JP2004359668A - 胆汁分泌を促進する経口用組成物 - Google Patents
胆汁分泌を促進する経口用組成物 Download PDFInfo
- Publication number
- JP2004359668A JP2004359668A JP2004076167A JP2004076167A JP2004359668A JP 2004359668 A JP2004359668 A JP 2004359668A JP 2004076167 A JP2004076167 A JP 2004076167A JP 2004076167 A JP2004076167 A JP 2004076167A JP 2004359668 A JP2004359668 A JP 2004359668A
- Authority
- JP
- Japan
- Prior art keywords
- oral composition
- bile
- extract
- turmeric
- ginger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 16
- 210000000941 bile Anatomy 0.000 title claims description 24
- 230000028327 secretion Effects 0.000 title claims description 14
- 230000001737 promoting effect Effects 0.000 title claims description 4
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 19
- 235000008397 ginger Nutrition 0.000 claims abstract description 19
- 241000234314 Zingiber Species 0.000 claims abstract description 18
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 8
- 229910052737 gold Inorganic materials 0.000 claims description 8
- 239000010931 gold Substances 0.000 claims description 8
- 239000004083 gastrointestinal agent Substances 0.000 claims description 4
- 229940127227 gastrointestinal drug Drugs 0.000 claims description 4
- 244000163122 Curcuma domestica Species 0.000 abstract description 7
- 208000022531 anorexia Diseases 0.000 abstract description 7
- 206010061428 decreased appetite Diseases 0.000 abstract description 7
- 210000002784 stomach Anatomy 0.000 abstract description 7
- 235000003392 Curcuma domestica Nutrition 0.000 abstract description 6
- 235000003373 curcuma longa Nutrition 0.000 abstract description 6
- 235000013976 turmeric Nutrition 0.000 abstract description 6
- 235000005911 diet Nutrition 0.000 abstract description 4
- 235000013305 food Nutrition 0.000 abstract description 4
- 230000037213 diet Effects 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 230000002496 gastric effect Effects 0.000 abstract description 2
- 230000003187 abdominal effect Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 18
- 239000003814 drug Substances 0.000 description 18
- 239000000284 extract Substances 0.000 description 11
- 235000020240 turmeric extract Nutrition 0.000 description 10
- 229940052016 turmeric extract Drugs 0.000 description 10
- 239000008513 turmeric extract Substances 0.000 description 10
- 239000003925 fat Substances 0.000 description 9
- 239000000843 powder Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241000207199 Citrus Species 0.000 description 5
- 206010015137 Eructation Diseases 0.000 description 5
- 206010000059 abdominal discomfort Diseases 0.000 description 5
- 208000027687 belching Diseases 0.000 description 5
- 235000020971 citrus fruits Nutrition 0.000 description 5
- 206010000060 Abdominal distension Diseases 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000000994 depressogenic effect Effects 0.000 description 4
- 102000038379 digestive enzymes Human genes 0.000 description 4
- 108091007734 digestive enzymes Proteins 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 229940069445 licorice extract Drugs 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 241000234299 Zingiberaceae Species 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 235000006694 eating habits Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- -1 for example Substances 0.000 description 3
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 3
- 230000007661 gastrointestinal function Effects 0.000 description 3
- 235000009200 high fat diet Nutrition 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical group N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- 239000003613 bile acid Substances 0.000 description 2
- 210000000013 bile duct Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229960000913 crospovidone Drugs 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000002183 duodenal effect Effects 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 108010004103 Chylomicrons Proteins 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- 101100136062 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) PE10 gene Proteins 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000003627 anti-cholesterol Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000002467 anti-pepsin effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940068682 chewable tablet Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229930007050 cineol Natural products 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 210000001953 common bile duct Anatomy 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- UVVWIYVATLQAFM-UHFFFAOYSA-I copper;tripotassium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,13,17-trimethyl-8-(oxidomethylidene)-17,18-dihydroporphyrin-21-ide-2-carboxylate Chemical compound [K+].[K+].[K+].[Cu+2].C1=C([N-]2)C(C)=C(C([O-])=O)C2=C(CC([O-])=O)C(C(C2C)CCC([O-])=O)=NC2=CC(C(=C2C=C)C)=NC2=CC\2=NC1=C(CC)C/2=C\[O-] UVVWIYVATLQAFM-UHFFFAOYSA-I 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
【解決手段】鬱金及び乾姜を含有することを特徴とする経口用組成物。
【選択図】なし
Description
酸化マグネシウム753g、リン酸水素カルシウム540g、乾姜(カンキョウ)末400g、鬱金(ウコン)末200g、ヒドロキシプロピルセルロース180g、乳糖115g、軽質無水ケイ酸45g、クロスポビドン30gを混合した後、精製水720gに銅クロロフィリンカリウム41.4gを溶解した溶液を溶媒として攪拌造粒を行った。乾燥後、脂肪消化酵素24g、蛋白消化酵素9g、結晶セルロース129g、クロスポビドン30g、軽質無水ケイ酸12g、ステアリン酸マグネシウム12g、香料2gを添加混合した後、錠径9mm、1錠重量420mgの錠剤を製した。
(実験方法)
SD系雄性ラット(11〜12週齢、体重約400g、日本チャールスリバー社)を用い、ラットをウレタン麻酔(1.5g/kg、皮下注射)して麻酔処置し、背位に固定後、開腹して胆管を切開し、カニューレ(日本ベクトンディッキンソン社製、PE10、内径0.28mm×外径0.61mm)を肝に向けて挿入した。また、被検薬投与のため、十二指腸上部にカニューレ(日本ベクトンディッキンソン社製、PE50、内径0.58mm×外径0.965mm)を挿入した。縫合1時間後、胆管カニューレより採取した胆汁流出量を測定した後、0.2%カルボキシメチルセルロースナトリウム溶液に懸濁調製した被験薬〔ウコンエキス(原生薬として100mg/kg)投与群、カンキョウエキス(原生薬として200mg/kg)投与群、ウコンエキス(原生薬として100mg/kg)+カンキョウエキス(原生薬として200mg/kg)投与群郡、対照群:0.2%カルボキシメチールセルロース溶液またはデヒドロコール酸ナトリウム150mg/kg〕を2mL/kg体重割合で十二指腸カニューレより投与した。その4時間後の胆汁流出量を測定し、被検薬投与前1時間の流出量に対する相対値を算出して胆汁分泌量とし、薬物の効果を比較した。
実薬群であるA:ウコンエキス100mg/kg投与群、B:カンキョウエキス200mg投与群、C:ウコンエキス100mg/kg+カンキョウエキス200mg投与群または対照群の胆汁分泌量を図1に示す。対照群の胆汁分泌量は3.4±0.1mL/4hであり、ウコンエキス単独での胆汁***量は4.0±0.1mL/4h、カンキョウエキス単独での胆汁***量は4.1±0.1mL/4hであり、それぞれのエキスは単独において有意な胆汁分泌作用の促進が観察された。さらに、ウコンエキスとカンキョウエキスを併用すると胆汁分泌量は4.72±0.1mL/4hと、単独投与群と比較しても有意に胆汁分泌が促進された。
Claims (4)
- 鬱金及び乾姜を含有することを特徴とする経口用組成物。
- 鬱金1質量部に対して乾姜を0.2〜5質量部含有することを特徴とする経口用組成物。
- 胆汁分泌促進作用を有する請求項1または2記載の経口用組成物。
- 胃腸薬である請求項1〜3の何れか1項に記載の経口用組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004076167A JP2004359668A (ja) | 2003-05-13 | 2004-03-17 | 胆汁分泌を促進する経口用組成物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003134585 | 2003-05-13 | ||
JP2004076167A JP2004359668A (ja) | 2003-05-13 | 2004-03-17 | 胆汁分泌を促進する経口用組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2004359668A true JP2004359668A (ja) | 2004-12-24 |
Family
ID=34067172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004076167A Pending JP2004359668A (ja) | 2003-05-13 | 2004-03-17 | 胆汁分泌を促進する経口用組成物 |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2004359668A (ja) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0873369A (ja) * | 1994-09-01 | 1996-03-19 | Fuairudo:Kk | 健康茶 |
JPH10236966A (ja) * | 1997-02-24 | 1998-09-08 | Nissei Marine Kogyo Kk | 血行改善効果を有する組成物 |
JPH11243913A (ja) * | 1998-03-03 | 1999-09-14 | Otsuka Yakuhin Kogyo Kk | 薬膳調味栄養食品 |
JP2001086953A (ja) * | 1999-09-21 | 2001-04-03 | Otsuka Yakuhin Kogyo Kk | 鎮痛健康補助食品 |
JP2002233331A (ja) * | 2001-02-07 | 2002-08-20 | Suehito Yamagami | 血行障害の改善作用を有する健康補助食品 |
JP2002325552A (ja) * | 2001-04-27 | 2002-11-12 | House Foods Corp | 調味用組成物の製造方法、調理食品又は調理食品用基材 |
JP2003026593A (ja) * | 2001-07-16 | 2003-01-29 | Otsuka Yakuhin Kogyo Kk | 強力な抗酸化作用を有する生薬処方 |
JP2003226650A (ja) * | 2001-11-30 | 2003-08-12 | Daito Kk | 医薬用組成物 |
-
2004
- 2004-03-17 JP JP2004076167A patent/JP2004359668A/ja active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0873369A (ja) * | 1994-09-01 | 1996-03-19 | Fuairudo:Kk | 健康茶 |
JPH10236966A (ja) * | 1997-02-24 | 1998-09-08 | Nissei Marine Kogyo Kk | 血行改善効果を有する組成物 |
JPH11243913A (ja) * | 1998-03-03 | 1999-09-14 | Otsuka Yakuhin Kogyo Kk | 薬膳調味栄養食品 |
JP2001086953A (ja) * | 1999-09-21 | 2001-04-03 | Otsuka Yakuhin Kogyo Kk | 鎮痛健康補助食品 |
JP2002233331A (ja) * | 2001-02-07 | 2002-08-20 | Suehito Yamagami | 血行障害の改善作用を有する健康補助食品 |
JP2002325552A (ja) * | 2001-04-27 | 2002-11-12 | House Foods Corp | 調味用組成物の製造方法、調理食品又は調理食品用基材 |
JP2003026593A (ja) * | 2001-07-16 | 2003-01-29 | Otsuka Yakuhin Kogyo Kk | 強力な抗酸化作用を有する生薬処方 |
JP2003226650A (ja) * | 2001-11-30 | 2003-08-12 | Daito Kk | 医薬用組成物 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Hajimonfarednejad et al. | Cinnamon: A systematic review of adverse events | |
US6224871B1 (en) | Dietary supplement for nutritionally promoting healthy joint function | |
KR100842193B1 (ko) | 다중 위험 인자 증후군의 예방 또는 개선용 조성물 | |
JP2004238365A (ja) | 美肌促進剤及び美容健康食品 | |
JP4009642B2 (ja) | 肥満改善用組成物 | |
FR3080989A1 (fr) | Composition liquide comprenant un extrait de feuilles de cassis et du jus de pomme concentre | |
JP2007277128A (ja) | 生活習慣病の予防・改善方法及び予防・改善剤 | |
CA2983823A1 (en) | Plant extracts for the treatment of excess weight and obesity | |
EP1609466B1 (de) | Pharmazeutische Zusammensetzung, Verwendung dieser pharmazeutischen Zusammensetzung zur Herstellung eines Medikaments und/oder eines Nahrungsergänzungmittels zur Behandlung von Übergewicht und/oder Symptomen, die mit Übergewicht einhergehen, beim Menschen oder Säugetier, sowie Verfahren zur Herstellung dieser pharmazeutischen Zusammensetzung | |
EP3124048B1 (en) | Composition for oral use in the treatment of gastro-oesophageal reflux disease or discomfort | |
US20220054571A1 (en) | Composition for preventing or treating gastritis or peptic ulcer | |
JP5064714B2 (ja) | 抗ストレス組成物 | |
KR101247611B1 (ko) | 기침, 가래 예방 효과를 갖는 기능성 조성물 및 이를 이용한 건강 식품 | |
WO2011115416A2 (ko) | 알코올분해 및 숙취해소용 돌나물 분획물 | |
US9616095B2 (en) | Method and a composition having prophylactic activity against venoms and toxins | |
JP2007246541A (ja) | 機能性咀嚼物及びその製造方法 | |
EP1677627B1 (en) | Dietetic preparation with hyaluronate for treatment of osteoporosis | |
JP2014148479A (ja) | ガレート型カテキンとタンパク質との複合体およびカフェインを含む抗肥満組成物 | |
JP2004359668A (ja) | 胆汁分泌を促進する経口用組成物 | |
CN117157088A (zh) | 用于治疗冠状病毒感染的草药提取物配方 | |
KR102180363B1 (ko) | 검은 참깨와 효모 가수분해물을 함유하는 남성 성기능 개선용 조성물 | |
JP7283216B2 (ja) | 経口組成物 | |
US20050112149A1 (en) | Single-dose taste inhibitor units | |
KR102045847B1 (ko) | 관능성 및 항당뇨 활성이 증대된 옥미수·호박 가미 경옥고 | |
KR101117491B1 (ko) | 지황 추출물을 함유하는 타액 분비 증강용 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070201 |
|
RD07 | Notification of extinguishment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7427 Effective date: 20090605 |
|
RD07 | Notification of extinguishment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7427 Effective date: 20090624 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100622 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20101026 |