JP2004305262A - Biological tissue connector - Google Patents

Biological tissue connector Download PDF

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Publication number
JP2004305262A
JP2004305262A JP2003099019A JP2003099019A JP2004305262A JP 2004305262 A JP2004305262 A JP 2004305262A JP 2003099019 A JP2003099019 A JP 2003099019A JP 2003099019 A JP2003099019 A JP 2003099019A JP 2004305262 A JP2004305262 A JP 2004305262A
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Prior art keywords
bone
living tissue
connector
hollow portion
biological tissue
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Koji Hakamazuka
康治 袴塚
Yuji Takamiya
裕児 高宮
Katsuya Sadamori
克也 貞森
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Olympus Corp
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Olympus Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/866—Material or manufacture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]

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  • Health & Medical Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biological tissue connector that has a high connection strength and biological affinity, well forms the biological tissue and increases a curing speed. <P>SOLUTION: The connector connects and fixes bones and has a connector body 11 made of a bioabsorbable material (PLA for example). The connector body 11 is a nearly cylindrical pin, a part of the tip of which is pointed and has a tapered face, and a hollow portion 12 is formed from the other end. The hollow portion 12 is filled with a bone anaplerosis material (biological tissue anaplerosis material) 13 formed of a calcium compound, β-calcium phosphate (β-TCP) for example in a granulated state. The bone anaplerosis material 13 is impregnated with a growth factor 14 to enhance the activity of cells. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

【０００１】
【発明の属する技術分野】
本発明は、骨接合材等の生体組織接合具に関する。
【０００２】
【従来の技術】
骨等の生体組織を骨折等によって切断した際、切断された骨同士を互いに接合して再生するために、接合状態を維持させる様々な骨接合具が用いられている。
この骨接合具に使用される材料には、毒性がなく、固定に必要な強度とともに生体親和性等が要求されており、従来から様々な金属材料やセラミックス材料、生体内吸収性材料が使用されている。最近では、強度的に問題なくしかも遅発性化学反応の少ないポリ乳酸（ＰＬＡ：ＰｏｌｙＬａｃｔｅｃ Ａｃｉｄ）が使用されるようになってきている（例えば、非特許文献１参照。）。
【０００３】
【非特許文献１】
水野耕作、「骨接合材の現況と展望」、整形外科におけるバイオマテリアルの現況と展望−その可能性、整形外科、１９９７年７月、第４８巻、第８号、ｐ１０９４−１０９８
【０００４】
【発明が解決しようとする課題】
しかしながら、上記従来の骨接合具の材料であるＰＬＡは、生分解性があっても骨伝導能に乏しい。そのため、重症度が大きい患部に使用した場合、骨形成に時間がかかる一方、ＰＬＡが生体に吸収されるので接合強度が低下してしまい、接合した箇所に分離方向の力が作用すると、接合箇所に緩みや位置ずれが生じたり極端な場合には分離して、接合箇所の治癒に時間がかかるという問題があった。
本発明は上記事情に鑑みて成されたものであり、接合強度及び生体親和性が高く、生体組織形成に優れ、治癒速度を向上させる生体組織接合具を提供することを目的とする。
【０００５】
【課題を解決するための手段】
本発明は、上記課題を解決するため、以下の手段を採用する。
本発明の生体組織接合具は、生体吸収性材料で構成され内部に中空部が形成された接合具本体を備え、前記中空部にカルシウム化合物からなる生体組織補填材が充填されていることを特徴とする。
【０００６】
この生体組織接合具によれば、生体吸収性材料で構成される接合具本体内部に、カルシウム化合物からなる生体組織補填材が充填されているので、接合具本体が生体内に吸収されて接合強度が低下しても、それに伴って内部に充填された生体組織補填材が周囲の生体組織と接触して生体組織形成作用を誘導する。そのため、生体組織補填材を足場として新しい生体組織が形成されてくるので接合部の強度を維持でき、患部の治癒速度を高めることができる。
【０００７】
また、本発明では、前記生体組織接合具であって、前記生体組織補填材が、顆粒状リン酸三カルシウムであることが好ましい。
さらに、本発明では、前記生体組織接合具であって、前記生体組織補填材に、細胞の活性を高める成長因子が含有されていることが好ましい。
この生体組織接合具によれば、生体組織の活性がさらに高まり生体組織形成が促進するので、接合強度が維持されるとともに、患部の治癒速度をより速めることができる。
【０００８】
本発明では、前記生体組織接合具であって、前記接合具本体に、外部と前記中空部とを連通する孔が設けられていることが好ましい。
この生体組織接合具によれば、孔を介して生体組織補填材と生体組織との接触が促進されるので、接合初期から生体組織形成を行うことができ、患部の治癒速度をより向上することができる。
【０００９】
【発明の実施の形態】
本発明の第１の実施形態に係る生体組織接合具について、図１及び図２を参照して説明する。
本実施形態に係る骨接合具（生体組織接合具）１０は、骨（生体組織）を接合して固定するものであって、図１に示すように、生体吸収性材料（例えば、ＰＬＡ）で構成されている接合具本体１１を備えている。
接合具本体１１は、先端の一部が尖鋭でテーパ面を有する略円錐形状のピンであって、他端部側から内部に中空部１２が形成されている。
【００１０】
この中空部１２には、カルシウム化合物、例えば、β―リン酸三カルシウム（β―ＴＣＰ）で構成された骨補填材（生体組織補填材）１３が顆粒状態で充填されている。
骨補填材１３には、細胞の活性を高める成長因子１４が含浸されている。成長因子１４としては、例えば、ＰＲＰ（ｐｌａｔｅｌｅｔ−ｒｉｃｈ ｐｌａｓｍａ）等のサイトカインであって、骨の再生や血管形成などを促す作用を有する。
【００１１】
次に、以上の構成からなる本実施形態の骨接合具１０の作用を説明する。
この骨接合具１０を、図２に示すように、事故等によって分離した骨同士を接合する際に使用する。
まず、一方の骨１５に設けられた挿入部１６から挿入し、他方の骨１７に圧入して両者を接合する。骨接合具１０の挿入後しばらくすると、接合具本体１１を構成するＰＬＡが加水分解し始めて周囲の生体内に吸収される。一方、内部に充填された骨補填材１３及び成長因子１４と周囲の骨組織とが接触し始める。
すると、成長因子１４によって周囲の骨細胞の活性が高められて骨形成を誘導し、骨補填材１１を足場とした新しい自家骨が形成される。
こうして、接合具本体１１が体内に吸収されることによって接合具としての強度が低下しても新しい自家骨が形成されてくるので、一方の骨１５と他方の骨１７との接合が維持され、やがて両者は再び一体化した骨となって治癒する。
治癒後はＰＬＡの加水分解が更に進行して全てが生体内に吸収され、最終的には自家骨と置換される。
【００１２】
この骨接合具１０によれば、接合具本体１１が生体内に吸収されることにより、骨同士の接合強度が低下しても新しい骨組織が形成されて、強度低下をカバーするので接合強度が維持され、患部の治癒速度を高めることができる。
【００１３】
次に、本発明に係る第２の実施形態について、図３及び図４を参照して説明する。なお、以下の説明において、上記実施形態において説明した構成要素には同一符号を付し、その説明は省略する。
第２の実施形態が上記第１の実施形態と異なる点は、第２の実施形態では接合具本体１８の中空部１２と外部とを連通させる貫通孔（孔）１９が設けられているとした点である。
【００１４】
本実施形態に係る骨接合具２０の接合具本体１８は、第１の実施形態と同じＰＬＡで構成されており、図３に示すように、先端の一部が尖状に突出しテーパ面を有する略円柱形状に形成され、スクリューとして円柱形状部の外周部にネジ山を有している。他端部２１側からは接合具本体１８の内部に向かって中空部１２が形成されている。そして、接合具本体１８の壁部には、中空部１２と外部とを連通させる貫通孔１９が設けられている。
中空部１２には、第１の実施形態と同様に成長因子１４が含浸された骨補填材１３が充填されており、他端部２１には蓋２２が配設されている。
【００１５】
次に、以上の構成からなる本実施形態の骨接合具２０の作用について説明する。
図４に示すように、一方の骨１５と他方の骨１７との間に人工骨スペーサ２３をわたして、人工骨スペーサ２３に設けられた挿入口２４から骨接合具２０を挿入して螺着し、一方の骨１５と他方の骨１７とを接合する。接合後しばらくすると、接合具本体１８を構成するＰＬＡが加水分解し始めて生体内の吸収が開始する。同時に、貫通孔１９に生体内の水分等が流入し、これを介して骨補填材１３が成長因子１４とともに一方の骨１５及び他方の骨１７と接触する。すると、骨細胞の活性が高まるので新しい骨が形成される。
この骨接合具２０によれば、接合初期から接合した周囲の骨細胞の活性を高めて骨形成を行うことができるので、接合具本体１８が生体内に吸収されて強度が低下しても、並行して骨補填材１３及び成長因子１４の働きによって新しい自家骨を形成し、一方の骨１５と他方の骨１７との接合を維持した状態でより短時間で治癒させることができる。
【００１６】
なお、本発明の技術範囲は上記実施の形態に限定されるものではなく、本発明の趣旨を逸脱しない範囲において種々の変更を加えることが可能である。
例えば、上記実施形態では、接合具本体１８に貫通孔１９を設けているが、図５に示すように、多数の孔を有する多孔体として接合具本体２５を作製しても構わない。
また、接合具本体の材質は、生体親和性を有し接合部同士の分離を抑制できる強度を有する材質であればＰＬＡに限らない。そして、内部に充填する生体組織補填材もβ―ＴＣＰのみならず、生体適合性があって、細胞が生体組織形成作用を生ずる際の足場となるものであればよく、ＨＡＰ（ＨｙｄｏｒｏｘｙＡＰａｔｉｔｅ）、α―ＴＣＰ等他のカルシウム化合物材料でもよい。
【００１７】
さらに、成長因子としては、ＰＲＰに限らず生体組織の再生において必要なものであればよく、ＢＭＰ（Ｂｏｎｅ Ｍｏｒｐｈｏｇｅｎｅｔｉｃ Ｐｒｏｔｅｉｎ）、ＦＧＦ（Ｆｉｂｒｏｂｌａｓｔ Ｇｒｏｗｔｈ Ｆａｃｔｏｒ）、ＴＧＦ−β（Ｔｒａｎｓｆｏｒｍｉｎｇ Ｇｒｏｗｔｈ Ｆａｃｔｏｒ−β）、ＩＧＦ（Ｉｎｓｕｌｉｎ−ｌｉｋｅ Ｇｒｏｗｔｈ Ｆａｃｔｏｒ）、ＰＤＧＦ（Ｐｌａｔｅｌｅｔ−Ｄｅｒｉｖｅｄ Ｇｒｏｗｔｈ Ｆａｃｔｏｒ）、ＶＥＧＦ（ＶａｓｃｕｌａｒＥｎｄｏｔｈｅｌｉａｌ ｃｅｌｌ Ｇｒｏｗｔｈ Ｆａｃｔｏｒ）などを単独又はこれらを複合させたものを補填してもよい。
【００１８】
【発明の効果】
以上説明した本発明の生体組織接合具においては以下の効果を奏する。
本発明によれば、生体組織同士の接合強度を低下させずに接合状態を維持することができる。また、生体組織形成作用に優れるので、患部の治癒速度を向上することができる。
【図面の簡単な説明】
【図１】本発明の第１実施形態における骨接合具の断面図である。
【図２】本発明の第１実施形態における骨接合具の使用例を示す図である。
【図３】本発明の第２実施形態における骨接合具の断面図である。
【図４】本発明の第２実施形態における骨接合具の使用例を示す図である。
【図５】本発明の第２実施形態における骨接合具の他の例を示す図である。
【符号の説明】
１０、２０ 骨接合具（生体組織接合具）
１１、１８、２５ 接合具本体
１２ 中空部
１３ 骨補填材（生体組織補填材）
１４ 成長因子
１９ 貫通孔（孔）[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a living tissue connector such as a bone bonding material.
