JP2002161011A - Germicide composition - Google Patents
Germicide compositionInfo
- Publication number
- JP2002161011A JP2002161011A JP2001276556A JP2001276556A JP2002161011A JP 2002161011 A JP2002161011 A JP 2002161011A JP 2001276556 A JP2001276556 A JP 2001276556A JP 2001276556 A JP2001276556 A JP 2001276556A JP 2002161011 A JP2002161011 A JP 2002161011A
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- acid ester
- component
- surfactant
- amine salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は殺菌剤組成物に関す
る。[0001] The present invention relates to a fungicide composition.
【０００２】[0002]
【従来の技術及び発明が解決しようとする課題】従来、
広範な環境における殺菌消毒剤として、次亜塩素酸ナト
リウム、次亜塩素酸カルシウム、ジクロロイソシアヌル
酸ナトリウム等の塩素系殺菌剤が広く用いられている。
中でも次亜塩素酸ナトリウム等の次亜塩素酸塩は、価格
面と効果の点で汎用されているが、医療、食品工業等、
種々の分野で要求される微生物の殺菌、滅菌に対して、
更にその効力を向上させるための多くの提案がなされて
いる。例えば、特開昭５５−１４０９４号には、次亜塩
素酸塩、非イオン界面活性剤、リン酸二水素一アルカリ
金属と共動してｐＨを所定値に保つリン酸一水素二アル
カリ金属を含有するｐＨ７〜８の滅菌液組成物が開示さ
れている。また、特開平９−３１４９４号には、金属封
鎖剤を含有する配合剤を、次亜塩素酸ナトリウムを主成
分とする洗浄液に混合して調製した、有効塩素濃度０．
０２〜０．２重量％の洗浄液を用いて人工透析装置等の
医療機器を洗浄することが開示されている。2. Description of the Related Art
As a disinfectant in a wide range of environments, chlorine-based disinfectants such as sodium hypochlorite, calcium hypochlorite, sodium dichloroisocyanurate and the like are widely used.
Above all, hypochlorites such as sodium hypochlorite are widely used in terms of price and effect, but medical, food industry, etc.
For sterilization and sterilization of microorganisms required in various fields,
Many proposals have been made to further improve its efficacy. For example, JP-A-55-14094 discloses a hypochlorite, a nonionic surfactant, and a monobasic alkali metal dihydrogen phosphate that cooperates with monobasic alkali metal dihydrogen phosphate to maintain the pH at a predetermined value. A sterile liquid composition having a pH of 7 to 8 is disclosed. Japanese Patent Application Laid-Open No. 9-31494 discloses that an effective chlorine concentration of 0.1 was prepared by mixing a compounding agent containing a sequestering agent with a cleaning solution containing sodium hypochlorite as a main component.
It is disclosed that a medical device such as an artificial dialysis device is cleaned using a cleaning solution of 02 to 0.2% by weight.
【０００３】しかしながら、次亜塩素酸塩を用いた従来
の殺菌洗浄剤や殺菌洗浄方法では、十分な殺菌効果を維
持しつつ、被処理物（殺菌対象物）や処理用装置の損傷
を抑制することは困難であった。前述の特開昭５５−１
４０９４号の系は、非腐食性で損傷を与えないとされて
いるが、殺菌効果と腐食抑制効果の両立という点では、
いまだ不十分である。また、特開平９−３１４９４号の
洗浄液は水酸化アルカリを配合してｐＨを１２．５〜１
４．０とすることにより、金属腐食性が緩和され洗浄対
象の機器に悪影響を及ぼさないとされているが、このよ
うな強アルカリ領域の洗浄液は取扱上の制約が大きい。[0003] However, in the conventional germicidal detergent and germicidal washing method using hypochlorite, damage to the object to be treated (object to be sterilized) and the processing apparatus is suppressed while maintaining a sufficient bactericidal effect. It was difficult. JP-A-55-1
Although the system of No. 4094 is said to be non-corrosive and not damaging, in terms of achieving both a sterilizing effect and a corrosion inhibiting effect,
Still not enough. Further, the washing liquid of JP-A-9-31494 is mixed with an alkali hydroxide to adjust the pH to 12.5-1.
By setting the value to 4.0, the metal corrosiveness is reduced and does not adversely affect the equipment to be cleaned. However, such a cleaning liquid in a strong alkaline region has great restrictions in handling.
【０００４】本発明は、簡易な処理により高い殺菌効果
が得られ、且つ被処理物や処理用装置の損傷を十分に抑
制できる殺菌剤組成物を提供することを目的とする。[0004] It is an object of the present invention to provide a bactericidal composition which can provide a high bactericidal effect by a simple treatment and can sufficiently prevent damage to a processing object and a processing apparatus.
【０００５】[0005]
【課題を解決するための手段】本発明は、次亜塩素酸及
び次亜塩素酸アルカリ金属塩から選ばれる１種以上
（Ａ）〔以下、（Ａ）成分という〕と、多価アルコール
誘導体型界面活性剤、陽イオン界面活性剤及び両性界面
活性剤から選ばれる１種以上（Ｂ）〔以下、（Ｂ）成分
という〕と、有機酸及びその塩から選ばれる１種以上
（Ｃ）〔以下、（Ｃ）成分という〕と、防錆剤（Ｄ）
〔以下、（Ｄ）成分という〕とを含有する殺菌剤組成物
に関する。According to the present invention, there is provided a polyhydric alcohol derivative comprising at least one selected from the group consisting of hypochlorous acid and alkali metal hypochlorite (A) (hereinafter referred to as component (A)). One or more (B) selected from surfactants, cationic surfactants and amphoteric surfactants (hereinafter, referred to as component (B)), and one or more selected from organic acids and salts thereof (C) [less than , (C) component] and a rust preventive (D)
[Hereinafter referred to as component (D)].
