JP2002338499A - Skin care preparation for external use - Google Patents
Skin care preparation for external useInfo
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- JP2002338499A JP2002338499A JP2001187323A JP2001187323A JP2002338499A JP 2002338499 A JP2002338499 A JP 2002338499A JP 2001187323 A JP2001187323 A JP 2001187323A JP 2001187323 A JP2001187323 A JP 2001187323A JP 2002338499 A JP2002338499 A JP 2002338499A
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- oil
- poe
- water
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- soluble
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Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は皮膚浸透性が高く且つ安
全性や製剤の安定性も高い皮膚外用剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin having high skin permeability and high safety and stability of the preparation.
【０００２】[0002]
【従来の技術】皮膚外用剤には当然のことながら、様々
な有効成分を配合する。しかしながら、配合しても皮膚
吸収されなければ、有効性を発揮することはない。その
ため、経皮吸収促進剤を配合することもよく行われるが
安全性や製剤安定性に問題があった。2. Description of the Related Art Various active ingredients are naturally blended in an external preparation for skin. However, even if it is incorporated, if it is not absorbed into the skin, it will not show its efficacy. Therefore, a transdermal absorption enhancer is often added, but there are problems in safety and formulation stability.
【０００３】[0003]
【発明が解決しようとする課題】本発明の目的は、安全
で製剤の安定性も極めて良好で且つ、有効成分の皮膚吸
収が優れている製剤を得ることを課題とした。SUMMARY OF THE INVENTION An object of the present invention is to provide a preparation which is safe, has extremely good stability of the preparation, and has excellent skin absorption of the active ingredient.
【０００４】[0004]
【課題を解決するための手段】本発明者らは、前記の課
題を解決するため、鋭意検討した結果、油溶性有効性成
分と油分と多価アルコールと界面活性剤を高圧乳化処理
し、水および水溶性成分に混合攪拌することにより上記
の課題が解決されることを見出した。Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, high-pressure emulsification treatment of an oil-soluble active ingredient, an oil component, a polyhydric alcohol and a surfactant was carried out, and water was obtained. It has been found that the above problem can be solved by mixing and stirring with a water-soluble component.
【０００５】すなわち、油溶性有効性成分と油分と多価
アルコールと界面活性剤を高圧乳化処理する第１段階と
水および水溶性成分に混合攪拌する第２段階を行うこと
によって、油溶性有効成分が経皮吸収促進剤等を用いな
くとも経皮吸収が優れた、且つ安全性や製剤の安定性が
優れた皮膚外用剤が得られた。この方法を取ることによ
って、高圧乳化方法の利点が最大限に活かされ微粒子化
が促進される。また、このことによって高圧乳化機で処
理する量が減少し、機器の有効利用が図られ、第１段階
の処理後、安定で防腐性もよいので、保管でき、必要量
のみ第２段階の処理を行うなど経済的にも有利である。That is, the first step of emulsifying the oil-soluble active ingredient, the oil, the polyhydric alcohol and the surfactant under high pressure and the second step of mixing and stirring the water-soluble ingredient with the water-soluble active ingredient are carried out. However, a skin external preparation having excellent transdermal absorption and excellent safety and stability of the preparation was obtained without using a transdermal absorption enhancer or the like. By adopting this method, the advantages of the high-pressure emulsification method are maximized and the formation of fine particles is promoted. This also reduces the amount to be processed by the high-pressure emulsifier, makes it possible to use the equipment effectively, and after the first-stage treatment, it is stable and has good antiseptic properties. Is also economically advantageous.
【０００６】油溶性有効性成分には特に限定はないので
製剤の用途等によって選択するが、α−トコフェロー
ル、ビタミンＡパルミテート等の油溶性ビタミン類およ
びその誘導体、油溶性甘草、油溶性ヨクイニン等の油溶
性植物エキス、γーオリザノール、グリチルレチン酸ス
テアリル等が例示される。The oil-soluble active ingredient is not particularly limited and is selected according to the use of the preparation. The oil-soluble vitamins such as α-tocopherol and vitamin A palmitate and derivatives thereof, oil-soluble licorice, oil-soluble yoquinin, etc. Oil-soluble plant extracts, γ-oryzanol, stearyl glycyrrhetinate and the like are exemplified.