[0002]
[Prior art]
BACKGROUND ART When a living tissue such as a bone is cut by a fracture or the like, various osteosynthesis tools that maintain a joined state are used in order to join and regenerate the cut bones with each other.
The materials used for this osteosynthesis device are not toxic, and are required to have biocompatibility with the strength required for fixation. Conventionally, various metallic materials, ceramic materials, and bioabsorbable materials have been used. ing. Recently, polylactic acid (PLA: PolyLactec Acid) which has no problem in strength and has few delayed chemical reactions has been used (for example, see Non-Patent Document 1).
[0003]
[Non-patent document 1]
Kosaku Mizuno, "Current Status and Prospects of Osteosynthesis Materials", Current Status and Prospects of Biomaterials in Orthopedic Surgery-Possibilities, Orthopedic Surgery, July 1997, Vol. 48, No. 8, p1094-1098
[0004]
[Problems to be solved by the invention]
However, PLA, which is a material of the above-mentioned conventional osteosynthesis device, has poor osteoconductive ability even though it is biodegradable. Therefore, when used in an affected area with a high degree of severity, it takes a long time for bone formation, while PLA is absorbed by the living body, so that the bonding strength is reduced. In the case where the joint is loosened or misaligned or in an extreme case, the joint is separated and it takes a long time to heal the joint.
The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a living tissue joining device that has high joining strength and biocompatibility, is excellent in living tissue formation, and improves the healing speed.
[0005]
[Means for Solving the Problems]
The present invention employs the following means in order to solve the above problems.
The living tissue connector of the present invention includes a connector main body formed of a bioabsorbable material and having a hollow portion formed therein, wherein the hollow portion is filled with a living tissue filler made of a calcium compound. And
[0006]
According to this biological tissue joining device, since the living tissue filling material made of a calcium compound is filled in the inside of the joining device body made of a bioabsorbable material, the joining device body is absorbed into the living body and the joining strength is increased. However, the living tissue replenishing material filled therein comes into contact with the surrounding living tissue to induce a living tissue forming action. Therefore, new living tissue is formed using the living tissue filling material as a scaffold, so that the strength of the joint can be maintained and the healing speed of the affected part can be increased.
[0007]
Further, in the present invention, it is preferable that in the living tissue joining device, the living tissue filling material is granular tricalcium phosphate.
Furthermore, in the present invention, it is preferable that in the living tissue joining device, the living tissue filling material contains a growth factor that enhances cell activity.
According to the living tissue joining device, the activity of the living tissue is further enhanced and the formation of the living tissue is promoted, so that the joining strength is maintained and the healing speed of the affected part can be further increased.
[0008]
In the present invention, it is preferable that the living tissue connector is provided with a hole in the connector main body, the hole communicating the outside with the hollow portion.
According to this biological tissue connector, since the contact between the biological tissue filler and the biological tissue is promoted through the hole, the biological tissue can be formed from the initial stage of the bonding, and the healing speed of the affected part can be further improved. Can be.
[0009]
BEST MODE FOR CARRYING OUT THE INVENTION
A biological tissue connector according to a first embodiment of the present invention will be described with reference to FIGS.
The osteosynthesis device (living tissue joining device) 10 according to the present embodiment joins and fixes bones (living tissue), and is made of a bioabsorbable material (for example, PLA) as shown in FIG. It has a connector body 11 configured.
The connector main body 11 is a substantially conical pin having a tip part that is sharp and has a tapered surface, and has a hollow part 12 formed inside from the other end side.
[0010]
The hollow portion 12 is filled with a bone filling material (living tissue filling material) 13 composed of a calcium compound, for example, β-tricalcium phosphate (β-TCP) in a granular state.
The bone replacement material 13 is impregnated with a growth factor 14 for increasing cell activity. The growth factor 14 is, for example, a cytokine such as PRP (platelet-rich plasma), and has an effect of promoting bone regeneration and angiogenesis.
[0011]
Next, the operation of the osteosynthesis device 10 according to the present embodiment having the above configuration will be described.
This osteosynthesis device 10 is used for joining bones separated by an accident or the like as shown in FIG.
First, one of the bones 15 is inserted from an insertion portion 16 and the other is press-fitted into the other bone 17 to join them together. Some time after the insertion of the osteosynthesis device 10, PLA constituting the osteosynthesis device body 11 starts to be hydrolyzed and absorbed into the surrounding living body. On the other hand, the bone filling material 13 and the growth factor 14 filled therein begin to come into contact with the surrounding bone tissue.
Then, the activity of the surrounding bone cells is enhanced by the growth factor 14 to induce bone formation, and a new autologous bone using the bone replacement material 11 as a scaffold is formed.
In this way, even if the strength of the connector decreases due to the absorption of the connector main body 11 into the body, new autogenous bones are formed, so that the connection between the one bone 15 and the other bone 17 is maintained, Eventually, the two will become a united bone and heal.
After healing, the hydrolysis of PLA proceeds further and all is absorbed into the living body, and eventually is replaced with autologous bone.
[0012]
According to the osteosynthesis device 10, even if the bonding strength between the bones is reduced, new bone tissue is formed even when the bonding strength between the bones is reduced by the absorption of the bonding body 11 into the living body. It can be maintained and the healing speed of the affected area can be increased.
[0013]
Next, a second embodiment according to the present invention will be described with reference to FIGS. In the following description, the same reference numerals are given to the components described in the above embodiment, and the description will be omitted.
The difference between the second embodiment and the first embodiment is that in the second embodiment, a through-hole (hole) 19 for communicating the hollow portion 12 of the connector body 18 with the outside is provided. Is a point.
[0014]
The connector body 18 of the bone connector 20 according to the present embodiment is made of the same PLA as in the first embodiment, and as shown in FIG. 3, a part of the tip protrudes sharply and has a tapered surface. It is formed in a substantially columnar shape, and has a screw thread on the outer peripheral portion of the columnar portion as a screw. The hollow portion 12 is formed from the other end 21 side toward the inside of the connector body 18. A through hole 19 is provided in the wall of the connector body 18 to allow the hollow portion 12 to communicate with the outside.
The hollow portion 12 is filled with a bone replacement material 13 impregnated with a growth factor 14 as in the first embodiment, and a lid 22 is provided at the other end 21.
[0015]
Next, the operation of the osteosynthesis device 20 according to the present embodiment having the above-described configuration will be described.
As shown in FIG. 4, the artificial bone spacer 23 is moved between the one bone 15 and the other bone 17, and the osteosynthesis 20 is inserted and screwed into the insertion hole 24 provided in the artificial bone spacer 23. Then, one bone 15 and the other bone 17 are joined. Some time after the joining, the PLA constituting the joining device main body 18 starts to be hydrolyzed, and absorption in the living body starts. At the same time, water or the like in the living body flows into the through hole 19, and the bone replacement material 13 contacts the one bone 15 and the other bone 17 together with the growth factor 14 via the hole. Then, the activity of the bone cells increases, so that new bone is formed.
According to this osteosynthesis device 20, since the bone formation can be performed by increasing the activity of the surrounding bone cells joined from the initial stage of the joining, even if the strength of the osteosynthesis device 18 is reduced by absorption into the living body, At the same time, a new autologous bone is formed by the action of the bone filling material 13 and the growth factor 14, and the bone can be healed in a shorter time while maintaining the joint between the one bone 15 and the other bone 17.
[0016]
The technical scope of the present invention is not limited to the above-described embodiment, and various changes can be made without departing from the spirit of the present invention.
For example, in the above embodiment, the through hole 19 is provided in the connector main body 18, but as shown in FIG. 5, the connector main body 25 may be manufactured as a porous body having many holes.