【０００６】[0006]
【発明の実施の形態】（Ａ）成分のうち、次亜塩素酸ア
ルカリ金属塩としては、次亜塩素酸ナトリウム、次亜塩
素酸カリウム、次亜塩素酸リチウム等が挙げられるが、
次亜塩素酸ナトリウムが好ましい。BEST MODE FOR CARRYING OUT THE INVENTION Among the components (A), examples of the alkali metal hypochlorite include sodium hypochlorite, potassium hypochlorite, lithium hypochlorite and the like.
Sodium hypochlorite is preferred.
【０００７】（Ｂ）成分のうち、多価アルコール誘導体
型界面活性剤としては、グリセリン脂肪酸エステル、ポ
リグリセリン脂肪酸エステル、プロピレングリコール脂
肪酸エステル、ポリプロピレングリコール脂肪酸エステ
ル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステ
ル、アルキルポリグリコシド等が挙げられる。脂肪酸エ
ステル型のものの脂肪酸部分の炭素数又はアルキルポリ
グリコシドにおけるアルキル基の炭素数は、何れも６〜
２４が好ましく、６〜１８がより好ましい。これらのう
ち、製剤化を容易にする観点から、ポリグリセリン（好
ましくは縮合度２〜５０）脂肪酸（好ましくは炭素数６
〜２４）エステル、アルキル（好ましくは炭素数６〜２
４）ポリグリコシドが好ましい。Among the components (B), polyhydric alcohol derivative type surfactants include glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polypropylene glycol fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, and alkyl. And polyglycosides. The number of carbon atoms of the fatty acid portion of the fatty acid ester type or the number of carbon atoms of the alkyl group in the alkyl polyglycoside is preferably 6 to
24 is preferable and 6 to 18 are more preferable. Among these, from the viewpoint of facilitating formulation, polyglycerin (preferably having a degree of condensation of 2 to 50) fatty acid (preferably having 6 carbon atoms)
-24) esters, alkyl (preferably having 6 to 2 carbon atoms)
4) Polyglycosides are preferred.
【０００８】（Ｂ）成分のうち、陽イオン界面活性剤と
しては、第１級アミン塩系陽イオン界面活性剤、第２級
アミン塩系陽イオン界面活性剤、第３級アミン塩系陽イ
オン界面活性剤、第４級アミン塩系陽イオン界面活性剤
が挙げられる。これらのうち第４級アミン塩系陽イオン
界面活性剤が特に好ましい。第４級アミン塩系陽イオン
界面活性剤、すなわち第４級アンモニウム塩としては、
４つの置換基の少なくとも１つが総炭素数８〜２８のア
ルキル又はアルケニル基であり、残余がベンジル基、炭
素数１〜５のアルキル基及び炭素数１〜５のヒドロキシ
アルキル基から選ばれる基である化合物が挙げられる。
総炭素数８〜２８のアルキル又はアルケニル基は、この
炭素数の範囲で、アルコキシル基、アルケニルオキシ
基、アルカノイルアミノ基、アルケノイルアミノ基、ア
ルカノイルオキシ基又はアルケノイルオキシ基で置換さ
れていてもよい。[0008] Of the component (B), the cationic surfactant includes a primary amine salt cationic surfactant, a secondary amine salt cationic surfactant, and a tertiary amine salt cationic surfactant. Surfactants and quaternary amine salt-based cationic surfactants are exemplified. Of these, quaternary amine salt-based cationic surfactants are particularly preferred. As the quaternary amine salt cationic surfactant, that is, the quaternary ammonium salt,
At least one of the four substituents is an alkyl or alkenyl group having a total of 8 to 28 carbon atoms, and the remainder is a group selected from a benzyl group, an alkyl group having 1 to 5 carbon atoms, and a hydroxyalkyl group having 1 to 5 carbon atoms. Certain compounds are mentioned.
The alkyl or alkenyl group having a total of 8 to 28 carbon atoms may be substituted with an alkoxyl group, an alkenyloxy group, an alkanoylamino group, an alkenoylamino group, an alkanoyloxy group or an alkenoyloxy group in the range of the number of carbon atoms. Good.
【０００９】また、（Ｂ）成分のうち、両性界面活性剤
としては、アミノ酸系、ベタイン系、イミダゾリン系、
アミンオキサイド系の両性界面活性剤が挙げられる。[0009] Of the component (B), amphoteric surfactants include amino acids, betaines, imidazolines, and the like.
Amine oxide-based amphoteric surfactants may be mentioned.
【００１０】アミノ酸系両性界面活性剤としては、アシ
ルアミノ酸塩、アシルサルコシン酸塩、アシロイルメチ
ルアミノプロピオン酸塩、アルキルアミノプロピオン酸
塩、アシルアミドエチルヒドロキシエチルメチルカルボ
ン酸塩等が挙げられる。Examples of the amino acid-based amphoteric surfactant include acyl amino acid salts, acyl sarcosine salts, acyloylmethylaminopropionates, alkylaminopropionates, and acylamidoethylhydroxyethylmethylcarboxylates.
【００１１】ベタイン系両性界面活性剤としては、アル
キルジメチルベタイン、アルキルヒドロキシエチルベタ
イン、アシルアミドプロピルヒドロキシプロピルアンモ
ニアスルホベタイン、アシルアミドプロピルヒドロキシ
プロピルアンモニアスルホベタイン、リシノレイン酸ア
ミドプロピルジメチルカルボキシメチルアンモニアベタ
イン等が挙げられる。Examples of the betaine amphoteric surfactant include alkyl dimethyl betaine, alkyl hydroxyethyl betaine, acylamidopropyl hydroxypropyl ammonia sulfobetaine, acylamidopropyl hydroxypropyl ammonia sulfobetaine, amide dimethyl carboxymethyl ammonia betaine ricinoleate, and the like. No.
【００１２】イミダゾリン系両性界面活性剤としては、
アルキルカルボキシメチルヒドロキシエチルイミダゾリ
ニウムベタイン、アルキルエトキシカルボキシメチルイ
ミダゾリウムベタイン等が挙げられる。The imidazoline amphoteric surfactants include
Alkyl carboxymethyl hydroxyethyl imidazolinium betaine, alkyl ethoxy carboxymethyl imidazolium betaine, and the like.
【００１３】アミンオキサイド系両性界面活性剤として
は、アルキルアミンオキサイドが好ましく、アルキルジ
メチルアミンオキサイド、アルキルジエタノールアミン
オキサイド、アルキルアミドプロピルアミンオキサイド
等が挙げられる。The amine oxide-based amphoteric surfactant is preferably an alkylamine oxide, and examples thereof include alkyldimethylamine oxide, alkyldiethanolamine oxide, and alkylamidopropylamine oxide.
【００１４】本発明の殺菌剤組成物は、（Ａ）成分と
（Ｂ）成分とを、好ましくは（Ａ）／（Ｂ）＝２０／１
〜１／１０、より好ましくは１０／１〜１／１０、更に
好ましくは１０／１〜１／５、より更に好ましくは５／
１〜１／５、特に好ましくは２／１〜１／２の重量比で
含有する。ただし、（Ａ）成分は有効塩素基準での重量
を示す。The fungicide composition of the present invention comprises the components (A) and (B), preferably (A) / (B) = 20/1.
To 1/10, more preferably 10/1 to 1/10, still more preferably 10/1 to 1/5, and still more preferably 5 /
The content is 1 to 1/5, particularly preferably 2/1 to 1/2 by weight. However, the component (A) indicates the weight based on available chlorine.
【００１５】（Ｃ）成分としては、マロン酸、コハク
酸、グルタル酸、アジピン酸、セバシン酸等の飽和二塩
基酸又はその塩や、フマル酸、マレイン酸等の不飽和二
塩基酸又はその塩等が挙げられる。（Ｃ）成分は、飽和
アルキル基を有する２塩基酸以上の有機酸及びその塩か
ら選ばれる１種以上が好ましく、より好ましくは飽和二
塩基酸又はその塩、更に好ましくは炭素数３〜１０の飽
和二塩基酸又はその塩であり、特にコハク酸又はその塩
が好ましい。（Ｃ）成分は、（Ａ）成分との重量比が
（Ａ）／（Ｃ）＝１０／１〜１／５、更に５／１〜１／
２、特に５／１〜１／１となるように用いられるのが好
ましい。The component (C) includes a saturated dibasic acid such as malonic acid, succinic acid, glutaric acid, adipic acid and sebacic acid or a salt thereof, and an unsaturated dibasic acid such as fumaric acid and maleic acid or a salt thereof. And the like. The component (C) is preferably at least one selected from dibasic or higher organic acids having a saturated alkyl group and salts thereof, more preferably saturated dibasic acids or salts thereof, and still more preferably 3 to 10 carbon atoms. It is a saturated dibasic acid or a salt thereof, and particularly preferably succinic acid or a salt thereof. The weight ratio of the component (C) to the component (A) is (A) / (C) = 10/1 to 1/5, and more preferably 5/1 to 1/1.
2, particularly preferably 5/1 to 1/1.
【００１６】（Ｄ）成分としては、リン酸、ポリリン
酸、ホスホン酸及びこれらの塩から選ばれる１種以上が
好ましく、塩は、ナトリウム、カリウム等のアルカリ金
属塩が好ましい。（Ｄ）成分は、（Ａ）成分との重量比
が（Ａ）／（Ｄ）＝１０／１〜１／１０、更に１０／１
〜１／５、特に５／１〜１／５となるように用いられる
のが好ましい。The component (D) is preferably at least one selected from phosphoric acid, polyphosphoric acid, phosphonic acid and salts thereof, and the salts are preferably alkali metal salts such as sodium and potassium. The weight ratio of the component (D) to the component (A) is (A) / (D) = 10/1 to 1/10, and more preferably 10/1.
It is preferably used so as to be 1/5 to 1/5, particularly 5/1 to 1/5.
【００１７】本発明の殺菌剤組成物は、アルカリ金属の
水酸化物及び／又はアルカリ土類金属の水酸化物（Ｅ）
〔以下、（Ｅ）成分という〕を含有してもよい。（Ｅ）
成分としては、例えば水酸化ナトリウム、水酸化カリウ
ム、水酸化カルシウム等が挙げられ、水酸化ナトリウ
ム、水酸化カリウムが好ましい。The fungicide composition of the present invention comprises a hydroxide of an alkali metal and / or a hydroxide of an alkaline earth metal (E).
[Hereinafter, referred to as component (E)]. (E)
Examples of the component include sodium hydroxide, potassium hydroxide, calcium hydroxide and the like, and sodium hydroxide and potassium hydroxide are preferable.