【０００７】油分も特に限定はないので、任意に選択す
るが使用感、用途、使用量によって選択する。以下に例
示すれば、天然動植物油脂例えば、オリーブ油、ミンク
油、ヒマシ油、パーム油、牛脂、月見草油、ヤシ油、ヒ
マシ油、カカオ油、マカデミアナッツ油等；蝋例えば、
ホホバ油、ミツロウ、ラノリン、カルナウバロウ、キャ
ンデリラロウ等；高級アルコール例えば、ラウリルアル
コール、ステアリルアルコール、セチルアルコール、オ
レイルアルコール等；高級脂肪酸例えば、ラウリン酸、
パルミチン酸、ステアリン酸イン、固形パラフィン、ス
クワラン、ワセリン、セレシン、マイクロクリスタリン
ワックス等；合成エステル油例えば、ブチルステアレー
ト、ヘキシルラウレート、ジイソプロピルアジペート、
ジイソプロピルセバケート、ミリスチン酸オクチルドデ
シル、イソプロピルミリステート、イソプロピルパルミ
テートイソプロピルミリステート、セチルイソオクタノ
エート、ジカプリン酸ネオペンチルグリコール；シリコ
ーン誘導体例えば、メチルシリコーン、メチルフェニル
シリコーン等のシリコーン油等が挙げられる。[0007] The oil content is not particularly limited, and may be arbitrarily selected, depending on the feeling of use, application, and amount used. For example, natural animal and vegetable oils and fats such as olive oil, mink oil, castor oil, palm oil, beef tallow, evening primrose oil, coconut oil, castor oil, cacao oil, macadamia nut oil, etc .;
Jojoba oil, beeswax, lanolin, carnauba wax, candelilla wax and the like; higher alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol and oleyl alcohol; higher fatty acids such as lauric acid;
Palmitic acid, stearic acid in, solid paraffin, squalane, petrolatum, ceresin, microcrystalline wax, etc .; synthetic ester oils such as butyl stearate, hexyl laurate, diisopropyl adipate,
Diisopropyl sebacate, octyl dodecyl myristate, isopropyl myristate, isopropyl palmitate isopropyl myristate, cetyl isooctanoate, neopentyl glycol dicaprate; silicone derivatives such as silicone oils such as methyl silicone and methyl phenyl silicone .
【０００８】多価アルコールにはプロピレングリコー
ル、ジプロピレングリコール、１，３−ブチレングリコ
ール、１，４−ブチレングリコール、ジエチレングリコ
ール、トリエチレングリコール、グリセリン、ジグリセ
リン、トリグリセリン等が利用できるがこのなかでも本
発明者らが検討した結果、グリセリン、ジグリセリン、
１，３−ブチレングリコールを中心に配合すると本発明
の主旨に合致することが判明した。As the polyhydric alcohol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, diethylene glycol, triethylene glycol, glycerin, diglycerin, triglycerin and the like can be used. As a result of the study by the present inventors, glycerin, diglycerin,
It has been found that blending mainly with 1,3-butylene glycol conforms to the gist of the present invention.
【０００９】界面活性剤は特に限定はないが以下のよう
な界面活性剤を例示することができる。パルミチン酸ナ
トリウム、ラウロイルサルコシンナトリウム、Ｎ−ミリ
ストイル−Ｎ−メチルタウリンナトリウム、ＰＯＥオレ
イルエーテルリン酸ナトリウム、Ｎ−ラウロイルグルタ
ミン酸モノナトリウム、Ｎ−ステアロイルグルタミン酸
ジナトリウム、Ｎ−ミリストイル−Ｌ−グルタミン酸モ
ノナトリウム、硬化ヤシ油脂肪酸グリセリン硫酸ナトリ
ウム、２−ウンデシル−Ｎ，Ｎ，Ｎ−（ヒドロキシエチ
ルカルボキシメチル）−２−イミダゾリンナトリウム、
２−ココイル−２−イミタゾリニウムヒドロキサイド−
１−カルボキシエチロキシ２ナトリウム塩、２−ヘプタ
デシル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチル
イミダゾリニウムベタイン、ラウリルジメチルアミノ酢
酸ベタイン、アルキルベタイン、ソルビタンモノオレエ
ート、ソルビタンモノイソステアレート、ソルビタンモ
ノラウレート、ソルビタンモノパルミテート、ソルビタ
ンモノステアレート、セスキオレイン酸グリセリン、モ
ノステアリン酸グリセリン、モノステアリン酸プロピレ
ングリコール、グリセリンアルキルエーテル、ポリオキ
シエチレン・メチルポリシロキサン共重合体、ＰＯＥソ
ルビタンモノオレエート、ＰＯＥ−ソルビタンモノステ
アレート、ＰＯＥ−ソルビタンモノオレート、ＰＯＥ−
