JP2000281537A - Hair tonic cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic cosmetic excellent in hair growth effects and preventing effects on alopecia. SOLUTION: The characteristic of this hair tonic cosmetic is a formulation of a γ-amino-β-hydroxybutyric acid ester such as an alkyl ester, e.g. methyl ester, ethyl ester, propyl ester, butyl ester, 2-ethylhexyl ester, hexadecyl ester, lauryl ester or stearyl ester, an alkenyl ester, e.g. oleyl ester, an aralkyl ester, e.g. benzyl ester, an aryl ester, e.g. phenyl ester, a polyhydric alcohol ester, etc., e.g. ethylene glycol ester, sorbitol ester, a polyoxyethylene glycol ester or glycerol ester.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【０００１】[0001]

【発明の属する技術分野】本発明は、育毛効果、脱毛予
防効果に優れた養毛化粧料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic having an excellent hair-growth effect and an effect of preventing hair loss.

【０００２】[0002]

【従来の技術および発明が解決しようとする課題】従来
より、トウガラシチンキおよびニコチン酸誘導体等の血
行促進物質、また毛髪の栄養成分であるアミノ酸および
ビタミン類を配合してなる養毛化粧料が知られている。
さらには、皮脂腺の肥大防止効果をもつ成分や、男性ホ
ルモンの抑制作用をもつ成分を配合する医療用養毛剤や
養毛化粧料も数多く提案されている。2. Description of the Related Art Conventionally, hair restoration cosmetics containing a blood circulation promoting substance such as pepper tincture and nicotinic acid derivatives, and amino acids and vitamins which are nutritional components of hair have been known. Have been.
Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

【０００３】しかし、従来より使用されている血行促進
物質は、皮膚刺激が強くその配合量に制限があったり、
血行促進の持続時間が短いという欠点がある。[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short.

【０００４】ところで、男性型脱毛症は男性ホルモンの
過剰作用が原因の一つと言われているが、血行の不良や
毛母細胞の活性低下、皮脂腺の肥大化、頭皮の線維化等
の現象が複雑に絡みあって生じていると推察されてい
る。[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.

【０００５】しかし、男性ホルモンの過剰作用が原因と
いわれる毛母細胞の活性低下や皮脂腺の肥大化を抑制す
るために、単に抗男性ホルモン剤等を育毛剤として用い
ても、育毛作用を発現するまでには至らないのが現状で
ある。また、毛母細胞賦活剤や血行促進剤を単独で用い
ても、良好な成績は得られない。[0005] However, even if an anti-androgen is simply used as a hair-growth agent, the hair-growth effect is exhibited in order to suppress the decrease in the activity of the hair matrix and the enlargement of the sebaceous gland, which are said to be caused by the excessive action of the androgen. This is not the case. In addition, good results cannot be obtained even when a hair matrix activator or a blood circulation promoter is used alone.

【０００６】前記の問題点を解決する手段として、特開
平５−５８８５０号公報における奇数炭素数を有する脂
肪酸類、アルコール類、ヒドロキシプロピルアルコー
ル、低級アルコールを含有する育毛剤組成物、特開平５
−１３９９３６号公報におけるある種のカルボキシルベ
タインを含有する発毛剤、特開平５−１７０６２５号公
報における酸性ムコ多糖類とホップエキスを含有する養
毛化粧料等を始めとして数多くの養毛・育毛剤が提案さ
れているが、末梢血流を促進し、毛母細胞の賦活化をす
る物質を単独で用いても格段の育毛作用については見出
せず、また組成物においても充分満足すべき効果を得る
までには至らず、育毛効果、脱毛予防効果に改良の余地
があるのが実情であった。本発明の目的とするところ
は、育毛効果、脱毛予防効果に優れた養毛化粧料を提供
することにある。As a means for solving the above-mentioned problems, Japanese Patent Application Laid-Open No. 5-58850 discloses a hair restorer composition containing fatty acids having an odd carbon number, alcohols, hydroxypropyl alcohol and lower alcohol.
No. 139936, a hair growth agent containing a certain carboxyl betaine, a hair growth cosmetic containing an acid mucopolysaccharide and a hop extract described in JP-A-5-170625, etc. However, even if a substance that promotes peripheral blood flow and activates hair cells is used alone, no remarkable hair-growth effect is found, and a sufficiently satisfactory effect is obtained in the composition. In fact, there was room for improvement in the hair growth effect and the hair loss prevention effect. It is an object of the present invention to provide a hair restoration cosmetic having an excellent hair-growth effect and an effect of preventing hair loss.

【０００７】[0007]

【課題を解決するための手段】かかる実情に鑑み、頭皮
の末梢血流の促進および毛母細胞の賦活作用のある物質
について鋭意検討した結果、γ−アミノ−β−ヒドロキ
シ酪酸エステルを含有した養毛化粧料が本発明の目的で
ある優れた育毛効果、脱毛予防効果を発現することを見
いだした。In view of such circumstances, as a result of intensive studies on substances having a stimulating effect on peripheral blood flow of the scalp and activating hair matrix cells, it has been found that nutrients containing γ-amino-β-hydroxybutyrate are contained. It has been found that hair cosmetics exhibit an excellent hair-growth effect and a hair loss-preventing effect, which are the objects of the present invention.

【０００８】すなわち、上述の目的は、γ−アミノ−β
−ヒドロキシ酪酸エステルを配合することを特徴とする
養毛化粧料によって達成される。[0008] That is, the above-mentioned object is to provide γ-amino-β
-It is achieved by a hair-growing cosmetic characterized by blending a hydroxybutyric acid ester.

【０００９】[0009]

【発明の実施の形態】以下、本発明の実施の形態につい
て詳述する。Embodiments of the present invention will be described below in detail.

【００１０】本発明に用いられるγ−アミノ−β−ヒド
ロキシ酪酸エステル（ＧＡＢＯＢエステルと略称す
る。）としては、メチルエステル、エチルエステル、プ
ロピルエステル、ブチルエステル、２−エチルヘキシル
エステル、ヘキサデシルエステル、ラウリルエステル、
ステアリルエステル等のアルキルエステル、オレイルエ
ステル等のアルケニルエステル、ベンジルエステル等の
アラルキルエステル、フェニルエステル等のアリルエス
テル、エチルグリコールエステル、ソルビトールエステ
ル、ポリオキシエチレングリコールエステル、グリセリ
ンエステル等の多価アルコールエステル等が挙げられ
る。The γ-amino-β-hydroxybutyric acid ester (abbreviated as GABOB ester) used in the present invention includes methyl ester, ethyl ester, propyl ester, butyl ester, 2-ethylhexyl ester, hexadecyl ester, lauryl ester,
Alkyl esters such as stearyl esters, alkenyl esters such as oleyl esters, aralkyl esters such as benzyl esters, allyl esters such as phenyl esters, polyhydric alcohol esters such as ethyl glycol esters, sorbitol esters, polyoxyethylene glycol esters, and glycerin esters. Is mentioned.

【００１１】本発明に用いられるγ−アミノ−β−ヒド
ロキシ酪酸エステルの配合量としては、本発明の目的で
ある、育毛効果、脱毛予防効果を示す範囲を検討した結
果、養毛化粧料の総量を基準として、０．０００１〜１
０．０重量％であればよく、より好ましくは０．００５
〜５．０重量％である。The amount of the γ-amino-β-hydroxybutyrate used in the present invention was determined by examining the range showing the hair-growth effect and the hair loss-preventing effect, which are the objects of the present invention. 0.0001 to 1 based on
It is sufficient that the content is 0.0% by weight, more preferably 0.005%.
~ 5.0% by weight.

【００１２】本発明の養毛化粧料には、公知のビタミン
Ｅ、ビタミンＥアセテート、ビタミンＥニコチネートな
どのビタミンＥ誘導体、パントテニルアルコール、パン
トテン酸カルシウムなどのパントテン酸誘導体、ニコチ
ン酸ベンジル、ニコチン酸アミドなどのニコチン酸誘導
体、グリチルリチン酸、グリチルリチン酸ジカリウム、
グリチルリチン酸モノアンモニウムなどのグリチルリチ
ン酸誘導体、グリチルレチン酸、グリチルレチン酸ステ
アリルなどのグリチルレチン酸誘導体、抗アンドロゲン
剤、センブリエキス、朝鮮ニンジンエキス、デュークエ
キス、トウガラシチンキ、ジイソプロピルアミンジクロ
ロアセテート、γ−アミノ酪酸誘導体などを本発明の目
的を達成する範囲で適宜組み合わせて配合できる。[0012] The hair restoration cosmetic of the present invention includes known vitamin E derivatives such as vitamin E, vitamin E acetate and vitamin E nicotinate, pantothenic acid derivatives such as pantothenyl alcohol and calcium pantothenate, benzyl nicotinate and nicotinic acid. Nicotinic acid derivatives such as amides, glycyrrhizic acid, dipotassium glycyrrhizinate,
Glycyrrhizic acid derivatives such as monoammonium glycyrrhizinate, glycyrrhetinic acid, glycyrrhetinic acid derivatives such as stearyl glycyrrhetic acid, antiandrogens, assembly extracts, Korean ginseng extracts, Duke extracts, red pepper tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid derivatives, etc. May be appropriately combined and compounded within a range that achieves the object of the present invention.

【００１３】本発明の養毛化粧料は、常法に従って、た
とえばヘアートニック、ヘアーローション、ヘアートリ
ートメント、ヘアークリーム、ヘアーコンディショナ
ー、シャンプー、リンス、ヘアージェル、ヘアーミス
ト、ヘアーフォーム等の剤型に製造し、使用することが
可能である。The hair nourishing cosmetic composition of the present invention is manufactured in a usual manner into dosage forms such as hair tonic, hair lotion, hair treatment, hair cream, hair conditioner, shampoo, rinse, hair gel, hair mist, and hair foam. And can be used.

【００１４】本発明の養毛化粧料は、養毛、育毛および
／または脱毛予防のために、それを目的とする局所（頭
皮）に、その剤型に従って塗布または噴霧して適用され
る。The hair growth cosmetic composition of the present invention is applied or sprayed to a topical area (scalp) for the purpose of hair growth, hair growth and / or hair loss prevention according to the dosage form.

【００１５】なお、本発明の養毛化粧料には、色素、香
料、殺菌剤、防腐剤、界面活性剤、顔料、角質溶解剤、
抗酸化剤等を適宜配合することができる。The hair nourishing cosmetic composition of the present invention includes a pigment, a fragrance, a bactericide, a preservative, a surfactant, a pigment, a keratolytic agent,
An antioxidant and the like can be appropriately compounded.

【００１６】[0016]

【実施例】以下、実施例および比較例により本発明を詳
細に説明するが、本発明はこれらに限定されるものでは
ない。なお、本発明に使用した試験方法は下記の通りで
ある。また、以下での配合量の単位は重量％でありｗｔ
％と略す。The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The test method used in the present invention is as follows. The unit of the compounding amount in the following is% by weight and wt
Abbreviated as%.

【００１７】（１）マウス毛成長促進効果試験法 Ｃ３Ｈ系マウス（雄・８週齢・平均体重３５ｇ）の背部
中央の皮膚を電気バリカンで刈った後、シェーバーによ
り完全に除毛した。翌日より実施例および比較例の各試
料を被験部皮膚に毎日１回、一匹当り０．２ｍｌ塗布し
た。一試料に対して動物は一群１０匹を使用した。実験
開始後１４日目に動物を屠殺し、被験部皮膚の写真撮影
を行なった。つぎに、写真を画像解析装置に取り込み、
最初に毛刈りした面積（Ａ）と、発毛面積（Ｂ）を求
め、さらに 発毛率＝（Ｂ）／（Ａ） を個々の動物について算出した。後述の表には実施例ま
たは比較例の各群の平均値を示した。(1) Mouse Hair Growth Promotion Effect Test Method The skin at the center of the back of a C3H mouse (male, 8 weeks old, average weight 35 g) was cut with an electric clipper, and the hair was completely removed with a shaver. From the next day, each sample of Example and Comparative Example was applied to the skin of the test part once a day, 0.2 ml per animal. A group of 10 animals was used for one sample. On the 14th day after the start of the experiment, the animals were sacrificed and photographs of the skin of the test area were taken. Next, take the picture into the image analysis device,
First, the shaved area (A) and the hair growth area (B) were determined, and the hair growth rate = (B) / (A) was calculated for each animal. The following table shows the average value of each group in the examples or comparative examples.

【００１８】（２）ヒト頭髪毛成長促進効果試験法 ３０〜４０代の毛成長に衰えの認められる男性被験者１
０名の頭頂部の頭髪を直径約７ｍｍの円形状に剃毛し
た。更に、毛刈り１日後及び３日後に林らの方法（ブリ
ティッシュ・ジャーナル・オブ・デルマトロジー、１２
５巻、１２３頁、１９９１年）により毛成長速度を対象
部位の毛髪（約３０〜４０本）について求めて、平均値
（Ａ）を計算した。次に各被験者に被験部位を中心とし
て、実施例又は比較例の試料を毎日朝夕２回、約３ｍｌ
塗布し、よくマッサージさせた。試験開始３ケ月目に同
様にして同一部位の毛成長速度の測定を行い、平均値
（Ｂ)を計算した。効果の判定は、各養毛化粧料使用前
後の比（Ｂ）／（Ａ）を比較することにより行った。(2) Human hair growth promotion effect test method Male test subject 1 in her 30s and 40s with decreased hair growth
The hair at the top of the head was shaved into a circular shape having a diameter of about 7 mm. One and three days after shaving, the method of Hayashi et al. (British Journal of Dermatology, 12
5, p. 123, 1991), the hair growth rate was determined for the hair at the target site (about 30 to 40 hairs), and the average value (A) was calculated. Next, about 3 ml of the sample of the example or the comparative example was applied to each subject twice a day every morning and evening around the test site.
Apply and massage well. The hair growth rate at the same site was measured in the same manner three months after the start of the test, and the average value (B) was calculated. The effect was determined by comparing the ratio (B) / (A) before and after use of each hair nourishing cosmetic.

【００１９】（３）実用試験法 男性型脱毛症患者２０名の頭部に毎日朝夕２回、連続６
ケ月間試料を塗布した後の効果を評価した。試験結果
は、育毛効果、および脱毛予防効果の各項に対して、
「生毛が剛毛化した、或いは剛毛が増加した」、「脱毛
が少なくなった」と各々回答した人数で示した。(3) Practical test method Twice in the morning and evening twice a day on the head of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results are for hair growth and hair loss prevention.
The number of respondents who answered, "Renewal hair has become bristle or bristle has increased" and "Reduction of hair loss" has been indicated.

【００２０】実施例１〜３、比較例１（ヘアートニッ
ク） 表１の原料組成において、表２に記載の如く有効成分を
配合してヘアートニックを調製し、前記の諸試験を実施
した。尚、該実施例では、ＧＡＢＯＢメチルエステルを
使用した。Examples 1 to 3, Comparative Example 1 (Heart Tonic) Hair tonics were prepared by mixing active ingredients as shown in Table 2 in the raw material composition shown in Table 1, and the above-mentioned various tests were carried out. In this example, GABOB methyl ester was used.

【００２１】[0021]

【表１】 [Table 1]

【００２２】[0022]

【表２】 [Table 2]

【００２３】（１）調製法 表１に記載の（Ａ）に属する成分を加熱溶解し、別に均
一に溶解した（Ｃ）に属する成分を徐々に添加し、更に
（Ｂ）成分を加えて均一に混合攪拌して製造した。(1) Preparation method The components belonging to (A) described in Table 1 were dissolved by heating, the components belonging to (C) which had been separately dissolved were gradually added, and the components (B) were further added. And mixed with stirring.

【００２４】（２）特性 各ヘアートニックの諸試験を実施した結果を表２に示し
た。表２の通り、比較例１はマウス毛成長促進効果およ
びヒト頭髪毛成長促進効果が低く、実用試験の結果も良
好ではなかった。(2) Characteristics Table 2 shows the results of various tests conducted for each hair tonic. As shown in Table 2, Comparative Example 1 had low mouse hair growth promoting effect and human hair growth promoting effect, and the results of practical tests were not good.

【００２５】一方、実施例１〜３の本発明の養毛化粧料
は、高いマウス毛成長促進効果およびヒト頭髪毛成長促
進効果を示し、さらに実用試験の結果も良好であり、諸
試験の全てにわたって明らかに良好な結果を示した。な
お、いずれの実施例の養毛化粧料を用いた場合にも、マ
ウスおよびヒトに炎症、その他副作用と考えられる症状
は発現せず、本発明の養毛化粧料は安全性にも優れるこ
とが明らかであった。On the other hand, the hair growth cosmetics of the present invention of Examples 1 to 3 show high mouse hair growth promoting effect and human hair growth promoting effect, and also have good results in practical tests. The results clearly showed good results over the entire range. In addition, in the case of using the hair restoration cosmetics of any of the examples, inflammation in mice and humans, and other symptoms considered to be side effects do not appear, and the hair restoration cosmetics of the present invention may be excellent in safety. It was clear.

【００２６】実施例４〜６、比較例２（オイリーヘアー
トニック） 表３の原料組成において、表４に記載の如く有効成分を
配合してオイリーヘアートニックを調製し、前記の諸試
験を実施した。尚、該実施例についても、実施例１〜３
と同様にしてγ−アミノ−β−ヒドロキシ酪酸メチルエ
ステルを用い調製した。Examples 4 to 6, Comparative Example 2 (oily hair tonic) Oily hair tonic was prepared by blending the active ingredients as shown in Table 4 in the raw material composition shown in Table 3, and the above-mentioned tests were carried out. . In addition, also about this Example, Examples 1-3
Γ-amino-β-hydroxybutyric acid methyl ester.

【００２７】[0027]

【表３】 [Table 3]

【００２８】[0028]

【表４】 [Table 4]

【００２９】（１）調製法 表３に記載の（Ａ）に属する成分を加熱溶解し、別に均
一に溶解した（Ｃ）に属する成分を徐々に添加し、更に
（Ｂ）成分を加えて均一に混合攪拌して製造した。(1) Preparation method The components belonging to (A) described in Table 3 were dissolved by heating, the components belonging to (C), which were separately dissolved, were gradually added, and the components (B) were further added. And mixed with stirring.

【００３０】（２）特性 各オイリーヘアートニックの諸試験を実施した結果を表
４に示した。表４の通り、比較例２はマウス毛成長促進
効果およびヒト頭髪毛成長促進効果が低く、実用試験の
結果も良好ではなかった。(2) Characteristics Table 4 shows the results of various tests performed on each oily hair art tonic. As shown in Table 4, Comparative Example 2 had low mouse hair growth promoting effect and human hair growth promoting effect, and the results of practical tests were not good.

【００３１】一方、実施例４〜６の本発明の養毛化粧料
は、高いマウス毛成長促進効果およびヒト頭髪毛成長促
進効果を示し、さらに実用試験の結果も良好であり、諸
試験の全てにわたって明らかに良好な結果を示した。な
お、いずれの実施例の養毛化粧料を用いた場合にも、マ
ウスおよびヒトに炎症、その他副作用と考えられる症状
は発現せず、安全性にも優れる。On the other hand, the hair restoration cosmetics of the present invention of Examples 4 to 6 show high mouse hair growth promotion effect and human hair growth promotion effect, and furthermore, the results of practical tests are good, and all the tests are performed. The results clearly showed good results over the entire range. In addition, in the case of using the hair nourishing cosmetic composition of any of the examples, inflammation and other symptoms considered to be side effects do not occur in mice and humans, and safety is excellent.