【００１８】また、本発明の殺菌剤組成物は、無機酸の
アルカリ金属塩及び／又は無機酸のアルカリ土類金属塩
（Ｆ）〔以下、（Ｆ）成分という〕を含有してもよい。
（Ｆ）成分としては硫酸ナトリウム、硝酸ナトリウム、
塩化ナトリウム、炭酸ナトリウム、炭酸水素ナトリウ
ム、硫酸マグネシウム、硝酸マグネシウム、塩化マグネ
シウム、炭酸マグネシウム、リン酸ナトリウム、ポリリ
ン酸ナトリウム、リン酸カリウム等が挙げられ、硫酸ナ
トリウム、硫酸マグネシウム、リン酸ナトリウム、ポリ
リン酸ナトリウム、リン酸カリウム、硝酸ナトリウムが
好ましい。Further, the germicidal composition of the present invention may contain an alkali metal salt of an inorganic acid and / or an alkaline earth metal salt of an inorganic acid (F) (hereinafter, referred to as component (F)).
(F) Components include sodium sulfate, sodium nitrate,
Sodium chloride, sodium carbonate, sodium hydrogen carbonate, magnesium sulfate, magnesium nitrate, magnesium chloride, magnesium carbonate, sodium phosphate, sodium polyphosphate, potassium phosphate, etc., and sodium sulfate, magnesium sulfate, sodium phosphate, polyphosphoric acid. Sodium, potassium phosphate and sodium nitrate are preferred.
【００１９】本発明の殺菌剤組成物は、上記（Ａ）〜
（Ｄ）成分を含有する水溶液からなることが好ましい。
この水溶液の有効塩素濃度は１〜５０００ｐｐｍ、更に
１０〜１０００ｐｐｍ、より更に５０〜５００ｐｐｍ、
特に５０〜２００ｐｐｍが好ましい。また、水溶液のｐ
Ｈ（２０℃）は、好ましくは３〜８、より好ましくは５
〜７、特に好ましくは６以上７未満である。水溶液のｐ
Ｈの調整は上記（Ｃ）成分や無機酸により行うことがで
きる。また、本発明の殺菌剤組成物となる水溶液中の各
成分の量は、（Ａ）成分が５ｐｐｍ〜１２重量％、
（Ｂ）成分が０．５ｐｐｍ〜３５重量％、（Ｃ）成分が
０．５ｐｐｍ〜６０重量％、（Ｄ）成分が０．５ｐｐｍ
〜６０重量％が好ましく、（Ｅ）成分を配合する場合
は、０．５ｐｐｍ〜１０重量％が好ましく、（Ｆ）成分
を配合する場合は、０．５ｐｐｍ〜３５重量％が好まし
い。使用にあたっては、この水溶液を更に希釈した水溶
液が用いられるが、この希釈水溶液は、（Ａ）成分を１
〜５０００ｐｐｍ、更に１０〜１０００ｐｐｍ、特に５
０〜５００ｐｐｍ、（Ｂ）成分を１〜５００００ｐｐ
ｍ、更に５〜１００００ｐｐｍ、特に１０〜５０００ｐ
ｐｍ、（Ｃ）成分を１〜１００００ｐｐｍ、更に１０〜
５０００ｐｐｍ、特に５０〜２０００ｐｐｍ、（Ｄ）成
分を１〜５００００ｐｐｍ、更に５〜１００００ｐｐ
ｍ、特に１０〜５０００ｐｐｍ含有することが好まし
い。なお、本発明の殺菌剤組成物の対象となる微生物と
は、一般細菌、糸状菌、ウイルス、カビ胞子、細菌芽胞
等を意味する。The fungicidal composition of the present invention comprises the above (A) to
It is preferable to comprise an aqueous solution containing the component (D).
The effective chlorine concentration of this aqueous solution is 1 to 5000 ppm, further 10 to 1000 ppm, even more 50 to 500 ppm,
In particular, 50 to 200 ppm is preferable. In addition, p
H (20 ° C.) is preferably 3 to 8, more preferably 5 to 8.
To 7, particularly preferably 6 or more and less than 7. Aqueous solution p
Adjustment of H can be performed by the above-mentioned component (C) or inorganic acid. Further, the amount of each component in the aqueous solution to be the bactericide composition of the present invention is such that the component (A) is 5 ppm to 12% by weight,
The component (B) is 0.5 ppm to 35% by weight, the component (C) is 0.5 ppm to 60% by weight, and the component (D) is 0.5 ppm.
The content is preferably 0.5 ppm to 10% by weight when the component (E) is blended, and preferably 0.5 ppm to 35% by weight when the component (F) is blended. In use, an aqueous solution obtained by further diluting this aqueous solution is used. This diluted aqueous solution contains one component (A).
-5000 ppm, more preferably 10-1000 ppm, especially 5
0 to 500 ppm, component (B) 1 to 50,000 pp
m, further 5 to 10000 ppm, especially 10 to 5000 p
pm, component (C) is 1 to 10000 ppm, and 10 to 10 ppm.
5000 ppm, especially 50 to 2000 ppm, (D) component is 1 to 50000 ppm, and further 5 to 10000 pp
m, particularly preferably 10 to 5000 ppm. The microorganism to be used as the target of the bactericide composition of the present invention means general bacteria, filamentous fungi, viruses, mold spores, bacterial spores and the like.
