JP2002523454A - 治療剤としてのホルムアミド類 - Google Patents
治療剤としてのホルムアミド類Info
- Publication number
- JP2002523454A JP2002523454A JP2000567200A JP2000567200A JP2002523454A JP 2002523454 A JP2002523454 A JP 2002523454A JP 2000567200 A JP2000567200 A JP 2000567200A JP 2000567200 A JP2000567200 A JP 2000567200A JP 2002523454 A JP2002523454 A JP 2002523454A
- Authority
- JP
- Japan
- Prior art keywords
- propyl
- ethyl
- phenyl
- butyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9795698P | 1998-08-26 | 1998-08-26 | |
GBGB9818613.3A GB9818613D0 (en) | 1998-08-26 | 1998-08-26 | Formamides as therapeutic agents |
GB9818613.3 | 1998-08-26 | ||
GB60/097,956 | 1998-08-26 | ||
PCT/US1999/019303 WO2000012083A1 (en) | 1998-08-26 | 1999-08-25 | Formamides as therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002523454A true JP2002523454A (ja) | 2002-07-30 |
Family
ID=26314265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000567200A Pending JP2002523454A (ja) | 1998-08-26 | 1999-08-25 | 治療剤としてのホルムアミド類 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1121118A4 (de) |
JP (1) | JP2002523454A (de) |
AU (1) | AU5582899A (de) |
WO (1) | WO2000012083A1 (de) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB202012671D0 (en) | 2020-08-13 | 2020-09-30 | Nrf Ithemba Labs | Theranostic Compounds |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
DK77487A (da) * | 1986-03-11 | 1987-09-12 | Hoffmann La Roche | Hydroxylaminderivater |
US5239078A (en) * | 1990-11-21 | 1993-08-24 | Glycomed Incorporated | Matrix metalloprotease inhibitors |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
US6037472A (en) * | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
ATE181055T1 (de) * | 1994-05-28 | 1999-06-15 | British Biotech Pharm | Succinyl hydroxamsäure-, n-formyl-n-hydroxy- aminocarbonsäure- und succinsäureamid-derivate und ihre verwendung als metalloprotease- inhibitoren |
GB9514867D0 (en) * | 1995-07-20 | 1995-09-20 | British Biotech Pharm | Metalloproteinase inhibitors |
AU711804B2 (en) * | 1995-11-23 | 1999-10-21 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
HRP980096A2 (en) * | 1997-02-26 | 1998-12-31 | Glaxo Group Ltd | Reverse hydroxamate derivatives as matrix metalloprotease inhibitors, metalloprotease inhibitors, and tnf alpha inhibitors |
GB9818621D0 (en) * | 1998-08-26 | 1998-10-21 | Glaxo Group Ltd | Formamide compounds as therapeutic agents |
WO2000012082A1 (en) * | 1998-08-26 | 2000-03-09 | Glaxo Group Limited | Formamide compounds as therapeutic agents |
-
1999
- 1999-08-25 JP JP2000567200A patent/JP2002523454A/ja active Pending
- 1999-08-25 AU AU55828/99A patent/AU5582899A/en not_active Abandoned
- 1999-08-25 EP EP99942456A patent/EP1121118A4/de not_active Withdrawn
- 1999-08-25 WO PCT/US1999/019303 patent/WO2000012083A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1121118A1 (de) | 2001-08-08 |
WO2000012083A1 (en) | 2000-03-09 |
AU5582899A (en) | 2000-03-21 |
EP1121118A4 (de) | 2002-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3277170B2 (ja) | メタロプロテアーゼ阻害剤 | |
JP2921673B2 (ja) | マトリックスメタロプロテアーゼ阻害剤 | |
US8785473B2 (en) | Plasminogen activator inhibitor-1 inhibitor | |
KR100432602B1 (ko) | 매트릭스메탈로프로테아제억제제 | |
US5753653A (en) | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses | |
JP3916064B2 (ja) | マトリックスメタロプレテイナーゼ阻害剤としての二酸置換ヘテロアリール誘導体 | |
JP4343690B2 (ja) | プロテアーゼ阻害薬としてのシアノアルキルアミノ誘導体 | |
JP3867196B2 (ja) | TNF−α産生阻害物質 | |
JP2001513767A (ja) | メタロプロテアーゼ阻害剤としての逆ヒドロキサメート誘導体 | |
JP2007530580A (ja) | 肥満細胞トリプターゼインヒビターとしての[4−(5−アミノメチル−2−フルオロ−フェニル)−ピペリジン−1−イル]−(4−ブロモ−3−メチル−5−プロポキシ−チオフェン−2−イル)−メタノンヒドロクロリド | |
SK73898A3 (en) | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation | |
KR20090033912A (ko) | 화학적 화합물 | |
JP2002504916A (ja) | 抗転移及び抗腫瘍活性を有するバルビツール酸誘導体 | |
TW200302084A (en) | N-(4-substituted phenyl)-anthranilic acid hydroxamate esters | |
JPH07118237A (ja) | プロペン酸誘導体 | |
JPH0673038A (ja) | ビフェニル誘導体、これらの化合物を含む医薬組成物及びそれらの調製法 | |
KR100293867B1 (ko) | 아미노스틸바졸유도체및의약 | |
US6172064B1 (en) | Formamides as therapeutic agents | |
WO2005030754A1 (en) | Indole or quinoline derivatives as non-pepticid npy y2 receptor inhibitors useful for the treatment of anxiolytic and depressive disorders and obesity | |
US6329400B1 (en) | Formamide compounds as therapeutic agents | |
KR20080023758A (ko) | 비만 및 관련 질환의 치료를 위한 신규한 아미노산 유도체 | |
US6191150B1 (en) | Formamide compounds as therapeutic agents | |
JP2002523454A (ja) | 治療剤としてのホルムアミド類 | |
JP2004520346A (ja) | Ldl受容体発現のインデューサーとしてのアリールピペリジン誘導体 | |
RU2713886C2 (ru) | Композиции и способы лечения заболеваний и состояний |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20041102 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050422 |