【００３２】実施例７および８、比較例３（ヘアートニ
ック） 表５の原料組成において、表６に記載の如く有効成分を
配合してヘアートニックを調製し、前記の諸試験を実施
した。尚、該実施例では、ＧＡＢＯＢエチルエステルを
使用した。Examples 7 and 8, Comparative Example 3 (Heart Tonic) Hair tonics were prepared by blending active ingredients as shown in Table 6 in the raw material composition shown in Table 5, and the above-mentioned tests were carried out. In this example, GABOB ethyl ester was used.

【００３３】[0033]

【表５】 [Table 5]

【００３４】[0034]

【表６】 [Table 6]

【００３５】（１）調製法 表５に記載の（Ａ）に属する成分を加熱溶解し、別に均
一に溶解した（Ｃ）に属する成分を徐々に添加し、更に
（Ｂ）成分を加えて均一に混合攪拌して製造した。(1) Preparation method The components belonging to (A) described in Table 5 were dissolved by heating, the components belonging to (C), which were separately dissolved, were gradually added, and the components (B) were further added. And mixed with stirring.

【００３６】（２）特性 各ヘアートニックの諸試験を実施した結果を表６に示し
た。表６の通り、比較例３はマウス毛成長促進効果およ
びヒト頭髪毛成長促進効果が低く、実用試験の結果も良
好ではなかった。(2) Characteristics Table 6 shows the results of various tests performed on each hair tonic. As shown in Table 6, Comparative Example 3 had a low mouse hair growth promoting effect and a low human hair growth promoting effect, and the results of practical tests were not good.

【００３７】一方、実施例７および８の本発明の養毛化
粧料は、高いマウス毛成長促進効果およびヒト頭髪毛成
長促進効果を示し、さらに実用試験の結果も良好であ
り、諸試験の全てにわたって明らかに良好な結果を示し
た。なお、いずれの実施例の養毛化粧料を用いた場合に
も、マウスおよびヒトに炎症、その他副作用と考えられ
る症状は発現せず、本発明の養毛化粧料は安全性にも優
れることが明らかであった。On the other hand, the hair restoration cosmetics of the present invention of Examples 7 and 8 show high mouse hair growth promoting effect and human hair growth promoting effect, and have good results in practical tests. The results clearly showed good results over the entire range. In addition, in the case of using the hair restoration cosmetics of any of the examples, inflammation in mice and humans, and other symptoms considered to be side effects do not appear, and the hair restoration cosmetics of the present invention may be excellent in safety. It was clear.

【００３８】[0038]

【発明の効果】以上記載の如く、本発明は、毛母細胞の
賦活化作用を有し、育毛効果、脱毛予防効果に優れた養
毛化粧料を提供することは明らかである。As described above, it is apparent that the present invention provides a hair restoration cosmetic having an effect of activating hair matrix cells and having an excellent hair-growth effect and an effect of preventing hair loss.

───────────────────────────────────────────────────── フロントページの続き Ｆターム(参考） 4C083 AA122 AC102 AC122 AC182 AC352 AC472 AC482 AC621 AC622 CC37 DD23 DD30 EE22  ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C083 AA122 AC102 AC122 AC182 AC352 AC472 AC482 AC621 AC622 CC37 DD23 DD30 EE22

Claims (1)

【特許請求の範囲】[Claims] 【請求項１】 γ−アミノ−β−ヒドロキシ酪酸エステ
ルを配合することを特徴とする養毛化粧料。1. A hair restoration cosmetic comprising a γ-amino-β-hydroxybutyrate ester.