【００２０】本発明の殺菌剤組成物は、殺菌スペクトル
が広く、細菌（カビ）のみならず、ウイルスや芽胞に対
する効果も高く、更に金属基材の損傷性が低いため、幅
広い分野での殺菌に有用である。例えば、病院、養護施
設、食品加工工場、クリーニング施設、厨房等の壁、
床、窓等あるいはそれらで用いられる器具、備品、及び
製品用（例えば飲料液用）容器等の殺菌に用いられる。The germicidal composition of the present invention has a broad bactericidal spectrum, has a high effect on not only bacteria (mold), but also viruses and spores, and has a low damaging property on metal substrates. Useful. For example, hospitals, nursing homes, food processing plants, cleaning facilities, kitchen and other walls,
It is used for sterilization of floors, windows and the like, instruments and equipment used therefor, and containers for products (for example, for beverages).
【００２１】[0021]
【発明の効果】本発明によれば、簡易な処理により高い
殺菌効果が得られ、且つ被処理物や処理用装置の損傷を
十分に抑制でき、安全性、作業性に優れた殺菌剤組成物
が得られる。According to the present invention, a bactericidal composition which can provide a high bactericidal effect by a simple treatment, and can sufficiently suppress damage to an object to be treated and a processing apparatus, and is excellent in safety and workability. Is obtained.
【００２２】[0022]
【実施例】実施例１〜９及び比較例１〜７ 表１に示す成分からなる組成物を用いて、以下の試験を
行った。結果を表１に示す。なお、表１中の有効塩素濃
度は、ＪＩＳ Ｋ−０１０１“ヨウ素法”により測定し
たものである。EXAMPLES Examples 1 to 9 and Comparative Examples 1 to 7 The following tests were carried out using compositions comprising the components shown in Table 1. Table 1 shows the results. The effective chlorine concentration in Table 1 is measured according to JIS K-0101 “Iodine method”.
【００２３】なお、各組成物は、次亜塩素酸ナトリウム
水溶液（有効塩素濃度６００００ｐｐｍ）と（Ｂ）成分
及び／又は（Ｄ）成分を所定量混合し得られたものを最
終配合濃度の２倍までイオン交換水で希釈したものと
（Ｃ）成分を最終配合濃度の２倍までイオン交換水で希
釈したものを等量混合して得たものである。Each composition was prepared by mixing a predetermined amount of an aqueous solution of sodium hypochlorite (effective chlorine concentration: 60,000 ppm) with the component (B) and / or the component (D), which was twice the final compounding concentration. The mixture was obtained by mixing equal amounts of the components diluted with ion-exchanged water and the components (C) diluted with ion-exchanged water to twice the final compounding concentration.
【００２４】これらの組成物を表１の有効塩素濃度とな
るように希釈し、水酸化ナトリウム又は塩酸により所定
のｐＨに調整した試験水溶液を用いて、以下の方法で殺
菌力及び腐食性の試験を行った。結果を表１に示す。These compositions were diluted to the effective chlorine concentration shown in Table 1 and tested for bactericidal activity and corrosiveness by the following method using a test aqueous solution adjusted to a predetermined pH with sodium hydroxide or hydrochloric acid. Was done. Table 1 shows the results.
【００２５】（１）殺菌力 （１−１）殺芽胞試験 芽胞形成菌である枯草菌（Bacillus subtilis ATCC663
3）とセレウス菌（Bacillus cereus IFO13494）を、そ
れぞれＳＣＤ寒天培地（日本製薬（株）製）に前培養し
た菌を一白金耳かきとり、１ｍｌの滅菌水に懸濁し、６
５℃、３０分間の熱処理後、２回遠心分離洗浄を行った
ものを試験に用いた（菌濃度は何れも１０ 5cell／ｍ
ｌ）。(1) Bactericidal activity (1-1) Spore killing test Bacillus subtilis ATCC663 which is a spore-forming bacterium
3) and Bacillus cereus IFO13494
Pre-culture on SCD agar medium (Nippon Pharmaceutical Co., Ltd.)
And scrape one platinum loop, suspend it in 1 ml of sterile water, and add
After heat treatment at 5 ° C. for 30 minutes, centrifugal washing was performed twice.
Was used for the test (the bacterial concentration was 10 Fivecell / m
l).
【００２６】この試験用芽胞菌液を０．１ｍｌとり、表
１の成分からなる組成物を更に滅菌したイオン交換水で
稀釈した水溶液（温度２５℃）１０ｍｌに接種し、室温
にて３分間作用させた。１０秒以内に菌接触液５０μｌ
を採取し、後培養用ＳＣＤＬＰ培地（チオ硫酸ナトリウ
ム３．３％含有）０．２ｍｌの入ったミクロシャーレ
（CORNING社製、96-Cell Wells）へ接種した。３０℃
で４８時間培養し、菌の発育を肉眼で観察し、ミクロシ
ャーレ上で菌が生育しているかどうかを観察し、菌の生
育がない（つまり１００％殺菌できる）最小の希釈倍率
（最小殺菌有効塩素濃度）を求めた。なお、有効塩素濃
度は、ＪＩＳ Ｋ−０１０１“ヨウ素法”により測定し
たものである。0.1 ml of this spore bacterium solution for testing is inoculated into 10 ml of an aqueous solution (temperature 25 ° C.) diluted with sterilized ion-exchanged water, and the composition comprising the components shown in Table 1 is inoculated for 3 minutes at room temperature. I let it. 50 μl of bacterial contact liquid within 10 seconds
Was collected, and inoculated into a micro Petri dish (manufactured by CORNING, 96-Cell Wells) containing 0.2 ml of SCDLP medium for post-culture (containing 3.3% of sodium thiosulfate). 30 ° C
For 48 hours, visually observe the growth of the bacterium, and observe whether the bacterium is growing on the micro Petri dish. Chlorine concentration). The effective chlorine concentration is measured according to JIS K-0101 “Iodine method”.