ソルビットモノラウレート、ＰＯＥ−ソルビットモノオ
レエート、ＰＯＥ−ソルビットペンタオレエート、ＰＯ
Ｅ−グリセリンモノステアレート、ＰＯＥ−グリセリン
モノイソステアレート、ＰＯＥモノオレエート、ＰＯＥ
ジステアレート、ＰＯＥモノジオレエート、ＰＯＥオレ
イルエーテル、ＰＯＥステアリルエーテル、ＰＯＥベヘ
ニルエーテル、ＰＯＥ２−オクチルドデシルエーテル、
ＰＯＥコレスタノールエーテル、ＰＯＥオクチルフェニ
ルエーテル、ＰＯＥノニルフェニルエーテル、ＰＯＥジ
ノニルフェニルエーテル、ＰＯＥ・ＰＯＰセチルエーテ
ル、、ＰＯＥ・ＰＯＰ水添ラノリン、ＰＯＥヒマシ油、
ＰＯＥ硬化ヒマシ油、ＰＯＥ硬化ヒマシ油モノイソステ
アレート、ＰＯＥ硬化ヒマシ油トリイソステアレート、
ＰＯＥ硬化ヒマシ油モノピログルタミン酸モノイソステ
アリン酸ジエステルが挙げられる。The surfactant is not particularly limited, but the following surfactants can be exemplified. Sodium palmitate, sodium lauroyl sarcosine, sodium N-myristoyl-N-methyltaurate, sodium POE oleyl ether phosphate, monosodium N-lauroylglutamate, disodium N-stearoylglutamate, monosodium N-myristoyl-L-glutamate, curing Palm oil fatty acid sodium glycerin sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium,
2-cocoyl-2-imitazolinium hydroxide-
1-carboxyethyloxy disodium salt, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetic acid betaine, alkyl betaine, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolau Rate, sorbitan monopalmitate, sorbitan monostearate, glycerin sesquioleate, glyceryl monostearate, propylene glycol monostearate, glycerin alkyl ether, polyoxyethylene / methyl polysiloxane copolymer, POE sorbitan monooleate, POE -Sorbitan monostearate, POE- sorbitan monooleate, POE-
Sorbit monolaurate, POE-Sorbit monooleate, POE-Sorbit pentaoleate, PO
E-glycerin monostearate, POE-glycerin monoisostearate, POE monooleate, POE
Distearate, POE monodioleate, POE oleyl ether, POE stearyl ether, POE behenyl ether, POE2-octyldodecyl ether,
POE cholestanol ether, POE octyl phenyl ether, POE nonyl phenyl ether, POE dinonyl phenyl ether, POE POP cetyl ether, POE POP hydrogenated lanolin, POE castor oil,
POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate,
POE hydrogenated castor oil monopyroglutamic acid monoisostearate diester.
【００１０】しかしながら、リン脂質（例示すれば、ホ
スファチジルコリン、ホスファチジルエタノールアミ
ン、リゾホスファチジルコリン、リゾホスファチジルエ
タノールアミン等）の１種以上の混合物あるいは、大豆
レシチン、とうもろこしレシチン、卵黄レシチンなどの
リン脂質混合物或いはこれらの水素添加物）や糖セラミ
ド（ガラクトシルセラミド、グルコシルセラミド、アシ
ルセレブロシド、セレブロシド硫酸エステル等のスフィ
ンゴ糖脂質あるいはこれらを含む動物性スフィンゴ脂
質、植物性スフィンゴ脂質）が特に界面活性剤のなかで
も本発明の主旨に合致することがわかった。However, a mixture of one or more of phospholipids (for example, phosphatidylcholine, phosphatidylethanolamine, lysophosphatidylcholine, lysophosphatidylethanolamine, etc.) or a phospholipid mixture of soybean lecithin, corn lecithin, egg yolk lecithin, etc. Hydrogenated products) and sugar ceramides (glycosphingolipids such as galactosylceramide, glucosylceramide, acyl cerebroside, cerebroside sulfate, and animal sphingolipids and vegetable sphingolipids containing these) are particularly preferred in the present invention. Was found to be consistent with the gist of this.
【００１１】また、油溶性有効性成分と油分と多価アル
コールと界面活性剤の割合は各成分の性質や製剤の用
途、第２段階で加える水および水溶性成分の量や性質な
どによって変化するが、油溶性有効性成分：油分：多価
アルコール：界面活性剤＝１：０．１〜１：１〜１０
０：０．０２〜１００の割合で配合することが好まし
い。The ratio of the oil-soluble active ingredient, the oil component, the polyhydric alcohol, and the surfactant varies depending on the properties of each component, the use of the preparation, and the amounts and properties of water and water-soluble components added in the second stage. But oil-soluble active ingredient: oil: polyhydric alcohol: surfactant = 1: 0.1 to 1: 1 to 10
It is preferable to mix at a ratio of 0: 0.02 to 100.
【００１２】これらを高圧乳化機において処理する。高
圧乳化機は様々な機種が販売されているが米国特許４５
３３２５４号に記載されているマイクロフルイダイザー
が優れている。これを用いて乳化する。これに水および
水溶性成分を加えて混合攪拌する。この段階では特に経
皮吸収に関係しないので、従来の回転式の攪拌機を用い
て混合攪拌すればよい。水溶性成分には特に限定はない
が、エマルジョンの破壊するものの配合は控えるか、量
的に少なくする必要がある。また、油溶性有効性成分、
多価アルコール、界面活性剤を混合したものの量と、水
および水溶性成分の量は、様々な条件によって変化する
が前者を１とすると、０．１〜１０００が好ましい。These are processed in a high-pressure emulsifier. Although various types of high-pressure emulsifiers are sold, US Pat.
The microfluidizer described in No. 33254 is excellent. Emulsify using this. Water and a water-soluble component are added thereto, and mixed and stirred. At this stage, since there is no particular relation to percutaneous absorption, mixing and stirring may be performed using a conventional rotary stirrer. The water-soluble component is not particularly limited, but it is necessary to refrain from mixing or reduce the amount of the water-soluble component in terms of breaking the emulsion. Also, oil-soluble active ingredients,
The amount of the mixture of the polyhydric alcohol and the surfactant, and the amounts of water and the water-soluble component vary depending on various conditions, but when the former is 1, the amount is preferably from 0.1 to 1,000.
【００１３】[0013]
【実施例】以下に実際の利用方法である実施例を記載す
るが、本発明はこの実施例によって何ら限定されるもの
ではない。EXAMPLES The following is an example of an actual use method, but the present invention is not limited to this example.
【００１４】実施例−１クリーム Ａ グリセリン ５．０ 水素添加大豆レシチン ０．７ Ｂ スクワラン １．０ αトコフェロール ０．５ Ｃ キサンタンガム ０．１ カルギキシビニルポリマー ０．１ １，３ブチレングリコール ２．０ 精製水 ９０．３ パラオキシ安息香酸メチル ０．１ １０％水酸化ナトリウム水溶液 ０．２ 作成方法 Ａ、Ｂを８０℃に加温分散したのち、マイクロフルイダ
イザー（マイクロフルイデクス社製、Ｍ−２１０−Ｅ／
Ｈ）を用いて１２５０ｋｇ／ｃｍ２で処理した。Ｃを８
０℃に加温分散したのち前者に攪拌しつつ加え、室温ま
で冷却した。Example-1 Cream A Glycerin 5.0 Hydrogenated soy lecithin 0.7 B Squalane 1.0 α Tocopherol 0.5 C Xanthan gum 0.1 Cargix vinyl polymer 0.1 1,3 butylene glycol 0 Purified water 90.3 Methyl parahydroxybenzoate 0.1 10% aqueous sodium hydroxide solution 0.2 Preparation method After A and B were heated and dispersed at 80 ° C, a microfluidizer (M-210, manufactured by Microfluidics Co., Ltd.) was used. -E /
H) at 1250 kg / cm 2. C to 8
After heating and dispersing to 0 ° C., the mixture was added to the former while stirring, and cooled to room temperature.
【００１５】実施例−２ クリーム Ａ グリセリン ５．０ スフィンゴ糖脂質 ０．５ Ｂ スクワラン １．０ ビタミンＡパルミテート ０．５ Ｃ キサンタンガム ０．１ カルギキシビニルポリマー ０．１ １，３ブチレングリコール ２．０ 精製水 ９０．５ パラオキシ安息香酸メチル ０．１ １０％水酸化ナトリウム水溶液 ０．２ 作成方法 Ａ、Ｂを８０℃に加温分散したのち、マイクロフルイダ
イザー（マイクロフルイデクス社製、Ｍ−２１０−Ｅ／
Ｈ）を用いて１２５０ｋｇ／ｃｍ２で処理した。Ｃを８
０℃に加温分散したのち前者に攪拌しつつ加え、室温ま
で冷却したExample 2 Cream A Glycerin 5.0 Glycosphingolipid 0.5 B Squalane 1.0 Vitamin A palmitate 0.5 C Xanthan gum 0.1 Cargixvinyl polymer 0.1 1,3 butylene glycol 0 Purified water 90.5 Methyl parahydroxybenzoate 0.1 10% aqueous solution of sodium hydroxide 0.2 Preparation method A and B were heated and dispersed at 80 ° C., and then microfluidizer (M-210, manufactured by Microfluidex) -E /
H) at 1250 kg / cm 2. C to 8
After heating and dispersing to 0 ° C., the mixture was added to the former while stirring, and cooled to room temperature.
【００１６】有効性確認試験−１ ヘアレスラットの腹部皮膚に、内径２８ｍｍのプラスチ
ック製の円筒管を接着剤で接着した。その管の中に実施
例−１を６ｍｌ注入した。６時間経過後、管を取り外
し、試料を拭き取った後、さらに７０％エタノールを含
ませた脱脂綿で皮膚表面を清拭した。皮膚投与部位を鋏
で摘出し、ミンチ状にした後、５０ｍｌの石油エーテル
（１００ｐｐｍＢＨＴ含有）で皮膚中のα−トコフェロ
ールを２０時間攪拌抽出した。抽出後、石油エーテルを
留去し、その残留物をメタノール２０ｍｌで溶解し、高
速液体クロマトグラフィーで定量した。分析条件はカラ
ムＯＤＳ−ＩＩ（島津製作所製）溶出溶媒＝メタノール
毎分１ｍｌ検出器＝蛍光検出器ＲＦ−５５０（島津製作
所製）励起波長２９８ｎｍ、蛍光波長３２５ｎｍなお、
繰り返し回数５回で行った。比較として、実施例−１と
同一の処方で作成方法において、、マイクロフルイダイ
ザイーを用いた部分で、ホモミキサー型式Ｍ ＳＰＥＣ
（特殊機化社製）で８０００ｒｐｍ、１０分間に置き換
えて実施した。Effectiveness Confirmation Test-1 A plastic cylindrical tube having an inner diameter of 28 mm was adhered to the abdominal skin of a hairless rat with an adhesive. 6 ml of Example-1 was injected into the tube. After 6 hours, the tube was removed, the sample was wiped off, and the skin surface was further wiped with absorbent cotton containing 70% ethanol. The skin administration site was removed with scissors and minced, and α-tocopherol in the skin was extracted with 50 ml of petroleum ether (containing 100 ppm BHT) with stirring for 20 hours. After the extraction, petroleum ether was distilled off, and the residue was dissolved in 20 ml of methanol and quantified by high performance liquid chromatography. Analysis conditions were as follows: column ODS-II (manufactured by Shimadzu Corporation) elution solvent = methanol 1 ml per minute detector = fluorescence detector RF-550 (manufactured by Shimadzu Corporation) excitation wavelength 298 nm, fluorescence wavelength 325 nm
The test was repeated five times. As a comparison, a homomixer type M SPEC was used in the method using the same formulation as in Example 1 except that the microfluidizer was used.
(Manufactured by Tokushu Kika Co., Ltd.) at 8000 rpm for 10 minutes.
【００１７】結果は実施例では皮膚中に吸収されたα−
トコフェロールの量は、１８．２±４．６μｇ比較例で
は５．２±１．２μｇとなり、本実施例の経皮吸収が非
常に優れていることがわかった。The results show that, in the examples, α-absorbed in the skin
The amount of tocopherol was 18.2 ± 4.6 μg in the comparative example, which was 5.2 ± 1.2 μg, indicating that the transdermal absorption of this example was extremely excellent.
