JP2008275353A - Collection apparatus of trace amount of liquid, and adapter - Google Patents

Collection apparatus of trace amount of liquid, and adapter Download PDF

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Publication number
JP2008275353A
JP2008275353A JP2007116389A JP2007116389A JP2008275353A JP 2008275353 A JP2008275353 A JP 2008275353A JP 2007116389 A JP2007116389 A JP 2007116389A JP 2007116389 A JP2007116389 A JP 2007116389A JP 2008275353 A JP2008275353 A JP 2008275353A
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capillary
adapter
coupling hole
suction side
hole
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JP4807587B2 (en
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Maki Suezawa
真樹 末澤
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Nippon Koden Corp
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Nippon Koden Corp
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Abstract

<P>PROBLEM TO BE SOLVED: To heighten accuracy of a liquid quantity sucked into a specimen measuring device, and to reduce an error. <P>SOLUTION: This apparatus is equipped with a capillary having openings on both ends; and an adapter equipped with a connection hole to be bonded to one end of the capillary, a suction side hole part formed to be enlarged gradually toward the outside in a tapered shape in the opposite direction in communication with the connection hole, a body part wherein the connection hole and the suction side hole part are formed, and a knob part provided protrusively from the body part to a radial direction of the capillary. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

この発明は、例えば新生児や小児などから血液などの微量サンプルを採取する際に用いるキャピラリーを含む微量液採取器具及びその器具を構成するアダプタに関するものである。   The present invention relates to a trace liquid collecting instrument including a capillary used when collecting a trace sample such as blood from a newborn or a child, for example, and an adapter constituting the instrument.

従来、キャピラリーによって血液などのサンプルを採取した場合には、例えば、図８に示すような底部が尖った蓋付の容器５５に対し、検体計測装置６０からサンプル吸引管６１を介して希釈用試薬を吐出させて蓄積し、図９に示すように、サンプルが入った状態のキャピラリー７０を先端側に取り付けたスポイト７１を操作して、サンプルを容器５５へ吐出する。   Conventionally, when a sample such as blood is collected by a capillary, for example, a dilution reagent is supplied from a sample measuring device 60 through a sample suction tube 61 to a container 55 with a lid having a sharp bottom as shown in FIG. As shown in FIG. 9, the sample 71 is discharged into the container 55 by operating the dropper 71 with the capillary 70 in a state where the sample is placed attached to the tip side.

次に図１０に示すように、容器５５の蓋を閉めて上下に振るなどして希釈用試薬とサンプルとの攪拌を行い、攪拌の後に容器５５の蓋を開けて検体計測装置６０のサンプル吸引管６１の先端が図１１（ｂ）に示されるように容器５５の底部に届くようにして、検体計測装置６０に吸引を行わせる。   Next, as shown in FIG. 10, the lid of the container 55 is closed and shaken up and down to stir the reagent for dilution and the sample, and after the stirring, the lid of the container 55 is opened and the sample aspiration of the sample measuring device 60 is performed. The tip of the tube 61 reaches the bottom of the container 55 as shown in FIG.

しかしながら、このような手法によれば、図９のスポイト７１を操作して吐出させるときにスポイト７１から完全に吐出できないことや、図１０の攪拌に作業者毎の攪拌むらが生じるなどという作業者の手技による誤差などの積み重ねにより正確な計測ができ難いという問題があった。   However, according to such a method, the operator cannot discharge completely from the dropper 71 when operating the dropper 71 of FIG. 9 to discharge, and the agitator of FIG. There was a problem that accurate measurement was difficult due to the accumulation of errors due to the procedure.

上記に対し特許文献１には、キャピラリーを自動分析装置にそのままセットするためのホルダが示されている。
実開平６−７０４２号公報 In contrast, Patent Document 1 discloses a holder for setting a capillary as it is in an automatic analyzer.
Japanese Utility Model Publication No. 6-7042

しかしながら、このホルダは、キャピラリー全体を空隙部４に挿入するものであり、内径が１ｍｍ以下のキャピラリーを挿入する際に折れるなどの危惧がある。また、有底のキャピラリーにサンプル吸引管を挿入して吸引を行う構造であり、小孔部５ａにおいてサンプル吸引管との間に空隙がなければ吸引時に空気が流入せず正確なサンプル吸引が困難なであるため、サンプル吸引管の外径は、キャピラリー内径より、十分小さくかつ管状構造でなければならないため、製法が困難であり現実的ではない。   However, this holder inserts the entire capillary into the gap portion 4, and there is a risk that it will break when a capillary having an inner diameter of 1 mm or less is inserted. In addition, the sample suction tube is inserted into a bottomed capillary to perform suction, and if there is no gap between the small hole portion 5a and the sample suction tube, air does not flow during suction and accurate sample suction is difficult. Therefore, the outer diameter of the sample suction tube must be sufficiently smaller than the inner diameter of the capillary and has a tubular structure, which makes the manufacturing method difficult and impractical.

