之牙用組成物 | |
JP4111916B2 (ja) | 口内乾燥症の軽減および関連疾病の治療のための組成物 | |
RU2622022C2 (ru) | Системы поверхностно-активных веществ для содержащих цинк композиций | |
TW201521771A (zh) | 牙齒增白口腔護理產品 | |
CN107106473A (zh) | 口腔护理产品及其使用和制造方法 | |
US8071076B2 (en) | Oral lubricating and stain retarding compositions | |
TWI422391B (zh) | 含有矽油珠之潔齒劑組成物 | |
JP2022000420A (ja) | 口腔用組成物 | |
AU2006265330B2 (en) | Oral composition comprising dimethicone copolyol | |
JP5512791B2 (ja) | 歯の組織の抗細菌剤取り込みを示す脱感作性歯磨剤 | |
JP3690442B2 (ja) | 唾液分泌促進剤、口腔用組成物及び義歯安定剤 | |
RU2462231C1 (ru) | Лечебно-профилактическая зубная паста | |
KR101568684B1 (ko) | 기포력이 우수한 구강용 조성물 | |
JPH07206650A (ja) | 口腔用組成物 | |
JP2002284691A (ja) | 食前使用口腔用組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080702 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110913 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111212 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120110 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120131 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 4919957 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150210 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |