JP2001521392A - 新規なヒト腫瘍抑制遺伝子 - Google Patents
新規なヒト腫瘍抑制遺伝子Info
- Publication number
- JP2001521392A JP2001521392A JP54456098A JP54456098A JP2001521392A JP 2001521392 A JP2001521392 A JP 2001521392A JP 54456098 A JP54456098 A JP 54456098A JP 54456098 A JP54456098 A JP 54456098A JP 2001521392 A JP2001521392 A JP 2001521392A
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- Ceased
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- C—CHEMISTRY; METALLURGY
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.次のN-末端アミノ酸配列: を含むタンパク質または該タンパク質の生物学的に活性な部分をコードするヌ クレオチド配列を含んでなる、単離されたポリヌクレオチド分子。 2.コードされたタンパク質が次のN-末端アミノ酸配列: を含む、請求項1に記載のポリヌクレオチド分子。 3.コードされたタンパク質がユビキチン−タンパク質リガーゼであり、約300k Daの分子量を有する、請求項1または2に記載のポリヌクレオチド分子。 4.図3Bに示したヌクレオチド34からヌクレオチド8424までのヌクレオチド配列 またはその部分に対して90%以上の相同性を示すヌクレオチド配列を含む、請 求項1〜3のいずれか1項に記載のポリヌクレオチド分子。 5.図3Bに示したヌクレオチド34からヌクレオチド8424までのヌクレオチド配列 またはその部分に対して95%以上の相同性を示すヌクレオチド配列を含む、請 求項1〜3のいずれか1項に記載のポリヌクレオチド分子。 6.図3Bに示したヌクレオチド34からヌクレオチド8424までのヌクレオチド配列 またはその部分に実質的に一致するヌクレオチド配列を含む、請求項1〜3の いずれか1項に記載のポリヌクレオチド分子。 7.図3Bに示したヌクレオチド34からヌクレオチド8424までのヌクレオチド配列 の8ヌクレオチド以上の部分に実質的に一致するかまたは相補的であるヌクレ オチド配列を含んでなる、適切に検出可能な標識で標識されたオリゴヌクレオ チドまたはポリヌクレオチドプローブ。 8.プロモーター配列に機能しうる形で連結された請求項1〜6のいずれか1項 に記載のポリヌクレオチド分子を含有する発現ベクターまたはカセット。 9.請求項1〜6のいずれか1項に記載のポリヌクレオチド分子で安定に形質転 換された非ヒト生物。 10.請求項8に記載の発現ベクターまたはカセットで安定に形質転換された非ヒ ト生物。 11.実質的に純粋な形の、次のN-末端アミノ酸配列: を含むタンパク質または該タンパク質の生物学的に活性な部分。 12.前記タンパク質が次のN-末端アミノ酸配列: を含む、請求項11に記載のタンパク質。 13.前記タンパク質がユビキチンータンパク質リガーゼであり、約300kDaの分子 量を有する、請求項11または12に記載のタンパク質。 14.前記タンパク質が図3Cに示したアミノ酸配列に実質的に一致するアミノ酸配 列を含む、請求項11〜13のいずれか1項に記載のタンパク質。 15.請求項11〜14のいずれか1項に記載のタンパク質またはその抗原性部分と特 異的に結合する抗体またはそのフラグメント。 16.抗pEDD抗体と結合することができるタンパク質またはその抗原性部分。 17.被験者におけるプロゲスチン応答性を評価するためのアッセイ法であって、 (i)被験者から細胞または組織を分離し、そして (ii)図3Cに示したアミノ酸配列に実質的に一致するアミノ酸配列を含むタン パク質の存在を検出する、 ことを含んでなるアッセイ法。 18.ステップ(ii)の前に、分離した細胞または組織をプロゲスチンまたはプロゲ スチンのアゴニストもしくはアンタゴニストにさらす、請求項17に記載のアッ セイ法。 19.請求項15に記載の抗体またはそのフラグメントを用いてステップ(ii)をおこ なう、請求項16または17に記載のアッセイ法。 20.過増殖性疾患を診断する、または過増殖性疾患に罹りやすい素質を判定する 方法であって、被験者において、図3Bに示したヌクレオチド34からヌクレオチ ド8424までのヌクレオチド配列に実質的に一致するヌクレオチド配列を含む遺 伝子の多型または変異を検出することを含んでなり、前記多型または変異が過 増殖性疾患もしくは過増殖性疾患に罹りやすい素質を示すものである、上記方 法。 21.過増殖性疾患が癌である、請求項20に記載の方法。 22.前記癌が乳癌である、請求項21に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU6334 | 1997-04-21 | ||
AUPO6334A AUPO633497A0 (en) | 1997-04-21 | 1997-04-21 | Novel human tumour suppressor gene |
PCT/AU1998/000280 WO1998048010A1 (en) | 1997-04-21 | 1998-04-20 | Novel human tumour suppressor gene |
Publications (1)
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JP2001521392A true JP2001521392A (ja) | 2001-11-06 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP54456098A Ceased JP2001521392A (ja) | 1997-04-21 | 1998-04-20 | 新規なヒト腫瘍抑制遺伝子 |
Country Status (7)
Country | Link |
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US (1) | US7105652B2 (ja) |
EP (1) | EP0979277B1 (ja) |
JP (1) | JP2001521392A (ja) |
AU (1) | AUPO633497A0 (ja) |
CA (1) | CA2287438A1 (ja) |
DE (1) | DE69823022T2 (ja) |
WO (1) | WO1998048010A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2002951346A0 (en) * | 2002-09-05 | 2002-09-26 | Garvan Institute Of Medical Research | Diagnosis of ovarian cancer |
US20090011488A1 (en) * | 2003-08-18 | 2009-01-08 | Rosetta Inpharmatics, Llc | Methods for storing compositions useful for synthesizing nucleic acid molecules |
EP1595945A1 (en) * | 2004-05-14 | 2005-11-16 | Boehringer Ingelheim International GmbH | Screening method for identifying compounds that have the ability to inhibit the activity of Myc |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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EP0865495A4 (en) * | 1995-10-24 | 2001-03-21 | Garvan Inst Med Res | GENE REGULATED BY PROGESTINE |
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1997
- 1997-04-21 AU AUPO6334A patent/AUPO633497A0/en not_active Abandoned
-
1998
- 1998-04-20 CA CA002287438A patent/CA2287438A1/en not_active Abandoned
- 1998-04-20 JP JP54456098A patent/JP2001521392A/ja not_active Ceased
- 1998-04-20 WO PCT/AU1998/000280 patent/WO1998048010A1/en active IP Right Grant
- 1998-04-20 EP EP98916636A patent/EP0979277B1/en not_active Expired - Lifetime
- 1998-04-20 DE DE69823022T patent/DE69823022T2/de not_active Expired - Fee Related
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2002
- 2002-05-16 US US10/151,736 patent/US7105652B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0979277A4 (en) | 2002-10-09 |
EP0979277A1 (en) | 2000-02-16 |
AUPO633497A0 (en) | 1997-05-15 |
WO1998048010A1 (en) | 1998-10-29 |
DE69823022T2 (de) | 2005-03-31 |
US7105652B2 (en) | 2006-09-12 |
EP0979277B1 (en) | 2004-04-07 |
US20020192160A1 (en) | 2002-12-19 |
DE69823022D1 (de) | 2004-05-13 |
CA2287438A1 (en) | 1998-10-29 |
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