【００２７】（１−２）殺カビ試験 被験菌としてカビ（真菌、Aspergillus niger IFO634
1）を、ＰＤＡ培地を用い、２５℃で７日間培養した。
得られた菌体をガラス玉法を用い、均一にした後、滅菌
ガーゼで異物を除去し、菌液を得た（菌濃度約１０5cel
l／ｍｌ）。この菌液を０．１ｍｌとり、表１の成分か
らなる組成物を更に滅菌したイオン交換水で希釈した水
溶液（温度２５℃）１０ｍｌに接種し、室温で１０秒間
作用させた後、０．１ｍｌを採取し、後培養用ＰＤＡ培
地（チオ硫酸ナトリウム３．３％含有）へ接種した。２
５℃で７時間培養し、菌の発育を肉眼で観察し、上記同
様に評価した。(1-2) Fungicidal test Mold (fungus, Aspergillus niger IFO634) was used as a test bacterium.
1) was cultured at 25 ° C. for 7 days using a PDA medium.
After the obtained cells were homogenized using a glass ball method, foreign substances were removed with sterile gauze to obtain a bacterial solution (bacterial concentration of about 10 5 cel).
l / ml). 0.1 ml of this bacterial solution is taken, and the composition comprising the components shown in Table 1 is inoculated into 10 ml of an aqueous solution (temperature: 25 ° C.) diluted with sterilized ion-exchanged water. Was collected and inoculated into a PDA medium for post-culture (containing 3.3% sodium thiosulfate). 2
After culturing at 5 ° C. for 7 hours, the growth of the bacteria was visually observed and evaluated in the same manner as described above.
【００２８】（２）腐食性 ＳＵＳ３０４Ｊ字型テストピース（神鋼商事株式会社製
ＴＰＲＷ ＳＵＳ３０４、幅約１５ｍｍ、長さ約５２ｍ
ｍ、厚さ約３ｍｍ）を、食器用洗剤、更にエタノールに
て洗浄後、乾燥させ重量を精秤する。この断面Ｊ字型の
テストピースを図１のように、表１の試験水溶液（有効
塩素濃度２０００ｐｐｍ）５０ｇ中に浸漬し、４０℃で
静置する。このとき、テストピースの試験水溶液の接触
面積は約１８７０ｍｍ2となる。試験水溶液は毎日（２
４時間毎）交換し、１５日後のテストピース重量を精秤
し、次式により重量損失を算出した。(2) Corrosive SUS304 J-shaped test piece (TPRW SUS304 manufactured by Shinko Shoji Co., Ltd., about 15 mm in width and about 52 m in length)
m, about 3 mm thick) was washed with a dishwashing detergent and further with ethanol, dried, and precisely weighed. This test piece having a J-shaped cross section is immersed in 50 g of the test aqueous solution (effective chlorine concentration 2000 ppm) shown in Table 1 and left at 40 ° C. as shown in FIG. At this time, the contact area of the test piece with the test aqueous solution is about 1870 mm 2 . The test aqueous solution is used daily (2
(Every 4 hours), the test pieces were exchanged, and the weight of the test pieces after 15 days was precisely weighed, and the weight loss was calculated by the following equation.
【００２９】[0029]
【数１】 (Equation 1)
【００３０】[0030]
【表１】 [Table 1]
【００３１】（１）：（ ）内は有効塩素濃度を示す。 （２）：コータミンＤ１０Ｐ（花王（株）製、有効分７
５％）を用いて有効分濃度が表１の数値となるようにし
た。 （３）：アンヒトール２４Ｂ（花王（株）製、有効分２
６％）を用いて有効分濃度が表１の数値となるようにし
た。 （４）：ＭＣＡ−７５０（阪本薬品工業（株）製、有効
分１００％）を用いて有効分濃度が表１の数値となるよ
うにした。 （５）：ＬＷＡ−１５７０（三菱化学フーズ（株）製、
有効分４０％）を用いて有効分濃度が表１の数値となる
ようにした。 （６）：マイドール１２（花王（株）製、有効分４０
％）を用いて有効分濃度が表１の数値となるようにし
た。 （７）：エマルゲン１０９（花王（株）製、有効分１０
０％）を用いて有効分濃度が表１の数値となるようにし
た。(1): The number in parentheses indicates the effective chlorine concentration. (2): Coatamine D10P (manufactured by Kao Corporation, active ingredient 7)
5%) so that the concentration of the active ingredient became the value in Table 1. (3): Amphitol 24B (manufactured by Kao Corporation, effective component 2)
6%) so that the concentration of the active ingredient became the numerical value in Table 1. (4): Using MCA-750 (manufactured by Sakamoto Yakuhin Kogyo Co., Ltd., effective component 100%), the concentration of the active component was adjusted to the value shown in Table 1. (5): LWA-1570 (manufactured by Mitsubishi Chemical Foods Corporation,
The effective component concentration was set to the numerical value in Table 1 using the effective component (40%). (6): My Doll 12 (manufactured by Kao Corporation, effective component 40)
%), The concentration of the active ingredient was adjusted to the value shown in Table 1. (7): Emulgen 109 (manufactured by Kao Corporation, active ingredient: 10
0%) so that the concentration of the active ingredient was the value in Table 1.
