JP2005200356A - Hair-fostering cosmetic - Google Patents
Hair-fostering cosmetic Download PDFInfo
- Publication number
- JP2005200356A JP2005200356A JP2004008758A JP2004008758A JP2005200356A JP 2005200356 A JP2005200356 A JP 2005200356A JP 2004008758 A JP2004008758 A JP 2004008758A JP 2004008758 A JP2004008758 A JP 2004008758A JP 2005200356 A JP2005200356 A JP 2005200356A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- extract
- fostering
- hair growth
- royal jelly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000003756 stirring Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
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- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
本発明は、育毛料に関し、更に詳しくは、発毛、養毛、脱毛予防、ふけ防止等の効果に優れた育毛料に関する。本発明の育毛料は、具体的には、医薬品、医薬部外品又は化粧品の分野において利用される。 The present invention relates to a hair growth material, and more particularly, to a hair growth material excellent in effects such as hair growth, hair restoration, hair loss prevention, and anti-dandruff. The hair restorer of the present invention is specifically used in the field of pharmaceuticals, quasi drugs or cosmetics.
一般的に、脱毛症は血行の不全、毛母細胞活性の低下や性ホルモンのアンバランス等の様々な要因が複雑に絡み合って生じていると考えられ、特に現代社会は高齢化社会、ストレス社会と言われるように、様々な原因によって脱毛の危機にさらされる機会が多くなっている。しかし、脱毛の発生機作やメカニズムが未だ十分に解明されていないのが現状である。従来の育毛料には育毛効果が期待される薬効成分として、例えば、トウガラシチンキ、センブリエキス、朝鮮ニンジンエキス、ニコチン酸誘導体等の頭皮の血行促進物質、セファランチン等の皮膚機能亢進物質、アセチルコリン誘導体等の血管拡張剤、エストラジオール等の女性ホルモン剤、パントテン酸誘導体等のメラニン合成触媒剤、サリチル酸、レゾルシン等の角質溶解剤、グリチルレチン酸、アズレン等の抗炎症剤が配合され、脱毛の予防や治療に用いられている（例えば、非特許文献１参照。）。しかしながら、これらの成分は、頭皮の養毛環境を整えたり、すでに生えている毛髪の成長速度を改善したりする効果があるものの、発毛作用が弱く、更に場合によっては皮膚刺激を引き起こしたりするため、配合量に制限があり、十分な効果を発揮するまでには至っていない。育毛料においては新生毛の発生を促すことも重要であり、発毛促進物質としてミノキシジルが配合された発毛料（例えば、特許文献１及び２参照。）が開示されていが、本物質は血圧降下作用を応用したものであり、副作用等を伴い安全性という観点で懸念される。またローヤルゼリー又はその抽出物を含有した育毛料（例えば、特許文献３及び４参照。）が開示されているが、、発毛・養毛効果においてはその効果が充分であるとは言えず、その為、発毛効果と養毛効果を兼ね備えた、より効果的な育毛料が強く要望されている。 In general, alopecia is thought to be caused by complex intertwining of various factors such as poor blood circulation, decreased hair matrix activity, and sex hormone imbalance. Especially in modern society, aging society and stress society As said, there are many opportunities to be at risk of hair loss due to various causes. However, the mechanism and mechanism of hair loss have not been fully elucidated yet. As a medicinal ingredient expected to have a hair-growth effect in conventional hair-growth materials, for example, red pepper tincture, assembly extract, ginseng extract, nicotinic acid derivative and other scalp blood circulation promoting substances, cephalanthin and other skin function enhancing substances, acetylcholine derivatives and the like Vascular dilators, female hormone agents such as estradiol, melanin synthesis catalyst agents such as pantothenic acid derivatives, keratolytic agents such as salicylic acid and resorcin, and anti-inflammatory agents such as glycyrrhetinic acid and azulene are combined to prevent and treat hair loss. It is used (for example, refer nonpatent literature 1). However, these ingredients have the effect of adjusting the hair growth environment of the scalp and improving the growth rate of hair that has already grown, but have a weak hair growth action and may cause skin irritation in some cases. Therefore, there is a limit to the amount of blending, and it has not yet reached a sufficient effect. In hair restorations, it is also important to promote the generation of new hair, and hair restorations containing minoxidil as a hair growth promoting substance (for example, see Patent Documents 1 and 2) have been disclosed. This is an application of the action, and is concerned from the viewpoint of safety with side effects. Moreover, although the hair growth material (for example, refer patent document 3 and 4) containing the royal jelly or its extract is disclosed, it cannot be said that the effect is sufficient in the hair growth and hair-restoration effect, Therefore, there is a strong demand for a more effective hair restorer that has a hair growth effect and a hair nourishing effect.
斯かる状況下、本発明の目的とするところは、脱毛症に対して優れた発毛、養毛、脱毛予防、ふけ防止作用を有する育毛料を提供するにある。 Under such circumstances, an object of the present invention is to provide a hair-growth material having excellent hair growth, hair restoration, hair loss prevention and anti-dandruff action against alopecia.
本発明者は、上記目的を達成するために、鋭意研究を重ねた結果、ジイソプロピルアミンジクロロアセテート、γ−アミノ酪酸誘導体、ニコチン酸類等の末梢血流促進剤とローヤルゼリー又はその抽出物とを組み合わせて配合することにより、発毛促進効果、毛成長
促進に優れた効果を示し、更に脱毛抑制効果及びふけ防止予防効果にも著しい効果を呈することを見出して本発明を完成するに至った。
In order to achieve the above object, the present inventor has conducted extensive research, and as a result, combined a peripheral blood flow promoter such as diisopropylamine dichloroacetate, γ-aminobutyric acid derivative, nicotinic acid and the like with royal jelly or an extract thereof. By blending, it was found that the hair growth promoting effect and the hair growth promoting effect were excellent, and that the hair removal inhibiting effect and the anti-dandruff preventing effect were also exhibited, and the present invention was completed.
即ち、本発明の請求項１の発明は、末梢血流促進剤とローヤルゼリー又はその抽出物を含有することを特徴とする育毛料であり、請求項２の発明は、末梢血流促進剤が、ジイソプロピルアミンジクロロアセテート、γ−アミノ酪酸誘導体、ニコチン酸類、ヒノキチオール、ビタミンＥ類、トランス−３，４’−ジメチル−３−ヒドロキシフラバノン、６−ベンジルアミノプリン及び塩化カプロニウムからなる群より選ばれる少なくとも一種以上である請求項１記載の育毛料である。 That is, the invention of claim 1 of the present invention is a hair-growth material comprising a peripheral blood flow promoter and royal jelly or an extract thereof, and the invention of claim 2 is a peripheral blood flow promoter comprising: At least one selected from the group consisting of diisopropylamine dichloroacetate, γ-aminobutyric acid derivatives, nicotinic acids, hinokitiol, vitamin E, trans-3,4′-dimethyl-3-hydroxyflavanone, 6-benzylaminopurine and capronium chloride The hair growth material according to claim 1, which is as described above.
本発明により、脱毛症に対して優れた発毛、養毛、脱毛予防、ふけ防止作用を有する育毛料を提供することができる。 According to the present invention, it is possible to provide a hair restorer having excellent hair growth, hair growth, hair loss prevention, and anti-dandruff action against alopecia.
以下、本発明の実施形態について詳述する。 Hereinafter, embodiments of the present invention will be described in detail.
本発明に係る育毛料には、第一の必須成分として末梢血流促進剤が配合される。末梢血流促進剤としては、ジイソプロピルアミンジクロロアセテート、γ−アミノ酪酸誘導体、ニコチン酸類、ミノキシジル類、ヒノキチオール、ビタミンＥ類、塩化カプロニウム、ヨウ化ニンニクエキス、カンフル、ノニル酸バニリルアミド、ペンタデカン酸グリセリル、トランス−３，４’−ジメチル−３−ヒドロキシフラバノン、６−ベンジルアミノプリン、イチョウ抽出物、オトギリ草抽出物、トウガラシチンキ、カンタリスチンキ等が挙げられる。これらの中でも、ジイソプロピルアミンジクロロアセテート、γ−アミノ酪酸誘導体、ニコチン酸類、ヒノキチオール、ビタミンＥ類、トランス−３，４’−ジメチル−３−ヒドロキシフラバノン、６−ベンジルアミノプリン、塩化カプロニウムが好ましい。 The hair restorer according to the present invention contains a peripheral blood flow promoter as the first essential component. Peripheral blood flow promoters include diisopropylamine dichloroacetate, γ-aminobutyric acid derivatives, nicotinic acids, minoxidil, hinokitiol, vitamin E, capronium chloride, garlic iodide extract, camphor, nonyl acid vanillylamide, glyceryl pentadecanoate, trans -3,4'-dimethyl-3-hydroxyflavanone, 6-benzylaminopurine, Ginkgo biloba extract, Hypericum herb extract, Pepper tincture, Cantalis tincture and the like. Among these, diisopropylamine dichloroacetate, γ-aminobutyric acid derivative, nicotinic acid, hinokitiol, vitamin E, trans-3,4'-dimethyl-3-hydroxyflavanone, 6-benzylaminopurine, and capronium chloride are preferable.
ジイソプロピルアミンジクロロアセテートは、アンズの核の水溶性成分中から発見されたＰａｎｇａｍｉｃ ａｃｉｄの活性成分で、脳代謝改善治療薬として日本薬局方外規準に収載されている公知の物質である。末梢血流促進作用を有する薬剤として現在市販されており、リバオール（三共製薬社製）が挙げられる。 Diisopropylamine dichloroacetate is an active ingredient of Panamic acid discovered from the water-soluble component of apricot nucleus, and is a known substance listed in the Japanese Pharmacopoeia as a therapeutic agent for improving brain metabolism. Currently marketed as a drug having peripheral blood flow promoting action, Ribaol (manufactured by Sankyo Pharmaceutical Co., Ltd.) can be mentioned.
γ−アミノ酪酸誘導体としては、γ−アミノ酪酸、γ−アミノ−β−ヒドロキシ酪酸を挙げることができ、脳代謝関連物質として公知の物質であり、現在市販されており、γ−アミノ酪酸（科研製薬社製）、バイサミン（科研製薬社製）が挙げられる。 Examples of the γ-aminobutyric acid derivative include γ-aminobutyric acid and γ-amino-β-hydroxybutyric acid, which are known substances related to brain metabolism and are currently available on the market. Pharmaceutical Co., Ltd.) and Visamine (Kaken Pharmaceutical Co., Ltd.).
ニコチン酸類としては、ニコチン酸ベンジル，ニコチン酸トコフェロール，ニコチン酸β−ブトキシエチル、ニコチン酸アミド、酒石酸ニコチニックアルコール等を挙げることができ、これらのニコチン酸類は、現在市販されているものを使用することができる。 Examples of nicotinic acids include benzyl nicotinate, tocopherol nicotinate, β-butoxyethyl nicotinate, nicotinic acid amide, and nicotinic alcohol tartrate. be able to.
ヒノキチオールは、ヒノキ、ヒバ、ウエスタンレッドシダーなどから得られる精油中に存在するトロポノイド化合物の一種であり、現在市販されており、ヒノキチオール（高砂香料社製）等、また、公知の方法で抽出して得ることができる。 Hinokitiol is a kind of troponoid compound present in essential oils obtained from hinoki, hiba, western red cedar, etc., and is currently commercially available, such as hinokitiol (manufactured by Takasago Fragrance Co., Ltd.), etc. Can be obtained.
ビタミンＥ類としては、α−トコフェロール、酢酸ＤＬ−α−トコフェロール，ニコチン酸トコフェロール、天然ビタミンＥ等を挙げることができる。これらのビタミンＥ類は、現在市販されており、Ｅ−ミックスＤ（岩瀬コスファ社製）、理研Ｅアセテートα（理研ビタミン社製）、酢酸ｄ−α−トコフェロール（佐々木化学工業社製）などが挙げられ、また公知の製造方法により製造することができる。 Examples of vitamin E include α-tocopherol, DL-α-tocopherol acetate, tocopherol nicotinate, and natural vitamin E. These vitamin Es are currently on the market, such as E-mix D (manufactured by Iwase Kosfa), RIKEN E acetate α (manufactured by RIKEN vitamins), d-α-tocopherol acetate (manufactured by Sasaki Chemical Co., Ltd.), etc. And can be produced by a known production method.
トランス−３，４’−ジメチル−３−ヒドロキシフラバノン、６−ベンジルアミノプリンは、現在市販されており、また、公知の製造方法により製造することができる。
塩化カルプロニウムは、昭和４８年にＯＴＣ薬として承認を受けた円形脱毛症などの治療に使用されている薬剤であり、現在市販されており、また、公知の製造方法により製造することができる。
Trans-3,4′-dimethyl-3-hydroxyflavanone and 6-benzylaminopurine are currently commercially available and can be produced by known production methods.
Carpronium chloride is a drug used for the treatment of alopecia areata, which was approved as an OTC drug in 1973, and is currently marketed and can be produced by a known production method.
本発明においては、これら末梢血流促進剤の中から、一種又は二種以上を適宜選択して用いることができる。これら、末梢血流促進剤の配合量は、育毛料の総量を基準として通常０．００１〜１０．０質量％（以下、％とする）であり、好ましくは、０．０２〜３．０％である。血流促進剤の配合量が、０．００１％未満では、充分な効果を発揮することができない場合があり、また１０．０％を超えると、皮膚刺激が生ずる等、安全性の点から問題が生じるおそれがあり好ましくない。 In the present invention, one or more of these peripheral blood flow promoters can be appropriately selected and used. The blending amount of these peripheral blood flow promoters is usually 0.001 to 10.0% by mass (hereinafter referred to as%), preferably 0.02 to 3.0%, based on the total amount of hair restorer. It is. If the blending amount of the blood flow promoter is less than 0.001%, sufficient effects may not be exhibited. If it exceeds 10.0%, skin irritation may occur, which is a problem from the viewpoint of safety. May occur, which is not preferable.
本発明に係る育毛料には、第二の必須成分として、ローヤルゼリー又はその抽出物が配合される。ローヤルゼリーは、ヨーロッパミツバチ又はトウヨウミツバチの分泌物であり、また、ローヤルゼリーの抽出物はローヤルゼリーより適当な溶媒により抽出することにより得ることができる。抽出溶媒としては、エタノール、メタノール、１，３−ブチレングリコール、プロピレングリコール、グリセリン等のアルコール類、冷水、熱水等から選ばれる１種又は２種以上の混液が使用可能である。これらのローヤルゼリー又はその抽出物として、「ローヤルゼリー」、「ローヤルゼリーエキス」、「油溶性ローヤルゼリーエキス」として粧配規に収載されているもの又はこれに準ずるものが好適に用いられる。 Royal hair jelly or its extract is mix | blended with the hair restorer which concerns on this invention as a 2nd essential component. Royal jelly is a secreted product of European honey bees or honey bees, and an extract of royal jelly can be obtained by extracting from royal jelly with a suitable solvent. As the extraction solvent, one or a mixture of two or more selected from alcohols such as ethanol, methanol, 1,3-butylene glycol, propylene glycol and glycerin, cold water, hot water and the like can be used. As these royal jelly or an extract thereof, those listed in the cosmetic regulations as “royal jelly”, “royal jelly extract”, “oil-soluble royal jelly extract” or those equivalent thereto are preferably used.
これらのローヤルゼリー又はその抽出物の好ましい配合量は、本発明の毛髪化粧料中に、乾燥物換算で０．０００１〜５％、より好ましくは０．００１〜１％である。０．０００１％未満では、配合しても本発明の効果が発揮されない場合があり、５％を越えると、乾燥後べたつき感が生じる場合があり好ましくない。 A preferable blending amount of these royal jelly or an extract thereof is 0.0001 to 5%, more preferably 0.001 to 1% in terms of dry matter in the hair cosmetic composition of the present invention. If it is less than 0.0001%, the effect of the present invention may not be exhibited even if it is blended. If it exceeds 5%, stickiness may occur after drying, which is not preferable.
本発明の育毛料は、種々の形態で用いることができ、例えば、ヘアートニック、ヘアーローション、ヘアークリーム、シャンプー、リンス、ヘアーフォーム、ヘアージェル、エアゾール等の直接頭皮に塗布する剤形に配合し、常法に従い製造することができる。 The hair restorer of the present invention can be used in various forms, for example, blended into a dosage form to be applied directly to the scalp such as hair tonic, hair lotion, hair cream, shampoo, rinse, hair foam, hair gel, aerosol, etc. Can be produced according to a conventional method.
また、本発明の育毛料には、前記の各成分に加えて必要に応じて、かつ本発明の効果を損なわない範囲において、化粧品、医薬部外品、医薬品等において一般的に用いられる各種の成分、例えば、油分、保湿剤、増粘剤、色素、香料、殺菌剤、防腐剤、紫外線吸収剤、溶剤、水、角質溶解剤、抗炎症剤、抗アンドロゲン剤、育毛剤、抗酸化剤、清涼剤、生薬抽出物やビタミン類等を適宜配合することができる。 In addition to the above-mentioned components, the hair growth material of the present invention is variously used in cosmetics, quasi-drugs, pharmaceuticals, etc. as necessary and within the range not impairing the effects of the present invention. Ingredients such as oils, moisturizers, thickeners, pigments, fragrances, bactericides, antiseptics, UV absorbers, solvents, water, keratolytic agents, anti-inflammatory agents, antiandrogens, hair restorers, antioxidants, A refreshing agent, a herbal medicine extract, vitamins, etc. can be mix | blended suitably.
以下、実施例により本発明を具体的に説明するが、これらの実施例により本発明の技術範囲が限定されるものではない。尚、実施例に記載の発毛促進効果試験、毛成長促進効果試験、脱毛防止効果試験、及びふけ防止効果試験に関する試験法を下記に示す。 EXAMPLES Hereinafter, although an Example demonstrates this invention concretely, the technical scope of this invention is not limited by these Examples. In addition, the test method regarding the hair growth promotion effect test, the hair growth promotion effect test, the hair loss prevention effect test, and the anti-dandruff effect test described in Examples is shown below.