【００１８】有効性確認試験−２ 女性５名に実施例−２と比較例−２のクリームをの顔面
を左右に分けて、毎日、１回以上使用してもらって、６
カ月後に、しわについて評価した。なお、比較例−２は
実施例−２と同一の処方で作成方法において、マイクロ
フルイダイザイーを用いた部分で、、ホモミキサー型式
Ｍ ＳＰＥＣ（特殊機化社製）で８０００ｒｐｍ、１０
分間に置き換えて実施したものである。Efficacy Confirmation Test-2 Five women were asked to use the creams of Example-2 and Comparative Example-2 on their faces on the left and right sides at least once a day.
After months, wrinkles were evaluated. Comparative Example-2 was prepared using the same formulation as in Example-2, except that a microfluidizer was used, and a homomixer type M SPEC (manufactured by Tokushu Kika Co., Ltd.) was used at 8000 rpm.
Minutes.
【００１９】評価の結果は実施例−２の方が比較例−２
に比較してしわが非常に減少したが１名、実施例−２の
方が比較例−２に比較してしわがかなり減少したが３
名、実施例−２の方が比較例−２に比較してしわがやや
減少したが１名であった。このようにビタミンＡパルミ
テートを同量配合したにも関わらず、実施例−２の方が
有効性を発揮しており、本発明の有効性が示された。The result of the evaluation is that Example 2 is Comparative Example 2
The wrinkles were significantly reduced as compared to Comparative Example 2, but the wrinkles were significantly reduced in Example 2 compared with Comparative Example 2.
In Example 2, wrinkles were slightly reduced in Example-2 as compared with Comparative Example-2, but only one person. Thus, despite the fact that vitamin A palmitate was blended in the same amount, Example-2 exhibited more effectiveness, indicating the effectiveness of the present invention.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 7/00 Ａ６１Ｋ 7/00 Ｗ 7/48 7/48 47/10 47/10 47/26 47/26 47/46 47/46 Ｆターム(参考） 4C076 AA16 BB31 CC23 DD01 DD34 DD38 DD45 DD63 DD67 EE08 EE30 FF16 FF32 FF36 FF43 4C083 AB032 AB051 AB052 AC022 AC111 AC122 AC482 AD092 AD201 AD352 AD571 AD572 AD622 AD662 BB01 BB11 DD31 EE01 EE03 EE09 FF05──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 W 7/48 7/48 47/10 47/10 47/26 47/26 47/46 47/46 F term (reference) 4C076 AA16 BB31 CC23 DD01 DD34 DD38 DD45 DD63 DD67 EE08 EE30 FF16 FF32 FF36 FF43 4C083 AB032 AB051 AB052 AC022 AC111 AC122 AC482 AD092 AD201 AD352 AD571 AD572 AD622 AD662 BB01 EE BB11 DD31
Claims (2)
と界面活性剤を高圧乳化処理し、水および水溶性成分に
混合攪拌することを特徴とする皮膚外用剤1. An external preparation for skin, comprising subjecting an oil-soluble active ingredient, an oil component, a polyhydric alcohol, and a surfactant to high-pressure emulsification, and mixing and stirring with water and a water-soluble ingredient.
ィンゴ糖脂質である請求項１に記載の皮膚外用剤2. The external preparation for skin according to claim 1, wherein the surfactant is a phospholipid or / and a glycosphingolipid.
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| JP2001187323A JP4756493B2 (en) | 2001-05-17 | 2001-05-17 | Topical skin preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001187323A JP4756493B2 (en) | 2001-05-17 | 2001-05-17 | Topical skin preparation |
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|---|---|
| JP2002338499A true JP2002338499A (en) | 2002-11-27 |
| JP4756493B2 JP4756493B2 (en) | 2011-08-24 |
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ID=19026625
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001187323A Expired - Lifetime JP4756493B2 (en) | 2001-05-17 | 2001-05-17 | Topical skin preparation |
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| JP (1) | JP4756493B2 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006160948A (en) * | 2004-12-09 | 2006-06-22 | Unitika Ltd | Sphingoglycolipid dissolved in oil and method for producing the same |
| JP2008156345A (en) * | 2006-11-27 | 2008-07-10 | Naris Cosmetics Co Ltd | Method for application of cosmetics |
| JP2008303203A (en) * | 2007-05-08 | 2008-12-18 | Naris Cosmetics Co Ltd | Cosmetic |
| WO2013145870A1 (en) * | 2012-03-30 | 2013-10-03 | 富士フイルム株式会社 | Aqueous dispersed composition |
| US9655821B2 (en) | 2013-04-05 | 2017-05-23 | The Procter & Gamble Company | Personal care composition comprising a pre-emulsified formulation |
| JP2018039782A (en) * | 2016-08-31 | 2018-03-15 | 御木本製薬株式会社 | Skin preparation for external use |
| US9993404B2 (en) | 2015-01-15 | 2018-06-12 | The Procter & Gamble Company | Translucent hair conditioning composition |
| WO2019106907A1 (en) * | 2017-11-30 | 2019-06-06 | キッコーマン株式会社 | Emulsion composition |
| US10806688B2 (en) | 2014-10-03 | 2020-10-20 | The Procter And Gamble Company | Method of achieving improved volume and combability using an anti-dandruff personal care composition comprising a pre-emulsified formulation |
| US10912723B2 (en) | 2016-01-20 | 2021-02-09 | The Procter And Gamble Company | Hair conditioning composition comprising monoalkyl glyceryl ether |
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| JP2000212066A (en) * | 1998-11-16 | 2000-08-02 | Eisai Co Ltd | Aqueous liquid preparation of fat-soluble material |
| JP2001039848A (en) * | 1999-07-27 | 2001-02-13 | Kao Corp | Skin lotion |
| JP2001081024A (en) * | 2000-04-10 | 2001-03-27 | Kokyu Alcohol Kogyo Co Ltd | Milky oil-in-water type emulsification composition and method for producing the same composition |
| JP2001113157A (en) * | 1999-10-19 | 2001-04-24 | Nonogawa Shoji Kk | Gel composition and emulsified composition |
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| JPH0278432A (en) * | 1988-06-20 | 1990-03-19 | Shiseido Co Ltd | Transparent composition |
| JPH1190211A (en) * | 1997-09-19 | 1999-04-06 | Lion Corp | Preparation of o/w type emulsion |
| JP2000212066A (en) * | 1998-11-16 | 2000-08-02 | Eisai Co Ltd | Aqueous liquid preparation of fat-soluble material |
| JP2001039848A (en) * | 1999-07-27 | 2001-02-13 | Kao Corp | Skin lotion |
| JP2001113157A (en) * | 1999-10-19 | 2001-04-24 | Nonogawa Shoji Kk | Gel composition and emulsified composition |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006160948A (en) * | 2004-12-09 | 2006-06-22 | Unitika Ltd | Sphingoglycolipid dissolved in oil and method for producing the same |
| JP2008156345A (en) * | 2006-11-27 | 2008-07-10 | Naris Cosmetics Co Ltd | Method for application of cosmetics |
| JP2008303203A (en) * | 2007-05-08 | 2008-12-18 | Naris Cosmetics Co Ltd | Cosmetic |
| WO2013145870A1 (en) * | 2012-03-30 | 2013-10-03 | 富士フイルム株式会社 | Aqueous dispersed composition |
| JP2014012656A (en) * | 2012-03-30 | 2014-01-23 | Fujifilm Corp | Aqueous dispersion composition |
| US9655821B2 (en) | 2013-04-05 | 2017-05-23 | The Procter & Gamble Company | Personal care composition comprising a pre-emulsified formulation |
| US10806688B2 (en) | 2014-10-03 | 2020-10-20 | The Procter And Gamble Company | Method of achieving improved volume and combability using an anti-dandruff personal care composition comprising a pre-emulsified formulation |
| US9993404B2 (en) | 2015-01-15 | 2018-06-12 | The Procter & Gamble Company | Translucent hair conditioning composition |
| US10912723B2 (en) | 2016-01-20 | 2021-02-09 | The Procter And Gamble Company | Hair conditioning composition comprising monoalkyl glyceryl ether |
| JP2018039782A (en) * | 2016-08-31 | 2018-03-15 | 御木本製薬株式会社 | Skin preparation for external use |
| JP7026375B2 (en) | 2016-08-31 | 2022-02-28 | 御木本製薬株式会社 | External skin preparation |
| WO2019106907A1 (en) * | 2017-11-30 | 2019-06-06 | キッコーマン株式会社 | Emulsion composition |
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