Further, the material of the connector main body is not limited to PLA as long as it has a biocompatibility and has a strength capable of suppressing separation between the joints. The material to be filled into the living tissue is not limited to β-TCP, but may be any material that has biocompatibility and serves as a scaffold when cells produce a living tissue forming effect. HAP (HydroxyAPatite), α -Other calcium compound materials such as TCP may be used.
[0017]
Further, the growth factor is not limited to PRP, but may be any factor required for the regeneration of living tissue. BMP (Bone Morphogenetic Protein), FGF (Fibroblast Growth Factor), TGF-β (Transforming Growth Factor-β), IGF (Insulin-like Growth Factor), PDGF (Platelet-Derived Growth Factor), VEGF (Vascular Endothelial cell Growth Factor), or a combination of these alone or in combination.
[0018]
【The invention's effect】
The living tissue connector of the present invention described above has the following effects.
ADVANTAGE OF THE INVENTION According to this invention, a joined state can be maintained, without lowering the joining strength of living tissues. In addition, since it is excellent in the action of forming a living tissue, the healing speed of the affected part can be improved.
[Brief description of the drawings]
FIG. 1 is a cross-sectional view of a osteosynthesis device according to a first embodiment of the present invention.
FIG. 2 is a diagram illustrating an example of use of a bone fastener according to the first embodiment of the present invention.
FIG. 3 is a sectional view of a osteosynthesis device according to a second embodiment of the present invention.
FIG. 4 is a view showing an example of use of a osteosynthesis device according to a second embodiment of the present invention.
FIG. 5 is a view showing another example of the osteosynthesis device according to the second embodiment of the present invention.
[Explanation of symbols]
10,20 Bone joints (living tissue joints)
11, 18, 25 Connector body 12 Hollow portion 13 Bone filling material (living tissue filling material)
14 Growth factor 19 Through-hole (hole)

Claims (4)

生体吸収性材料で構成され内部に中空部が形成された接合具本体を備え、
前記中空部にカルシウム化合物からなる生体組織補填材が充填されていることを特徴とする生体組織接合具。With a connector body composed of a bioabsorbable material and having a hollow portion formed inside,
A living tissue joining device, wherein the hollow portion is filled with a living tissue filling material made of a calcium compound. 前記生体組織補填材が、顆粒状リン酸三カルシウムであることを特徴とする請求項１記載の生体組織接合具。The living tissue joining device according to claim 1, wherein the living tissue filling material is granular tricalcium phosphate. 前記生体組織補填材に、細胞の活性を高める成長因子が含有されていることを特徴とする請求項１又は２記載の生体組織接合具。The living tissue joining device according to claim 1 or 2, wherein the living tissue filling material contains a growth factor that enhances cell activity. 前記接合具本体に、外部と前記中空部とを連通する孔が設けられていることを特徴とする請求項１から３の何れか１項に記載の生体組織接合具。The living tissue connector according to any one of claims 1 to 3, wherein the connector main body is provided with a hole communicating the outside with the hollow portion.
JP2003099019A 2003-04-02 2003-04-02 Biological tissue connector Pending JP2004305262A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011019900A (en) * 2009-07-16 2011-02-03 Tyco Healthcare Group Lp Composite fixation device
US9044277B2 (en) 2010-07-12 2015-06-02 DePuy Synthes Products, Inc. Pedicular facet fusion screw with plate
KR101538620B1 (en) * 2015-03-31 2015-07-22 (주) 웹스 Biodegradable Intervertebral Fusion Cage

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011019900A (en) * 2009-07-16 2011-02-03 Tyco Healthcare Group Lp Composite fixation device
US9044277B2 (en) 2010-07-12 2015-06-02 DePuy Synthes Products, Inc. Pedicular facet fusion screw with plate
US9089372B2 (en) 2010-07-12 2015-07-28 DePuy Synthes Products, Inc. Pedicular facet fusion screw with plate
KR101538620B1 (en) * 2015-03-31 2015-07-22 (주) 웹스 Biodegradable Intervertebral Fusion Cage

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