（１）マウス発毛試験法
Ｃ３Ｈマウス（８週齢、オス、平均重量３５ｇ）の背部皮膚（２ｃｍ×４ｃｍ）を電気バリカンで刈り、休止期毛に誘導する。翌日より実施例及び比較例の各試料を被験部皮膚に朝夕２回、一匹当り０．２ｍＬを３ヶ月間連用塗布した。一試料に対して動物一群１０匹使用した。塗布開始３ヶ月目に各試料の被験部皮膚をビデオカメラに撮影し、画像解析装置にて毛刈り部及び発毛部の面積を測定した。
発毛効果の判定は、下記に示す発毛率（％）を対照群と比較することにより行った。
発毛率（％）＝（発毛部の面積／毛刈り部の面積）×１００
(1) Mouse hair growth test method The back skin (2 cm × 4 cm) of C3H mice (8 weeks old, male, average weight 35 g) is cut with an electric clipper and induced to resting hair. From the next day, the samples of Examples and Comparative Examples were applied to the skin of the test area twice a day in the morning and evening, 0.2 mL per animal for 3 months. A group of 10 animals was used for one sample. Three months after the start of application, the skin of the test part of each sample was photographed with a video camera, and the area of the hair-cut part and the hair-growth part was measured with an image analyzer.
The hair growth effect was determined by comparing the hair growth rate (%) shown below with the control group.
Hair growth rate (%) = (Area of hair growth part / Area of hair cutting part) × 100
（２）マウス毛成長促進効果試験法
Ｃ３Ｈマウス（８週齢、オス、平均重量３５ｇ）の背部皮膚（２ｃｍ×４ｃｍ）を電気バリカン及びシェーバーで刈り、成長期毛に誘導する。翌日より実施例及び比較例の各試料を被験部皮膚に朝夕２回、一匹当り０．２ｍＬを二週間連用塗布した。一試料に対して動物一群１０匹使用した。塗布開始１４日目に各試料の被験部皮膚をビデオカメラに撮影し、画像解析装置にて毛刈り部及び発毛部の面積を測定した。
毛成長促進効果の判定は、下記に示す発毛率（％）を対照群と比較することにより行った。
毛成長促進効果（％）＝（成長毛髪部の面積／毛刈り部の面積）×１００
(2) Mouse hair growth promoting effect test method The back skin (2 cm × 4 cm) of C3H mice (8 weeks old, male, average weight 35 g) is mowed with an electric clipper and a shaver, and induced to the growing hair. From the next day, the samples of Examples and Comparative Examples were applied to the skin of the test area twice a day in the morning and evening, 0.2 mL per animal for two weeks. A group of 10 animals was used for one sample. On the 14th day from the start of application, the skin of the test part of each sample was photographed with a video camera, and the areas of the hair cutting part and the hair growth part were measured with an image analyzer.
The hair growth promoting effect was determined by comparing the hair growth rate (%) shown below with the control group.
Hair growth promoting effect (%) = (Area of growing hair part / Area of hair cutting part) × 100
（３）ヒト頭皮毛成長促進効果試験法
男性型脱毛症患者である被試験者１０名の頭部の耳の上５ｃｍの位置の頭髪を左右２カ所に於いて直径１ｃｍの円形状に剃毛した被験部位に、実施例及び比較例の各試料を左側に毎日朝夕２回、約３ｍＬ塗布し、無処置の右側と比較した。効果の判定は、試験開始後２８日目に、左右の被験部位の毛髪各々２０本ずつを剃毛し、下記の式で求めた値で毛成長促進度を評価した。
毛成長促進度 ＝ （Ｂ）／（Ａ）
（Ａ）：右側（無処置）の毛２０本の長さの平均値
（Ｂ）：左側（実施例及び比較例の試料を塗布）の毛２０本の長さの平均値
(3) Human scalp hair growth promoting effect test method Shaving the hair 5 cm above the ears of the heads of 10 test subjects who are male pattern baldness in a circular shape with a diameter of 1 cm at two left and right positions. About 3 mL of each sample of Examples and Comparative Examples was applied to the left side twice a day in the morning and evening every day, and compared with the untreated right side. On the 28th day after the start of the test, the effect was determined by shaving 20 hairs on each of the left and right test sites, and evaluating the degree of hair growth promotion with the value determined by the following formula.
Hair growth promotion level = (B) / (A)
(A): Average value of length of 20 hairs on the right side (no treatment) (B): Average value of length of 20 hairs on the left side (the sample of the example and the comparative example is applied)
（４）ヒト脱毛防止試験法
男性型脱毛症患者である被試験者１０名の頭部に毎日朝夕２回、４カ月間塗布し、試験開始前に専門美容師により洗髪を３日間行った。洗髪時に抜けた毛髪を採取し、その本数を計測し、１日当りの抜け毛本数を算出した。試料塗布後の４ヶ月目に再度専門美容師により洗髪を３日間行い、洗髪時に抜けた毛髪を採取、本数計測を行い、１日当りの抜け毛本数を算出した。試験開始前と４ヶ月後の１日あたりの抜毛本数を下記の式で求めた値で脱毛防止効果を評価した。
脱毛防止効果（％） ＝ （Ｄ）／（Ｃ）
（Ｃ）：塗布前の１日あたりの抜け毛本数
（Ｄ）：塗布４ヶ月後の１日あたりの抜け毛本数
(4) Human hair loss prevention test method The test was carried out twice daily in the morning and evening for 4 months on the heads of 10 test subjects who were male pattern baldness patients, and the hair was washed by a professional hairdresser for 3 days before the start of the test. The hair that was lost during shampooing was collected, the number of hairs was measured, and the number of hairs lost per day was calculated. In the fourth month after the application of the sample, hair washing was again performed by a professional hairdresser for 3 days, the hair that was lost during the hair washing was collected, the number of hairs was measured, and the number of hair loss per day was calculated. The hair removal prevention effect was evaluated based on the value obtained by the following formula for the number of hairs removed per day before the start of the test and after 4 months.
Hair loss prevention effect (%) = (D) / (C)
(C): Number of hair loss per day before application (D): Number of hair loss per day 4 months after application
（５）ヒトフケ防止試験法
男性型脱毛症患者である被試験者１０名の頭部に毎日朝夕２回、４カ月間塗布した後のフケの発生状況について評価した。試験結果は、「ふけが少なくなった」と回答した人数で示した。
(5) Human Dandruff Prevention Test Method The occurrence of dandruff was evaluated after being applied twice daily in the morning and evening for 4 months to the heads of 10 test subjects who were male pattern baldness patients. The test results are shown by the number of respondents who answered that “dandruff was reduced”.
実施例１〜１０、比較例１〜３
表１に示す処方の育毛料を常法に従って作成し、前記の諸試験を実施して評価を行った。その結果を併せて表１に示す。
Examples 1-10, Comparative Examples 1-3
A hair restoration having the formulation shown in Table 1 was prepared according to a conventional method, and the above tests were performed for evaluation. The results are also shown in Table 1.
表１から明らかなように、本発明の育毛料は、比較例と比べて明らかに発毛率、毛成長促進効果、毛成長促進度、脱毛防止、フケ防止のいずれの評価においても優れていた。 As is clear from Table 1, the hair-growth material of the present invention was clearly superior in all evaluations of hair growth rate, hair growth promoting effect, hair growth promoting degree, hair loss prevention, and dandruff prevention as compared with the comparative example. .
以下、本発明育毛料のその他の処方例を実施例として挙げる。なお、これらの実施例の本発明育毛料についても、上記の発毛率、毛成長促進効果、毛成長促進度、脱毛防止、フ
ケ防止効果を検討したところ、いずれの実施例においても、優れた特性を有しており良好であった。
Hereinafter, other prescription examples of the hair growth material of the present invention will be given as examples. In addition, the hair growth rate of the present invention of these examples also examined the above-mentioned hair growth rate, hair growth promoting effect, hair growth promoting degree, hair loss prevention, anti-dandruff effect, and was excellent in any of the examples. It had good characteristics and was good.
実施例８（トニック）
配合量（％）
（１）９５％エタノール ６０．０
（２）γ−アミノ−β−ヒドロキシ酪酸 ０．５
（３）ニコチン酸ベンジル ０．０５
（４）ローヤルゼリーエキス
丸善製薬社製、ローヤルゼリー抽出液 １．０
（５）プロピレングリコール １．０
（６）ポリエチレングリコール２００ １．０
（７）香料 ０．１
（８）色素 適 量
（９）精製水 残 部
Example 8 (Tonic)
Compounding amount (%)
(1) 95% ethanol 60.0
(2) γ-amino-β-hydroxybutyric acid 0.5
(3) Benzyl nicotinate 0.05
(4) Royal jelly extract
Maruzen Pharmaceutical Co., Ltd. Royal Jelly Extract 1.0
(5) Propylene glycol 1.0
(6) Polyethylene glycol 200 1.0
(7) Fragrance 0.1
(8) Dye proper amount
(9) Purified water balance
（製法）（１）に、（２）〜（７）を溶解し、次いで（８）〜（９）を溶解させたものを添加し、攪拌することにより、透明液状のトニックを得た。 (Manufacturing method) To (1), (2) to (7) were dissolved, then (8) to (9) were added and stirred to obtain a transparent liquid tonic.