【図１】実施例における腐食性の評価方法を示す概略図
である。FIG. 1 is a schematic view showing a method for evaluating corrosiveness in an example.
１：Ｊ字型テストピース ２：試験水溶液 1: J-shaped test piece 2: Test aqueous solution
───────────────────────────────────────────────────── フロントページの続き (72)発明者 松尾 登 和歌山県和歌山市湊1334 花王株式会社研 究所内 (72)発明者 田村 成 和歌山県和歌山市湊1334 花王株式会社研 究所内 Ｆターム(参考） 4H011 AA02 BA01 BB18 BC03 BC04 BC08 BC09 BC17 DA13 DC05 DD05 DG16 ──────────────────────────────────────────────────の Continued on the front page (72) Inventor Noboru Matsuo 1334 Minato 1334 Minato, Wakayama City, Wakayama Prefecture Inside (72) Inventor Shigeru Tamura 1334 Minato 1 Minato, Wakayama City, Wakayama Prefecture F-term (reference) 4H011 AA02 BA01 BB18 BC03 BC04 BC08 BC09 BC17 DA13 DC05 DD05 DG16
Claims (5)
塩から選ばれる１種以上（Ａ）と、多価アルコール誘導
体型界面活性剤、陽イオン界面活性剤及び両性界面活性
剤から選ばれる１種以上（Ｂ）と、有機酸及びその塩か
ら選ばれる１種以上（Ｃ）と、防錆剤（Ｄ）とを含有す
る殺菌剤組成物。1. One or more (A) selected from hypochlorous acid and alkali metal hypochlorite, and selected from polyhydric alcohol derivative surfactants, cationic surfactants and amphoteric surfactants. A disinfectant composition comprising one or more (B), one or more (C) selected from organic acids and salts thereof, and a rust preventive (D).
Ｈ（２０℃）が３〜８である請求項１記載の殺菌剤組成
物。2. An effective chlorine concentration of 1 to 5000 ppm, p
The fungicide composition according to claim 1, wherein H (20 ° C) is 3 to 8.
ポリグリセリン脂肪酸エステル、プロピレングリコール
脂肪酸エステル、ポリプロピレングリコール脂肪酸エス
テル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステ
ル、アルキルポリグリコシド、第１級アミン塩系陽イオ
ン界面活性剤、第２級アミン塩系陽イオン界面活性剤、
第３級アミン塩系陽イオン界面活性剤、第４級アミン塩
系陽イオン界面活性剤、アミンオキサイド系両性界面活
性剤、アミノ酸系両性界面活性剤、ベタイン系両性界面
活性剤及びイミダゾリン系両性界面活性剤から選ばれる
１種以上である請求項１又は２記載の殺菌剤組成物。(B) a glycerin fatty acid ester,
Polyglycerin fatty acid ester, propylene glycol fatty acid ester, polypropylene glycol fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, alkyl polyglycoside, primary amine salt cationic surfactant, secondary amine salt cationic surfactant Agent,
Tertiary amine salt cationic surfactant, quaternary amine salt cationic surfactant, amine oxide amphoteric surfactant, amino acid amphoteric surfactant, betaine amphoteric surfactant and imidazoline amphoteric surfactant The fungicidal composition according to claim 1 or 2, which is at least one selected from activators.
基酸以上の有機酸及びその塩から選ばれる１種以上であ
る請求項１〜３の何れか１項記載の殺菌剤組成物。4. The fungicidal composition according to claim 1, wherein (C) is at least one selected from dibasic or more organic acids having a saturated alkyl group and salts thereof.
ン酸及びこれらの塩から選ばれる１種以上である請求項
１〜４の何れか１項記載の殺菌剤組成物。5. The fungicide composition according to claim 1, wherein (D) is at least one selected from phosphoric acid, polyphosphoric acid, phosphonic acid, and salts thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001276556A JP3607652B2 (en) | 2000-09-14 | 2001-09-12 | Disinfectant composition |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000-280374 | 2000-09-14 | ||
| JP2000280374 | 2000-09-14 | ||
| JP2001276556A JP3607652B2 (en) | 2000-09-14 | 2001-09-12 | Disinfectant composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002161011A true JP2002161011A (en) | 2002-06-04 |
| JP3607652B2 JP3607652B2 (en) | 2005-01-05 |
Family
ID=26600025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001276556A Expired - Fee Related JP3607652B2 (en) | 2000-09-14 | 2001-09-12 | Disinfectant composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3607652B2 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2003082008A1 (en) * | 2002-03-29 | 2005-07-28 | クミアイ化学工業株式会社 | Granular pesticide composition |
| JP2009269822A (en) * | 2008-04-30 | 2009-11-19 | Lion Chemical Kk | Degerming and cleaning agent composition |
| CN102167997A (en) * | 2011-03-11 | 2011-08-31 | 刘小清 | Preservative-free natural disinfecting detergent composition |
| JP2013199390A (en) * | 2012-03-23 | 2013-10-03 | Kurita Water Ind Ltd | Method for preserving sodium hypochlorite |
| JP2020012056A (en) * | 2018-07-18 | 2020-01-23 | 株式会社ニイタカ | Hard surface detergent composition, sterilization method of microorganism or bacterial flora, method for preventing bacterial flora coagulation from generating in a washing machine, cleaning method of article having hard surface by washing machine and bactericidal agent |
| JP2021091829A (en) * | 2019-12-12 | 2021-06-17 | クリーンケミカル株式会社 | Sodium hypochlorite preparation |
| JP7066155B1 (en) | 2021-01-22 | 2022-05-13 | 株式会社トクヤマデンタル | Rust preventive for hypochlorous acid aqueous solution, sterilizing / cleaning agent with rust preventive effect, and its preparation method |
| JP7479624B2 (en) | 2020-03-23 | 2024-05-09 | 株式会社トクヤマデンタル | Weakly acidic hypochlorous acid disinfectant composition containing rust inhibitor |
-
2001
- 2001-09-12 JP JP2001276556A patent/JP3607652B2/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2003082008A1 (en) * | 2002-03-29 | 2005-07-28 | クミアイ化学工業株式会社 | Granular pesticide composition |
| JP4603797B2 (en) * | 2002-03-29 | 2010-12-22 | クミアイ化学工業株式会社 | Granular pesticide composition |
