JP2005283306A - プローブアレイ製造用部材及びプローブアレイの製造方法 - Google Patents
プローブアレイ製造用部材及びプローブアレイの製造方法 Download PDFInfo
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Abstract
【解決手段】 プローブアレイ製造用部材M1、M2、・・・Mnを切断して切断片F1、F2、・・・Fnを製造し、所定個数の切断片F1、F2、・・・Fnを剥離シート13から剥がし、接着剤層12を介して支持部材2aの所定箇所に接着する。
【選択図】 図4
Description
プローブアレイの製造方法としては、スポッティング用ピン内に吸い上げられたプローブ含有液を基材上の所定部位にスポッティングする方法(特許文献1参照)が知られている。また、DNAチップの製造方法としては、半導体製造のフォトリソグラフィー技術を応用して基材上で直接オリゴヌクレオチドを合成する方法(特許文献2参照)が知られている。
したがって、本発明のプローブアレイ製造用部材又はその切断片を支持部材表面に接着して配列させることにより、プローブアレイを製造することができる。
図1に示すように、本実施形態に係るプローブアレイ製造用部材M1は、矩形シート状の基材11と、基材11の上面に固定されたプローブP1と、基材11の下面に積層された接着剤層12とを備えており、接着剤層12の下面には剥離シート13が積層されている。
プローブアレイ1b又は1cを利用する場合、例えば、毛細管現象、シリンジ等を利用して液体試料をプローブアレイ1b又は1cの中空部に流入させることにより、液体試料とプローブP1、P2・・・Pnとを接触させることができる。
プローブアレイ1b又は1cを利用する場合、例えば、毛細管現象、シリンジ等を利用して洗浄液をプローブアレイ1b又は1cの中空部に流入させることにより、プローブP1、P2・・・Pnを洗浄することができる。
標識物質が蛍光物質である場合、励起光を照射し、発せられる蛍光を蛍光検出器で検出することにより、標的物質を検出することができる。標識物質が酵素である場合、酵素呈色反応により標的物質を検出することができる。
厚さ50μmのポリエチレンテレフタレートフィルム(以下「PETフィルム」という。)をポリL−リジン溶液(濃度:0.01%、溶媒:0.1×PBS)に浸漬し、1時間振盪した。次いで、超純水中で4回激しく洗浄し、余分なポリL−リジンを洗い流した。次いで、バキュームオーブンによりPETフィルムを60℃で4時間乾燥させ、ポリL−リジンをPETフィルムにコーティングした。
P1〜Pn・・・プローブ
F1〜Fn・・・プローブアレイ製造用部材の切断片
1a〜1c・・・プローブアレイ
11・・・基材
12・・・接着剤層
13・・・剥離シート
2a〜2c・・・支持部材
3・・・円筒状部材
4・・・スペーサー部
Claims (10)
- 基材と、前記基材表面の第一領域に固定されたプローブと、前記基材表面の第二領域に設けられた接着剤層とを備えたプローブアレイ製造用部材。
- 前記基材がシート状基材であり、前記第一領域が前記シート状基材の一方の面に位置し、前記第二領域が前記シート状基材の他方の面に位置する請求項1記載のプローブアレイ製造用部材。
- 前記第一領域に一種類のプローブのみが固定されている請求項1又は2記載のプローブアレイ製造用部材。
- 支持部材と、前記支持部材表面に配列された請求項1〜3のいずれかに記載のプローブアレイ製造用部材又はその切断片とを備えたプローブアレイであって、
前記プローブアレイ製造用部材又はその切断片が、前記プローブが露出するように前記接着剤層を介して前記支持部材に接着されている前記プローブアレイ。 - 前記支持部材が筒状部材であり、前記プローブ製造用部材又はその切断片が前記筒状部材の内周面に接着されている請求項4記載のプローブアレイ。
- 前記プローブアレイが筒状部材をさらに備えており、前記プローブが前記筒状部材の中空部に露出するように、前記支持部材が前記筒状部材の中空部に収容されている請求項4記載のプローブアレイ。
- 前記支持部材の外周面と前記筒状部材の内周面との接触を防止するスペーサー部材が前記支持部材の外周面又は前記筒状部材の内周面に設けられている請求項6記載のプローブアレイ。
- 支持部材と、前記支持部材表面に配列された請求項1〜3のいずれかに記載のプローブアレイ製造用部材又はその切断片とを備えたプローブアレイの製造方法であって、
前記プローブアレイ製造用部材又はその切断片を、前記プローブが露出するように前記接着剤層を介して前記支持部材に接着する工程を含むプローブアレイの製造方法。 - 前記支持部材が筒状部材であり、前記工程において、前記プローブ製造用部材又はその切断片を前記筒状部材の内周面に接着する請求項8記載のプローブアレイの製造方法。
- 前記プローブアレイが筒状部材をさらに備えており、前記プローブが前記筒状部材の中空部に露出するように、前記支持部材を前記筒状部材に収容する工程をさらに含む請求項8記載のプローブアレイの製造方法。
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JP2004097230A JP2005283306A (ja) | 2004-03-29 | 2004-03-29 | プローブアレイ製造用部材及びプローブアレイの製造方法 |
EP05251928A EP1582254A1 (en) | 2004-03-29 | 2005-03-29 | Member for producing a probe array and probe array producing method |
US11/091,707 US20050250139A1 (en) | 2004-03-29 | 2005-03-29 | Member for producing a probe array and probe array producing method |
US11/826,060 US20070275405A1 (en) | 2004-03-29 | 2007-07-12 | Member for producing a probe array and probe array producing method |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007255999A (ja) * | 2006-03-22 | 2007-10-04 | National Institute Of Advanced Industrial & Technology | マイクロアレイ作製方法、転写フィルム作製方法および転写フィルム |
WO2014142330A1 (ja) * | 2013-03-15 | 2014-09-18 | 株式会社ニコン | バイオチップ固定方法、バイオチップ固定装置及び生体分子アレイのスクリーニング方法 |
JP2014228424A (ja) * | 2013-05-23 | 2014-12-08 | 株式会社ニコン | 検査用パッケージ及びその検査方法、スクリーニング方法並びにスクリーニング装置 |
JP2014228411A (ja) * | 2013-05-23 | 2014-12-08 | 株式会社ニコン | 検査用パッケージ及びその検査方法、スクリーニング方法並びにスクリーニング装置 |
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US20070240984A1 (en) * | 2006-04-18 | 2007-10-18 | Popovich Natasha D | Biosensors comprising heat sealable spacer materials |
DE102006027517A1 (de) * | 2006-06-09 | 2007-12-13 | Euroimmun Medizinische Labordiagnostika Ag | Verfahren zur Erzeugung perfekter Macro- und Microarrays durch Kombinieren vorselektierter beschichteter Festphasen-Fragmente |
US20090188866A1 (en) * | 2008-01-25 | 2009-07-30 | Benjamin Elias Blumenthal | Desalination with production of brine fuel |
DE102010006725B4 (de) * | 2010-02-03 | 2016-03-03 | Siltronic Ag | Verfahren zur Herstellung einer Halbleiterscheibe aus Silizium mit einer epitaktisch abgeschiedenen Schicht |
WO2017188095A1 (en) * | 2016-04-25 | 2017-11-02 | Ricoh Company, Ltd. | Testing device and method for producing same, testing method, and testing kit and transfer medium for producing testing device |
CN109853045B (zh) * | 2018-12-03 | 2023-10-24 | 江苏苏博生物医学科技南京有限公司 | 一种高通量检测的基因芯片 |
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US20030113724A1 (en) * | 2001-10-12 | 2003-06-19 | Schembri Carol T. | Packaged microarray apparatus and a method of bonding a microarray into a package |
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- 2005-03-29 US US11/091,707 patent/US20050250139A1/en not_active Abandoned
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JPH10185923A (ja) * | 1996-10-31 | 1998-07-14 | Hewlett Packard Co <Hp> | 化学成分のアレイを構成する方法および結合検定に用いられる生体有機分子プローブのアレイを構成する方法 |
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Cited By (5)
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JP2007255999A (ja) * | 2006-03-22 | 2007-10-04 | National Institute Of Advanced Industrial & Technology | マイクロアレイ作製方法、転写フィルム作製方法および転写フィルム |
WO2014142330A1 (ja) * | 2013-03-15 | 2014-09-18 | 株式会社ニコン | バイオチップ固定方法、バイオチップ固定装置及び生体分子アレイのスクリーニング方法 |
JPWO2014142330A1 (ja) * | 2013-03-15 | 2017-02-16 | 株式会社ニコン | バイオチップ固定装置及びバイオチップ固定方法 |
JP2014228424A (ja) * | 2013-05-23 | 2014-12-08 | 株式会社ニコン | 検査用パッケージ及びその検査方法、スクリーニング方法並びにスクリーニング装置 |
JP2014228411A (ja) * | 2013-05-23 | 2014-12-08 | 株式会社ニコン | 検査用パッケージ及びその検査方法、スクリーニング方法並びにスクリーニング装置 |
Also Published As
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EP1582254A1 (en) | 2005-10-05 |
US20070275405A1 (en) | 2007-11-29 |
US20050250139A1 (en) | 2005-11-10 |
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