本発明は上記のような従来の微量液採取器具における問題点を解決せんとしてなされたもので、その目的は、検体計測装置へ吸入される液量の精度が高く、誤差を少なくすることができる微量液採取器具及びアダプタを提供することである。また、計測作業を行い易く、また検体計測装置の要求にも合せ易い微量液採取器具及びアダプタを提供することを目的とする。   The present invention has been made as a solution to the above-described problems in the conventional trace liquid collecting device, and its purpose is that the accuracy of the amount of liquid sucked into the sample measuring device is high and errors can be reduced. It is to provide a trace liquid collection device and an adapter. It is another object of the present invention to provide a trace liquid collecting instrument and an adapter that can easily perform measurement work and can easily meet the requirements of a sample measuring apparatus.

本発明に係る微量液採取器具は、両端に開口を有するキャピラリーと、このキャピラリーの一端部に結合する結合孔と、この結合孔と連通して反対方向にテーパ状に外側へ大きくなるように形成された吸引側穴部と、前記結合孔及び前記吸引側穴部が形成された本体部と、この本体部から突出して設けられたツマミ部とを備えるアダプタとを具備することを特徴とする。   A trace liquid collecting device according to the present invention is formed such that a capillary having openings at both ends, a coupling hole coupled to one end portion of the capillary, and a taper-shaped outside in a reverse direction communicating with the coupling hole. And an adapter including a main body portion in which the coupling hole and the suction side hole portion are formed, and a knob portion that protrudes from the main body portion.

本発明に係る微量液採取器具は、アダプタが弾性を有する合成樹脂により作成されていることを特徴とする。   The trace liquid collecting instrument according to the present invention is characterized in that the adapter is made of a synthetic resin having elasticity.

本発明に係る微量液採取器具は、キャピラリーとアダプタとは別部材により構成されることを特徴とする。   The trace liquid collecting instrument according to the present invention is characterized in that the capillary and the adapter are constituted by separate members.

本発明に係るアダプタは、キャピラリーの一端部に結合する結合孔と、この結合孔と連通して反対方向にテーパ状に外側へ大きくなるように形成された吸引側穴部と、前記結合孔及び前記吸引側穴部が形成された本体部と、この本体部から突出して設けられたツマミ部とを具備することを特徴とする。   The adapter according to the present invention includes a coupling hole coupled to one end of the capillary, a suction side hole formed so as to be tapered outward in communication with the coupling hole in the opposite direction, the coupling hole, The main body part in which the said suction side hole part was formed, and the knob part provided by protruding from this main body part are comprised.

本発明に係るアダプタは、弾性を有する合成樹脂により作成されていることを特徴とする。   The adapter according to the present invention is made of a synthetic resin having elasticity.

本発明に係る微量液採取器具は、結合孔及び吸引側穴部が形成された本体部が結合孔においてキャピラリーの一端部に結合する構成であるため、細長いキャピラリーを挿入する際に折れるなど心配をなくすることができる。また、キャピラリーに入った液体を吸引側穴部から吸引するとキャピラリーの他端側の開口から空気が流入して適切な吸引が保証される。また、キャピラリーの容量により液量が決定されるため作業者の手技による誤差のない計測が可能である効果がある。更に、ツマミ部により扱いが容易である利点を有している。   The trace liquid collecting device according to the present invention has a structure in which the main body portion in which the coupling hole and the suction side hole portion are formed is coupled to one end portion of the capillary in the coupling hole, and therefore, there is a concern that it may be broken when an elongated capillary is inserted. Can be eliminated. Further, when the liquid that has entered the capillary is sucked from the suction side hole, air flows from the opening on the other end side of the capillary, thereby ensuring proper suction. Further, since the amount of liquid is determined by the capacity of the capillary, there is an effect that measurement without error due to the operator's technique is possible. Furthermore, there is an advantage that the handle portion is easy to handle.

アダプタは、弾性を有する合成樹脂により作成されているので、様々な外径の大きさのキャピラリーを用いることができ、別途シール材が不要となる。また、検体計測装置のサンプル吸引管との衝突などによる毀損の心配がなく、作業性に優れる。   Since the adapter is made of an elastic synthetic resin, capillaries having various outer diameters can be used, and a separate sealing material is not necessary. In addition, there is no risk of damage due to collision with the sample suction tube of the sample measuring device, and the workability is excellent.

キャピラリーとアダプタとは別部材により構成されるので、市販のキャピラリーを用いることができる利点がある。   Since the capillary and the adapter are configured by separate members, there is an advantage that a commercially available capillary can be used.

以下図面を参照して、本発明に係る微量液採取器具及びアダプタの実施例を説明する。各図において、同一の構成要素には、同一の符号を付して重複する説明を省略する。実施例に係る微量液採取器具１０は、図１、図２に示すようにガラス、プラスチックなどにより作成され、両端に開口を有するキャピラリー１１を備える。キャピラリー１１の外径寸法は、例えば０．８〜０．９ｍｍ、容量は３〜１５μＬ程度のものを用いる。   Embodiments of a trace liquid collecting device and an adapter according to the present invention will be described below with reference to the drawings. In each figure, the same components are denoted by the same reference numerals and redundant description is omitted. As shown in FIGS. 1 and 2, the trace liquid collecting device 10 according to the embodiment is made of glass, plastic, or the like, and includes a capillary 11 having openings at both ends. For example, the capillary 11 has an outer diameter of 0.8 to 0.9 mm and a capacity of about 3 to 15 μL.

アダプタ２０は、ゴムなどの弾性を有する合成樹脂により構成され、概ね直方体状の本体部２１と、ツマミ部２２とを有している。本体部２１の一側面には、キャピラリー１１の一端部に結合する結合孔２３が形成されており、この結合孔２３と連通して反対方向にテーパ状に外側へ大きくなるようにテーパ部２４ａが形成された吸引側穴部２４が形成されている。   The adapter 20 is made of a synthetic resin having elasticity such as rubber, and has a substantially rectangular parallelepiped main body portion 21 and a knob portion 22. A coupling hole 23 that is coupled to one end of the capillary 11 is formed on one side of the main body 21, and a tapered portion 24 a that communicates with the coupling hole 23 and increases outward in a taper shape in the opposite direction. The formed suction side hole 24 is formed.

結合孔２３と吸引側穴部２４の境界部分は、段部２５となっており、キャピラリー１１を挿入した場合のストッパの機能を有している。本体部２１における吸引側穴部２４の開口を有する面の周縁部は本体部２１から外側へ僅かに突出したフランジ部２１ａとなっており、本体部２１の面積が大きい面には、結合孔２３と吸引側穴部２４に応じた緩やかな膨部２６が形成されている。   A boundary portion between the coupling hole 23 and the suction side hole portion 24 is a step portion 25, which has a stopper function when the capillary 11 is inserted. The peripheral portion of the surface of the main body portion 21 having the opening of the suction side hole portion 24 is a flange portion 21a that slightly protrudes outward from the main body portion 21, and the surface of the main body portion 21 having a large area has a coupling hole 23. A gentle bulging portion 26 corresponding to the suction side hole portion 24 is formed.

ツマミ部２２は、薄板状であって、結合孔２３に挿入されたキャピラリー１１のラジアル方向へ突出して設けられている。また、結合孔２３の開口部は本体部２１からやや突出したスリーブ２７に形成されている。   The knob portion 22 has a thin plate shape and is provided so as to protrude in the radial direction of the capillary 11 inserted into the coupling hole 23. The opening of the coupling hole 23 is formed in a sleeve 27 that slightly protrudes from the main body 21.

以上の通り構成される微量液採取器具１０は、図３〜図５に示される組立治具３０を用いて作成される。組立治具３０は、キャピラリー１１が配置される一端側に壁部３２を有する溝部３１と、溝部３１の他端側に設けられアダプタ２０を配置する配置台部３３を備えている。配置台部３３の一側部にはガイド壁３４が設けられ、配置台部３３と溝部３１の境界部分はアダプタ２０の進行を停止させるストッパの機能を有する壁面３５となっている。また、壁面３５の下端部にはアダプタ２０のスリーブ２７が入り込む穴部３６が形成されている。   The trace liquid collecting device 10 configured as described above is created using the assembly jig 30 shown in FIGS. The assembly jig 30 includes a groove portion 31 having a wall portion 32 on one end side where the capillary 11 is arranged, and an arrangement table portion 33 provided on the other end side of the groove portion 31 on which the adapter 20 is arranged. A guide wall 34 is provided on one side of the placement table 33, and a boundary portion between the placement table 33 and the groove 31 is a wall surface 35 that functions as a stopper that stops the progression of the adapter 20. A hole 36 into which the sleeve 27 of the adapter 20 enters is formed at the lower end of the wall surface 35.

微量液採取器具１０を組み立てる場合には、図３に示されるように、溝部３１にキャピラリー１１を、その一端部が壁部３２に当接した状態で配置する。このとき、図４に示されるようにキャピラリー１１の他端側は壁面３５から配置台部３３に突出した状態となる。   When assembling the trace liquid collecting instrument 10, as shown in FIG. 3, the capillary 11 is disposed in the groove portion 31 with one end thereof in contact with the wall portion 32. At this time, as shown in FIG. 4, the other end side of the capillary 11 protrudes from the wall surface 35 to the placement table 33.

図４に示されるような状態において、アダプタ２０をツマミ部２２が配置台部３３のオープン側に位置するようにして、ツマミ部２２と対向する面をガイド壁３４に沿わせて、キャピラリー１１側へ押し付ける。壁面３５から突出したキャピラリー１１の端部は、アダプタ２０の結合孔２３に入り込み、アダプタ２０の進行はストッパの機能を有する壁面３５によって阻止される。このとき壁面３５から突出したキャピラリー１１の端部は結合孔２３に入り込むが、段部２５のストッパとしての作用により停止され、微量液採取器具１０が出来上がる。これにより、市販のキャピラリー１１をそのまま用いることができる。   In the state shown in FIG. 4, the adapter 20 is positioned on the open side of the placement base 33, the adapter 20 is positioned on the side of the capillary 11 so that the surface facing the knob 22 is along the guide wall 34. Press to. The end portion of the capillary 11 protruding from the wall surface 35 enters the coupling hole 23 of the adapter 20, and the progression of the adapter 20 is blocked by the wall surface 35 having a stopper function. At this time, the end portion of the capillary 11 protruding from the wall surface 35 enters the coupling hole 23, but is stopped by the action of the step portion 25 as a stopper, and the trace liquid collecting device 10 is completed. Thereby, the commercially available capillary 11 can be used as it is.

微量液採取器具１０は次のようにして用いることができる。図６に示される血液などの液体サンプル５１に、キャピラリー１１の先端を差し込んで、毛細管現象により液体サンプル５１をキャピラリー１１内に満たす。このときツマミ部２２を指で挟んで作業を行うことができ、作業性を向上させる。   The trace liquid collecting device 10 can be used as follows. The tip of the capillary 11 is inserted into a liquid sample 51 such as blood shown in FIG. 6, and the capillary 11 is filled with the liquid sample 51 by capillary action. At this time, the work can be performed with the knob portion 22 held between fingers, which improves workability.

図７に示すように、ツマミ部２２を指で挟んでアダプタ２０の吸引側穴部２４の開口を、検体計測装置６０のサンプル吸引管６１の下方に位置付けて、サンプル吸引管６１の先端が吸引側穴部２４におけるテーパ部２４ａに当接するように操作し、検体計測装置６０を操作して液体サンプル５１の吸引を行わせる。   As shown in FIG. 7, the opening of the suction side hole 24 of the adapter 20 is positioned below the sample suction tube 61 of the sample measuring device 60 with the knob portion 22 sandwiched between fingers, and the tip of the sample suction tube 61 is sucked. The liquid sample 51 is aspirated by operating the specimen measuring device 60 so as to contact the tapered portion 24a in the side hole portion 24.

検体計測装置６０は、吸引した液体サンプル５１と先に所定量を吸引してある希釈用試薬とを混合攪拌して、分析を行い、結果を出力する。   The sample measuring device 60 mixes and agitates the aspirated liquid sample 51 and the dilution reagent that has previously aspirated a predetermined amount, performs analysis, and outputs the result.

以上の通りの作業が行われる結果、液体サンプル５１の容量はキャピラリー１１の容量となり、作業者の作業精度に拘らず一定となり、また、希釈用試薬の量や攪拌作業が一定となり、バラツキによる誤差を少なくして測定精度を向上させることができる。また作業性の向上により、作業時間を短縮できる効果も生じる。   As a result of the operation as described above, the volume of the liquid sample 51 becomes the capacity of the capillary 11 and becomes constant regardless of the work accuracy of the operator, and the amount of the dilution reagent and the stirring work become constant, and errors due to variations. And the measurement accuracy can be improved. In addition, the improvement in workability also has the effect of shortening the work time.

本発明に係る微量液採取器具の実施例を示す斜視図。The perspective view which shows the Example of the trace amount liquid collection instrument based on this invention. 本発明に係る微量液採取器具の実施例を示す断面図。Sectional drawing which shows the Example of the trace amount liquid collection instrument based on this invention. 本発明に係る微量液採取器具の実施例に関する組み立て工程を示す斜視図。The perspective view which shows the assembly process regarding the Example of the trace amount liquid collection instrument based on this invention. 本発明に係る微量液採取器具の実施例に関する組み立て工程を示す斜視図。The perspective view which shows the assembly process regarding the Example of the trace amount liquid collection instrument based on this invention. 本発明に係る微量液採取器具の実施例に関する組み立て工程を示す斜視図。The perspective view which shows the assembly process regarding the Example of the trace amount liquid collection instrument based on this invention. 本発明に係る微量液採取器具の実施例を用いた計測工程を示す斜視図。The perspective view which shows the measurement process using the Example of the trace amount liquid collection instrument based on this invention. 本発明に係る微量液採取器具の実施例を用いた計測工程を示す斜視図であり、（ａ）は要部を示し、（ｂ）は要部を拡大したものであり、（ｃ）は（ｂ）のＡ−Ａ断面図である。It is a perspective view which shows the measurement process using the Example of the trace amount liquid collection instrument which concerns on this invention, (a) shows a principal part, (b) expands the principal part, (c) is ( It is AA sectional drawing of b). キャピラリーを用いた従来の計測工程を示す斜視図。The perspective view which shows the conventional measurement process using a capillary. キャピラリーを用いた従来の計測工程を示す斜視図。The perspective view which shows the conventional measurement process using a capillary. キャピラリーを用いた従来の計測工程を示す斜視図。The perspective view which shows the conventional measurement process using a capillary. キャピラリーを用いた従来の計測工程を示す斜視図。The perspective view which shows the conventional measurement process using a capillary.

符号の説明Explanation of symbols

１０ 微量液採取器具
１１ キャピラリー
２０ アダプタ
２１ 本体部
２１ａ フランジ部
２２ ツマミ部
２３ 結合孔
２４ 吸引側穴部
２４ａ テーパ部
２５ 段部
２７ スリーブ
３０ 組立治具
３１ 溝部
３２ 壁部
３３ 配置台部
５１ 液体サンプル
６０ 検体計測装置
６１ サンプル吸引管 DESCRIPTION OF SYMBOLS 10 Trace liquid collection instrument 11 Capillary 20 Adapter 21 Main body part 21a Flange part 22 Knob part 23 Joint hole 24 Suction side hole part 24a Taper part 25 Step part 27 Sleeve 30 Assembly jig 31 Groove part 32 Wall part 33 Placement part 51 Liquid sample 60 Sample measuring device 61 Sample suction tube

Claims (5)

両端に開口を有するキャピラリーと、
このキャピラリーの一端部に結合する結合孔と、この結合孔と連通して反対方向にテーパ状に外側へ大きくなるように形成された吸引側穴部と、前記結合孔及び前記吸引側穴部が形成された本体部と、この本体部から突出して設けられたツマミ部とを備えるアダプタと、
を具備することを特徴とする微量液採取器具。 A capillary having openings at both ends;
A coupling hole coupled to one end of the capillary; a suction side hole formed to be tapered outward in communication with the coupling hole in the opposite direction; and the coupling hole and the suction side hole. An adapter including the formed main body and a knob provided so as to protrude from the main body;
A trace liquid collecting device comprising: アダプタが弾性を有する合成樹脂により作成されていることを特徴とする請求項１に記載の微量液採取器具。 2. The trace liquid collecting device according to claim 1, wherein the adapter is made of a synthetic resin having elasticity. キャピラリーとアダプタとは別部材により構成されることを特徴とする請求項１または２に記載の微量液採取器具。 The micro fluid collecting device according to claim 1 or 2, wherein the capillary and the adapter are constituted by separate members. キャピラリーの一端部に結合する結合孔と、
この結合孔と連通して反対方向にテーパ状に外側へ大きくなるように形成された吸引側穴部と、
前記結合孔及び前記吸引側穴部が形成された本体部と、
この本体部から突出して設けられたツマミ部と
を具備することを特徴とするアダプタ。 A coupling hole coupled to one end of the capillary;
A suction side hole formed so as to increase outward in a taper shape in the opposite direction in communication with the coupling hole;
A body portion in which the coupling hole and the suction side hole portion are formed;
An adapter comprising: a knob portion protruding from the main body portion. 弾性を有する合成樹脂により作成されていることを特徴とする請求項４に記載のアダプタ。 The adapter according to claim 4, wherein the adapter is made of a synthetic resin having elasticity.
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