実施例９（育毛ローション）
配合量（％）
（１）９５％エタノール ５５．０
（２）ジイソプロピルアミンジクロロアセテート ０．５
（３）ヒノキチオール ０．０５
（４）ニコチン酸ベンジル ０．０２
（５）ローヤルゼリーエキス
丸善製薬社製、ローヤルゼリーエキスＢＧ ２．０
（６）メントールＪＰ ０．５
（７）Ｄ−パントテニルアルコール ０．４
（８）イソプロピルメチルフェノール ０．２
（９）水素添加ビサボロール ０．５
（１０）ジプロピレングリコール ２．０
（１１）ポリオキシエチレン（４０）硬化ヒマシ油 ０．５
（１２）エデト酸四ナトリウム ０．０２
（１３）Ｌ−セリン ０．１
（１４）Ｌ−スレオニン ０．１
（１５）Ｎ−アセチル−ＤＬ−メチオニン ０．１
（１６）精製水 残 部
Example 9 (hair growth lotion)
Compounding amount (%)
(1) 95% ethanol 55.0
(2) Diisopropylamine dichloroacetate 0.5
(3) Hinokitiol 0.05
(4) Benzyl nicotinate 0.02
(5) Royal jelly extract
Made by Maruzen Pharmaceutical Co., Ltd., Royal Jelly Extract BG 2.0
(6) Menthol JP 0.5
(7) D-pantothenyl alcohol 0.4
(8) Isopropylmethylphenol 0.2
(9) Hydrogenated bisabolol 0.5
(10) Dipropylene glycol 2.0
(11) Polyoxyethylene (40) hydrogenated castor oil 0.5
(12) Tetosodium edetate 0.02
(13) L-serine 0.1
(14) L-threonine 0.1
(15) N-acetyl-DL-methionine 0.1
(16) Balance of purified water
（製法）（１）に（２）〜（１１）を溶解させた。次いで（１６）に（１２）〜（１５）を溶解させたものと混合攪拌し、透明液状の育毛ローションを得た。 (Production Method) (2) to (11) were dissolved in (1). Next, the mixture of (16) and (12) to (15) dissolved therein was mixed and stirred to obtain a transparent liquid hair growth lotion.
実施例１０（エアゾール育毛料）
配合量（％）
＜原液処方＞
（１）９５％エタノール ８０．０
（２）トランス−３，４’−ジメチル
−３−ヒドロキシフラバノン ０．５
（３）ジイソプロピルアミンジクロロアセテート ０．５
（４）ローヤルゼリーエキス
一丸ファルコス社製、ローヤルゼリーエキス ５．０
（５）ラウリル硫酸ナトリウム ０．１
（６）ポリオキシエチエレン（６０）硬化ヒマシ油 ０．５
（７）サリチル酸 ０．１
（８）乳酸ナトリウム ０．０５
（９）香料 ０．２
（１０）色素 微 量
（１１）精製水 残 部
＜充填処方＞
（１２）原液 ５０．０
（１３）液化石油ガス ５０．０
Example 10 (aerosol hair restorer)
Compounding amount (%)
<Undiluted solution formulation>
(1) 95% ethanol 80.0
(2) trans-3,4′-dimethyl
-3-Hydroxyflavanone 0.5
(3) Diisopropylamine dichloroacetate 0.5
(4) Royal jelly extract
Made by Ichimaru Falcos, Royal Jelly Extract 5.0
(5) Sodium lauryl sulfate 0.1
(6) Polyoxyethylene (60) hydrogenated castor oil 0.5
(7) Salicylic acid 0.1
(8) Sodium lactate 0.05
(9) Fragrance 0.2
(10) Dye amount
(11) Purified water balance
<Filling prescription>
(12) Stock solution 50.0
(13) Liquefied petroleum gas 50.0
（製法）原液処方の各成分を混合溶解させて原液を調製し、これを缶に充填し、バルブ装着後、液化石油ガスを充填してエアゾール育毛料を調製した。 (Manufacturing method) Each component of the stock solution formulation was mixed and dissolved to prepare a stock solution, which was filled in a can. After mounting the valve, liquefied petroleum gas was filled to prepare an aerosol hair restorer.
実施例１１（乳液型育毛料）
配合量（％）
（１）イソステアリン酸イソプロピル ３．０
（２）カルボキシビニルポリマー（カーボポール９４０ ＊） ０．３
（３）カルボキシビニルポリマー（カーボポール９４１ ＊） ０．３
（４）ジクロロ酢酸ジイソプロピルアミン ０．５
（５）酢酸ｄｌ−α−トコフェロール ０．４
（６）ローヤルゼリーエキス
丸善製薬社製、ローヤルゼリーエキスＢＧ ２．０
（７）ニンジンエキスＫ（丸善製薬社製） １．０
（８）Ｌ−メントール ０．２
（９）イソプロピルメチルフェノール ０．１
（１０）水素添加ビサボロール ０．５
（１１）スクワラン ０．１
（１２）トリエタノールアミン ０．５
（１３）ムラサキセンブリ抽出液（丸善製薬社製） １．０
（１４）レイシ抽出液（一丸ファルコス社製） ０．５
（１５）ゲンチアナ抽出液（一丸ファルコス社製） ０．５
（１６）シルク抽出液 ０．５
（１７）Ｌ−セリン ０．１
（１８）Ｌ−スレオニン ０．１
（１９）Ｎ−アセチル−ＤＬ−メチオニン ０．１
（２０）魚由来加水分解コラーゲン液 ０．５
（２１）エタノール １０．０
（２２）ポリオキシエチレン（８０）硬化ヒマシ油 ０．５
（２３）エデト酸二ナトリウム ０．１
（２４）香料 ０．２
（２５）精製水 残 部
＊；Ｂ．Ｆ．ＧＯＯＤＲＩＣＨ社製
Example 11 (Emulsion type hair restorer)
Compounding amount (%)
(1) Isopropyl isostearate 3.0
(2) Carboxyvinyl polymer (Carbopol 940 *) 0.3
(3) Carboxyvinyl polymer (Carbopol 941 *) 0.3
(4) Diisopropylamine dichloroacetate 0.5
(5) dl-α-tocopherol acetate 0.4
(6) Royal jelly extract
Made by Maruzen Pharmaceutical Co., Ltd., Royal Jelly Extract BG 2.0
(7) Carrot extract K (manufactured by Maruzen Pharmaceutical Co., Ltd.) 1.0
(8) L-menthol 0.2
(9) Isopropylmethylphenol 0.1
(10) Hydrogenated bisabolol 0.5
(11) Squalane 0.1
(12) Triethanolamine 0.5
(13) Murasaki assembly extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) 1.0
(14) Ganoderma lysate (Ichimaru Falcos) 0.5
(15) Gentian extract (manufactured by Ichimaru Falcos) 0.5
(16) Silk extract 0.5
(17) L-serine 0.1
(18) L-threonine 0.1
(19) N-acetyl-DL-methionine 0.1
(20) Fish-derived hydrolyzed collagen solution 0.5
(21) Ethanol 10.0
(22) Polyoxyethylene (80) hydrogenated castor oil 0.5
(23) Disodium edetate 0.1
(24) Fragrance 0.2
(25) Purified water balance *; F. GOODRICH made
（製法）（２１）に（１），（４）〜（１２），（２２），（２４）を添加し、攪拌溶解した後、（２５）に（２）〜（３），（１３）〜（２０），（２３）を添加し、撹拌溶解したものを加えて、乳液型育毛料を得た。 (Production method) (1), (4) to (12), (22), (24) are added to (21), and after stirring and dissolving, (2) to (3), (13) are added to (25). -(20), (23) was added, and what was stirred and dissolved was added to obtain an emulsion type hair restorer.
尚、上記各処方中で用いた香料は下記のものである。 In addition, the fragrance | flavor used in each said prescription is the following.
以上記載の如く、本発明が脱毛症に対して優れた発毛、養毛、脱毛予防、ふけ防止等の作用を有する育毛料を提供できることは明らかである。 As described above, it is apparent that the present invention can provide a hair-growth material having excellent hair growth, hair growth, hair loss prevention, dandruff prevention and the like against alopecia.
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004008758A JP4469617B2 (en) | 2004-01-16 | 2004-01-16 | Hair restoration |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004008758A JP4469617B2 (en) | 2004-01-16 | 2004-01-16 | Hair restoration |
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| Publication Number | Publication Date |
|---|---|
| JP2005200356A true JP2005200356A (en) | 2005-07-28 |
| JP4469617B2 JP4469617B2 (en) | 2010-05-26 |
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|---|---|---|---|
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007291014A (en) * | 2006-04-25 | 2007-11-08 | Kenji Okajima | Edible composition having effect of promoting production and release of calcitonin gene-associated peptide |
| JP2008110992A (en) * | 2008-01-29 | 2008-05-15 | Mandom Corp | Antibacterial composition and skin care preparation |
| JP2010150203A (en) * | 2008-12-25 | 2010-07-08 | Lion Corp | Hair growing agent composition |
| JP2012184220A (en) * | 2011-02-17 | 2012-09-27 | Lion Corp | Scalp and hair cosmetic |
| JP2013209301A (en) * | 2012-03-30 | 2013-10-10 | Pola Chemical Industries Inc | Skin care preparation |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105188850A (en) | 2013-05-16 | 2015-12-23 | 宝洁公司 | Hair thickening compositions and methods of use |
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| JP4469617B2 (en) | 2010-05-26 |
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