| JP2009269822A (en) * | 2008-04-30 | 2009-11-19 | Lion Chemical Kk | Degerming and cleaning agent composition |
| CN102167997A (en) * | 2011-03-11 | 2011-08-31 | 刘小清 | Preservative-free natural disinfecting detergent composition |
| JP2013199390A (en) * | 2012-03-23 | 2013-10-03 | Kurita Water Ind Ltd | Method for preserving sodium hypochlorite |
| JP2020012056A (en) * | 2018-07-18 | 2020-01-23 | 株式会社ニイタカ | Hard surface detergent composition, sterilization method of microorganism or bacterial flora, method for preventing bacterial flora coagulation from generating in a washing machine, cleaning method of article having hard surface by washing machine and bactericidal agent |
| JP7222513B2 (en) | 2018-07-18 | 2023-02-15 | 株式会社ニイタカ | HARD SURFACE DETERGENT COMPOSITION, METHOD FOR ELIMINATING MICROORGANISMS OR BACTERIA CLAGGEMENTS, METHOD FOR PREVENTING PRODUCTION OF BACTERIA CLAGUE IN WASHING MACHINE, METHOD FOR CLEANING ARTICLES HAVING HARD SURFACES WITH WASHING MACHINE, AND DISINFECTANT |
| JP2021091829A (en) * | 2019-12-12 | 2021-06-17 | クリーンケミカル株式会社 | Sodium hypochlorite preparation |
| JP7479624B2 (en) | 2020-03-23 | 2024-05-09 | 株式会社トクヤマデンタル | Weakly acidic hypochlorous acid disinfectant composition containing rust inhibitor |
| JP7066155B1 (en) | 2021-01-22 | 2022-05-13 | 株式会社トクヤマデンタル | Rust preventive for hypochlorous acid aqueous solution, sterilizing / cleaning agent with rust preventive effect, and its preparation method |
| WO2022158522A1 (en) | 2021-01-22 | 2022-07-28 | 株式会社トクヤマデンタル | Corrosion inhibitor for hypochlorous acid aqueous solution, bactericidal detergent having corrosion inhibiting effect, and preparation method therefor |
| JP2022112615A (en) * | 2021-01-22 | 2022-08-03 | 株式会社トクヤマデンタル | Corrosion inhibitor for hypochlorous acid aqueous solution, bactericidal detergent having corrosion inhibiting effect, and preparation method therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3607652B2 (en) | 2005-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2843442B2 (en) | Compositions and methods of using them | |
| EP3136861B1 (en) | Composition containing peroxide and an antimicrobial agent and process of killing spores | |
| US6793846B2 (en) | Microbicide compositions | |
| US5320805A (en) | Methods of using a cleaner, sanitizer, disinfectant, fungicide, sporicide, chemical sterilizer | |
| US4715980A (en) | Antimicrobial sanitizing composition containing n-alkyl and n-alkenyl succinic acid and methods for use | |
| EP0844827B1 (en) | Tuberculocidal synergistic disinfectant compositions and methods of disinfecting | |
| CN102459551A (en) | Binary foaming cleaner and disinfectant solution | |
| CN112970752B (en) | Environment-friendly efficient surface disinfectant and preparation method thereof | |
| KR101913718B1 (en) | Compositions for sterilization and disinfection comprising octenidine and benzalconium chloride | |
| JP5095308B2 (en) | Disinfectant composition | |
| JP3607652B2 (en) | Disinfectant composition | |
| JP2004130264A (en) | Method for producing electrolytic water | |
| CA3130812A1 (en) | Ambient moisture-activated surface treatment powder | |
| JP2001311095A (en) | Bactericidal detergent composition | |
| JP2004002229A (en) | Method for sterilization | |
| AU2017306039B2 (en) | Aluminum-compatible compositions for 2-part alkaline disinfectants and sanitizers | |
| US20070286907A1 (en) | Germicide composition | |
| JP2001181115A (en) | Bactericide composition and its method for use | |
| JP3607601B2 (en) | Disinfectant composition | |
| JP3607559B2 (en) | Disinfectant composition | |
| RU2475268C1 (en) | Disinfecting preparation | |
| JP5784964B2 (en) | Disinfectant composition and disinfecting method | |
| JP3607555B2 (en) | Disinfectant composition | |
| WO2012148004A1 (en) | Bactericide composition and bactericidal cleaning composition | |
| WO2001037659A2 (en) | Biocide compositions |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040316 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040517 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20041005 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20041007 |
|
| R151 | Written notification of patent or utility model registration |
Ref document number: 3607652 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R151 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20071015 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081015 Year of fee payment: 4 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20091015 Year of fee payment: 5 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20101015 Year of fee payment: 6 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111015 Year of fee payment: 7 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20121015 Year of fee payment: 8 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131015 Year of fee payment: 9 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |